• Tuberculosis and Respiratory Diseases
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• 제53권2호
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• pp.148-160
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• 2002

배 경 : 쥐를 고농도의 산소에 60시간 이상 노출시켰을 때 급성 폐손상이 유발되지만 내독소를 저용량으로 투여시에는 이러한 폐손상이 경감된다고 알려져 있으나 그 기전에 대하여는 확실히 밝혀지지 않고 있다. 산화질소(nitric oxide, NO)는 내독소나 염증성 사이토카인(cytokine) 등의 자극에 의해서 폐내 여러 염증세포에서 만들어지며 이 산화질소는 경우에 따라 우리 몸에 이롭거나 해로운 양면성을 지니고 있다. 저자들은 쥐에서 고농도의 산소에 의한 폐손상이 저농도의 내독소 투여로 경감되는 기전에, 산화질소가 중요한 역할을 하는지 또는 황산화효소나 다른 항염증성 사이토카인이 중요한 역할을 하는지를 규명하고자 하였다. 방 법 : 총 120마리의 쥐 (Sprague-Dawley rat)를 24마리씩 5군으로 나누어 대조군은 실내 공기를, 고농도 산소군은 100%의 산소를 100%의 산소를 60시간 투여하였고 내독소군은 100% 산소 투여시 2일간 저용량의 내독소를 투여하였다. 다른 두 군은 산화질소 합성 억제물인 aminoguanidine(AG)과 N-nitro-L-arginine methyl ester (L-NAME)를 각각 2일간 고농도 산소와 내독소에 더하여 투여하였다. 각각의 군에서 폐손상의 정도와 사망률을 관찰하고 superoxide dismutase(SOD), catalase, nitric oxide, IL-6, IL-11을 기관지폐포세척액에서 측정하고, 고농도산소 투여군의 폐조직에서 iNOS synthase rnRNA의 발현을 비교하였다. 결 과: 1. 100%의 산소에 60시간 노출시켰을 때 쥐의 사망률은 8.3% 이었고 내독소 투여군은 4.2%, NAME 투여군이 37.5%, AG 투여군이 25%로 산화질소 합성 억제제에 의하여 사망률의 증가가 관찰되었다. 2. 폐의 손상 정도를 나타내는 폐의 wet/dry 중량비와 늑막액도 100%의 산소에 노출된 군에서 증가되었고 내독소 투여에 의하여 감소되었으며 NAME나 AG 투여군에서는 오히려 증가되었다. 3. 이러한 내독소에 의한 폐손상 억제효과가 항산화효소인 SOD나 catalase, 또는 protective cytokine인 IL-6나 IL-11등의 증가와 관련이 있는지를 관찰하였으나 이들 모두에서 유의한 변화를 관찰하지 못하였다. 4. 산화질소는 100% 산소에 노출시킨 군에서도 증가하였으나 내독소 투여군에서 유의하게 더욱 증가하였고 이는 L-NAME 나 aminoguanidine의 투여시 감소하였다. 5. iNOS mRNA의 발현도 내독소 투여군에서 유의하게 증가하였다. 결 론 : 쥐의 고농소 산소 투여에 의한 폐손상은 저용량의 내독소 투여로 경감되며, 이는 주로 내독소 투여에 의한 iNOS mRNA의 발현을 유도하여 생성된 산화질소의 증가에 기인하는 것으로 생각된다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2011년도 춘계 종합학술대회 논문집
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• pp.189-190
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• 2011

이 연구는 브랜드 네임 스펙트럼 이론을 이용하여 병원 명칭의 특성을 분석하였다. 연구대상은 수도권 지역에 위치하는 모든 병원을 대상으로 하였고, 명칭은 의미있는 단위로 분류한 후 스펙트럼 이론에 따라 분류하였다. 분석결과 임의적 명칭의 빈도가 가장 높았고, 다음으로는 암시적, 서술적, 그리고 조어적 명칭의 순이었다. 단일 스펙트럼 구성된 명칭이 가장 많았으며, 스펙트럼이 2개와 3개로 구분된 명칭의 순이었다.

