• Biomolecules & Therapeutics
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• 제25권3호
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• pp.337-343
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• 2017

Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic effect of kahweol is not known. Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which kahweol stimulates ATF3 expression and apoptosis in human colorectal cancer cells. Kahweol increased apoptosis in human colorectal cancer cells. It also increased ATF3 expression through the transcriptional activity. The responsible cis-element for ATF3 transcriptional activation by kahweol was CREB located between -147 to -85 of ATF3 promoter. ATF3 overexpression increased kahweol-mediated cleaved PARP, while ATF3 knockdown attenuated the cleavage of PARP by kahweol. Inhibition of ERK1/2 and $GSK3{\beta}$ blocked kahweol-mediated ATF3 expression. The results suggest that kahweol induces apoptosis through ATF3-mediated pathway in human colorectal cancer cells.

• 보건의료산업학회지
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• 제6권4호
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• pp.153-163
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• 2012

The purpose of this study is to measure IPA(Importance Performance Analysis) of the hospital choice factors between internal and external customers at rural general hospital. This study was used 5 types of choice factor such as physical, human, accessibility, connection, and external image. Also, this study was used IPA which can be applied to identify the strengths and weaknesses quality attributes from customers' viewpoint by simultaneously evaluating importance and performance. IPA was assessed using a sample of 98 patients and 96 internal employees who work at C general hospital in Chunkcheongbuk-do. Data were collected with self-administered questionnaires from February 13 to March 30 in 2012 and analyzed SPSS 18 by using frequency, paired t-test and scatter plot graph. The results of IPA show that "Keep up the good work" quadrant was human factor and "Low Priority" quadrant was physical and connection factors between internal and external customers. The finding of this study will be applied to improve human service quality in administrative department of hospital. Also, this study presents primary data for correct decision making to authorities of local hospitals that have concern about hospital strategy. The implications of this study are discussed and areas for future research are presented.

• 감성과학
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• 제6권2호
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• pp.9-16
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• 2003

본 연구는 인간의 물리적인 요소(머리너비, 가슴너비, 팔길이 등)에 따른 반응속도의 변화에 대해 다룬다. 본 연구에 따르면, 머리 앞뒤 너비나 팔길이 등의 요소들은 반응속도에 영향을 미치지 않았으나, 너비에 해당하는 요소들은 인간의 반응속도에 영향을 미치는 것으로 평가되었다. 본 연구의 결과는 특수상황에 보다 우수한 작업자를 선정하거나, 운동선수를 테스트 없이 우선적으로 선정하는 데 사용될 수 있다. 또한, 본 연구의 결과는 인간정보전달 경로상의 노이즈라고 명명된 채널 노이즈와 시간과의 관계를 규명하기 위한 채널 노이즈 타임분석을 위해 사용될 수 있다.

• 한국생활과학회지
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• 제14권6호
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• pp.1027-1035
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• 2005

The purpose of this study was to investigate the factor of feminization in men's fashion according to Sex Role Stereotype of 20's$\sim$30's mens. The investigators surveyed 260 men who aged twenties and thirties in pusan. For data analysis, we used Chi-Square Test, Factor Analysis, Reliability Analysis, T-test and ANOVA along with SPSS 12.0 package. The results of this study were as followings: First, the result of sex role stereotype according to vital statistics was different with age, scholarship, job, and employer. Androginy type and Undiffer type highly showed most variable. That showed the change of Sex Role Stereotype. Second, the result of the factor of feminization in men's fashion according to Sex Role Stereotype was identified as 'pursuit of fashion,' 'pursuit of sense,' 'feminity,' 'secession of sex role.' Third, the result of the factor of feminization in men's fashion according to the vital statistics was different with scholarship, job, and employer. Forth, the factor of feminization in men's fashion according to sex role stereotype was different with 'pursuit of fashion,' 'pursuit of sense,' 'secession of sex role.' Especially, 'pursuit of fashion' and 'pursuit of sense' was importantly understood with the factor of feminization in men's fashion in Androginy type.

• 한국병원경영학회지
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• 제7권3호
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• pp.102-120
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• 2002

The purpose of study is to understand human-technology integration mechanism by using the study model that takes the core concept and motivation assumptions of technology acceptance model(TAM) into account. This study identifies three motivation mechanisms in adopting or using computer mediated communication(CMC) tool for work. The mechanism comprises with extrinsic, extrinsic motivation, and subjective norm pressure. One hospital with 430 beds and 367 human power was identified and we administered the questionnaire during their work hours. There is 32.4% response rate. The fitting index of the study model surpass the acceptable level, GFI = .980 for none-users, GFI =.986 for users, NNFI = .973 for none-users, and NNFI = .989 for users. In the case of none-users, perceived ease of use determines perceived usefulness that explains behavioral intention to use. As a result, adotpers' usage motivation is based on extrinsic motivation that does not consider their affective factor, attitude, in use of CMC. Users considers their attitudes as the mediating factor of all behavioral beliefs for using CMC continually. Thus, users are likely to depend their adoption behaviors on their affective factor. Moreover, users' behavioral intention is subject to pressures of use from other persons who are important to them, such as supervisor, director, or boss. Achieving human-technology integration in a hospital may cause cost saving and work efficiency. However, the success of information system should base on a profound understanding of employees' adoption behaviors in rejecting, adopting, using, continually using of IT, and organization culture in using IT.

