• 한국정밀공학회지
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• 제25권9호
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• pp.126-134
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• 2008

Kendo is one of the popular sports in modem life. Head, wrist and thrust attack are the fast skill to get a score on a match. Human muscle skeletal model was developed for biomechanical study. The human model was consists with 19 bone-skeleton and 122 muscles. Muscle number of upper limb, trunk and lower limb part are 28, 60, 34 respectively. Bone was modeled with 3D beam element and muscle was modeled with spar element. For upper limb muscle modelling, rectus abdominis, trapezius, deltoideus, biceps brachii, triceps brachii muscle and other main muscles were considered. Lower limb muscle was modeled with gastrocenemius, gluteus maximus, gluteus medius and related muscles. The biomechanical stress and strain analysis of human muscle was conducted by proposed human bone-muscle finite element analysis model under head, wrist and thrust attack for kendo training.

• 한국정밀공학회지
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• 제24권11호
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• pp.116-125
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• 2007

Human muscle skeletal model was developed for biomechanical study. The human model was consists with 19 bone-skeleton and 122 muscles. Muscle number of upper limb, trunk and lower limb part are 28, 60, 34 respectively. Bone was modeled with 3D beam element and muscle was modeled with spar element. For upper limb muscle modelling, rectus abdominis, trapezius, deltoideus, biceps brachii, triceps brachii muscle and other main muscles were considered. Lower limb muscle was modeled with gastrocenemius, gluteus maximus, gluteus medius and related muscles. The biomechanical stress and strain analysis of human was conducted by proposed finite element analysis model under Kumdo head hitting motion. In this study structural analysis has been performed in order to investigate the human body impact by Kumdo head hitting motion. As the results, the analytical displacement, stress and strain of human body are presented.

• Journal of Mechanical Science and Technology
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• 제15권7호
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• pp.982-994
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• 2001

Commercially available software packages permit to position human models of various geometries in practical scenarios while respecting the anatomical constraints of the skeletal joints and of the bulk of the bodies. Beyond such features, the PAM-Comfort(sup)TM software has been conceived to provide direct access to the muscular forces needed by humans to perform physical actions where muscle force is required. The PAM-Comfort(sup)TM human models are made of multi-body linked anatomical skeletons, equipped with finite elements of the relevant skeletal muscles. The hyper-static problem of determination of muscle forces is solved by optimisation technique. Voluntary stiffening of muscles can be added to the basic contraction levels needed to perform a specific task. The calculated muscle forces obey Hills model. The model and software have been applied in several interesting scenarios of various fields of application, such as car industry, handling of equipment and sports activities.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.261-267
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• 2000

A mathematical model was developed to calculate the muscle force of lower extremity during the gait. We constructed a model of human locomotion, which includes a muscle-skeletal system with 7 segments and 16 lower limb muscles. Using a optimization technique, muscle forces variation of the lower extremity during the gait were generated and its result was verified by comparing a experimental results of EMG analysis. Moreover. the walking movement of the model could be compared quantitatively with those of experimental studies in human by inverse dynamics.

• 대한기계학회논문집A
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• 제35권7호
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• pp.785-790
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• 2011

본 연구에서는 인체의 하지부를 다물체 시스템으로 모델링하여 무릎관절에 걸리는 구속력의 불확실성을 추정하였다. 일반적으로 근육의 기계적인 특성은 Hill-type muscle model 이 사용되며 여기에 적용되는 인체의 특성과 해부학적인 데이터는 지난 십 수년 동안 크게 발전되었다. 그러나 정확하게 그것들을 안다는 것은 불가능하며 개인마다 다른점을 고려해야 할 필요가 있다. 본 논문에서는 Hill-type muscle model 과 함께 인체의 해부학적인 데이터를 통계 방법론을 이용하여 무릎 관절에 걸리는 구속력의 불확실성을 추정하였다. 초기 앉아있는 자세에서 일어서는 과정에서 작용하는 구속력을 추정하였으며 이때 인체 하지 근육의 특성을 musculoskeleton-actuator 를 이용하여 해석하였다.

