• The Korean Journal of Pain
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• v.12 no.1
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• pp.27-35
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• 1999

Background: Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive histological or laboratory abnormality in diagnosis, it has often been considered a form of "psychogenic rheumatism". Fibromyalgia causes much distress to the affected patients and often frustrates physicians, who are unable to start rational therapy on any logical disease pathology. Methods: Growth hormone is essential for muscular homeostasis. In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of somatomedin C were measured; somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis. Serum levels of somatomedin C using acid-extraction procedure and two-site immunoradiome-tric assay (IRMA) and number of tender points were measured in 27 female patients with fibromyalgia from 40 to 60 years old and 27 healthy controls. Results: There were no differences in the concentration of somatomedin C between fibromyalgia patients and controls ($mean{\pm}SD$: $178.3{\pm}75.5$ ng/ml versus $166.3{\pm}76.6$ ng/ml; p=0.55). And there were no correlations between number of tender point and serum somatomedin C level by linear regression analysis. Conclusions: These findings did not support that there is a distinctive disruption of the growth hormone-somatomedin C neuroendocrine axis in a fibromyalgia syndrome. But we can not discard the hypothesis that disturbed sleep predispose to muscle pain.

• 한국노년학
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• v.30 no.3
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• pp.933-946
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• 2010

The purpose of this study was to examine the changes of body composition and aging-related hormones by rhythmic exercise in elderly women. The subjects in this study were 20 olders living in a rural community, >60 years of age and were performed rhythmic exercise program during 12 weeks. The measurement of the body composition, body mass (t=3.125, p=.006), body mass index (t=3.225, p=0.004), body fat mass (t=3.782, p=0.001), waist-to-hip ratio (t=3.867, p=0.001) were significant difference after exercise program, but had no effect on lean body mass. Also, growth hormone (t=-2.221, p=0.039) and somatomedin-C (t=-9.186, p=0.000) were significantly increased after rhythmic exercise, however, rhythmic exercise had no effect on DHEA-S. These results suggest that rhythmic exercise appeared to effect of control on body composition and some aging-related hormones in elderly women.