• Journal of Preventive Medicine and Public Health
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• v.55 no.3
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• pp.234-242
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• 2022

Objectives: This study assessed the validity and reliability of the Health-related Quality of Life Instrument with 8 Items (HINT-8) in patients with diabetes. HINT-8 is a newly-developed, generic health-related quality of life (HRQoL) instrument. Methods: Three HRQoL instruments-HINT-8, EuroQoL 5-Dimension 5-Level (EQ-5D-5L), and Short Form Health Survey version 2.0 (SF-36v2)-were provided to 300 patients with diabetes visiting a tertiary hospital for follow-up visits in Korea. The HRQoL scores obtained using the HINT-8 were evaluated for subgroups with known differences based on demographics and diabetes-related characteristics (known-group validity). The mean scores of the instruments were compared between groups segmented by their responses to the HINT-8 (discriminatory ability). Correlation coefficients of the HINT-8 with other instruments were calculated (convergent and divergent validity). The Cohen kappa and intra-class correlation coefficient (ICC) were also evaluated (test-retest reliability). Results: The average HINT-8 indexes were lower among women, older, and less-educated subjects. Subjects who did not list any problems on the HINT-8 had significantly higher HRQoL scores than those who did. The correlation coefficients of the HINT-8 with the EQ-5D-5L index and EuroQoL visual analogue scale were 0.715 (p<0.001) and 0.517 (p<0.001), respectively. The correlation coefficients between the HINT-8 index and the scores of 8 domains of the SF-36v2 ranged from 0.478 (p<0.001) to 0.669 (p<0.001). The Cohen kappa values for the HINT-8 ranged from 0.268 to 0.601, and the ICC of the HINT-8 index was 0.800 (95% confidence interval [CI], 0.720 to 0.860). Conclusions: This study showed that the HINT-8 is a valid and reliable HRQoL instrument for patients with diabetes.

• ETRI Journal
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• v.41 no.2
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• pp.242-253
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• 2019

We devise a layer-wise hint training method to improve the existing hint-based knowledge distillation (KD) training approach, which is employed for knowledge transfer in a teacher-student framework using a residual network (ResNet). To achieve this objective, the proposed method first iteratively trains the student ResNet and incrementally employs hint-based information extracted from the pretrained teacher ResNet containing several hint and guided layers. Next, typical softening factor-based KD training is performed using the previously estimated hint-based information. We compare the recognition accuracy of the proposed approach with that of KD training without hints, hint-based KD training, and ResNet-based layer-wise pretraining using reliable datasets, including CIFAR-10, CIFAR-100, and MNIST. When using the selected multiple hint-based information items and their layer-wise transfer in the proposed method, the trained student ResNet more accurately reflects the pretrained teacher ResNet's rich information than the baseline training methods, for all the benchmark datasets we consider in this study.

• Molecules and Cells
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• v.42 no.1
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• pp.56-66
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• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• Journal of the Korean Dietetic Association
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• v.30 no.2
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• pp.112-124
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• 2024

This study investigated the factors associated with HINT-8 (Korean health-related quality of life instrument with eight items), including health habits, hand grip strength, chronic disease, chewing function, mental health, and nutrient intake. In this study, the health-related quality of life (HRQoL; HINT-8) was assessed using the data from the 2019 Korea National Health and Nutrition Examination Survey (KNHANES VIII) among Koreans aged over 65, with HINT-8 being evaluated based on the general characteristics. Of the participants from KNHANES VIII, 1,455 subjects were analyzed using SPSS statistics complex samples (Windows ver. 27.0). The HINT-8 score was significantly lower in females and in those aged 75 years or older, lowest educational level, lowest income level, and single households. Logistic regression analysis, adjusted for the general characteristics, revealed a significant association between a lower HINT-8 group and various factors: low aerobic physical activity (OR=1.71, 95% CI=1.25~2.35), low hand grip strength (OR=1.34, 95% CI=1.02~1.78), chewing difficulties (OR=2.17, 95% CI=1.62~2.92), poor self-rated health status (OR=6.11, 95% CI=4.42~8.45), stressful mental status (OR=3.57, 95% CI=2.27~5.63) and poor calcium status (OR=1.45, 95% CI=1.11~1.88). On the other hand, this study could not reveal a significant association between a lower HINT-8 group and factors such as smoking, drinking, chronic disease, and nutrient intake status, except for calcium intake. This study suggests that HINT-8 is associated with aerobic physical activity, hand grip strength, chewing function, mental health, and calcium intake, but not with smoking, drinking, chronic disease, and nutrient intake.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.3
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• pp.35-47
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• 2023

Purpose : As the population aging deepens, the number of elderly people with arthritis is also continuously increasing. Accordingly, this study intended to identify the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to household type and provide baseline data for developing a measure to enhance the life quality of the elderly with arthritis. Methods : The factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis were identified based on the raw data from the Korea national health and nutrition examination survey conducted in 2021. Data were analyzed with SPSS Statistics ver 25.0 for windows (IBM Corp), and the significance level (α) was set to .05. Statistical analysis was performed with t-test, ANOVA, multiple regression analysis, and post-hoc analysis with Duncan test. Results : The factors that influenced the health-related quality of life (HINT-8) of single-households were medical aid (β=-.17, p=.045), restriction of activity (β=-.17, p=.023), self-rated health status (β=.29, p<.001), and anxiety scale (β=-.36, p<.001). The factors that influenced the health-related quality of life (HINT-8) of multi-households were an age of 75 or over (β=-.14, p=.011), living in rural (β=-.14, p=.003), the outpatient department treatment experience (β=-.09, p=.047), self-rated health status (β=.26, p<.001), anxiety scale (β=-.29, p<.001), and stress (β=-.22, p<.001). Conclusion : Factors affecting the health-related quality of life (HINT-8) of the elderly with arthritis were found to be different between single-person households and multi-person household. Therefore, it is necessary to prepare measures to improve the quality of life of the elderly with arthritis by considering the factors influencing the health-related quality of life (HINT-8) of the elderly with arthritis according to the household type identified in this study.

