• International Journal of Oral Biology
• /
• v.30 no.3
• /
• pp.105-110
• /
• 2005

Periodontitis is a chronic infectious disease that leads to the destruction, one of the major cause of tooth loss in human. Osteoclast Differentiation Factor(ODF), also called as Receptor activator of NF-${\kappa}B$ ligand(RANKL), a surface-associated ligand on bone marrow stromal cells and osteoblasts, activates its cognate receptor RANK on osteoclast progenitor cells, which leads to differentiation of these mononucleated precursor cells. Osteoprotegerin(OPG), a decoy receptor, is released from stromal cells and osteoblasts to inhibit the interaction between RANKL and RANK. The experiment for the effect of pregnancy on gingival health showed greater gingival inflammation and edema during pregnancy, despite similar plaque index. There should be many factors affecting the periodontal health in pregnancy. In this experiment, we examined the direct effects of sex hormones(estrogen and progesterone) on the ODF/OPG expression in human gingival fibroblasts and periodontal ligament cells at the serum concentration of pregnancy. The ratio was high in the 1st trimester of pregnancy by estrogen and in the late 2nd trimester by progesterone. Therefore, the local periodontal destruction might be accelerated by these hormonal effect on the periodontal cells.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.37 no.1
• /
• pp.26-32
• /
• 2014

Mental fatigue is inevitable in the workplace. Since mental fatigue can lead to decreased efficiency and critical accidents, it is important to manage mental fatigue from the viewpoint of accident prevention. An experiment was performed to evaluate mental fatigue using the formant frequency analysis of human voices. The experimental task was to mentally add or subtract two one-digit numbers. After completing the tasks with four different levels of mental fatigue, subjects were asked to read Korean vowels and their voices were recorded. Five vowel sounds of "아", "어", "오", "우", and "이" from the voice recorded were then used to extract formant 1 frequency. Results of separate ANOVAs showed significant main effects of mental fatigue on formant 1 frequencies of all five vowels concerned. However, post-hoc comparisons revealed that formant 1 frequencies of "아" and "어" were most sensitive to mental fatigue level employed in this experiment. Formant 1 frequencies of "아" and "어" significantly decrease as the mental fatigue accumulates. The formant frequency extracted from human voice would be potentially applicable for detecting mental fatigue induced during industrial tasks.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.1435-1439
• /
• 2004

Most recently, CP(Cellular Phone) has been one of the most important technologies in the IT(Information Tech-nology) field, and it is situated in a position of great importance industrially and economically. To produce the best CP in the world, a new technological concept and its advanced implementation technique is required, due to the extreme level of competition in the world market. The RT(Robot Technology) has been developed as the next generation of a future technology. Current robots require advanced technology, such as soft computing, human-friendly interface, interaction technique, speech recognition, object recognition etc. unlike the industrial robots of the past. Therefore, this paper explains conceptual research for development of the RCP(Robotic Cellular Phone), a new technological concept, in which a synergy effect is generated by the merging of IT & RT. RCP infra consists of $RCP^{Mobility}$ $RCP^{Interaction}$, $RCP^{Integration}$ technologies. For $RCP^{Mobility}$, human-friendly motion automation and personal service with walking and arming ability are developed. $RCP^{Interaction}$ ability is achieved by modeling an emotion-generating engine and $RCP^{Integration}$ that recognizes environmental and self conditions is developed. By joining intelligent algorithms and CP communication network with the three base modules, a RCP system is constructed. Especially, the RCP mobility system is focused in this paper. $RCP^{Mobility}$ is to apply a mobility technology, which is popular robot technology, to CP and combine human-friendly motion and navigation function to CP. It develops a new technological application system of auto-charging and real-world entertainment function etc. This technology can make a CP companion pet robot. It is an automation of human-friendly motions such as opening and closing of CPs, rotation of antenna, manipulation and wheel-walking. It's target is the implementation of wheel and manipulator functions that can give service to humans with human-friendly motion. So, this paper presents the definition, the basic theory and experiment results of the RCP mobility system. We confirm a good performance of the RCP mobility system through the experiment results.

