• Journal of Microbiology and Biotechnology
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• 제27권6호
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• pp.1198-1203
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• 2017

Hrr25, a casein kinase $1{\delta}/{\varepsilon}$ homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.

• 대한의생명과학회지
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• 제24권3호
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• pp.245-252
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• 2018

Heart rate recovery (HRR) is simply an indicator of autonomic balance and is a useful physiological indicator to predict cardiovascular morbidity and mortality. The purpose of this study was to compare the differences in HRR between metabolically healthy obesity group and metabolically unhealthy obesity and to ascertain whether heart rate recovery is a predictor of metabolic syndrome. Metabolic syndrome was defined according to the standards of the National Cholesterol Education Program Adult Care Panel III. Obesity was assessed according to WHO Asian criteria. It was classified into three groups of metabolically healthy non-obesity group (MHNO, n=113), metabolically healthy obesity group (MHO, n=66), metabolically unhealthy obesity (MUO, n=18). Exercise test was performed with Bruce protocol using a treadmill instrument. There was no difference in HRR between MHO and MUO ($32.71{\pm}12.25$ vs $25.53{\pm}8.13$), but there was late HRR in MUO than MHNO ($25.53{\pm}8.13$ vs $34.51{\pm}11.80$). HRR in obese was significantly correlated with BMI (r=-0.342, P=0.004), waist circumference (r=-0.246, P=0.043), triglyceride (r=-0.350, P=0.003), HbA1c (r=-0.315, P=0.009), insulin (r=-0.290, P=0.017) and uric acid (r=-0.303, P=0.012). HRR showed a lower prevalence of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol in the third tertile than in the first tertile. In conclusion, MHO had no difference in vagal activity compared with MHNO, but MUO had low vagal activity. HRR is associated with metabolic parameters and is a useful predictor of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterolemia.

• 한국운동역학회지
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• 제25권2호
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• pp.141-147
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• 2015

Objective : This study aimed to understand how increased heart rates at the time of drop landing during a step test would affect biomechanical variables of the lower extremity limbs. Background : Ballet performers do more than 200 landings in a daily training. This training raises the heart rate and the fatigability of the lower extremity limbs. Ballet performance high heart rate can trigger lower extremity limb injury. Method : We instructed eight female ballet dancers with no instability in their ankle joints(mean ${\pm}$ SD: age, $20.7{\pm}0.7yr$; body mass index, $19.5{\pm}1.2kg/m^2$, career duration, $8.7{\pm}2.0yr$) to perform the drop landing under the following conditions: rest, 60% heart rate reserve (HRR) and 80% HRR. Results : First, the study confirmed that the increased heart rates of the female ballet dancers did not affect the working ranges of the knee joints during drop landing but only increased angular speeds, which was considered a negative shock-absorption strategy. Second, 80% HRR, which was increased through the step tests, led to severe fatigue among the female ballet dancers, which made them unable to perform a lower extremity limb-neutral position. Hence, their drop landing was unstable, with increased introversion and extroversion moments. Third, we observed that the increasing 80% HRR failed to help the dancers effectively control ground reaction forces but improved the muscular activities of the rectus femoris and vastus medialis oblique muscles. Fourth, the increasing heart rates were positively related to the muscular activities of the vastus medialis oblique and rectus femoris muscles, and the extroversion and introversion moments. Conclusion/Application : Our results prove that increased HRR during a step test negatively affects the biomechanical variables of the lower extremity limbs at the time of drop landing.

