• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.281-296
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• 2021

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetes-induced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury. Sixteen-week old db/db (diabetic) and C57BL/6 (non-diabetic) mice were employed. There was a significant impairment in cognitive function (Morris Water Maze test), endothelial function (acetylcholine-induced relaxation in aortic rings) and a significant increase in IR-induced heart injury (Langendorff apparatus) in db/db mice. WBHP stimulus was given by exposing mice to four alternate cycles of low (8%) and normal air O₂ for 10 min each. A single episode of WBHP failed to produce protection; however, two and three episodes of WBHP significantly produced beneficial effects on the heart, brain and blood vessels. There was a significant increase in the levels of brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) in response to 3 episodes of WBHP. Moreover, pretreatment with the BDNF receptor, TrkB antagonist (ANA-12) and NO synthase inhibitor (L-NAME) attenuated the protective effects imparted by three episodes of WBHP. These pharmacological agents abolished WBHP-induced restoration of p-GSK-3β/GSK-3β ratio and Nrf2 levels in IR-subjected hearts. It is concluded that repeated episodes of WHBP attenuate cognitive impairment, vascular dysfunction and enhancement in IR-induced myocardial injury in diabetic mice be due to increase in NO and BDNF levels that may eventually activate GSK-3β and Nrf2 signaling pathway to confer protection.

• 한국컴퓨터산업학회논문지
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• 제3권1호
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• pp.9-18
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• 2002

최근 의료환경의 변화와 함께 병원 간 경쟁이 더욱 심화되어 병원경영의 목표가 새로 정립되고 있다. 이러한 목표를 달성하기 위해 진료지원부서인 병원 급식 및 영양 서비스 분야에서도 혁신적인 방안을 모색하고 있다. 모색된 여러 가지 방안들을 구체적으로 실행하는데 있어 전산화를 기반으로 한 정보시스템의 구축은 필수적이다. 본 연구에서는 병원 급식 및 영양서비스분야에서 사용하고 있는 각종 정보의 통합적 관리를 위한 정보시스템을 구축하고자 하였다. 기존의 단순 반복적인 업무들을 전산화하는 것은 물론이고, 병원 정보시스템과 유기적으로 연계할 수 있는 정보시스템 구축을 통해 급식분야의 생산성을 향상시키고, 비용 절감의 효과를 얻고자 하였다. 이는 병원 경영의 효율성을 제고하고 타 병원에 대한 경쟁력을 확보할 뿐 아니라 궁극적으로는 최고의 환자 식사 서비스 만족을 도모하는데 큰 역할을 할 것이다. 본 연구를 통해 구축된 병원 급식 및 영양서비스 분야의 정보시스템을 TASTY(Time-based Advanced Service Technology for Yong-Dong Severance Hospital, Nutrition Department)라 명명하였다. TASTY는 식단관리, 구매관리, 임상영양서비스관리, 작업관리, 급식경영분석의 5가지 업무 분야와 이들의 바탕이 되는 기본 정보관리 업무를 수행한다.

• 보건의료산업학회지
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• 제2권1호
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• pp.155-165
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• 2008

This study is aims finding out characteristics and change levels of medical advertizing between before and after revised medical laws. We investigated to medical advertizing of 3 major newspaper(Josen, Joongang, Donga) to achieve study purpose. After revised medical laws, major change is seen below. 1. Increase rates of medical advertizing was 65.5%. Specially, increase rates of medical advertizing by each department were differently each department; Dermatology was 450%, dentist's clinic was 342%, orthopedic surgery was 171%, and plastic surgery was 133%. In spite of increasing trends of most departments, urology decreased to 50% than before revised medical laws. 2. Of types of medical advertizing, Question and Answer type increased to 230% than before. Illegal level of medical advertizing was 10.4%. 3. The contents of medical advertizing were hospital location, photograph before and after treatments, and carrier, name and introduction of medical staffs. 4. The size of medical advertizing increased 1.73 column then before. The size of medical advertizing in clinics was shown statistically increase than hospital level. With above results, it is cleared that increase rates and trends of medical advertizing are more increased and complicated before revised medical laws. We try to be better situations for patients to get more exactly information and facts.

