• Journal of Korea Trade
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• 제23권7호
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• pp.128-146
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• 2019

Purpose - The purpose of this paper is to investigate the relationship between internal control, economic policy uncertainty, and performance of cross-border merger and acquisition (M&A) based on the panel data of Chinese listed firms. The authors expected that internal control has a positive moderating effect on the performance of cross-border M&A and that it mainly occurs during periods when economic policies are relatively stable. In addition, the authors tried to find out the mechanism of internal control affecting cross-border M&A and the corporate performance. Design/methodology - The authors tested the hypotheses by a multivariate regression model based on the panel data of Chinese listed firms from 2009 to 2017. The dependent variable is the change value of business performance (DROA_1,2,3) and the explanatory variables are cross-border M&A (MA), China's uncertainty of economic policy (EPU), and internal control level (IC) respectively. Findings - The authors find that internal control has a positive moderating effect on the relationship between cross-border M&A and corporate performance. Further, the authors find that the moderating effect is more significant in state-owned enterprises and that it mainly occurs during periods when economic policies are relatively stable. Originality/value - This paper is the leading study that tries to analyze empirically the relationship between internal control, economic policy uncertainty, and performance of cross-border M&A. It provides a new avenue through which internal control might reasonably mitigate the risks of cross-border M&A and correspondingly improve the performance of cross-border M&A. It also confirms the moderating effect of internal control on the performance of cross-border M&A under the uncertainty of economic policy.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권1호
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• pp.91-105
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• 2016

Carbon Nanotube Field-Effect Transistors (CNTFETs) have been studied as candidates for post Si CMOS owing to the better electrostatic control and high mobility. To enhance the immunity against short - channel effects (SCEs), the novel channel and gate engineered architectures have been proposed to improve CNTFETs performance. This work presents a comprehensive study of the influence of channel and gate engineering on the CNTFET switching, high frequency and circuit level performance of carbon nanotube field-effect transistors (CNTFETs). At device level, the effects of channel and gate engineering on the switching and high frequency characteristics for CNTFET have been theoretically investigated by using a quantum kinetic model. This model is based on two-dimensional non-equilibrium Green's functions (NEGF) solved self - consistently with Poisson's equations. It is revealed that hetero - material - gate and lightly doped drain and source CNTFET (HMG - LDDS - CNTFET) structure can significantly reduce leakage current, enhance control ability of the gate on channel, improve the switching speed, and is more suitable for use in low power, high frequency circuits. At circuit level, using the HSPICE with look - up table(LUT) based Verilog - A models, the impact of the channel and gate engineering on basic digital circuits (inverter, static random access memory cell) have been investigated systematically. The performance parameters of circuits have been calculated and the optimum metal gate workfunction combinations of ${\Phi}_{M1}/{\Phi}_{M2}$ have been concluded in terms of power consumption, average delay, stability, energy consumption and power - delay product (PDP). In addition, we discuss and compare the CNTFET-based circuit designs of various logic gates, including ternary and binary logic. Simulation results indicate that LDDS - HMG - CNTFET circuits with ternary logic gate design have significantly better performance in comparison with other structures.

• Asian-Australasian Journal of Animal Sciences
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• 제16권12호
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• pp.1705-1710
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• 2003

A small body size of Brown Tsaiya laying duck is desirable to reduce maintenance requirements, so the body weight at 40 weeks of age (BW40) has to be maintained at its current level. Egg weight has to be maintained at around 65 g to meet market requirements. Eggshell strength at 40 weeks of age (ES40) must to be increased in order to maintain a low incidence of broken eggs. Thus, number of eggs laid up to 52 weeks of age (EN52) has to be increased without negative correlated response on ES40. A new linear genetic selection index was used: $I_g=a_0{\times}GEW40\;(g)+a_1{\times}GBW40\;(g)+a_2{\times}GES40\;(kg/cm^2)+a_3{\times}GEN52\;(eggs)$ where GEW40, GBW40, GES40 and GEN52 were the multitrait best linear unbiased prediction (MT-BLUP) animal model predictors of the breeding values respectively of egg weight and body weight at 40 weeks of age (EW40, BW40), ES40 and EN52. The coefficients $a_0$, $a_1$, $a_2$ and $a_3$ were calculated with constraints of 0.0 g, 0.0 g and $0.013kg/cm^2$ for expected genetic gains in EW40, BW40 and ES40 respectively and maximum gain in EN52. Since 1997, the drakes and the ducks were selected according to their own indexes, with this new genetic selection index. From G0 to G4, the average per generation predicted genetic responses in female duck were +0.05 g for EW40, +0.92 g for BW40, $+0.035kg/cm^2$ for ES40 and +2.13 eggs for EN52. Which represented respectively 0.07%, 0.06%, 0.67% and 1.0% of the means of the EW40, BW40, ES40 and EN52. For ES40 and EN52, it represented also respectively 16.1% and 21.6% of the additive genetic standard deviation of these traits. Thevse results indicated that selection of laying Brown Tsaiya by a restricted genetic selection index and with MT-BLUP animal model could be an efficient tool for improving the efficiency of egg production, increasing egg shell strength and egg number while holding egg weight and body weight constants.