• 대한임상검사과학회지
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• 제45권3호
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• pp.96-101
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• 2013

Increased waist circumference has shown to be more strongly associated with cardiovascular disease risk factors. The purpose of this study is to investigate the association between exercise capacity and cardiovascular risk factors among obese types in adult men. The subjects of this study were a total fifty-four obese persons and obesity criteria is body mass index $(BMI){\geq}25kg/m^2$. Diagnostic criteria for obesity was defined as a waist circumference of ${\geq}90cm$. The BMI in the obese subjects, as judged by the presence or absence of abdominal obesity, were classified into two groups (non-AO: without abdominal obesity group, AO: with abdominal obesity group). AO presented lower total exercise time, metabolic equivalents (METs) than Non-AO. AO showed slow HRR (heart rate recovery) response. HRR was negative correlated with BMI, body fat mass, waist circumference. AO had a high heart rate and a low cardiac output in submaximal exercise stage 1~2. In conclusion, AO's (with abdominal obesity groups) total exercise time, METs and HRR are lower than Non-AO. HRR is related with BMI, body fat mass and waist circumference.

• 대한기계학회논문집A
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• 제25권4호
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• pp.756-763
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• 2001

In the process of integrity evaluation for nuclear power plant components, a series of fracture mechanics evaluation on surface cracks in reactor pressure vessel(RPV) must be conducted. These fracture mechanics evaluation are based on stress intensity factor, K. However, under pressurized thermal shock(PTS) conditions, the combination of thermal and mechanical stress by steep temperature gradient and internal pressure causes considerably high tensile stress at the inside of RPV wall. Besides, the internal pressure during the normal operation produces high tensile stress at the RPV wall. As a result, cracks on inner surface of RPVs may experience elastic-plastic behavior which can be explained with J-integral. In such a case, however, J-integral may possibly lose its validity due to constraint effect. In this paper, in order to verify the suitability of J-integral, tow dimensional finite element analyses were applied for various surface cracks. A total of 18 crack geometries were analyzed, and $\Omega$ stresses were obtained by comparing resulting HRR stress distribution with corresponding actual stress distributions. In conclusion, HRR stress fields were found to overestimate the actual crack-tip stress field due to constraint effect.

• 대한안전경영과학회지
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• 제14권2호
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• pp.65-70
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• 2012

This study was performed to test the combustive properties of the pipe insulation materials which are mainly used in the industries and buildings. Fire characteristic test of pipe insulation film according to the KS F ISO 5660-1 was performed. The experimental materials commonly used in the pipe insulation were used four kinds of films. Two kinds of 4 types of products that have the flame retardant performance and the other two types of them have no flame retardant performance. They were selected for fire characteristic test. The result of finding 25kW/$m^2$ radiation from the ignition was that flame retardant products were 140sec and the other one were 69sec in average of heat release rate(HRR). The result of flame retardant products in the 50kW/$m^2$ was 34sec and the other one were 15sec in average of HRR. However, the HRR of flame retardant products was much higher than the other one. Flame propagation test was conducted according to the KOFEIS 1001. The result of flame retardant products was that flame retardant products had a hold without fire spread after firing them. But the other one were completely fired after firing them. Therefore, I want to recommend that flame retardant products need to be used by the regulation to prevent or decrease a fire spread.

• 한국안전학회지
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• 제26권6호
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• pp.20-25
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• 2011

This study presents on the fire hazard analysis of communication cable in buildings. In order to analyze fire hazards for communication cable IEC 60332-1, UL 94 and cone calorimeter test are conducted. The number of cable used to experiment is 10 communication cable which are generally applied to data communication in buildings. The results show that 9 cables do meet the performance requirement of IEC 60332-1 and 8 cables are V-0 classification. IEC 60332-1 and UL 94 test are inadequate for fire hazard classification. The various parameters obtained by cone calorimeter test such as HRR, peak HRR, smoke production rate and so on. Also it is able to evaluate multiply fire hazard for communication cable with cone calorimeter test results.