• Development and Reproduction
• /
• v.12 no.2
• /
• pp.141-149
• /
• 2008

This study was conducted to develop an efficient cryopreservation method of human embryonic stem (ES) cells using vitrification. In an initial experiment, sub-clumps of human ES cells (CHA-hES3 and CHA-hES4) were vitrified using grids after incubation with STO feeder cells for 1 or 16 h (Groups 1-1 and 1-2, respectively). After storage for $2{\sim}4$ months, thawed clumps were re-plated on a fresh feeder layer. The survival rates of warmed CHA-hES3 and CHA-hES4 cells of Group 1-2 were significantly higher than those of the corresponding Group 1-1 cells. In the second experiment, human ES cells were vitrified after incubation with feeder or feeder-conditioned medium (Groups 2-1 to -7). Relative mRNA expression of BM proteins and survival rates were increased following incubation of ES cells with fresh feeder cells for 16 h. In conclusion, increasing of tight adhesion between ES cells by extended incubation with feeder could reduce cryoinjury after vitrifying/warming.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.9 no.6
• /
• pp.54-62
• /
• 2010

The scientific analysis of car-pedestrian accidents is not an easy task because of the characteristic of the accidents itself. Since the analysis involved human being, there were few experimental data that could be used for the analysis. The coefficient of friction of human body was the one of crucial data for accident analysis, but no field experiment report was available for various roadway conditions. This study intends to measure the coefficient of friction of human body through field studies. Results showed that the coefficient of friction of human body for dry asphalt pavement conditions was 0.59~0.62, and for dry concrete pavement conditions was 0.59~0.61. In addition, the coefficients for wet asphalt pavement and for wet concrete pavement conditions were 0.56~0.59 and 0.51~0.54 respectively, indicating 5.0% and 8.3% reduction compared to the dry conditions. The deduced coefficients were validated using the simulation program. It has been confirmed that the experiment values were close to the simulation results.

• Journal of Animal Science and Technology
• /
• v.63 no.2
• /
• pp.272-280
• /
• 2021

Cumulus-oocyte complexes (COCs), which contain immature oocytes, are matured in vitro for in vitro embryo production. Oocyte and cumulus cells are then separated using hyaluronidase. To date, there have only been a few reported cases of the toxic effects of hyaluronidase on porcine oocytes. The aim of this study was to compare the effects of bovine testis-derived hyaluronidase and recombinant human hyaluronidase on oocyte denudation and quality. Porcine COCs were matured for 44 h and denuded using different hyaluronidase concentrations and exposure times. Then, oocytes were activated by electrical parthenogenesis. In experiment 1, COCs were denuded using bovine-derived, ovine-derived (Hirax), and human recombinant (ALT-BC4) hyaluronidases for 10 and 20 min. In experiment 2, bovine-derived and human recombinant (ALT-BC4 and ICSI Cumulase®) hyaluronidases were used to denude the COCs for 2 and 20 min. In both experiments the oocytes were all completely denuded, and there was no degeneration. Rate of embryo development was significantly increased in group treated ALT-BC4 for 2 min and not significantly different in other treatment groups. In general it slightly decreased with longer exposure times. These results have confirmed that different sources of hyaluronidase do not have detrimental effects on the quality of porcine oocytes and suggest that the human recombinant hyaluronidase ALT-BC4 is suitable for oocyte denudation with an increased blastocyst rate.

• Development and Reproduction
• /
• v.3 no.1
• /
• pp.39-44
• /
• 1999

In the present study, we investigated the effect of maturity and motility of spermatozoa on the formation of pronuc-leus and subsequent developmental capacity of the human embryo in vitro. The fertilization was performed by means of intracytoplasmic sperm injection (ICSI) in HEPES-buffered m-TCM-199 medium. In the first part of the experiment, motile or im-motile human spermatozoa ejaculated were injected into cumulus-enclosed human oocytes matured in vivo. Significantly (p<0.002) higher proportion of oocytes that was injected with motile spermatozoa formed 2 pronuclei than the oocytes injected with immotile spermatozoa (79.8% vs 51.7%). In the second part of the experiment, cumulus-enclosed human oocytes matured in vivo were injected with motile or immotile spermatozoa collected from testes. There was no difference between motile and immotile spermatozoa. In the third part of the experiment, using modified Tyrode's medium containing 10.0 mM lactate, 0.5 mM pyruvate, 0.2 mM taurine, 1.0 mM glutamine, 2.22 mM MEM amino acids, vitamin and 10% human follicular fluid, we found that the development of oocytes that formed 2 pronuclei were able to develop to 9-16 cells regardless of maturity and motility of spermatozoa.

