• 제목/요약/키워드: Human Response Model

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Comparison of porcine and human acellular dermal matrix outcomes in wound healing: a deep dive into the evidence

  • Saricilar, Erin Cihat;Huang, Sarah
    • Archives of Plastic Surgery
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    • 제48권4호
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    • pp.433-439
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    • 2021
  • Acellular dermal matrices (ADM) are a novel graft. The goal of this systematic review is to evaluate the evidence behind differences in human and porcine ADM, irrelevant of manufacturing method, and to determine if there is enough of an evidence base to change clinical practice. An extensive literature search was performed through MEDLINE and Embase with search terms defining a population, intervention and outcome. Title and abstract exclusion were performed with other exclusion criteria. In 191 articles were found after exclusion of duplicates, with only 29 remaining following exclusions. Ten studies were found to have level I and II evidence (I=3, II=8), of which two were histopathological, one was an animal model, one was a systematic review, and six were clinical. The remaining studies were reviewed and considered for discussion, but did not hold high enough standards for medical evidence. Strong clinical evidence already exists for the use of human ADM, but questions of access, cost, and ethics require consideration of a xenograft. Histopathologically, evidence suggests minimal long-term differences between human and porcine ADM, although there is a short acute immune response with porcine ADM. Clinically, there is limited difference in outcomes, with a small range in effect of different ADM preparations. Considering the effectiveness of ADM in wound healing, more high-level research with appropriate statistical analysis to facilitate a future meta-analysis is recommended to justify a transition from human to porcine ADM.

치과용 레이저 조사가 배양 치수 섬유모세포에 미치는 영향에 관한 연구 (The EFFECTS OF DENTAL LASER ON PULP FIBROBLAST IN VITRO)

  • 정혜전;민병순
    • Restorative Dentistry and Endodontics
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    • 제22권2호
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    • pp.519-535
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    • 1997
  • The responses of human pulp fibroblastic cells to Ga-As Semi-Conductor-Dens-Bio Laser (Frequency: 5 Hz~10,000 Hz Model: SD-101A RCA, U.SA)) were examined in vitro using pulp fibroblastic cells obtained from the pulp tissue of human tooth. The mitogenic effect of soft laser was assessed by measuring the MTT assay. The morphologic effect for soft laser showed under the scanning and transmission electron microscopy. The results as follows; 1. The mitogenic response of the soft laser was not observed until 4th time of radiation, while the mitogenic response at 4th time increased mitogenic effect by as much as 1.7 fold compared to the control value. 2. The mitogenic response of the soft laser on pulp fibroblast differ from the mitogenic response on other fibroblasts. 3. In scanning electron microscopic study, The microvilli of cell surface increased gradually with width and length after laser radiation, it demonstrate that development of microvilli have close connection with differentiation of cells. 4. Under the transmission electron microscope, The laser-treated cells maintained their elongated shape and a high degree of cellular polarization. The large cell body containing a well developed Golgi complex, a large number of profiles of rough endoplasmic reticulum, and great numbers of mitochondria. 5. The laser-treated cells maintained the long straight bundles of closely apposed microfilaments or individual filaments forming a cross-linked network. These findings suggest that the laser may have important roles in promotion of pulp healing and consequently may be useful for clinical application in pulp regenerative procedures.

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Human Postural Dynamics in Response to the Horizontal Vibration

  • Shin Young-Kyun;Fard Mohammad A.;Inooka Hikaru;Kim Il-Hwan
    • International Journal of Control, Automation, and Systems
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    • 제4권3호
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    • pp.325-332
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    • 2006
  • The dynamic responses of human standing postural control were investigated when subjects were exposed to long-term horizontal vibration. It was hypothesized that the motion of standing posture complexity mainly occurs in the mid-sagittal plane. The motor-driven support platform was designed as a source of vibration. The AC Servo-controlled motors produced anterior/posterior (AP) motion. The platform acceleration and the trunk angular velocity were used as the input and the output of the system, respectively. A method was proposed to identify the complexity of the standing posture dynamics. That is, during AP platform motion, the subject's knee, hip and neck were tightly constrained by fixing assembly, so the lower extremity, trunk and head of the subject's body were individually immovable. Through this method, it was assumed that the ankle joint rotation mainly contributed to maintaining their body balance. Four subjects took part in this study. During the experiment, the random vibration was generated at a magnitude of $0.44m/s^2$, and the duration of each trial was 40 seconds. Measured data were estimated by the coherence function and the frequency response function for analyzing the dynamic behavior of standing control over a frequency range from 0.2 to 3 Hz. Significant coherence values were found above 0.5 Hz. The estimation of frequency response function revealed the dominant resonance frequencies between 0.60 Hz and 0.68 Hz. On the basis of our results illustrated here, the linear model of standing postural control was further concluded.