• 한국콘텐츠학회논문지
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• 제17권2호
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• pp.327-336
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• 2017

최근 실외 및 실내 공기의 질에 대한 사람들의 관심이 증가하면서 다양한 관련기기들이 사용되고 있다. 실내 환경의 여러 요소 중 특히 사람들의 쾌적감에 직접 영향을 주는 온열 환경과 눈에 보이지 않는 실내 공기 환경의 시각화는 그러한 이유로 매우 중요하게 부각되고 있다. 본 연구는 거주자가 공기 질 등과 같은 실내 환경 상태를 기존의 숫자나 그래프 등 보다 쉽고 직관적으로 파악하는 것을 지원하기 위하여 기존의 실내 환경 시각화 사례들을 분석하고 이를 보완하기 위한 개선방법을 모색하여 보다 효과적인 웹 및 건물정보모델기반 시각화 방법을 제안하고자 한다. 본 연구에서 제시하는 해당 실내 환경 시각화 과정은 크게 네부분으로 구성된다. 이는 건물 모델 데이터 생성, 실내 환경 데이터 생성, 시각화 표현 요소 생성, 데이터 매핑 및 시각화 결과 생성 과정으로 요약될 수 있다. 생성된 시각화 결과는 다양한 실내 환경 요소의 동시 파악을 지원할 뿐만 아니라, 대상 공간의 기하학적 모델과 측정된 실내 환경 데이터를 연계하여 시각화함으로써 실내 환경 상태의 파악이 직관적이며 즉각적이다. 본 논문은 IoT 등의 기술로 즉각적이고 자동화된 실내 환경 관리시스템의 개발방향과는 별개로, 실내 환경 데이터를 적절히 가공함으로써 사용자 및 관리자 등에게 관련 시각정보를 효율적으로 제공하는 접근방법을 모색하는 것을 목적으로 한다.

• The Korean Journal of Physiology and Pharmacology
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• 제22권4호
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• pp.409-417
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• 2018

Pre-eclampsia (PE) is a pregnancy disorder that is characterised by severe hypertension and increased risks of foetal and maternal mortality. The aetiology of PE not completely understood; however, maternal nutrition and oxidative stress play important roles in the development of hypertension. The treatment options for PE are currently limited to anti-hypertensive drugs. Punicalagin, a polyphenol present in pomegranate juice, has a range of bioactive properties. The effects of supplementation with punicalagin on angiogenesis and oxidative stress in pregnant rats with induced hypertension were investigated. The pregnant rats were randomly divided into five experimental groups (n=12 per group). Hypertension was induced using an oral dose of NG-nitro-L-arginine methyl ester (L-NAME, 50 mg/kg/day) on days 14-19 of pregnancy. Punicalagin (25, 50 or 100 mg/kg) was given orally on days 14-21 of pregnancy. Punicalagin treatment at the tested doses significantly reduced diastolic, systolic, and mean arterial blood pressure in L-NAME treated rats from day 14. Punicalagin also restored angiogenic balance by increasing the expression of vascular endothelial growth factor and downregulating vascular endothelial growth factor receptor-1/fms-like tyrosine kinase-1. Punicalagin, significantly increased the placental nitric oxide levels as compared to PE group. The increased levels of oxidative stress in rats with PE were markedly decreased by treatment with punicalagin. Punicalagin at the tested doses markedly (p<0.05) enhanced the placental antioxidant capacity in L-NAME-treated rats. The raised catalase activity observed following L-NAME induction was significantly (p<0.05) and restored to normal activity levels in punicalagin treatment. Further, 100 mg dose of punicalagin exhibited higher protective effects as compared to lower doses of 25 and 50 mg. This study shows that supplementation with punicalagin decreased blood pressure and oxidative stress and restored angiogenic balance in pregnant rats with induced PE.

• Journal of Ginseng Research
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• 제43권3호
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• pp.460-474
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• 2019

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

• 동양고전연구
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• 제62호
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• pp.67-85
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• 2016

본고는 원말명초(元末明初) 문학의 전개과정을 검토하면서 명대(明代) 초기 관각문학의 기틀을 다졌던 송렴(宋濂) 문학의 위치를 점검해 보았다. 그는 명대 문학사에서 도학자적 문학관을 견지했던 것으로 단순 요약되고 있지만, 그 과정은 그리 간단하지 않다. 본고는 문학론과 관련된 송렴의 글을 연대기적으로 분석함을 통해 그가 청 장년기까지도 진한고문(秦漢古文) 등의 고문사(古文辭)에 빠져 오랫동안 헤어 나오지 못했음을 밝힐 수 있었다. 송렴은 삼십 세에 스승 황진(黃?)과의 만남을 계기로 육경에 침잠하며 도학적 문예관을 가지게 되었지만 고문사의 유혹을 완전히 떨쳐버리지는 못했다. 오십 이후 주원장(朱元璋)을 도와 명 건국의 주역으로 참여하게 되면서 비로소 자신의 경세적 문학관을 실천적으로 확립하였고, 이후 자신의 도학적-경세적 문학관을 이론적으로 정립할 수 있었다. 그리고 이 과정은 또한 청 장년기 그 자신의 문학 수련의 주요한 대상이자 명초의 가장 중요한 문학적 전범이기도 하였던, "사기" 등의 진한고문을 부정하는 과정이기도 하였다. 요약하면, 원말명초의 격동의 시기에 송렴은 개인적, 시대적으로 문학관의 변화를 겪으며, 그 생애 말년에 육경 및 송대의 도학자와 한유(韓愈) 구양수(歐陽脩) 등의 당송고문을 성인(聖人)의 문(文)으로 통하는 치세의 문학으로 재정립함으로써 명대 문학의 이념적 좌표와 새로운 문학적 전범을 제시하고 있었던 것이다.