• 산업경영시스템학회지
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• 제42권4호
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• pp.126-134
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• 2019

Nowadays, since there are so many big data available everywhere, those big data can be used to find useful information to improve design and operation by using various analysis methods such as data mining. Especially if we have event log data that has execution history data of an organization such as case_id, event_time, event (activity), performer, etc., then we can apply process mining to discover the main process model in the organization. Once we can find the main process from process mining, we can utilize it to improve current working environment. In this paper we developed a new method to find a final diagnosis of a patient, who needs several procedures (medical test and examination) to diagnose disease of the patient by using process mining approach. Some patients can be diagnosed by only one procedure, but there are certainly some patients who are very difficult to diagnose and need to take several procedures to find exact disease name. We used 2 million procedure log data and there are 397 thousands patients who took 2 and more procedures to find a final disease. These multi-procedure patients are not frequent case, but it is very critical to prevent wrong diagnosis. From those multi-procedure taken patients, 4 procedures were discovered to be a main process model in the hospital. Using this main process model, we can understand the sequence of procedures in the hospital and furthermore the relationship between diagnosis and corresponding procedures.

• 보건의료산업학회지
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• 제11권4호
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• pp.213-224
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• 2017

Objectives : The purpose of this study was to analyze representative topics and topic trends of papers in Korean Society and Health Service Management(KSHSM) Journal. Methods : We collected English abstracts and key words of 516 papers in KSHSM Journal from 2007 to 2017. We utilized Python web scraping programs for collecting the papers from Korea Citation Index web site, and RStudio software for topic analysis based on latent Dirichlet allocation algorithm. Results : 9 topics were decided as the best number of topics by perplexity analysis and the resultant 9 topics for all the papers were extracted using Gibbs sampling method. We could refine 9 topics to 5 topics by deep consideration of meanings of each topics and analysis of intertopic distance map. In topic trends analysis from 2007 to 2017, we could verify 'Health Management' and 'Hospital Service' were two representative topics, and 'Hospital Service' was prevalent topic by 2011, but the ratio of the two topics became to be similar from 2012. Conclusions : We discovered 5 topics were the best number of topics and the topic trends reflected the main issues of KSHSM Journal, such as name revision of the society in 2012.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 춘계학술대회
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• pp.326-329
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• 2009

기존의 Nurse Call 제품은 환자가 비상 call을 하였을 때 환자의 이름과 병실만 간호사의 단말기에 표시되므로, 환자가 병실이 아닌 다른 장소에 있는 경우에는 환자의 위치를 찾기가 어려운 상황이다. 따라서 환자가 병실이 아닌 다른 장소에서 긴급 call을 하는 경우에는 환자의 위치를 알 수 없어 찾는데 많은 시간을 소요할 수가 있어 위급한 환자에게는 큰 타격을 줄 수 있다. 따라서 본 논문에서는 SOFM을 이용하여 중계기를 최적으로 배치하고 배치한 정보와 RSSI를 이용하여 환자의 위치를 찾아낼 수 있는 무선 너스 콜 시스템을 제안하였다. 제안한 시스템의 유용성을 확인하기 위하여 실험한 결과 위치 정보를 오차 범위 내에서 얻을 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권5호
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• pp.377-381
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• 2014

