• Molecules and Cells
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• 제44권7호
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• pp.517-528
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• 2021

A recent genetic study with Brucella abortus revealed the secretion activator gene A (SagA) as an autolysin component creating pores in the peptidoglycan (PGN) layer for the type IV secretion system (T4SS) and peptidoglycan hydrolase inhibitor A (PhiA) as an inhibitor of SagA. In this study, we determined the crystal structures of both SagA and PhiA. Notably, the SagA structure contained a PGN fragment in a space between the N- and C-terminal domains, showing the substrate-dependent hinge motion of the domains. The purified SagA fully hydrolyzed the meso-diaminopimelic acid (DAP)-type PGN, showing a higher activity than hen egg-white lysozyme. The PhiA protein exhibiting tetrameric assembly failed to inhibit SagA activity in our experiments. Our findings provide implications for the molecular basis of the SagA-PhiA system of B. abortus. The development of inhibitors of SagA would further contribute to controlling brucellosis by attenuating the function of T4SS, the major virulence factor of Brucella.

• 대한골관절종양학회지
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• 제13권2호
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• pp.96-104
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• 2007

목적: 슬관절 주위에서 탄력성 있는 골수강 내고정물과 회전경첩 슬관절 전치환물을 이용한 재건술이 종양인공관절과 자가골 경계부위의 골 흡수를 억제할 수 있는지를 35례에서 분석하였다. 대상 및 방법: 재건 술식은 다음과 같다. 1) 종양 절제, 2) 근위부나 원위부의 골수강에 다수의 Ender 정 삽입, 3) Ender 정과 Endo-Link 형 슬관절 전치환물을 강선 과 골 시멘트를 이용하여 결합 결과: 평균 추시기간은 53개월(30~79개월) 이었다. 최종 추시 상 29명의 환자가 가동관절을 유지하였다. 장관골 길이의 40% 이상을 절제한 군에서 종양인공관절과 자가골 경계부위 골질의 비후가 나타났다(p=0.028). 내고정 금속정의 파괴가 8례 있었으며, 조기 및 지연 감염으로 8례의 내고정물을 제거하였다. 본 재건술의 생존율은 6년에 33%였다. Musculoskeletal Tumor Society System 평가 법에 따른 기능적 결과는 26.8(89.3%)였다. 결론: 본 술식의 단-중기적 결과는 양호하였으며 합병증 발생시 재수술이 매우 용이하였다. 본 술식에서 관찰된 종양인공관절-자가골 이행 부위의 골 비후 소견은 추후 더 연구해 볼 문제로 생각된다.

• 한국지반공학회논문집
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• 제24권7호
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• pp.61-73
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• 2008

다수의 말뚝을 캡(확대기초)으로 연결하여 하중을 지지하는 다주식 기초에 대하여 캡의 연결부를 강결합 조건과 힌지결합 조건으로 구분하여 말뚝 반력 해석의 합리성을 분석하였으며, 널리 사용 중인 탄성변위법과 라멘식 프레임 해석에 기반한 비선형 해석기법을 비교하여 검토하였다. 특히 실제 해상 장대교량의 조건을 대상으로 상부구조와 기초를 연계한 전체 구조계 해석 결과를 분석하여 말뚝머리 구속 조건에 대한 기초 부재 단면력 산정의 적정성을 파악하였다. 이를 위해 캡과 연결된 각 말뚝에서 발생하는 휨모멘트, 전단력, 압축력 등 반력을 산정하고 PM상관도 분석과 지지력 산정을 통해 말뚝 부재의 안정성을 검토하였다. 일반적인 규모의 교량, 또는 강성이 크지 않은 말뚝을 적용한 기초에서는 말뚝-캡 결합 조건에 따른 말뚝 단면 설계의 차이가 현저하지 않으나, 말뚝이 지면 위로 일정 길이 이상 돌출되는 다주식 기초의 해상교량에서는 말뚝머리를 힌지로 고려할 경우 지중부에서 매우 큰 휨모멘트와 전단력이 유발되며, 말뚝머리의 수평변위량이 극단적으로 증가하였다. 해상 장대교량에 대해서는 비현실적 가정조건에 기반한 탄성변위법 보다는 말뚝머리를 캡에 강결합하고 말뚝이 탄성판에 지지된 보로 간주하는 라멘(rahmen) 모델링을 통해 상부구조와 연계한 전체 구조계 해석을 수행하는 것이 바람직하다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1439-1443
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• 2007

In this paper, vibration reduction techniques of a voice coil motor (VCM) actuator are presented for AFM imaging system. The damping coefficient of the actuator driven by VCM with a flexure hinge is quite low and it cause the about 30dB peak amplitude response at the resonance frequency. To decrease this peak response, we design and apply elliptical band-stop filters to xy and z axis VCM actuator. Frequency response of each actuator with filter is measured to verify the effect of the filters. As a sensor, capacitive sensor is used. Vibration reduction rate of the xy actuator with the filter is also measured while real AFM scanning condition. As another method, closed loop control with the capacitive sensor is applied to the xy axis actuator to add an electrical damping effect and vibration reduction rate measured. These vibration reduction rates with each method are compared. In the case of z axis actuator, the frequency response of force (gap) control loop is measured. For comparison, the frequency response using a conventional PID controller is also obtained. Finally, the AFM image of a standard grid sample is measured with the designed controller to analyze the effect in the AFM imaging.

