• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9283-9289
• /
• 2014

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. Materials and Methods: This study investigated alterations in the displacement loop (d-loop) region of mitochondrial DNA (mtDNA) as a risk factor and diagnostic biomarker for early detection and diagnosis of acute lymphoblastic leukemia. Using mtDNA from 23 subjects diagnosed with acute lymphoblastic leukemia, the first 450 bp of the d-loop region were amplified and successfully sequenced. Results: This revealed 132 mutations at 25 positions in this region, with a mean of 6 alterations per subject. The d-loop alterations in mtDNA in subjects were all identified as single nucleotide polymorphisms in a homoplasmic distribution pattern. Mutant alleles were observed in all subjects with individual frequency rates of up to 95%. Thirteen mutant alleles in the d-loop region of mtDNA occurred with a high frequency. Novel alleles and locations were also identified in the d-loop of mtDNA as follows: 89 G insertions (40%), 95 G insertions (13%), 182 C/T substitutions (5%), 308 C insertions (19%), and 311 C insertions (80%). The findings of this study need to be replicated to be confirmed. Conclusions: Further investigation of the relationship between mutations in mitochondrial d-loop genes and incidence of acute lymphoblastic leukemia is recommended.

• International Journal of Automotive Technology
• /
• 제5권2호
• /
• pp.109-114
• /
• 2004

This paper presents a closed-loop evaluation of the Vehicle Stability Control (VSC) system using a vehicle simulator. Human driver-VSC interactions have been investigated under realistic operating conditions in the laboratory. Braking control inputs for vehicle stability enhancement have been directly derived from the sliding control law based on vehicle planar motion equations with differential braking. A driving simulator has been validated using actual vehicle driving test data. Real-time human-in-the loop simulation results in realistic driving situations have shown that the proposed controller reduces driving effort and enhances vehicle stability.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
• /
• 한국정보과학회언어공학연구회 2022년도 제34회 한글 및 한국어 정보처리 학술대회
• /
• pp.559-561
• /
• 2022

Data-centric AI의 발전으로 데이터의 중요성이 나날이 커져가고 있다. 학계, 기업, 정부 모두에서 데이터의 중요성을 인지하여 다양한 연구와 정책이 개발되고 있다. 물론 데이터를 활용하는 능력도 중요하지만, 데이터를 제작하는 능력도 매우 중요한 요소 중 하나이다. 이러한 흐름에 비추어 본 논문은 데이터 제작이 필요한 경우 과제의 도메인과 무관하게 범용적으로 적용 가능하며 데이터를 쉽고 빠르게 효율적으로 구축할 수 있는 human-in-the-loop 데이터 파이프라인을 제안하고자 한다. 이를 통해 기업이 데이터를 설계하고, 제작하는데 드는 시간과 비용 절감하게 하여 운영 효율화를 돕고자 한다.

• 오토저널
• /
• 제26권4호
• /
• pp.6-10
• /
• 2004

자동차의 능동안전(Active Safety)을 중요시하는 경향은 1990년대부터 부각되기 시작하였다. 사고발생 후에 피해를 최소화하려는 Passive Safety 기술과 사고를 방지하고 사고의 피해를 줄이는 Active Safety 기술의 효과적인 조합을 통하여 안전을 확보하는 차량을 첨단 안전차량(ASV, Advanced Safety Vehicle)이라 한다.(중략)

• 드라이브 ㆍ 컨트롤
• /
• 제17권3호
• /
• pp.76-84
• /
• 2020

• Biomolecules & Therapeutics
• /
• 제4권1호
• /
• pp.103-109
• /
• 1996

To investigate the effect of the third intracellular loop (i3 loop) peptide of human $\beta$$_2$-adrenergic receptor on receptor agonist binding, we expressed third intracellular loop region of human $\beta$$_2$-adrenergic receptor as glutathione S-transferase fusion protein in E. coli. DNA fragment of the receptor gene which encodes amino acid 221-274 of human $\beta$$_2$-adrenergic receptor was amplified by polymerase chain reaction and subcloned into the bacterial fusion protein expression vector pGEX-CS and expressed as a form of glutathione-S-transferase (GST) fusion protein in E. coli DH5$\alpha$. The receptor fusion protein was identified by SDS-PAGE and Western blot using monoclonal anti-GST antibody. The fusion protein expressed in this study was purified to an apparent homogeneity by glutathione Sepharose CL-4B affinity chromatography. The purified i3 loop fusion proteins at a concentration of 10 $\mu\textrm{g}$/ι caused right shift of the isoproterenol competition curve of [$^3$H]Dihydroalprenolol binding to hamster lung $\beta$$_2$-adrenergic receptor indicating lowered affinity of isoproterenol to $\beta$$_2$-adrenergic receptor possibly due to the uncoupling of receptor and G protein in the presence of the fusion protein. The uncoupling of receptor and G protein suggests that i3 loop region plays a critical role on $\beta$$_2$-adrenergic receptor G protein coupling.

