• Food Science and Biotechnology
• /
• v.17 no.2
• /
• pp.408-412
• /
• 2008

Determining the elution of water-soluble substances from herbal teas is an important factor in their efficient use in terms of taste, perfume, and content of health-related components. The antioxidant activity and content of catechins in commercial Chrysanthemum indicum (gamguk) teas were determined for optimum elution conditions. The water extract of gamguk teas did not differ significantly in yield compared to methanol extracts and showed stronger antioxidant activity. Catechin contents in gamguk teas were 8-18% of the extracts when individual peaks in high-performance liquid chromatography analysis were compared to standard catechin peaks. Gamguk teas exhibited faster release of antioxidants, and the antioxidant activity was positively correlated with the thermal treatments. Gukhwacha (GC) was the best tea for rapid release (30 sec) of antioxidants with the $50^{\circ}C$ treatment, whereas antioxidants in other teas were relatively slower released.

• Journal of Korean Society on Water Environment
• /
• v.30 no.6
• /
• pp.596-604
• /
• 2014

This research has studied the physicochemical environmental factors and communities of epilithic diatom and phytoplanktons at Hongcheon river from December 2011 to September 2012. In case of TN, the result was hypertrophic, and for TP, it ranged from mesotrophic to eutrophic. As for BOD, Hongcheon river was rated level II or better, according to the water quality level; values were found to be below 3mg/L at most sites. Total of 83 and 114 taxa of epilithic diatom and phytoplanktons respectively, were found during the research. When assessed using the TSI, it ranged from oligomesotrophic to eutrophic. In case of DAIpo, it ranged from 64.1 to 99.5, and TDI ranged from 51.5 to74.0. These results signify good water quality, level B or better, for Hongcheon river. P-IBI was rated moderate to low, which showed higher pollution than other indices. Among the biological water quality measures analyzed in the Hongcheon river study, DAIpo best matches TDI and BOD, while TDI showed greater pollution. Therefore, P-IBI appears to be inappropriate when assessing the domestic small rivers and lakes.

• Korean Journal of Environmental Biology
• /
• v.22 no.3
• /
• pp.446-455
• /
• 2004

The ichthyofauna and community structure in Hongcheon river, Korea, was investigated from April to October 2002. During the surveyed period, 52 species belonging 11 families were collected. There were 23 Korean endemic species (44.23%), including Rhodeus uyekii, Acheilognathus signifer, A. yamatsutae, Coreoleuciscus splendidus, Koreocobitis rotundicaudata and Silurus microdorsalis. Dominant species were Zacco platypus (20.38%), and subdominant species were Z. temmincki (19.62%). Also, Rhynchocypris oxycephalus (8.45%), Pungtungia herzi (8.01%), C. splendidus (6.63%) were numerous. Of the 6 introduced fishes in Hongcheon river Carassius cuvieri, Lepomis macrochirus and Micropterus salmoides were originated from foreign countries but Anguilla japonica, Gymnogobius urotaenia, Rhinogobius giurinus were introduced from other native river systems. According to the fish distribution, the fish community of Hongcheon river was divided into 4 groups by principle component analysis (PCA).

• Natural Product Sciences
• /
• v.24 no.1
• /
• pp.21-27
• /
• 2018

Psoriasis is an auto-immune skin disease, which is characterized by the excessive generation of plaques on the skin with typically a long-lasting red, itchy and scaly symptoms. Imiquimod, which has been used for the treatment of external genital warts, actinic keratosis, and superficial basal cell carcinoma, induced of psoriasis-like skin disorders with skin erythema and thickness in mice. In the present study, we tried to find the bioactive herbal extract against imiquimod-induced psoriasis-like skin disorder in mice. During the searching of the herbal extract with anti-psoriatic effect, the ethanolic extract of Cnidium officinale ameliorated imiquimod-induced psoriasis-like skin disorder in mice. The morphological evaluation, H&E staining and Psoriasis Area and Severity Index (PASI) score showed that ear and back thickness, and erythema induced by imiquimod were significantly reversed after the treatment of the cream of the ethanolic extract of C. officinale. The overexpressed myeloperoxidase (MPO) and keratin 6A levels were decreased by the treatment of C. officinale cream. Also, $IFN-{\gamma}$, c-fos and $I{\kappa}B-{\alpha}$ mRNA levels, which are related to the progression of psoriasis, were reduced by C. officinale cream. Thus, the ethanolic extract of C. officinale ameliorated psoriasis-like skin disorder induced by imiquimod and might be the therapeutic agent for psoriasis.