Development of A Performance Model of the Foodservice Industry

  • Seo, Kyung Hwa;Jeon, Yu Jung Jennifer;Lee, Soo Bum
    • 한국조리학회지
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    • 제22권6호
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    • pp.132-144
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    • 2016
  • This study reviewed previous researches about the competence selection of foodservice firms, and shows firm's performance model through the results. The study classified factors according to core competence, differentiation strategy, and management performance. Out of 400 survey responses from by the firm's executive and employees who had worked for over three years at the headquarters (sales, financial, marketing/plan, R & D, etc.), a total of 302 questionnaires were used for the final analysis due to missing values and biased responses (response rate: 75.5%). As the results of analyzing final research model of this study, it appeared that ${\chi}^2(df=170)=384.88$, ${\chi}^2/df=2.26$, GFI=0.90, NFI=0.92, CFI=0.95, RMSEA=0.07. The results indicated that the CEO leadership, organizational culture, and human resource competencies are a driving force in all aspects of competitive advantage differentiation strategies. In addition, the R & D innovation, service, and marketing differentiation strategies are positively related to performance. The results validate the fact that foodservice firms could reinforce strategic decisions through a variety core competencies and achieve continuous performance through competitive strategies.

On the properties of brain sub arachnoid space and biomechanics of head impacts leading to traumatic brain injury

  • Saboori, Parisa;Sadegh, Ali
    • Advances in biomechanics and applications
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    • 제1권4호
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    • pp.253-267
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    • 2014
  • The human head is identified as the body region most frequently involved in life-threatening injuries. Extensive research based on experimental, analytical and numerical methods has sought to quantify the response of the human head to blunt impact in an attempt to explain the likely injury process. Blunt head impact arising from vehicular collisions, sporting injuries, and falls leads to relative motion between the brain and skull and an increase in contact and shear stresses in the meningeal region, thereby leading to traumatic brain injuries. In this paper the properties and material modeling of the subarachnoid space (SAS) as it relates to Traumatic Brain Injuries (TBI) is investigated. This was accomplished using a simplified local model and a validated 3D finite element model. First the material modeling of the trabeculae in the Subarachnoid Space (SAS) was investigated and validated, then the validated material property was used in a 3D head model. In addition, the strain in the brain due to an impact was investigated. From this work it was determined that the material property of the SAS is approximately E = 1150 Pa and that the strain in the brain, and thus the severity of TBI, is proportional to the applied impact velocity and is approximately a quadratic function. This study reveals that the choice of material behavior and properties of the SAS are significant factors in determining the strain in the brain and therefore the understanding of different types of head/brain injuries.

시간지연을 갖는 로미오와 줄리엣의 사랑모델에서의 거동해석 (Behavior Analysis in Love Model of Romeo and Juliet with Time Delay)

  • 황림운;배영철
    • 한국지능시스템학회논문지
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    • 제25권2호
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    • pp.155-160
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    • 2015
  • 사람은 감정을 가진 동물이라고 말한다. 사람의 감정은 다양한 종류가 있으며 그 중 하나인 사랑은 사회학과 심리학에서 주된 관심사로 연구되어 왔다. 본 논문에서는 로미오와 줄리엣의 사랑 방정식에서 시간 지연 요소를 사랑에 대한 반응시간으로 가정하여 반영하였다. 줄리엣에만 시간지연이 있는 경우, 로미오에만 시간지연이 있는 경우, 로미오와 줄리엣 모두에 시간지연이 있는 경우를 고려하여 이들의 거동을 시계열과 위상 공간으로 나타내고 이들 사이의 차이를 분석하였다.

Violent crowd flow detection from surveillance cameras using deep transfer learning-gated recurrent unit

  • Elly Matul Imah;Riskyana Dewi Intan Puspitasari
    • ETRI Journal
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    • 제46권4호
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    • pp.671-682
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    • 2024
  • Violence can be committed anywhere, even in crowded places. It is hence necessary to monitor human activities for public safety. Surveillance cameras can monitor surrounding activities but require human assistance to continuously monitor every incident. Automatic violence detection is needed for early warning and fast response. However, such automation is still challenging because of low video resolution and blind spots. This paper uses ResNet50v2 and the gated recurrent unit (GRU) algorithm to detect violence in the Movies, Hockey, and Crowd video datasets. Spatial features were extracted from each frame sequence of the video using a pretrained model from ResNet50V2, which was then classified using the optimal trained model on the GRU architecture. The experimental results were then compared with wavelet feature extraction methods and classification models, such as the convolutional neural network and long short-term memory. The results show that the proposed combination of ResNet50V2 and GRU is robust and delivers the best performance in terms of accuracy, recall, precision, and F1-score. The use of ResNet50V2 for feature extraction can improve model performance.