• 디지털융복합연구
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• 제11권7호
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• pp.271-279
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• 2013

본 연구는 공공의료기관의 인지도와 재방문여부와의 관계 및 영향을 미치는 요인을 살펴봄으로써 인지도를 높일 수 있는 방안을 제시하여 병원 재방문 증가에 기여하고자 하는데 그 의의가 있다. 분석방법은 빈도분석, 신뢰도 및 탐색적 요인분석, t-test, ANOVA, 상관관계분석, 위계적 다중회귀분석을 실시하여 결론을 도출하였다. 결과를 보면 상관관계분석에서는 재방문여부와 독립변수들간에 모두 유의한 상관관계를 보였고, 서비스품질인식 및 진료환경적 요인이 독립변수들의 설명력을 증가시켜 의료기관의 재방문과의 높은 관련성이 있음을 보여주고 있으며, 평소 이미지 및 의료서비스, 진료환경은 재방문의사에 긍정적인 영향을 미친다는 결과를 도출하였다. 본 연구를 통해서 공공의료기관의 인지도와 재방문과의 관련성을 확인 할 수 있었으며, 공공의료기관은 의료서비스 질과 인프라를 개선시키기 위해서 지속적으로 이미지 및 의료서비스, 진료환경에 대한 기대수준을 파악하여 재방문을 향상시킬 수 있는 대안 연구가 필요할 것이다.

• 대한수의학회지
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• 제41권3호
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• pp.299-304
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• 2001

토끼 적출 신동맥에 있어서 acetylcholin(Ach)에 의한 이완작용에 대한 nitric oxide(NO) 합성 억제제인 $N^{G}$-nitro-L-arginine methyl ester(L-NAME)과 prostanoid 합성 억제제인 indomethacin의 영향을 관찰하였다. Ach($10^{-8}-3{\times}10^{-5}M$)에 대한 이완작용은 내피세포를 제거시킴으로서 완전히 사라졌다. L-NAME ($10^{-4}M$)은 Ach ($10^{-8}-3{\times}10^{-5}M$)의 이완작용을 현저히 감소시켰으며 L-arginine ($10^{-3}M$)에 의해 Ach의 이완작용에 대한 L-NAME ($10^{-4}M$)의 억제효과가 현저히 약하게 나타났다. Indomethacin ($10^{-6}M$)은 Ach ($10^{-8}-3{\times}10^{-5}M$)의 이완작용에 영향을 미치지 못하였다. L-NAME ($10^{-4}M$)에 indomethacin ($10^{-6}M$)의 첨가는 Ach ($10^{-8}-3{\times}10^{-5}M$)의 이완작용이 L-NAME ($10^{-4}M$) 단독의 경우보다 더 큰 억제효과를 나타내었다. 이와 같은 결과로 토끼적출 신동맥에서 Ach은 내피세포 의존성 이완작용을 나타내며, NO와 prostanoid가 수반되어 나타나는 것으로 사료되어진다.

• The Korean Journal of Physiology and Pharmacology
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• 제10권4호
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• pp.213-216
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• 2006

The present study was aimed to determine whether nitric oxide (NO) plays a role in the regulation of aquaporin (AQP) channels in the kidney. Male Brattleboro rats ($250{\sim}300\;g$ body weight) were used. The experimental group was treated with $N^G$-nitro-L-arginine methyl ester (L-NAME, 100 mg/L drinking water) for 1 week, and cotreated with indomethacin (5 mg/kg, twice a day, i.p.) for the last two days. Control groups were treated with either L-NAME for 1 week, indomethacin for 2 days, or without any drug treatment. The abundance of AQP1, AQP2 and AQP3 proteins in the kidney was determined by Western blot analysis. Indomethacin downregulated AQP channels, whereas L-NAME by itself showed no significant effects on them. The indomethacin-induced downregulation of AQP2 and AQP3 was significantly blunted in L-NAME-treated rats, while that of AQP1 was not affected. These results suggest that endogenous NO, when stimulated, may downregulate AQP channels that are specifically regulated by AVP/cAMP pathway in the kidney.

• The Korean Journal of Physiology and Pharmacology
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• 제20권5호
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• pp.441-447
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• 2016

Despite the complex vascular effects of dexmedetomidine (DEX), its actions on human pulmonary resistance arteries remain unknown. The present study tested the hypothesis that DEX inhibits vascular tension in human pulmonary arteries through the endothelial nitric oxide synthase (eNOS) mediated production of nitric oxide (NO). Pulmonary artery segments were obtained from 62 patients who underwent lung resection. The direct effects of DEX on human pulmonary artery tension and changes in vascular tension were determined by isometric force measurements recorded on a myograph. Arterial contractions caused by increasing concentrations of serotonin with DEX in the presence or absence of L-NAME (endothelial nitric oxide synthase inhibitor), yohimbine (${\alpha}_2$-adrenoceptor antagonist) and indomethacin (cyclooxygenase inhibitor) as antagonists were also measured. DEX had no effect on endothelium-intact pulmonary arteries, whereas at concentrations of $10^{-8}{\sim}10^{-6}mol/L$, it elicited contractions in endothelium-denuded pulmonary arteries. DEX (0.3, 1, or $3{\times}10^{-9}mmol/L$) inhibited serotonin-induced contraction in arteries with intact endothelium in a dose-dependent manner. L-NAME and yohimbine abolished DEX-induced inhibition, whereas indomethacin had no effect. No inhibitory effect was observed in endothelium-denuded pulmonary arteries. DEX-induced inhibition of vasoconstriction in human pulmonary arteries is mediated by NO production induced by the activation of endothelial ${\alpha}_2$-adrenoceptor and nitric oxide synthase.

