• Geomechanics and Engineering
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• v.14 no.5
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• pp.429-437
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• 2018

In order to reduce deformation of roadway floor heave in deep underground soft rockmass, four support design patterns were analyzed using the Fast Lagrangian Analysis of Continua (FLAC)3D, including the traditional bolting (Design 1), the bolting with the backbreak in floor (Design 2), the full anchorage bolting with the backbreak in floor (Design 3) and the full anchorage bolting with the bolt-grouting backbreak in floor (Design 4). Results show that the design pattern 4, the full anchorage bolting with the bolt-grouting backbreak in floor, was the best one to reduce the deformation and failure of the roadway, the floor deformation was reduced at 88.38% than the design 1, and these parameters, maximum vertical stress, maximum horizontal displacement and maximum horizontal stress, were greater than 1.69%, 5.96% and 9.97%. However, it was perfectly acceptable with the floor heave results. The optimized design pattern 4 provided a meaningful and reliable support for the roadway in deep underground coal mine.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10045-10051
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• 2015

Chemotherapy is a major therapeutic approach for malignant neoplasms; however, due to the most common adverse events of nausea and vomiting, scheduled chemotherapeutic programs may be impeded or even interrupted, which severely impairs the efficacy. Aprepitants, 5-HT3 antagonists and dexamethasone are primary drugs used to prevent chemotherapy-induced nausea and vomiting (CINV). These drugs have excellent efficacy for control of acute vomiting but are relatively ineffective for delayed vomiting. Aprepitant may remedy this deficiency. Substance P was discovered in the 1930s and its association with vomiting was confirmed in the 1950s. This was followed by a period of non-peptide neurokinin-1 (NK-1) receptor antagonist synthesis and investigation in preclinical studies and clinical trials (phases I, II and III). The FDA granted permission for the clinical chemotherapeutic use of aprepitant in 2003. At present, the combined use of aprepitant, 5-HT3 antagonists and dexamethasone satisfactorily controls vomiting but not nausea. Therefore, new therapeutic approaches and drugs are still needed.

• Animal Systematics, Evolution and Diversity
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• v.21 no.1
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• pp.1-10
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• 2005

In the lepidopteran surveys in Mt. Changbai, China, during 2000-2003, 10 species of the genus Zanclognatha Lederer of Noctuidae were recognized. Of them, a new species, Zanclognatha lui sp. novo is described, two species (Zanclognatha umbrosalis Staudinger and Z. perfractalis Bryk) are reported for the first time from China, and four species (Z. fumosa, Z. lilacina, Z. violacealis and Z. tarsipennalis) are newly known from Mt. Changbai. Synonymies, distributional ranges, photos of the genitalia, and images of the new and newly recorded species are given.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7913-7917
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• 2014

Apoptotic cell death plays a predominant role in histone deacetylase (HDAC) inhibitor-induced cytotoxicity. Nuclear morphological changes and activation of apoptotic executors are involved in CTS203-induced cell death. However, emerging issues of HDAC inhibitor-resistance have been observed in patients. Herein, MCF-7 cells were continuously exposed to CTS203 until the derived cells could proliferate normally in its presence. The newly obtained CTS203-resistant cells were nominated as MCF-7/203R. Compared to MCF-7 original cells, the MCF-7/203R cells were less sensitive to CTS203-induced apoptosis, with a minimal 6-fold higher $IC_{50}$ value. In contrast, the expression of Beclin-1 was dramatically up-regulated, positively correlated to the acquisition of CTS203-resistance. Our results revealed the participation of autophagy in acquired HDAC inhibitor-resistance and further identified Beclin-1 as a promising target for anti-drug resistance.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.8
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• pp.1190-1196
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• 2012

This study was conducted to evaluate effects of storage temperatures ($4^{\circ}C$ and $20^{\circ}C$) and pig breeds (Laiwu pig and Large White pig) on the main antioxidative enzymes (superoxide dismutase, catalase, and glutathione peroxidase) activity and lipid oxidation in porcine Longissimus dorsi muscle. Activities of antioxidative enzymes (AOE) decreased slightly during storage, regardless of storage temperatures. Muscle antioxidative enzymes activities stored at $4^{\circ}C$ were higher than that stored at $20^{\circ}C$. Laiwu pig's enzymes activities were significantly (p<0.01) higher than Large White's. The level of malondialdehyde is a direct expression of the grade of lipid oxidation in meat. In our study, the malondialdehyde contents increased after 6 days storage. However, malondialdehyde contents of Laiwu pig were significantly (p<0.01) lower than Large White's. A lower content of malondialdehyde corresponds to a lower oxidation of lipids. These results indicated the muscle antioxidative ability of Laiwu pig was higher than Large White pig. It also implied that antioxidative enzymes were involved in the essentials and deciding mechanisms of meat quality by quenching oxygen free radicals and inhibiting lipid oxidation in muscle.

