• Title/Summary/Keyword: Host University

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Charge Trapping Host Structure for High Efficiency in Phosphorescent Organic Light-Emitting Diodes

  • Lee, Jun-Yeob
    • Journal of Information Display
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    • v.9 no.2
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    • pp.14-17
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    • 2008
  • A charge trapping host structure was developed to improve the light-emitting efficiency of green phosphorescent organic light-emitting diodes. N, N'-dicarbazolyl-3,5-benzene(mCP) and a spirobifluorene based triplet host(PHl) were co-deposited as hosts in the emitting layer and the device performance was examined according to the composition mCP and PH1. The results showed that the quantum efficiency could be improved by 30 % using a mixed host of mCP and PH1.

Home-Field Advantage: Why Host-Specificity is Important for Therapeutic Microbial Engraftment

  • Tyler J. Long
    • Microbiology and Biotechnology Letters
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    • v.51 no.1
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    • pp.124-127
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    • 2023
  • Among certain animals, gut microbiomes demonstrate species-specific patterns of beta diversity. This host-specificity is a potent driver of exogenous microbial exclusion. To overcome persistent translational limitations, translational microbiome research and therapeutic development must account for host-specific patterns of microbial engraftment. This commentary seeks to highlight the important implications of host-specificity for microbial ecology, Fecal Microbiota Transplantation (FMT), next-generation probiotics, and translational microbiota research.

OPTIMAL CONTROL PROBLEM FOR HOST-PATHOGEN MODEL

  • P. T. Sowndarrajan
    • Nonlinear Functional Analysis and Applications
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    • v.28 no.3
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    • pp.659-670
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    • 2023
  • In this paper, we study the distributed optimal control problem of a coupled system of the host-pathogen model. The system consists of the density of the susceptible host, the density of the infected host, and the density of pathogen particles. Our main goal is to minimize the infected density and also to decrease the cost of the drugs administered. First, we prove the existence and uniqueness of solutions for the proposed problem. Then, the existence of the optimal control is established and necessary optimality conditions are also derived.

Innate immune response to oral bacteria and the immune evasive characteristics of periodontal pathogens

  • Ji, Suk;Choi, Youngnim
    • Journal of Periodontal and Implant Science
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    • v.43 no.1
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    • pp.3-11
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    • 2013
  • Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interaction of nonperiodontopathic versus periodontopathic bacteria with innate immune components encountered in the gingival sulcus will be described. In particular, we will describe the susceptibility of these microbes to antimicrobial peptides (AMPs) and phagocytosis by neutrophils, the induction of tissue-destructive mediators from neutrophils, the induction of AMPs and interleukin (IL)-8 from gingival epithelial cells, and the pattern recognition receptors that mediate the regulation of AMPs and IL-8 in gingival epithelial cells. This review indicates that true periodontal pathogens are poor activators/suppressors of a host immune response, and they evade host defense mechanisms.

Ascophyllum and its symbionts. VI. Microscopic Characterization of the Ascophyllum nodosum (Phaeophyceae), Mycophycias ascophylli (Ascomycetes) Symbiotum

  • Deckert, R. J.;Garbary, D. J.
    • ALGAE
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    • v.20 no.3
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    • pp.225-232
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    • 2005
  • Optical microscopy of recently living and cleared material of the fucoid, Ascophyllum nodosum (L.) Le Jolis, revealed novel aspects of its interaction with the ascomycete Mycophycias ascophylli (Cotton) Kohlmeyer and Kohlmeyer (previously Mycosphaerella ascophylli Cotton). Most host cells are associated with hyphae by lateral attachment of cell walls. Hyphae form extensive networks throughout the host thallus and show considerable differentiation in the various host tissues. In the base of epidermal cells, hyphae form multicellular rings around each host cell to produce a continuous network. In medullary regions, long, relatively unbranched and longitudinally aligned hyphae occur, with radial branches extending into cortical regions. Scattered in the inner cortex of host tissue are numerous multicellular nodes of smaller, polygonal to irregular shaped cells with five or more radiating arms of hyphae. Individual hyphal cells show a variety of specializations including swellings and appressoria-like attachments to some host cells. These observations provide the morphological basis for the mutualistic symbiosis supported by recent experimental work. We conclude that this association is best described by the term “symbiotum.”

