• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9283-9289
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• 2014

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. Materials and Methods: This study investigated alterations in the displacement loop (d-loop) region of mitochondrial DNA (mtDNA) as a risk factor and diagnostic biomarker for early detection and diagnosis of acute lymphoblastic leukemia. Using mtDNA from 23 subjects diagnosed with acute lymphoblastic leukemia, the first 450 bp of the d-loop region were amplified and successfully sequenced. Results: This revealed 132 mutations at 25 positions in this region, with a mean of 6 alterations per subject. The d-loop alterations in mtDNA in subjects were all identified as single nucleotide polymorphisms in a homoplasmic distribution pattern. Mutant alleles were observed in all subjects with individual frequency rates of up to 95%. Thirteen mutant alleles in the d-loop region of mtDNA occurred with a high frequency. Novel alleles and locations were also identified in the d-loop of mtDNA as follows: 89 G insertions (40%), 95 G insertions (13%), 182 C/T substitutions (5%), 308 C insertions (19%), and 311 C insertions (80%). The findings of this study need to be replicated to be confirmed. Conclusions: Further investigation of the relationship between mutations in mitochondrial d-loop genes and incidence of acute lymphoblastic leukemia is recommended.

• International Journal of Automotive Technology
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• v.5 no.2
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• pp.109-114
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• 2004

This paper presents a closed-loop evaluation of the Vehicle Stability Control (VSC) system using a vehicle simulator. Human driver-VSC interactions have been investigated under realistic operating conditions in the laboratory. Braking control inputs for vehicle stability enhancement have been directly derived from the sliding control law based on vehicle planar motion equations with differential braking. A driving simulator has been validated using actual vehicle driving test data. Real-time human-in-the loop simulation results in realistic driving situations have shown that the proposed controller reduces driving effort and enhances vehicle stability.

• Annual Conference on Human and Language Technology
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• 2022.10a
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• pp.559-561
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• 2022

Data-centric AI의 발전으로 데이터의 중요성이 나날이 커져가고 있다. 학계, 기업, 정부 모두에서 데이터의 중요성을 인지하여 다양한 연구와 정책이 개발되고 있다. 물론 데이터를 활용하는 능력도 중요하지만, 데이터를 제작하는 능력도 매우 중요한 요소 중 하나이다. 이러한 흐름에 비추어 본 논문은 데이터 제작이 필요한 경우 과제의 도메인과 무관하게 범용적으로 적용 가능하며 데이터를 쉽고 빠르게 효율적으로 구축할 수 있는 human-in-the-loop 데이터 파이프라인을 제안하고자 한다. 이를 통해 기업이 데이터를 설계하고, 제작하는데 드는 시간과 비용 절감하게 하여 운영 효율화를 돕고자 한다.

• Journal of the korean Society of Automotive Engineers
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• v.26 no.4
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• pp.6-10
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• 2004

자동차의 능동안전(Active Safety)을 중요시하는 경향은 1990년대부터 부각되기 시작하였다. 사고발생 후에 피해를 최소화하려는 Passive Safety 기술과 사고를 방지하고 사고의 피해를 줄이는 Active Safety 기술의 효과적인 조합을 통하여 안전을 확보하는 차량을 첨단 안전차량(ASV, Advanced Safety Vehicle)이라 한다.(중략)

• Journal of Drive and Control
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• v.17 no.3
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• pp.76-84
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• 2020

• Biomolecules & Therapeutics
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• v.4 no.1
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• pp.103-109
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• 1996