• Advances in aircraft and spacecraft science
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• 제1권1호
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• pp.69-91
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• 2014

Numerical investigations are presented, which show that a back-flow flap can improve the dynamic stall characteristics of oscillating airfoils. The flap was able to weaken the stall vortex and therefore to reduce the peak in the pitching moment. This paper gives a brief insight into the method of function of a back-flow flap. Initial wind tunnel experiments were performed to define the structural requirements for a detailed experimental wind tunnel characterization. A structural integration concept and two different actuation mechanisms of a back-flow flap for a helicopter rotor blade are presented. First a piezoelectric actuation system was investigated, but the analytical model to estimate the performance showed that the displacement generated is too low to enable reliable operation. The seond actuation mechanism is based on magnetic forces to generate an impulse that initiates the opening of the flap. A concept based on two permanent magnets is further detailed and characterized, and this mechanism is shown to generate sufficient impulse for reliable operation in the wind tunnel.

• 한국산학기술학회논문지
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• 제2권1호
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• pp.59-66
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• 2001

본 논문은 네트워크에서 가상현실 입체영상을 응용하여 현실과 가까운 실감형 입체영상을 볼 수 있도록 설계하였으며, 또한 멀티미디어 영상분야에서 제작할 수 있는 저작도구의 구현을 목표로 하였다. 네트워크 가상현실 시스템은 원격지의 사용자에게 일관성 있는 가상의 세계를 제공하며, 군사ㆍ오락ㆍ네트웍게임ㆍ건축ㆍ쇼핑몰 등의 응용 분야에서 실감형 시스템으로 볼 수 없었던 것을 네트워크 가상현실 시스템의 가장 보편적 플랫폼 구조인 클라이언트-서버 구조로서 인터넷 상에서 가상현실 입체영상을 표현하는 구조이다. 그리고, 네트워크 상에서 쉽게 응용할 수 있도록 저작도구를 설계하여 Library(Parser 및 Scene Graph생성)를 구축하고, 여러 사용자가 네트워크 상의 3차원 가상세계를 쉽게 구현하여 사용할 수 있도록 연구 하였다.

• Steel and Composite Structures
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• 제25권4호
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• pp.505-521
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• 2017

The steel plate shear wall with beam-only connected infill plate (SSW-BO) is an innovative lateral load resisting system consisting of infill plates connected to surrounding beams and separated from the main columns. In this research, the effects of perforation diameter as well as slenderness ratios of infill plates on the hysteresis behavior of SSW-BO systems were studied experimentally. Experimental testing is performed on eight one-sixth scaled one-story SSW-BO specimens with two plate thicknesses and four different circular opening ratios at the center of the panels under fully reversed cyclic quasi-static loading in compliance with the SAC test protocol. Strength, stiffness, ductility and energy absorption were evaluated based on the hysteresis loops. It is found that the systems exhibited stable hysteretic behavior during testing until significant damage in the connection of infill plates to surrounding beams at large drifts. It is also seen that pinching occurred in the hysteresis loops, since the hinge type connections were used as boundaries at four corners of surrounding frames. The strength and initial stiffness degradation of the perforated specimens containing opening ratio of 0.36 compared to the solid one is in the range of 20% to 30% and 40% to 50%, respectively.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2005년도 학술발표회 논문집
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• pp.308-315
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• 2005

The capacity protection is normally related with slenderness effect of the columns, force transfer in connections between columns and adjacent elements, and shear design of columns. It is intends to prevent brittle failure of the structural components of bridges, so that the whole bridge system may show ductile behavior and failure during earthquake events. For bridge systems, this means it is necessary to assess the overstrength capacity of columns prior to proceeding with the design of foundation and superstructure. The objective of this paper is to develop a capacity design approach that applies an overstrength factor for determination of possible maximum shear force in the plastic hinge zone of reinforced concrete bridge columns. In order to estimate and determine overstrength factor, material strength was developed to investigate for actual material strength total 3,407 steel and 5,405 concrete by domestic product. Based on actual material strength, this paper was conducted on moment overstrength factors using moment-curvature analysis program. And also design recommendations for capacity design are presented to revise the annual report, KEERC 2002.

• 한국소음진동공학회논문집
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• 제18권2호
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• pp.192-198
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• 2008

A dynamic analysis of a tilting actuator for a projection TV is presented in this study. Severe vibration of a tilting actuator deteriorates the video quality of a projection TV. For this reason, a dynamic analysis of the tilting actuator system is essential to improve the video quality. The dynamic behaviors of the mirror reactive-type tilting actuator are examined in order to obtain design requirements of the lens transmissive-type tilting actuator. Based on these design requirements, a basic design is performed for the lens transmissive-type tilting actuator. With the basic design, the dynamic characteristics of the lens transmissive-type actuator are investigated by the finite element analysis After the prototype of the actuator is manufactured, the dynamic behaviors of the prototype are examined by experiments. As a result of this study, a new design for the hinge configuration of the actuator is suggested for better performance.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1993년도 춘계학술대회논문집
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• pp.1-9
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• 1993

A human gait study is required for the biomechanical design of running shoes. A tow-dimensional dynamic model was developed in order to analyze lower extremity kinematics and loadings at the right ankle, knee, and hip joints. The dynamic model consists of three segments, the upper leg, the lower leg, and the foot. Each segment was assumed to be a rigid body with one or two frictionless hinge joints. The lower extremity motion was assumed to be planar in the sagittal plane. A young male subject was involved in the gait test and his anthropometric data were measured for the calculation of segement mass and moment of inertia. The experimental data were obtained from three trials of walking at 1.2m/s. The foot-floor reaction data were measured from a Kistler force plate. The kinematic data were acquired using a three-dimensional motion measurement system (Expert Vision) with six markers, five of which were placed on the right lower extremity segments and the rest one was attached to the force plate. Based on the model and experimental data for the stance phase of the right foot, the calculated vertical forces reached up to 492, 540, and 561 N at the hip, knee, ankle joints, respectively. The flexion-extension moments reached up to 155, 119, and 33 Nm in magnitude at the corresponding joints.