• Health Policy and Management
• /
• v.33 no.1
• /
• pp.3-18
• /
• 2023

Background: A chronic disease management program including patient education, recall and remind service, and reduction of out-of-pocket payment was implemented in Korea through a chronic care model. This study aimed to assess the effect of a community-based intervention program for improving medication adherence of patients with diabetes mellitus in rural areas of Korea. Methods: We applied a non-equivalent control group design using Korean National Health Insurance Big Data. Hongcheon County has been continuously adopting this program since 2012 as an intervention region. Hoengseong County did not adopt such program. It was used as a control region. Subjects were a cohort of patients with diabetes mellitus aged more than 65 years but less than 85 years among residents for 11 years from 2010 to 2020. After 1:1 matching, there were 368 subjects in the intervention region and 368 in the control region. Indirect indicators were analyzed using the difference-in-difference regression according to Andersen's medical use model. Results: The increasing percent point of diabetic patients who continuously received insurance benefits for more than 240 days from 2010 to 2014 and from 2010 to 2020 were 2.6%p and 2.7%p in the intervention region and 3.0%p and 3.9%p in the control region, respectively. The number of dispensations per prescription of diabetic patient in the intervention region increased by approximately 4.61% by month compared to that in the control region. Conclusion: The intervention program encouraged older people with diabetes mellitus to receive continuous care for overcoming the rule of halves in the community. More research is needed to determine whether further improvement in the continuity of comprehensive care can prevent the progression of cardiovascular diseases.

• Korean journal of applied entomology
• /
• v.43 no.4 s.137
• /
• pp.267-273
• /
• 2004

To select indicator insects, the abundance of which is one of the major criteria for the evaluation of agricultural environment, was designated and monitored in the three sites (Hongcheon A, B, and Yangpyeong) from 2001 to 2003. Characteristics of rice cultivation are usual cultivation with 2 or 3 times sprayed chemical agents per year in Hongcheon A site, duck cultivation with non-sprayed chemical agent, green manure and mowing in Hongcheon B site, and pond snail with non-sprayed chemical agent, green manure and mowing in Yangpyeong site. Dominant floral species are Digitaria ciliaris (Retz.) Koel., Persicaria thunbergii (Siebold & Zuccarini) H. Gross, Echinochioa crus-galli (L.) Beauvois, and Humulus scandens (Lour.) Merr. in Hongcheon A site, Digitaria ciliaris (Retz.) Koel., Persicaria thunbergii (Siebold & Zuccarini) H. Gross, and Echinochloa crus-galli (L.) Beauvois in Hongcheon B site, and Digitaria ciliaris (Retz.) Koel., Setaria viridis (L.) Beauv., and Persicaria langiseta (De Btuyn) Kitagawa in Yangpyeong site. Degree of green naturality (DGN) was higher in Hongcheon B site (2.0) and Yangpyeong site (3.6) than in Hongcheon A site (1.6). Number of species and individual of insects collected in the three sites were abundant on August and September. The species diversity was higher in Hongcheon B and Yangpyeong than in Hongcheon A. And Coleoptera was dominant in the all sites. The dominance index (DI) was the lowest, but diversify index (H'), evenness index (E) and richness index (RI) were the highest in Hongcheon B site. Based on three results, indicator insects for the evaluation of agricultural environment were selected as Dolichus halensis in Hongeheon A site, as Pheropsophus. javanus and Polionemobius mikado in Hongcheon B and Yangpyeong sites.

• Natural Product Sciences
• /
• v.26 no.2
• /
• pp.136-143
• /
• 2020

Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% - 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques on the skin with typical long-lasting red, itchy, and scaly lesions. In this study, we aimed to elucidate the anti-psoriatic effect of the methanolic extract of Persicaria senticosa (PS), a bioactive edible plant extract used in traditional medicine, using a mouse model of imiquimod (IMQ)-induced psoriasis. The daily topical application of IMQ could induce human psoriasis-like lesion. The extract ameliorated IMQ-induced psoriasis. Furthermore, hematoxylin and eosin staining and the Psoriasis Area and Severity Index (PASI) scores indicated that topical application of PS led to an improvement in erythema, scaling, and thickness scores of the mouse dorsal skin and a considerable decrease in the epidermal thickness of the ear and dorsal skin in the IMQ-induced psoriatic mouse model. We also studied the effect of PS on the proliferation of keratinocytes using HaCaT cells. The extract inhibited cell proliferation and IL-6 and pSTAT3 expression induced by M5 cocktail (comprising interleukin [IL]-1α, IL-17A, IL-22, oncostatin M, and tumor necrosis factor-α) in HaCaT cells. Thus, PS might serve as a potential therapeutic agent for the treatment of psoriasis.