Host-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment

  • Kim, Ye-Ram;Yang, Chul-Su
    • Journal of Microbiology and Biotechnology
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    • v.27 no.9
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    • pp.1549-1558
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    • 2017
  • Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a prevalent infectious disease worldwide owing to the limitations of current TB therapeutic regimens. Recent work on novel TB treatment strategies has suggested that directly targeting host factors may be beneficial for TB treatment. Such strategies, termed host-directed therapeutics (HDTs), focus on host-pathogen interactions. HDTs may be more effective than the currently approved TB drugs, which are limited by the long durations of treatment needed and the emergence of drug-resistant strains. Targets of HDTs include host factors such as cytokines, immune checkpoints, immune cell functions, and essential enzyme activities. This review article discusses examples of potentially promising HDTs and introduces novel approaches for their development.

Relationship Between Plant Viral Encoded Suppressor to Post-transcriptional Gene Silencing and Elicitor to R Gene-specific Host Resistance

  • Park, Chang-Won;Feng Qu;Tao Ren;T. Jack Morris
    • The Plant Pathology Journal
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    • v.20 no.1
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    • pp.22-29
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    • 2004
  • Many important horticultural and field crops are susceptible to virus infections or may possess a degree of resistance to some viruses, but become infected by others. Plant viruses enter cells through the presence of wounds, and replicate intracellularly small genomes that encode genes required for replication, cell-to-cell movement and encapsidation. There are numerous evidences from specific virus-host interactions to require the involvement of host factors and steps during viral replication cycle. However, viruses should deal with host defense responses either by general or specific mechanisms, targeting viral components or genome itself. On the other hand, the host plants have also adapted to defend themselves against viral attack by operating different lines of resistance responses. The defense-related interactions provide new insights into the complex molecular strategies for hosts for defense and counter-defense employed by viruses.

Host galaxy of tidal disruption object, Swift J1644+57

  • Yoon, Yongmin;Im, Myungshin;Lee, Seong-Kook;Pak, Soojong
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.1
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    • pp.48.2-48.2
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    • 2014
  • We present long-term optical to NIR data of the tidal disruption object, Swift J1644+57. The data were obtained with CQUEAN, UKIRT WFCAM observations. We analyze the morphology of the host galaxy of this object and decompose the bulge component using high resolution HST WFC3 images. We conclude that the host galaxy is bulge dominant. We also estimate the multi-band fluxes of the host galaxy through the light curves based on the long-term observational data. We fit the SED models to the multi-band fluxes of the host galaxy and determine its stellar mass. Finally, we estimate the mass of the central super massive black hole which is responsible for the tidal disruption event. The estimated stellar mass and black hole mass are ${\sim}10^{9.1}M_{\odot}$, ${\sim}10^{6.8}M_{\odot}$, respectively. We compare our results to other previous estimates.

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HOST GALAXY OF TIDAL DISRUPTION OBJECT, SWIFT J1644+57

  • YOON, YONGMIN;IM, MYUNGSHIN;LEE, SEONG-KOOK;PAK, SOOJONG
    • Publications of The Korean Astronomical Society
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    • v.30 no.2
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    • pp.475-476
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    • 2015
  • We analyze the host galaxy of the tidal disruption object, Swift J1644+57, based on long-term optical to NIR data obtained with CQUEAN and UKIRT WFCAM observations. We decompose the bulge component using high resolution HST WFC3 images. We conclude that the host galaxy is bulge dominant. We investigate optical to NIR light curves and estimate the multi-band fluxes of the host galaxy. We fit spectral energy distribution (SED) models in order to determine the stellar mass. Finally, we estimate the mass of the black hole in the center of the host galaxy based on several scale relations.

The Impact of Environmental and Host Specificity in Seed Germination and Survival of Korean Mistletoe [Viscum album var. coloratum (Kom.) Ohwi]

  • Lee, Bo Duck;Lee, Young Woo;Kim, Seong Min;Cheng, Hyo Cheng;Shim, Ie Sung
    • Korean Journal of Plant Resources
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    • v.28 no.6
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    • pp.710-717
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    • 2015
  • Humankind has been searching for medicinal materials from various plant sources in an attempt to treat disease. Mistletoe is one indubitable plant source for these materials due to its effectiveness in treating various diseases, but it has almost disappeared from the mountainous areas of Korea due to excessive harvesting. In this study, in order to select host tree species for Korean mistletoe [Viscum album var. coloratum (Kom.) Ohwi] by seed inoculation and to clarify the effect of host specificity among various tree species were conducted for the purpose of gaining basic information for the artificial cultivation of Korean mistletoe. Almost all the seeds of Korean mistletoe germinated in vitro at the temperature of 15℃. Among host trees used in this study, Prunus mume showed the highest parasitic affinity with inoculated Korean mistletoe, compared with any other host plants. However, treatment of hormones could not increase the low survival rate of Korean mistletoe on the host trees.