• 성인간호학회지
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• 제18권4호
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• pp.660-667
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• 2006

Purpose: The purpose of this study was to investigate the effects of 12-week brisk walking and brisk walking plus diet program on C-Reactive Protein(CRP) in middle-aged obese hypertriglycemic($triglyceride{\geq}150mg/d{\ell}$) Korean women. Method: The subjects were 16 obese ($BMI{\geq}25$) hypertriglycemic middle-aged women (7 for brisk walking group, 9 for brisk walking plus diet group) who participated in a health promotion program at one public health center. Initially the brisk walking intervention consisted of walking for 20 minutes/day at an intensity of 40 to 50% of heart rate reserve(HRR) for 3 days/week and progressed to 50 minutes/day, 60 to 70% of their HRR, and 6 days/week. The diet intervention consisted of 60 minutes of group education and 20 to 30 minutes of individual counseling with a nutritionist every week. Data were analyzed with SPSS PC program. Results: There was no significant reduction in CRP levels in both brisk walking (Z=-1.70, p=0.088) and brisk walking plus diet group(Z=-0.31, p=0.752). In brisk walking only group, CRP levels were increased after the intervention. Conclusion: Brisk walking could increase the level of CRP when it is in the course of progression and diet could decrease the acute phase inflammatory response.

• 한국화재소방학회논문지
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• 제32권5호
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• pp.6-14
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• 2018

본 연구는 건축용 목재의 화재위험성에대하여 열방출 특성을 중심으로 조사하였다. 열방출 성질은 cone calorimeter (ISO 5660-1)를 이용하여 측정하였으며 4종의 목재를 사용하였다. 외부 열유속 $25kW/m^2$에서 연소시킨 후 측정된 착화시간은 35 s부터 55 s까지였다. 나왕(lauan)과 적송의 착화 시간은 각각 54 s, 55 s로 가장 지연된 값으로 얻어졌다. 최대열방출율은 $156.87{\sim}235.1kW/m^2$ 였고 화재초기의 위험성은 가문비나무가 가장 높았다. 삼나무의 평균유효연소열은 19.1 MJ/kg였고 시료들 중에서 가장 높게 나타났다. 화재성능지수(FPI)에 의한 목재의 화재위험성은 나왕($0.2468s{\cdot}m^2/kW$) < 적송($0.2339s{\cdot}m^2/kW$) < 가문비나무($0.2308s{\cdot}m^2/kW$) < 삼나무($0.2231s{\cdot}m^2/kW$) 순으로 높았고 화재성장지수(FGI)에 의한 목재의 화재위험성은 나왕($0.5088kW/m^2{\cdot}s$) < 적송($0.511kW/m^2{\cdot}s$) < 삼나무 ($2.8522kW/m^2{\cdot}s$) < 가문비나무($3.0662kW/m^2{\cdot}s$) 순으로 높았다. 그러므로 목재의 열방출 특성에 대한 화재위험성은 가문비나무와 삼나무가 높은 것으로 나타났다.

• 한국화재소방학회논문지
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• 제25권3호
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• pp.20-27
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• 2011

본 논문은 건축물 내부 마감 재료로 사용되는 스펀지형 흡음재의 연소특성에 관하여 연구하였다. 연소특성 평가를 위하여 일반 재질 및 난연 재질의 스펀지형 흡음재를 대상으로 연소실험을 수행하였으며, 건축용 내부 마감 재료 사용의 적합성 평가를 위하여 콘칼로리미터법을 이용한 열방출률 및 연기밀도를 측정 분석하였다. 연소특성 실험 결과, 일반 재질의 흡음재는 착화와 동시에 급속히 연소되는 특성을 나타내었으며, 난연 재질의 흡음재는 착화와 동시에 소화되는 특성을 나타내었다. 그러나 난연 재질의 흡음재에 착화시간을 길게 하는 경우, 연소가 진행되는 것으로 평가되었다. 열방출률 및 연기밀도는 한국산업규격 KS F ISO 5660-1 및 국제해사기구의 FTP Code를 만족하지 못하는 것으로 평가되었으며, 이러한 결과로 볼 때, 스펀지형 흡음재는 건축용 내부 마감 재료로 사용하기 부적합한 것으로 판단된다.