• Smart Structures and Systems
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• v.21 no.5
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• pp.611-621
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• 2018

Compared with the highway bridges, the relatively higher requirement on the safety and comfort of vehicle makes the high-speed railway (HSR) bridges need to present enhanced dynamic performance. To this end, installing a health monitor system (HMS) on selected key HSR bridges has been widely applied. Typically, the HSR takes fully enclosed operation model and its skylight time is very short, which means that it is not easy to operate the acquisition devices and download data on site. However, current HMS usually involves manual operations, which makes it inconvenient to be used for the HSR. Hence, a HMS named DASP-MTS (Data Acquisition and Signal Processing - Monitoring Test System) that integrates the internet, cloud computing (CC) and virtual instrument (VI) techniques, is developed in this study. DASP-MTS can realize data acquisition and transmission automatically. Furthermore, the acquired data can be timely shared with experts from various locations to deal with the unexpected events. The system works in a Browser/Server frame so that users at any places can obtain real-time data and assess the health situation without installing any software. The developed integrated HMS has been applied to the Xijiang high-speed railway arch bridge. Preliminary analysis results are presented to demonstrate the efficacy of the DASP-MTS as applied to the HSR bridges. This study will provide a reference to design the HMS for other similar bridges.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.1057-1060
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• 2014

Adiposity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease, and recently there is increasing evidence that excess body weight is an avoidable cause of cancer, including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal malignancies. The mechanisms whereby adiposity is associated with tumor development remains not well understood. There are some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors, sex hormones, adipocytokines, and inflammatory cytokines, adiposity-induced hypoxia, and so on. The potential mechanisms and conclusions in adiposity associated with increased risk for developing malignancy, and the underlying cellular and molecular mechanisms will be studied very well in the near future.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1077-1082
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• 2013

Background: Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. We aimed to explore whether the expression of Long Non-Coding RNA (LncRNA) growth arrest-specific transcript 5 (GAS5) is associated with RCC genesis. Methods: We selected twelve clinical samples diagnosed for renal clear cell carcinoma and found that the LncRNA GAS5 transcript levels were significantly reduced relative to those in adjacent unaffected normal renal tissues. Results: In addition, expression of GAS5 was lower in the RCC cell line A498 than that in normal renal cell line HK-2. Furthermore, using functional expression cloning, we found that overexpression of GAS5 in A498 cells inhibited cell proliferation, induced cell apoptosis and arrested cell cycling. At the same time, the migration and invasion potential of A498 cells were inhibited compared to control groups. Conclusion: Our study provided the first evidence that a decrease in GAS5 expression is associated with RCC genesis and progression and overexpression of GAS5 can act as a tumor suppressor for RCC, providing a potential attractive therapeutic approach for this malignancy.

• Advances in concrete construction
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• v.11 no.3
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• pp.183-192
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• 2021

Due to economic and environmental benefits, increasing the substitution ratio of ordinary cement by industry by-products like fly ash (FA) is one of the best approaches to reduce the impact of the concrete industry on the environment. However, as the substitution rate of FA increases, it will have an adverse impact on the performance of cement-based materials, so the actual substitution rate of FA is limited to around 10-30%. Therefore, in order to increase the early-age strength of high replacement (30-70%) low-calcium ultrafine FA blended cement paste, sodium sulfate and calcium sulfate dihydrate were used to improve the reactivity of FA. The results show that sodium sulfate has a significant enhancement effect on the strength of the composite pastes in the early and late ages, while calcium sulfate dihydrate has only a slight effect in the late ages. The addition of sodium sulfate in the cement-FA blended system can enhance the gain rate of non-evaporation water, and can decrease the Ca(OH)2 content. In addition, when the sulfate chemical activators are added, the ettringite content increases, and the surface of the FA is dissolved and hydrated.

• Wind and Structures
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• v.35 no.6
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• pp.369-383
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• 2022

Wind tunnel experiment was carried out to study the cross-wind layer forces on a square cross-section building model using a synchronous multi-pressure sensing system. The stationarity of measured wind loadings are firstly examined, revealing the non-stationary feature of cross-wind forces. By converting the measured non-stationary wind forces into an energetically equivalent stationary process, the characteristics of local wind forces are studied, such as power spectrum density and spanwise coherence function. Mathematical models to describe properties of cross-wind forces at different layers are thus established. Then, a conditional simulation method, which is able to ex-tend pressure measurements starting from experimentally measured points, is proposed for the cross-wind loading. The method can reproduce the non-stationary cross-wind force by simulating a stationary process and the corresponding time varying amplitudes independently; in this way the non-stationary wind forces can finally be obtained by combining the two parts together. The feasibility and reliability of the proposed method is highlighted by an ex-ample of across wind loading simulation, based on the experimental results analyzed in the first part of the paper.