• Journal of Korean society of Dental Hygiene
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• v.24 no.2
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• pp.109-119
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• 2024

Objectives: This study aimed to confirm the correlation between oral frailty and health-related quality of life (HINT-8) among older adults in Korea. Methods: The data of 1,318 individuals aged ≥65 years who participated in the eighth Korean National Health and Nutrition Examination Survey (2019) were analyzed using complex sample statistical analysis. Results: Chewing discomfort was found to decrease the HINT-8 scores by 1.246, 1.324, and 1.089 times in the physical, social, and mental domains, respectively. Speech discomfort was found to decrease the HINT-8 scores by 1.275, 1.449, and 1.175 times in the physical, social, and mental domains, respectively. The HINT-8 scores of participants with ≤19 natural teeth were lower in the physical and social domains. Similarly, the HINT-8 scores of participants with brushing frequency of ≤2 were lower in the positive health domain. Non-use of oral hygiene products led to a reduction in the HINT-8 score in the social health domain. Conclusions: Oral frailty in older adults reduces the health-related quality of life. Thus, it is necessary to formulate policies to manage oral frailty in this population and develop specialized programs for the management of oral frailty.

• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.127-135
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• 2022

This study intends to provide basic data to confirm the convergence effects of economic activity on the quality of life and oral health of middle-aged Korean women. Data from the 2019 National Health and Nutrition Examination Survey were used, and complex sample logistic regression analysis and linear regression analysis were performed to confirm the effect of economic activity on health-related quality of life (Korean Health-related Quality of Life Instrument with 8 Items; HINT-8) and oral health-related factors. As a result, in the case of controlling for demographic characteristics and economic activity, there was a significant effect in 4 items (energy, work, memory, sleep) out of HINT-8. When the oral health status was adjusted, there was a significant effect only in 2 items (working and memory) of HINT-8 (p<.05). Therefore, although economic activity of middle-aged Korean women has a positive effect on quality of life, it is considered to be valuable in that oral health status can reduce the influencing factors.

• IEMEK Journal of Embedded Systems and Applications
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• v.15 no.2
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• pp.43-49
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• 2020

In this paper, we propose a stage-wise knowledge transfer method that uses block-wise retraining to transfer the useful knowledge of a pre-trained residual network (ResNet) in a teacher-student framework (TSF). First, multiple hint information transfer and block-wise supervised retraining of the information was alternatively performed between teacher and student ResNet models. Next, Softened output information-based knowledge transfer was additionally considered in the TSF. The results experimentally showed that the proposed method using multiple hint-based bottom-up knowledge transfer coupled with incremental block-wise retraining provided the improved student ResNet with higher accuracy than existing KD and hint-based knowledge transfer methods considered in this study.

• Carbon letters
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• v.13 no.1
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• pp.1-16
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• 2012

The near explosion of attention given to graphene has attracted many to its research field. As new studies and findings about graphene synthesis, properties, electronic quality control, and possible applications simultaneous burgeon in the scientific community, it is quite hard to grasp the breadth of graphene history. At this stage, graphene's many fascinating qualities have been amply reported and its potential for various electronic applications are increasing, pulling in ever more newcomers to the field of graphene. Thus it has become important as a community to have an equal understanding of how this material was discovered, why it is stirring up the scientific community and what sort of progress has been made and for what purposes. Since the first discovery, the hype has expediently led to near accomplishment of industrial-sized production of graphene. This review covers the progress and development of synthesis and transfer techniques with an emphasis on the most recent technique of chemical vapor deposition, and explores the potential applications of graphene that are made possible with the improved synthesis and transfer.

• Journal of Korean Academy of Nursing
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• v.53 no.3
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• pp.359-369
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• 2023

Purpose: This study evaluated the internal structure (structural validity, internal consistency, and measurement invariance) of the Health-Related Quality of Life Instrument with Eight Items (HINT-8), developed to measure Korean people's health-related quality of life. Methods: A secondary analysis was conducted using data from the Korea National Health and Nutrition Examination Survey, involving 6,167 adults aged over 18 years. The structural validity of the HINT-8 was assessed using exploratory graph analysis and confirmatory factor analysis. Internal consistency and measurement invariance were analyzed using McDonald's omega (ω) and multigroup confirmatory factor analysis, respectively. Results: The HINT-8 had a single dimension and good internal consistency (ω =.804). The one-dimension HINT-8 exhibited matric invariance but not scalar invariance across sociodemographic groups (sex, age, education, and marital status). Further, it exhibited scalar or partial scalar invariance across medical condition groups (hypertension, diabetes, depressive symptoms, and cancer). Conclusion: The study finds that the HINT-8 demonstrated satisfactory structural validity and internal consistency, indicating its suitability for practice and research. However, the HINT-8 scores cannot be compared across different groups regarding sex, age, education, and marital status, as the interpretation varies within each sociodemographic category. Conversely, interpretation of the HINT-8 is consistent for individuals with and without hypertension, diabetes, depressive symptom, and cancer.