To investigate the effect of the third intracellular loop (i3 loop) peptide of human $\beta$$_2$-adrenergic receptor on receptor agonist binding, we expressed third intracellular loop region of human $\beta$$_2$-adrenergic receptor as glutathione S-transferase fusion protein in E. coli. DNA fragment of the receptor gene which encodes amino acid 221-274 of human $\beta$$_2$-adrenergic receptor was amplified by polymerase chain reaction and subcloned into the bacterial fusion protein expression vector pGEX-CS and expressed as a form of glutathione-S-transferase (GST) fusion protein in E. coli DH5$\alpha$. The receptor fusion protein was identified by SDS-PAGE and Western blot using monoclonal anti-GST antibody. The fusion protein expressed in this study was purified to an apparent homogeneity by glutathione Sepharose CL-4B affinity chromatography. The purified i3 loop fusion proteins at a concentration of 10 $\mu\textrm{g}$/ι caused right shift of the isoproterenol competition curve of [$^3$H]Dihydroalprenolol binding to hamster lung $\beta$$_2$-adrenergic receptor indicating lowered affinity of isoproterenol to $\beta$$_2$-adrenergic receptor possibly due to the uncoupling of receptor and G protein in the presence of the fusion protein. The uncoupling of receptor and G protein suggests that i3 loop region plays a critical role on $\beta$$_2$-adrenergic receptor G protein coupling.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.137-142
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• 2016

We have successfully synthesized of 4-cyano-1-(2,4-dichlorophenyl)-5-(4-[$^{11}C$]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxzmide ([$^{11}C$]OMAR), which has been shown a progressing candidate to human brain PET study, from fully automated loop method using ethanol as the only solvent for the entire manufacturing process. The radiochemical yield of [$^{11}C$]OMAR was observed in $4.1{\pm}0.2%$ with $4990{\pm}384Ci/mmol$ of the specific activity and total synthesis time was about 45 minutes after HPLC purification (n = 3, decay corrected) from ethanolic loop system, which was exhibited to better results compared with conventional methods. Ethanolic loop chemistry is favorable and efficient method by simplifies manufacturing procedures as well as satisfied suitable for human administration.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.63 no.3
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• pp.404-408
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• 2014

In this research we evaluate the excitation homogeneity and SAR of three different Tx arrays after B1+ Shimming in the human body at 3T. Through the simulations, we compared the field properties that are standard deviation and mean value of transverse magnetization for 1) strip line TEM array, 2) rectangular loop array, 3) combined array of strip line element and rectangular loop and shown the utilities of B1+ shimming in human body model. After B1+ shimming, it is evaluated four different types of SAR for body mesh through whole body simulation; those are average, maximum 1-cell, maximum 1-gram, and maximum 10-gram SAR. It appears that in this particular comparison an array based on strip line elements can produce better homogeneity and lower SAR than an array of rectangular loops or an array of combined elements (strip line and loop). While many factors are considered in designing coils for production, it is hoped that methods and results like these will be used in the future to guide decisions and maximize benefit.

• Korean System Dynamics Review
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• v.2 no.2
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• pp.63-84
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• 2001

There are many activities to improve Nuclear Power Plant(NPP) performance and safety such as equipment improvement, redundancy and the like. Since public perception about NPP safety affects nuclear policy of site selection. Recent researches for NPP safety are including not only technical approaches but also social ones. In. this contexture, the purpose of this study is to develope cuassal loop digaram for assessment of organizational and human factors in NPP safety. Through real data from interview with NPP employees we develope causal loop diagram which can explain the relations of cause and effect among variables, and depict social system for organizational and human factors in NPP safety.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.8
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• pp.739-747
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• 2015

With rapid growth in the technologies and demand of Remotely Piloted Aircraft Systems (RPASs), integration of such systems into the existing airspace system is becoming an issue in many countries. RPAS have different flight performances, communication characteristics, separation assurance mechanisms, and human machine interfaces from manned aircraft. To establish rules and regulations for RPAS integration, it is important to understand the impacts of RPASs on the airspace system. A simulation system that integrates manned aircraft, air traffic control, and RPASs is developed in Inha University to investigate these impacts through Human-in-The-Loop (HiTL) simulations. Three conflict resolution scenarios between a manned aircraft and a Remotely Piloted Aircraft (RPA) were constructed and tested. Human factors such as the response times of pilots and controllers were measured and analyzed as well as the risk of each maneuver.