• 대한방사성의약품학회지
• /
• 제2권2호
• /
• pp.137-142
• /
• 2016

We have successfully synthesized of 4-cyano-1-(2,4-dichlorophenyl)-5-(4-[$^{11}C$]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxzmide ([$^{11}C$]OMAR), which has been shown a progressing candidate to human brain PET study, from fully automated loop method using ethanol as the only solvent for the entire manufacturing process. The radiochemical yield of [$^{11}C$]OMAR was observed in $4.1{\pm}0.2%$ with $4990{\pm}384Ci/mmol$ of the specific activity and total synthesis time was about 45 minutes after HPLC purification (n = 3, decay corrected) from ethanolic loop system, which was exhibited to better results compared with conventional methods. Ethanolic loop chemistry is favorable and efficient method by simplifies manufacturing procedures as well as satisfied suitable for human administration.

• 전기학회논문지
• /
• 제63권3호
• /
• pp.404-408
• /
• 2014

In this research we evaluate the excitation homogeneity and SAR of three different Tx arrays after B1+ Shimming in the human body at 3T. Through the simulations, we compared the field properties that are standard deviation and mean value of transverse magnetization for 1) strip line TEM array, 2) rectangular loop array, 3) combined array of strip line element and rectangular loop and shown the utilities of B1+ shimming in human body model. After B1+ shimming, it is evaluated four different types of SAR for body mesh through whole body simulation; those are average, maximum 1-cell, maximum 1-gram, and maximum 10-gram SAR. It appears that in this particular comparison an array based on strip line elements can produce better homogeneity and lower SAR than an array of rectangular loops or an array of combined elements (strip line and loop). While many factors are considered in designing coils for production, it is hoped that methods and results like these will be used in the future to guide decisions and maximize benefit.

• 한국항공우주학회지
• /
• 제43권8호
• /
• pp.739-747
• /
• 2015

무인항공기시스템 수요의 증가와 기술의 급격한 발전에 따라, 많은 국가들에서 기존의 공역 시스템에 무인항공기를 통합하려는 시도가 이루어지고 있다. 통합 운용을 위한 규정을 제정하기 위해서는 비행성능의 차이, 통제와 통신의 특징, 항공기간 분리 방법, 인간과 기계의 상호작용과 같은 무인항공기의 통합이 전체 시스템에 끼치는 영향에 대한 이해가 중요하다. 인하대학교에서는 공역 내에서의 무인항공기의 영향을 실제 운용 인력이 참여하는 Human-in-The-Loop(HiTL) 시뮬레이션을 통하여 연구할 수 있는 항공관제시뮬레이션 시스템을 개발하였다. 본 논문에서는 이를 이용하여 무인항공기와 유인기가 조우하는 3가지의 시나리오를 설정하고, 관제사의 관제명령을 통하여 위험 상황을 해결하는 시험을 진행하여 조종사와 관제사의 반응 속도와 각 기동에 대한 위험도를 분석한 과정과 결과를 제시한다.

• 한국시스템다이내믹스연구
• /
• 제2권2호
• /
• pp.63-84
• /
• 2001

There are many activities to improve Nuclear Power Plant(NPP) performance and safety such as equipment improvement, redundancy and the like. Since public perception about NPP safety affects nuclear policy of site selection. Recent researches for NPP safety are including not only technical approaches but also social ones. In. this contexture, the purpose of this study is to develope cuassal loop digaram for assessment of organizational and human factors in NPP safety. Through real data from interview with NPP employees we develope causal loop diagram which can explain the relations of cause and effect among variables, and depict social system for organizational and human factors in NPP safety.