• 사상체질의학회지
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• 제23권3호
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• pp.304-317
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• 2011

1. Objectives: Aromatherapy is one of the alternative medical treatments by flavors of essential oils extracted from plants. This study was to investigate the classification of aroma essential oils by Sasang Constitution for clinical applications. 2. Methods: 1) We searched scientific name of aroma essential oils and scientific name of herbs, classify aroma essential oils according to Sasang Constitution. 2) If the method 1) is impossible, sort them by regard of aroma essential oils' flavors, specific characters and efficacies. 3. Results: Aroma essential oils suitable for Soeumin are 27 kinds, for Soyangin and Taeeumin are each 16 kinds, and for Taeyangin are 5 kinds.(Duplicates are allowed.) The cases which can not be classified clearly, are 10 kinds, so they are able to consider the Constitution of the more than two-phase. 4. Conclusions: Most of aromatic herbs are warm and spicy by pre-reports. So, aroma essential oils suitable for Soeumin are most often. After this study, studies about Sasang Constitutional herb recipes and more clinical studies are needed.

• Journal of Acupuncture Research
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• 제18권4호
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• pp.13-21
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• 2001

Objective : This study is performed to evaluate the clinical effect of acupuncture to acu-points in the normal side by means of amperage measured from chong points. Methods : Among the outpatients with ankle sprain who visited to Department of Acupuncture & Maxibustion, Jaseng oriental medicine hospital from 21, December 2000 to 10, February 2001, we selected 11 persons who showed normal finding in the X-ray. They were divided into two groups. One group was treated with acupuncture to acu-points in the painful side and the other was treated with acupuncture to acu-points in the normal side. Before and after acupuncture, we measured the amperage from their chong points. We selected 10 persons who we thought they were healthy as a control group. We also measured the amperage from their chong points. Results : Between the control and the ankle sprain group, there were significant differences of differences between the amperages of Rt. chong point and Lt. thong point of the same name. Between the group treated with acupuncture to acu-points in the painful side and the group treated with acupuncture to acu-points in the normal side, there were no significant differences of differences between the amperages of Rt. chong point and Lt. chong point of the same name. Conclusion : This result indicated that the acupuncture to acu-points in the painful side was not less effective than the acupuncture to acu-points in the normal side, and so the more study is needed continuously.

• 대한물리의학회지
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• 제5권2호
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• pp.151-164
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• 2010

Purpose : The purpose of this study was to investigate curriculums of physical therapy department in order to provide the basic data for developing educational standard. Methods : We identified the curriculums of physical therapy department in the world from January to may 2010 by internet, e-mail, fax and telephone. We compared the credits, education semesters, the names of departments, the numbers of departments for physical therapy education in all countries of the world and suggested some alternative for improvement. Results : The mean credits of 25 senior colleges were 140 and the mean credits of 22 Junior colleges were 136.6 in south Korea. The mean educational semesters and the mean credits were 9 semesters, 175.8credits of 1,363 universities in 73countries in the world. Of the 1,289 universities in the world, South Korea was ranked the fifth in the number of existing physical therapy education institutions with the number of 72. The name of department were comprised of physical therapy(1,289, 94.6%) and compound name(75, 5.4%) Conclusion : We suggest that the KAPT gradually rearranges senior college(4years), 170 creditS and consider time of community services and forms commission on accreditation in physical therapy education for developing educational standard. Also, we suggest to change the name of department into compound name because the student can have a chance to studies various subjects and get a chance to more occupations. We hope that the results of study can be helpful in order to rearrange the curriculum and the KAPT encourages the universities about following the educational standard.

• 한국병원경영학회지
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• 제19권2호
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• pp.55-65
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• 2014

The objective of this study is to identify the effect of brand evidence on customer satisfaction, and the effect of customer satisfaction on brand verdict in case of hospital management. To achieve this objective, 250 hospital customers were surveyed in Busan and Gyeongnam province. Of these, 220 respondents were used for the analysis. The research results show that brand name, employee service, core service and feelings have a positive effect on customer satisfaction. However, services cape failed to affect customer satisfaction.