• Journal of Ecology and Environment
• /
• v.36 no.4
• /
• pp.315-325
• /
• 2013

Taxa in the order Chlorococcales inhabiting Hongcheon River, South Korea were collected and identified from December 2011 to September 2012. As a result, nine taxa in the Order Chlorococcales including unrecorded genera Oocystidium and Heleococcus were newly added to the Korean flora: Oocystidium ovale, Heleococcus mucicola, Chlorella mirabilis, Monoraphidium convolutum var. pseudosabulosum, M. minutum, Raphidocelis mucosa, Eutetramorus tetrasporus, Scenedesmus flavescens, and S. multicauda. The morphological characteristics of the nine taxa identified in this study mostly corresponded to already reported characteristics; however, M. minutum had a shorter cell length than the recorded description, Raphidocelis mucosa and S. flavescens were larger than previous descriptions, and Scenedesmus multicauda had larger spines than the cell itself. Eight of the nine taxa were found in planktonic samples, whereas Heleococcus mucicola was found in an epilithic sample. Therefore the Korean order Chlorococcales, including these newly reported ones, totals to 255 species.

• Korean Journal of Environment and Ecology
• /
• v.28 no.3
• /
• pp.302-313
• /
• 2014

This study was conducted to compare the characteristics of fish distribution according to sand type stream and cobble type stream the 4 stream selected every season. The collected Korea endemic species during the survey period were 24, including Acheilognathus gracilis. Dominant species of Hongcheon stream and Muju Namdae stream was Zacco koreanus, each accounting for 39.9% and 28.4% in order, and dominant species in Yanghwa stream was Rhodeus notatus, 13.6%, and those in Gap stream was Z. platypus, by 26.0%. As a result of community analysis, dominant index was 0.27~0.63, diversity index was 1.92~2.67, evenness index was 0.6~0.79, richness index was 3.09~3.53, and dominant index was the highest in Hongcheon stream, and the indices of diversity, evenness and richness were the highest in Yanghwa stream. As a result of tolerance guild analysis, Hongcheon stream and Muju Namdae stream with a variety of substrates accounted for relatively higher rate by 50.1% and 46.4% in sensitive species respectively, and Yanghwa stream and Gap stream with greater sand substrates had 0.5% and 5.3% scarce rate of sensitive species. As a result of similarity analysis using the species, population and substrate structures of the fisheries appeared in each stream, cobble type streams such as Hongcheon stream and Muju Namdae stream were the most similar by 50.4% in species and population, 95.2% in bed structure. As a result of IBI analysis, Hongcheon stream and Muju Namdae stream appeared as 'Class A,' Yanhwa stream and Gap stream as 'Class B' and the two groups of cobble type stream and sand type stream were divided as a result of principal components analysis.

• The Journal of the Petrological Society of Korea
• /
• v.12 no.3
• /
• pp.135-153
• /
• 2003

In order to understand its origin and petrogenesis, petrochemical studies of major, trace elements, REE, and stable isotopes of oxygen and carbon from the Hongcheon Fe-REE deposits have been investigated. The Hongcheon Fe-REE deposit intruding into Precambrian metasedimentary rocks consists of magnetite, various carbonates such as ankerite, siderite, magnesite and strontianite, monazite, aegirine-augite, Na-amphibole, and sulfides. Compared with major elements abundances of typical ferro-carbonatites, the Hongcheon Fe-REE deposit is enriched in FeO and depleted in CaO with increasing of $SiO_2$, where $TiO_2$and $A1_2O_3$increased and CaO, FeO, MgO and $P_2O_5$ are slightly decreased, but those are rather scattered and their trends are somewhat ambiguous. V Ni, U and Rb slightly increasing with of $SiO_2$increase and scattering or no trends of other detected elements. Nb, Zr and Zn are depleted then the abundances of typical ferro-carbonatites (Woolley and Kempe, 1989). In rare earth elements a large enrichment of total REE (maximum 14.8 wt%) and LREE relative to chondrites and HREE depleted more then the values of ferro-carbontites therefore La/Lu ratios shows large abundances (max. 16,197). The results of stable isotopes of O and C from minerals of ankerite and strontianite and whole rocks represent studied rocks are from igneous carbonatitic melts. Although petrochemical characteristics of the Hongcheon Fe-REE deposits are somewhat different from normal ferro-carbonatites from the world, this discrepancy suggests another conclusion that petrochemical characteristic of the studied Fe-REE mineralized rocks are similar to those of phoscorites from Kovdor, Russia and Sokli, Finland showing the same petrochemical compositions described above.