• The Korean Journal of Pain
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• 제12권1호
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• pp.27-35
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• 1999

Background: Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive histological or laboratory abnormality in diagnosis, it has often been considered a form of "psychogenic rheumatism". Fibromyalgia causes much distress to the affected patients and often frustrates physicians, who are unable to start rational therapy on any logical disease pathology. Methods: Growth hormone is essential for muscular homeostasis. In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of somatomedin C were measured; somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis. Serum levels of somatomedin C using acid-extraction procedure and two-site immunoradiome-tric assay (IRMA) and number of tender points were measured in 27 female patients with fibromyalgia from 40 to 60 years old and 27 healthy controls. Results: There were no differences in the concentration of somatomedin C between fibromyalgia patients and controls ($mean{\pm}SD$: $178.3{\pm}75.5$ ng/ml versus $166.3{\pm}76.6$ ng/ml; p=0.55). And there were no correlations between number of tender point and serum somatomedin C level by linear regression analysis. Conclusions: These findings did not support that there is a distinctive disruption of the growth hormone-somatomedin C neuroendocrine axis in a fibromyalgia syndrome. But we can not discard the hypothesis that disturbed sleep predispose to muscle pain.

• 한국노년학
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• 제30권3호
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• pp.933-946
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• 2010

이 연구는 노인 여성을 위한 율동적 운동프로그램이 체구성과 노화관련 호르몬에 미치는 영향을 구명하기 위한 목적을 두고 연구가 이루어졌다. 이 연구의 대상자들은 C시 노인복지관에서 60세 이상 노인여성 20명을 대상으로 하였으며, 12주 동안 율동적 운동프로그램을 실시하였다. 율동적 운동프로그램 적용 후 체중(t=3.125, p=.006), 신체질량지수(t=3.225, p=0.004), 체지방량(t=3.782, p=0.001), 그리고 허리/엉덩이 둘레 비율(t=3.867, p=0.001)의 유의한 감소를 보였으며, 제지방량의 유의한 차이는 관찰할 수 없었다. 율동적 운동프로그램 적용 후 성장호르몬(t=-2.221, p=0.039), 소마토메딘-C (t=-9.186, p=0.000)의 유의한 증가를 관찰하였지만 DHEA-S는 유의하게 증가하지 않았다. 이상의 결과로 율동적 운동프로그램이 노인 여성의 체구성 조절과 일부 노화관련 호르몬 변화에 효과적인 운동프로그램임을 확인하였다.