Propofol is a widely used anesthetic. Many studies have shown that propofol has direct effects on blood vessels, but the precise mechanism is not fully understood. Secondary intrapulmonary artery rings from male rats were prepared and mounted in a Multi Myograph System. The following constrictors were used to induce contractions in isolated artery rings: high $K^+$ solution (60 mmol/L); U46619 solution (100 nmol/L); 5-hydroxytryptamine (5-HT; $3{\mu}mol/L$); or phenylephrine (Phe; $1{\mu}mol/L$). The relaxation effects of propofol were tested on high $K^+$ or U46619 precontracted rings. Propofol also was added to induce relaxation of rings preconstricted by U46619 after pretreatment with the nitric oxide synthase inhibitor $N^G$-nitro-L-arginine methyl ester (L-NAME). The effects of propofol on $Ca^{2+}$ influx via the L-type $Ca^{2+}$ channels were evaluated by examining contraction-dependent responses to $CaCl_2$ in the absence or presence of propofol (10 to $300{\mu}mol/L$). High $K^+$ solution and U46619 induced remarkable contractions of the rings, whereas contractions induced by 5-HT and Phe were weak. Propofol induced dose-dependent relaxation of artery rings precontracted by the high $K^+$ solution. Propofol also induced relaxation of rings precontracted by U46619 in an endothelium-independent way. Propofol at different concentrations significantly inhibited the $Ca^{2+}$-induced contractions of pulmonary rings exposed to high $K^+$-containing and $Ca^{2+}$-free solution in a dose-dependent manner. Propofol relaxed vessels precontracted by the high $K^+$ solution and U46619 in an endothelium-independent way. The mechanism for this effect may involve inhibition of calcium influx through voltage-operated calcium channels (VOCCs) and receptor-operated calcium channels (ROCCs).

• Korean Journal of Radiology
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• 제22권5호
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• pp.801-810
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• 2021

Objective: To investigate imaging biomarkers of microperfusion in contrast-induced nephropathy (CIN) using contrast-enhanced ultrasound (CEUS). Materials and Methods: The CIN model was fabricated by administering indomethacin (10 mg/kg), L-NAME (15 mg/kg), and iopamidol (10 mL/kg) to Sprague-Dawley rats. After 24 hours, CEUS was performed on CIN (n = 6) and control (n = 6) rats with sulphur hexafluoride microbubbles (SonoVue). From time-intensity curves obtained from the kidney arriving time (AT), acceleration time (AC), time to peak (TTP), and peak enhancement (PE) were measured and compared between the groups. After CEUS, the rats were sacrificed, and cell apoptosis markers were evaluated to confirm the development of CIN. Results: Among CEUS parameters, AT (7.8 ± 1.6 vs. 4.2 ± 0.5 s, p = 0.002), AC (4.7 ± 1.4 vs. 2.0 ± 0.4 s, p = 0.002), and TTP (12.5 ± 2.9 vs. 6.2 ± 0.6 s, p = 0.002) were significantly prolonged in the CIN group compared to controls. PE was significantly higher in the control group than in the CIN group (17.1 ± 1.9 vs. 12.2 ± 2.0 dB, p = 0.004). In kidney tissue, mRNA and protein levels of the apoptotic makers were significantly higher in the CIN group than in the control group (p = 0.003 and p = 0.002). Conclusion: CEUS parameters can be used as imaging biomarkers for microperfusion in CIN. In rats with CIN, AT, AC, and TTP were significantly prolonged, while PE was significantly lower compared to controls.

• 한국도서관정보학회지
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• 제44권4호
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• pp.93-122
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• 2013

본 연구에서는 전문사서 유형 중 최근 웰빙 및 건강에 대한 관심이 증가하면서 그 역할이 증대되고 있는 건강정보전문사서의 역할을 규명하고자 하였다. 즉 구인구직사이트 분석을 기반으로 건강정보전문사서가 갖추어야 할 학력, 경력, 수행할 직무 등을 제시하고자 하였다. 연구결과 첫째, 건강정보전문사서의 명칭은 매우 다양하게 나타나고 있으나 공공도서관에는 건강정보 전문사서, 병원도서관 및 의학도서관에는 의학전문사서의 명칭이 적합하다고 본다. 둘째, 건강정보전문사서는 석사 이상의 문헌정보학 교육 경력 및 학사 이상의 건강관련 교육 경력이 요구된다. 셋째, 적어도 2년 이상의 해당분야 경력이 요구되며 특히 건강정보서비스 경험이 요구된다. 넷째, 뛰어난 커뮤니케이션 능력 및 대인관계능력이 요구되며, 특히 건강관련 정보자원에 대한 높은 지식이 요구된다. 다섯째, 수행해야 할 주요 직무는 도서관운영업무, 교육업무, 연구업무, 정보자원의 접근과 공유업무, 장서관리 업무, 정보관리기술업무, 지지활동 등이 있다.

• Biomolecules & Therapeutics
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• 제24권5호
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• pp.536-542
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• 2016

Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.