• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.3817-3825
• /
• 2015

Background: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression. Inhibition of DOT1L activity by shRNA or small-molecule inhibitors has been established to prevent proliferation of various MLL-rearranged leukemia cells in vitro, establishing DOT1L an attractive therapeutic target for mixed lineage leukemia (MLL). Most of the drugs currently in use for the MLL treatment are reported to have low efficacy, hence this study focused on various natural compounds which exhibit minimal toxic effects and high efficacy for the target receptor. Materials and Methods: Structures of human protein methyl-transferase DOT1L and natural compound databases were downloaded from various sources. Virtual screening, molecular docking, dynamics simulation and drug likeness studies were performed for those natural compounds to evaluate and analyze their anti-cancer activity. Results: The top five screened compounds possessing good binding affinity were identified as potential high affinity inhibitors against DOT1L's active site. The top ranking molecule amongst the screened ligands had a Glide g-score of -10.940 kcal/mol and Glide e-model score of -86.011 with 5 hydrogen bonds and 12 hydrophobic contacts. This ligand's behaviour also showed consistency during the simulation of protein-ligand complex for 20000 ps, which is indicative of its stability in the receptor pocket. Conclusions: The ligand obtained out of this screening study can be considered as a potential inhibitor for DOT1L and further can be treated as a lead for the drug designing pipeline.

• 한국컴퓨터정보학회논문지
• /
• 제17권5호
• /
• pp.177-183
• /
• 2012

익명성이라는 특성으로 인하여 사이버공간에서는 다양한 범죄가 발생한다. 그 중에서도 표현의 자유라는 이유로 타인에 대한 명예훼손행위가 가장 심각하다. 즉 사이버공간에서 일어나는 명예훼손은 그 침해가 순간적이고 광범위하며 피해자가 대응할 시간적 여유가 없다는 점에서 오프라인에서 발생하는 명예훼손과 비교할 때 피해의 충격성과 심각성은 매우 크다고 아니할 수 없다. 그러나 표현의 자유도 중요하지만 인간의 존엄과 가치를 존중하는 자유민주주의 사회에서는 헌법 제21조 제4항에 규정된 것처럼 언론 출판은 타인의 명예나 권리 또는 공중도덕이나 사회윤리를 침해해서는 안 된다. 표현의 자유 못지 않게 개인의 명예보호도 헌법상 보장된 기본권이며, 개인의 명예나 인격을 침해하는 행위까지 표현의 자유영역에 포함시킬 수 없기 때문이다. 이러한 점에서 명예훼손죄는 표현의 자유의 최소한의 한계라고 보아야 한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권2호
• /
• pp.765-768
• /
• 2013

Background and Aims: Prostate cancer is the most commonly diagnosed cancer in males in many populations. Metformin is the most widely used anti-diabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines. MicroRNAs (miRNAs) are a class of small, non-coding, single-stranded RNAs that downregulate gene expression. We aimed to evaluate the effects of metformin treatment on changes in miRNA expression in PC-3 cells, and possible associations with biological behaviour. Materials and Methods: Average cell viability and cytotoxic effects of metformin were investigated at 24 hour intervals for three days using the xCELLigence system. The $IC_{50}$ dose of metformin in the PC-3 cells was found to be 5 mM. RNA samples were used for analysis using custom multi-species microarrays containing 1209 probes covering 1221 human mature microRNAs present in miRBase 16.0 database. Results: Among the human miRNAs investigated by the arrays, 10 miRNAs were up-regulated and 12 miRNAs were down-regulated in the metformin-treated group as compared to the control group. In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important. This study may emphasize a new role of metformin on the regulation of miRNAs in prostate cancer.

• 한국의류학회지
• /
• 제31권4호
• /
• pp.604-614
• /
• 2007

As the role of retail stores in distribution channels becomes more significant and competition among them becomes more fierce, retail stores are making efforts to gain a dominant position in market share. And as such, consumer store choice behaviour is becoming more diverse and complex. The purpose of this study was to analysis the store choice process and to aid in understanding the types of store choice behaviors. 30 subjects were sampled by focus sampling and investigated by in-depth interview. Some consumers went through all stages of store choice process and others skipped some. The consumers who usually had no plan to visit stores and who purchase without problem recognition process were categorized as opportunity-taking type, and the consumers who visited just one store without external search of other store information were categorized as store-loyal type. Finally, the consumers who searched store information externally were divided into brand-oriented type and value-seeking type. The brand-oriented type represented the consumers who did not evaluate stores in detail because which store to visit was decided on brand; and the value-seeking type represented the consumers who did in fact evaluate stores in more detail according to the items and trends in fashion. This study is meaningful in that it provides a dynamic store choice process and examines related variables thereto.

• 가족자원경영과 정책
• /
• 제9권3호
• /
• pp.31-43
• /
• 2005

The purposes of this study were to (1) examine the sub-dimensions of time management behaviors and satisfaction with time management, and (2) to identify the variables that can affect satisfaction with time management. Data was collected through an Internet survey answered by 611 working men and women. The data were analyzed using descriptive statistics, factor analysis, and multiple linear regression analysis. As a result of the study, the sub-dimensions of time management behaviour were extracted into three subordinate categories, which were, planning, human relation orientation, and urgency. The sub-dimensions of the satisfaction with time management were extracted into three subordinate categories, which were, satisfaction with the management results, satisfaction with time distribution, and satisfaction of spare time. Management result satisfaction displayed a positive relationship with planning and work time. The satisfaction with time distribution displayed a positively relationship with planning, relations-intention, the level of education, and sleeping time, while displaying a negative relationship with work time. Also, Women tended to be more satisfied with time distribution than men. Finally, the satisfaction of spare time was positively related with age, while negatively related to urgency and work time.