• 한국가스학회지
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• 제4권2호
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• pp.52-57
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• 2000

본 연구에서는 자료를 통한 국내 가스산업시설의 인적오류에 관한 산업재해를 분석하고 국외에서 발전된 정량화 방법을 이용하여 인적 오류 가능성을 예측할 수 있도록, 먼저 PIF(Performance Influencing Factor)분류구조를 바탕으로 보다 객관적이고 정확한 자료를 얻기 위해 평가 Sheet를 제시하였다. 그리고 평가 Sheet를 이용하여 가스산업시설의 인적 오류변수들을 평가하고, 평가 자료를 가지고 정량화 기법을 이용하여 HEP(Human Error Probability)를 산출하게 된다. 마지막으로, 보다 현장 작업자들이 편하고 쉽게 적용시킬 수 있도록 프로그램화를 시켰다. 본 연구의 결과로써 신뢰성 있는 인적오류 D/B를 구축함으로써 이를 공유할 수 있으며, 그리고 인간의 능률을 현저히 향상시킴과 동시에 인적오류감소 전략을 수립하는데 많은 도움이 될 것이다.

• Biomolecules & Therapeutics
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• 제9권4호
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• pp.311-317
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• 2001

YHB6211, a newly developed recombinant human granulocyte colonystimulating factor, was administered at dose levels of 0, 3, 15, and 75 $\mu$g/kg/day intravenously to the pregnant New Zealand White rabbits (20 rabbits per group) during the organogenetic period, days 6 to 18 of gestation. All dams were subjected to Caesarian section on day 28 of gestation and their fetuses were examined for external, visceral, and skeletal abnormalities. No abnormalities in clinical signs, body weight changes, gross findings, mortality, and external appearance were found in all dams and fetuses exposed to 0, 3, and 15 $\mu$g/kg/day of YHB6211. However, in the group treated with 75 $\mu\textrm{g}$/kg/day of YHB6211, maternal body and uterine weights, fetal body weights and length, and the number of live fetuses were significantly decreased and further fetal mortality was remarkably increased. It is suggested that YHB6211 may have no side effect up to the dose level of 15 $\mu$g/kg/day, and there would be no teratogenicity for fetuses of rabbits up to 75 $\mu\textrm{g}$/kg/day even if it may have some toxic effects over 75$\mu\textrm{g}$/kg/day for dams and fetuses of rabbits.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4426-4430
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• 2023

In this article, Exposure Buildup Factor(EBF) and the Energy Absorption Buildup Factor(EABF) have been determined for blood, brain, and muscle using the Monte Carlo method which is represented by MCNP5 codes and compared with geometric progression(G-P) fitting method which is represented by Phy-X/PSD online platform. The novelty of the present work is used an energy source of less than 0.1 MeV to determine buildup factors using MCNP5 and using Phy-X/PSD for some human tissues. thus, the energy range used in this case study was 0.06-3 MeV for penetration depths covered 0.5-3 MFP. Results of MCNP5 and Phy-X/PSD are validated against reference values of water that were reported at ANS-6.4.3. present results of EABFs and EBFs for the previously mentioned human tissues appeared good agreement between MCNP5 in comparison with Phy-X/PSD, whereas, the maximum average relative deviation did not exceed 2.37%. results of our article can be used in different medical applications, such as brachytherapy, radiotherapy, and diagnostics.

• 한국안전학회지
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• 제36권3호
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• pp.60-65
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• 2021

Human error is often in part in the cause of accidents and the result of various factors in an organization. Accidents should be investigated to elucidate all causes. Therefore, to reduce accidents, it is necessary to identify which factors affect human error within the organization. In this study, five groups of influencing factors on human error were selected using previousresearch, and operational definitions were made based on them. In addition, a questionnaire for measuring latent variables by operational definition was developed as an observation variable, and responses were received from employees of chemical companies in Ulsan. Based on SEM (structural equation modeling) analysis, 1) confirmatory factor analysis of variables in the human error model, 2) reliability and validity of latent variables, 3) correlations among latent variables, 4) influencing coefficients among influence factors, and 5) the verification results of the paths that these influencing factors have on human error are introduced in this study.

• The Journal of Asian Finance, Economics and Business
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• 제6권1호
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• pp.321-328
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• 2019

The purpose of the study is to analyze the main approaches to assessing human capital and develop proposals for its most objective assessment of it at the different levels of manifestation - individual, microeconomic and macroeconomic. The article considers the basic approaches to the evaluation of human capital, used in practice: retrospective (costly) and prospective (income based). Cost based methods involve measuring the value of human capital based on the total costs associated with its formation. The proposed additional evaluation criteria, in particular, the use of the expert approach and the developed indicators of a qualitative assessment of the human capital of the enterprise will allow development that is more efficient and use of available human resources. Human capital is becoming a major factor in the formation and development of an innovative economy and knowledge economy. Accordingly, the proposed additions to the assessment of human capital at the country level are aimed at assessing it from a new angle, taking into account the current global trends in the formation of an innovative economy and digitalization. They meet qualitatively new requirements for human capital as the main productive factor in the creation of new highly efficient technologies that promote the active development of the social sphere, science, education, health, etc.