• 약학회지
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• 제45권1호
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• pp.108-115
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• 2001

We have recently reported the development of a high efficiency expression vector, pCK, which can drive a high level of gene expression in mouse skeletal muscle. In this study, we tested the therapeutic potential of pCK expressing human VEGF165, pCK-VEGF in the rabbit ischemic hind limb model. To determine the optimal dose of plasmid DNA, various concentrations of pCK-CAT were injected into the muscle of a rabbit hind limb and the levels of CAT activity were determined. It was found that the expression level of the exogenously added gene became stable between 250 and 1,000 $\mu$g. Based on this result, we tested whether intramuscular transfer of 500$\mu$g of pCK-VEGF could actually modulate collateral vessel development in a rabbit ischemic hind limb model. It was found that relative to the control group injected with the pCK lacking the VEGF sequence, single intramuscular doses (500$\mu$g) of pCK-VEGF produced statistically significant augmentation of collateral vessels as determined by the angiographic vessel count, maximal blood flow by Doppler flowmeter and the number of capillaries by histology. These results suggest that a single 500$\mu$g-delivery of pCK-VEGF is potent enough to induce sufficient angiogenic activity and achieve therapeutic benefit on this rabbit model.

• 한국식품영양학회지
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• 제30권2호
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• pp.371-377
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• 2017

Muscle atrophy is characterized by a decrease in the mass of the muscle. With an increase in life expectancy and chronic illnesses, the incidence of muscle atrophy is increasing and the quality of life of patients is decreasing. Thus, reducing muscle atrophy is of high clinical and socio-economic importance. Mistletoe is a semi-parasitic plant that has been used as a traditional medicine in many countries to treat various human illnesses. It has been reported that Korean mistletoe extract (KME) has diverse biological functions including anti-tumor, anti-oxidant, anti-diabetic, anti-obesity properties, and extension of lifespan. Especially, we have recently reported that KME improves exercise endurance in mice, indicating its beneficial roles in enhancing the capacity of skeletal muscle. In this study, we investigated whether KME could activate the signaling pathway related to protein synthesis in a mouse model of muscle atrophy. Interestingly, KME efficiently activated the Akt/mTOR pathway, and Akt and mTOR are important signaling hub molecules for the acceleration of protein synthesis in muscle cells. In addition, KME also increased the activity of S6 kinase which is involved in the regulation of muscle cell size. Moreover, the ERK activity, required for transcription of ribosomal RNA for protein synthesis, was also enhanced in KME-treated mouse muscle. These data support the idea that KME increases muscle mass via increased protein synthesis. Our findings also suggest that Korean mistletoe might be a promising candidate for the development of functional foods that are beneficial for preventing muscle atrophy.

• 비파괴검사학회지
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• 제31권5호
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• pp.494-499
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• 2011

인체 근골격 시스템에 대한 다물체 동역학 모델을 이용한 동작중의 인체 내부의 생체역학 분석 및 평가 기술에 대하여 기술하였다. 의료영상과 사체실험 결과를 기본으로 하는 인체 다물체 동역학 모델과 3차원 동작분석 시스템을 이용한 인체 동작분석기술을 이용하여 생체내 발생하는 관절기구학, 관절모멘트 관절접촉력 및 근력을 예측하는 기술을 보행과 팔굽혀펴기 두 동작에 적용하였다. 본 연구에서 개발한 인체 다물체 동역학 모델링 기술과 3차원 동작분석기술은 다양한 동작을 수행하는 생체의 분석 및 평가 기술로 활용성이 높을 것으로 생각한다.

• 운동영양학회지
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• 제16권2호
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• pp.65-71
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• 2012

Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

• 대한기계학회논문집A
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• 제41권8호
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• pp.691-701
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• 2017

본 연구에서는 스미스 머신을 이용한 스쿼트 운동에 대한 가상 테스트 프레임웍을 제안하고 구현하였다. 이를 위하여 인체 및 제품의 통합 모델을 개발하고, 실험 데이터를 바탕으로 자세의 변화에 따른 새로운 동작을 생성하는 알고리즘을 개발한 후, 가상의 조건에서 동작을 생성하여 인체의 관절에 걸리는 토크와 근육에 걸리는 힘을 시뮬레이션 하는 전체 시스템을 개발하였다. 이 시스템을 검증하기 위하여 동작 수집과 더불어 EMG와 지면반력에 대한 데이터를 수집하여 시뮬레이션 결과가 실제와 잘 맞는지 확인하였다. 이 시스템을 확장시켜 사용한다면 다양한 조건에서 운동하였을 때 신체 근육과 관절에 어떤 영향을 끼치는 지 시뮬레이션 해봄으로써 적절한 운동 프로그램을 효과적으로 개발할 수 있을 것으로 기대된다.