• Journal of the Korea Society of Computer and Information
• /
• v.23 no.8
• /
• pp.9-16
• /
• 2018

In this paper, a kidnapping detection scheme in which human pose estimation is used to classify accurately between kidnapping cases and normal ones is proposed. To estimate human poses from input video, human's 10 joint information is extracted by OpenPose library. In addition to the features which are used in the previous study to represent the size change rates and the regularities of human activities, the human pose estimation features which are computed from the location of detected human's joints are used as the features to distinguish kidnapping situations from the normal accompanying ones. A frame-based kidnapping detection scheme is generated according to the selection of J48 decision tree model from the comparison of several representative classification models. When a video has more frames of kidnapping situation than the threshold ratio after two people meet in the video, the proposed scheme detects and notifies the occurrence of kidnapping event. To check the feasibility of the proposed scheme, the detection accuracy of our newly proposed scheme is compared with that of the previous scheme. According to the experiment results, the proposed scheme could detect kidnapping situations more 4.73% correctly than the previous scheme.

• International Journal of Internet, Broadcasting and Communication
• /
• v.16 no.1
• /
• pp.47-54
• /
• 2024

With the rapid development of 3D animation, MetaHuman is widely used in film production, game development and VR production as a virtual human creation platform.In the animation production of virtual humans, motion capture is usually used.Since different motion capture solutions use different skeletons for motion recording, when the skeleton level of recorded animation data is different from that of MetaHuman, the animation data recorded by motion capture cannot be directly used on MetaHuman. This requires Reorient the skeletons of both.This study explores an efficient skeleton reorientation method that can maintain the accuracy of animation data by reducing the number of bone chains.In the experiment, three skeleton structures, Rokoko, Mixamo and Xsens were used for efficient redirection experiments, to compare and analyze the adaptability of different skeleton structures to the MetaHuman skeleton, and to explore which skeleton structure has the highest compatibility with the MetaHuman skeleton.This research provides an efficient skeleton reorientation idea for the production team of 3D animated video content, which can significantly reduce time costs and improve work efficiency.

• Journal of Haehwa Medicine
• /
• v.8 no.1
• /
• pp.425-449
• /
• 1999

For the evaluation of the effect on SWS, experiments were made on hyperlipidemia induced by hypercholesterol diet, inhibitory reaction to human platelet aggregation, Pulmonary thrombosis induced by collagen and epinephrine, global cerebral ischemia induced by KCN, brain ischemia induced by MCA occlusion, cytotoxicity of PC12 cells induced by amyloid ${\beta}$ protein(25-35), and NO production in RAW cells stimulated by lipopolysaccharide. The results were obtained as follows : 1. In the experiment on hyperlipidemia, the level of serum total cholesterol, phospholipid, and LDL-cholesterol were significantly decreased while the level of triglyceride, VLDL-cholesterol, and HDL-cholesterol had no significant change. 2. In the experiment on inhibitory reaction to platelet aggregation, SWS inhibited platelet aggregation induced by ADP(36.05%), by collagen(20.4%), and by thrombin(0.6%). 3. In the experiment on pulmonary thrombosis induced by collagen and epinephrine, the protective effect was found(37%). 4. In the experiment on global cerebral ischemia, coma duration induced by KCN changed insignificantly. 5. In the experiment on MCA occlusion, the change of neurologic grades on hind limb was significant only after the operation. Besides brain ischemic area and edema ratio were significantly decreased. 6. In the experiment on cytotoxicity of PC 12 cells induced by amyloid ${\beta}$ protein, the significant protective effect was found as concentration increases. 7. In the experiment on NO production in RAW cells stimulated by lipopolysaccharide, NO was significantly decreased. According to the results, it is expected that SWS might be effective on hyperlipidemia and brain damage.