Tuned mass dampers for human-induced vibration control of the Expo Culture Centre at the World Expo 2010 in Shanghai, China

  • Lu, Xilin;Ding, Kun;Shi, Weixing;Weng, Dagen
    • Structural Engineering and Mechanics
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    • 제43권5호
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    • pp.607-621
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    • 2012
  • The Expo Culture Centre is one of the permanent buildings at the World Expo 2010 in Shanghai, China. The main structure has an oval shape and consists of 36 radial cantilever steel trusses with different lengths and inner frames made of concrete-filled rectangular steel tube members. Tuned mass dampers are used to reduce the excessive vibrations of the sixth floor that are caused by human-induced resonance. A three-dimensional analytical model of the system is developed, and its main characteristics are established. A series of field tests are performed on the structure, and the test results show that the vertical vibration frequencies of most structural cantilevers are between 2.5 Hz and 3.5 Hz, which falls in the range of human-induced vibration. Twelve pairs of tuned mass dampers weighing 115 tons total were installed in the structure to suppress the vibration response of the system. These mass dampers were tuned to the vertical vibration frequency of the structure, which had the highest possibility of excitation. Test data obtained after the installation of the tuned mass dampers are used to evaluate their effectiveness for the reduction of the vibration acceleration. An analytical model of the structure is calibrated according to the measured dynamic characteristics. An analysis of the modified model is performed and the results show that when people walk normally, the structural vibration was low and the tuned mass dampers have no effect, but when people run at the structural vibration frequency, the tuned mass dampers can reduce the floor vibration acceleration by approximately 15%.

Structural behavior of arch dams considering experimentally validated prototype model using similitude and scaling laws

  • Altunisik, Ahmet Can;Kalkan, Ebru;Basaga, Hasan B.
    • Computers and Concrete
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    • 제22권1호
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    • pp.101-116
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    • 2018
  • As one of the most important engineering structures, arch dams are huge constructions built with human hands and have strategical importance. Because of the fact that long construction duration, water supply, financial reasons, major loss of life and material since failure etc., the design of arch dams is very important problem and should be done by expert engineers to determine the structural behavior more accurately. Finite element analyses and non-destructive experimental measurements can be used to investigate the structural response, but there are some difficulties such as spending a long time while modelling, analysis and in-situ testing. Therefore, it is more useful to conduct the research on the laboratory conditions and to transform the obtained results into real constructions. Within the scope of this study, it is aimed to determine the structural behavior of arch dams considering experimentally validated prototype laboratory model using similitude and scaling laws. Type-1 arch dam, which is one of five arch dam types suggested at the "Arch Dams" Symposium in England in 1968 is selected as reference prototype model. The dam is built considering dam-reservoir-foundation interaction and ambient vibration tests are performed to validate the finite element results such as dynamic characteristics, displacements, principal stresses and strains. These results are considered as reference parameters and used to determine the real arch dam response with different scales factors such as 335, 400, 416.67 and 450. These values are selected by considering previously examined dam projects. Arch heights are calculated as 201 m, 240 m, 250 m and 270 m, respectively. The structural response is investigated between the model and prototype by using similarity requirements, field equations, scaling laws etc. To validate these results, finite element models are enlarged in the same scales and analyses are repeated to obtain the dynamic characteristics, displacements, principal stresses and strains. At the end of the study, it is seen that there is a good agreement between all results obtained by similarity requirements with scaling laws and enlarged finite element models.

Using machine learning to forecast and assess the uncertainty in the response of a typical PWR undergoing a steam generator tube rupture accident

  • Tran Canh Hai Nguyen ;Aya Diab
    • Nuclear Engineering and Technology
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    • 제55권9호
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    • pp.3423-3440
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    • 2023
  • In this work, a multivariate time-series machine learning meta-model is developed to predict the transient response of a typical nuclear power plant (NPP) undergoing a steam generator tube rupture (SGTR). The model employs Recurrent Neural Networks (RNNs), including the Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and a hybrid CNN-LSTM model. To address the uncertainty inherent in such predictions, a Bayesian Neural Network (BNN) was implemented. The models were trained using a database generated by the Best Estimate Plus Uncertainty (BEPU) methodology; coupling the thermal hydraulics code, RELAP5/SCDAP/MOD3.4 to the statistical tool, DAKOTA, to predict the variation in system response under various operational and phenomenological uncertainties. The RNN models successfully captures the underlying characteristics of the data with reasonable accuracy, and the BNN-LSTM approach offers an additional layer of insight into the level of uncertainty associated with the predictions. The results demonstrate that LSTM outperforms GRU, while the hybrid CNN-LSTM model is computationally the most efficient. This study aims to gain a better understanding of the capabilities and limitations of machine learning models in the context of nuclear safety. By expanding the application of ML models to more severe accident scenarios, where operators are under extreme stress and prone to errors, ML models can provide valuable support and act as expert systems to assist in decision-making while minimizing the chances of human error.