• The Korean Journal of Pain
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• 제20권2호
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• pp.100-105
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• 2007

Background: Ginseng has been used to manage various types of pain in folk medicine. This study characterized the effect of treatment with intrathecal ginsenosides, the active components of ginseng in a postoperative pain model. Methods: Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters. An incision was made in the plantar surface of the hindpaw. Withdrawal thresholds following the application of a von Frey filament to the wound site were measured. To determine the role of the opioid or GABA receptors following treatment with the ginsenosides, naloxone, bicuculline (a $GABA_A$ receptor antagonist), and saclofen (a $GABA_B$ receptor antagonist) were administered intrathecally 10 min before the delivery of the ginsenosides and the changes of the withdrawal thresholds after application of the von Frey filament were Observed. Results: Treatment with the intrathecal ginsenosides increased the withdrawal threshold in a dose dependent manner. Pre-treatment with intrathecal naloxone reversed the antinociceptive effect of the ginsenosides. However, pre-treatment with intrathecal bicuculline and saclofen failed to have an effect on the activity of the ginsenosides. Conclusions: These results suggest that ginsenosides are effective to alleviate the postoperative pain evoked by paw incision. The opioid receptor, but not GABA receptors, may be involved in the antinociceptive action of the ginsenosides at the spinal level.

• Steel and Composite Structures
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• 제50권3호
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• pp.281-298
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• 2024

Stainless steel bolts (SSB) are increasingly utilized in bolted steel connections due to their good mechanical performance and excellent corrosion resistance. Fire accidents, which commonly occur in engineering scenarios, pose a significant threat to the safety of steel frames. The post-fire behavior of SSB has a significant influence on the structural integrity of steel frames, and neglecting the effect of temperature can lead to serious accidents in engineering. Therefore, it is important to evaluate the performance of SSB at elevated temperatures and their residual strength after a fire incident. To investigate the mechanical behavior of SSB after fire, 114 bolts with grades A4-70 and A4-80, manufactured from 316L austenitic stainless steel, were subjected to elevated temperatures ranging from 20℃ to 1200℃. Two different cooling methods commonly employed in engineering, namely cooling at ambient temperatures (air cooling) and cooling in water (water cooling), were used to cool the bolts. Tensile tests were performed to examine the influence of elevated temperatures and cooling methods on the mechanical behavior of SSB. The results indicate that the temperature does not significantly affect the Young's modulus and the ultimate strength of SSB. Up to 500℃, the yield strength increases with temperature, but this trend reverses when the temperature exceeds 500℃. In contrast, the ultimate strain shows the opposite trend. The strain hardening exponent is not significantly influenced by the temperature until it reaches 500℃. The cooling methods employed have an insignificant impact on the performance of SSB. When compared to high-strength bolts, 316L austenitic SSB demonstrate superior fire resistance. Design models for the post-fire mechanical behavior of 316L austenitic SSB, encompassing parameters such as the elasticity modulus, yield strength, ultimate strength, ultimate strain, and strain hardening exponent, are proposed, and a more precise stress-strain model is recommended to predict the mechanical behavior of 316L austenitic SSB after a fire incident.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.327-335
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• 2019

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Theracurmin is more bioavailable form of curcumin, generated with submicron colloidal dispersion. Mice were treated with Theracurmin (100, 300 and 1,000 mg/kg) for 12 weeks and were subjected to the novel object recognition test and the Barnes maze test. Theracurmin-treated mice showed significant amelioration in recognition and spatial memories compared those of the vehicle-treated controls. In addition, the antioxidant activities of Theracurmin were investigated by measuring the superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels. The increased MDA level and decreased SOD and GSH levels in the vehicle-treated 5XFAD mice were significantly reversed by the administration of Theracurmin. Moreover, we observed that Theracurmin administration elevated the expression levels of synaptic components, including synaptophysin and post synaptic density protein 95, and decreased the expression levels of ionized calcium-binding adapter molecule 1 (Iba-1), a marker of activated microglia. These results suggest that Theracurmin ameliorates cognitive function by increasing the expression of synaptic components and by preventing neuronal cell damage from oxidative stress or from the activation of microglia. Thus, Theracurmin would be useful for treating the cognitive dysfunctions observed in AD.