• 패션비즈니스
• /
• 제13권1호
• /
• pp.34-50
• /
• 2009

The purpose of this study was to compare the curricula majored in fashion retail related area at 4-year colleges in Korea and the USA. Courses were divided into 15 elements including basics, design, production, textile, marketing, industry, merchandise planning, promotion, consumer behaviour, management, business, organization, internship and etc.. The research findings were as follows: 1. Most of 'industry' related majors in Korea consisted of fashion manufacture-oriented curricula elements including design, pattern making, tailoring, draping and textile sciences. 2. Fashion Marketing major stressed on a merchandising element and a marketing one, and the Fashion major focused on the promotion element and the merchandising element as well. However, the retail element was less focused than other elements in the Korean colleges. 3. Fashion Retail related majors in the USA College were likely to focus on the practical fashion retail management elements including retail, marketing, management, business, organization behavior and internship specialized by the major. The different curricula between two countries were clearly existed in terms of the major name and the construction of the course element. The results made in the research would be applied with some modification or adjustments in the fashion retail oriented curricula in order to produce the competitive retail human resource in Korea.

• International Journal of Human Ecology
• /
• 제5권2호
• /
• pp.111-122
• /
• 2004

This paper outlines the findings of a consumer survey conducted in 1996 and 2001 by the University of Bonn, Germany, across 15 European countries. The survey involved a sample of 3,300 respondents in 1996 and around 11,000 respondents in 2001, throughout all 15 EU countries. Children and adolescents, between the ages of 10 and 17, were surveyed about their consumption habits and their attitudes towards the environment. The paper outlines the key findings on 'Children's fears and future prospects'. Children are exposed to a great mass of information, not only derived from the media but also from what they experience directly in their everyday-life. Some of this information translates into worries that adopt a clearer (more realistic) form when children become adolescents, as they might be easily involved in those events, and the understanding of the processes that may cause or continue them is deeper. Today's children and adolescents are under more pressure, since the social/political/economical spectrum is constantly changing. Change produces anxiety, fear of what will result from these transformations, as it implies that the social order will be reorganized. This paper reports on a long term comparative study among children and adolescents throughout the European Union, analyzed by country, age group and gender. It draws different preoccupations of young generations and consequent future expectations. It concludes by considering the influence of social and political organizations, as well as the family, on children and adolescents, as these might help to sustain a positive attitude towards various future events.

• International Journal of Human Ecology
• /
• 제2권1호
• /
• pp.57-75
• /
• 2001

Since the Korean economic crisis in 1997, consumers are selecting goods that are more economical and more reasonably priced. Markets for wealthy people, however, have seldom been influenced by economic conditions. Consequently, 'noble marketing' is a new term that marketers should become acquainted with (Kim, 1998). The continuously expanding 'noble market' that generates high profit for marketers needs to be explored, especially the men's wear market. This study adopted a qualitative method (i.e., in-depth interview) with 16 male consumers each. These men who spent more than 3,600,000 won on apparel goods in 2000 and each man had purchased at least one item-suit, jacket, trousers, or coat-from a list of high-priced brands that were selected by the researcher. Findings imply that material or functional benefit of the high-priced apparel were not a critical determinant for choosing the brand. Rather, a socially well-established image for the brand name, especially in terms of psychological/symbolic appeal, played a more important role. This finding supported previous studies. Therefore, for high-priced men s wear, the role of promotion, including advertising or word of mouth, is critical; the image that advertisers should promote is one that characterizes the clothing, and ultimately the wearers, as dignified, legitimate, traditional, and upper class.

• 건축역사연구
• /
• 제17권4호
• /
• pp.83-95
• /
• 2008

This study was firstly to reflect upon the background of the generation and the urban spatial value and significance of the medieval plaza. The main aim of this study was to extract the spatial determinants which give the great influence on the formation of the medieval plaza and in addition the endogenous rules and aesthetical grounds regarding the respective elements. Especially they could be applied to the design guideline. They are dimension(volume and scale), shape, elevation as the morphological elements and enclosure, proportion, grade difference, spatial sequence and plaza group as the spatial determinants and visual sequence, visual or spatial boundary, approaching axis and perspective effect as the aesthetic and visual elements and function(use), human behaviour as the social-behavioral elements and otherwise, for instance, plaza furniture, ground decoration and vegetation. This study was intended to analyze each elements based on the classical historical literatures and to suggest the planning conditions for composing the ideal plaza referring to the cases and literature review on the medieval plaza and finally is expected to contribute to the plaza design methodology.

• 한국자동차공학회논문집
• /
• 제13권1호
• /
• pp.153-158
• /
• 2005

Titanium alloy has widely been used as material for automotive parts because it has high specific strength. It is also light and harmless to human body. But, we have little design data about the creep behaviors of the alloy. Therefore, in this study, creep tests under four constant stress conditions have been conducted with low different temperature conditions. A series of creep tests had been performed to get the basic design data and life prediction of titanium products and we have gotten the fallowing results. First, the stress exponents decrease as the test temperatures increased. Secondly, the creep activation energy gradually decrease as the stresses became bigger. Thirdly, the constant of Larson-Miller parameter on this alloy was estimated as about 7.5. And for the last, the fractographs at the creep rupture showed the ductile fracture due to the intergranullar rupture.