• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권2호
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• pp.174-179
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• 2001

The authors analyzed retrospectively the 19 patients with mucoepidermoid carcinoma of salivary glands who were treated at Department of Oral and Maxillofacial Surgery, Pusan National University Hospital from June, 1986 to September, 1998. The results obtained were as follows: 1. There were 4 males(21%) and 15 females(79%). Age distribution was wide and the mean age was 45.2. 2. Of all mucoepidermoid carcinomas of salivary gonads, 4 cases arose in the major salivary glands and 15 cases in the minor salivary glands. The incidence according to the anatomic primary site for minor salivary glands was 8 cases in the palate, 2 cases each arising in the tongue and floor of mouth and 1 case each arising in the mandible, buccal mucosa and the lower lip. 3. In histopathological classification of mucoepidermoid carcinoma, 5 cases were low grade. 9 cases, intermediate grade and 5 cases, high grade. 4. Perineural invasion was observed 40%(2/5) in high grade and 22%(2/9) in the intermediate grade of mucoepidermoid carcinoma. 5. The incidence of cervical lymph node metastasis according to histopathologic grade was 40% (2/5) in high grade and 11%(1/9) in intermediate grade of mucoepidermoid carcinoma. 6. The lung was the commonest site for metastasis comprising 3 cases among 3 cases of distant spread of which 2 cases in high grade and 1 case in intermediate grade of mucoepidermoid carcinoma.

• Journal of Trauma and Injury
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• 제30권3호
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• pp.91-97
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• 2017

Purpose: Purpose: The prognostic factors of non-operative management (NOM) in high-grade spleen injuries have been extensively studied, but factors that would help treatment decisions are lacking. We compared the characteristics of the patients to identify the factors affecting treatment choices. Methods: This is a review of 207 blunt spleen injury patients from January 2004 to December 2013. We compared clinical features and mortality between surgery and NOM, and used multivariate regression analysis to find the factor most strongly associated with prognosis. Results: Of the 207 patients, 107 had high-grade spleen injury patents (grade III or above). Of these, 42 patients underwent surgery and 65 patients underwent NOM. The mortality was 7% following surgery, 3% with NOM. The amount of packed red blood cells transfused in the first 24 hours and spleen injury grade were associated with management type, and mortality was highly associated with activated partial thromboplastin time (aPTT) and spleen injury grade. Conclusions: The grade of spleen injury was associated with management and mortality, so correctly assessing the spleen injury grade is important.

• 대한골관절종양학회지
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• 제8권1호
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• pp.32-37
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• 2002

고등급 표면(high grade surface) 골육종은 골의 표면에서 발생하는 골육종의 희귀한 아형으로, 발생빈도는 전체 골육종의 1%에 못 미친다고 한다. 몇 편의 증례 보고와 연구 논문에서 이 고등급 표면 골육종을 소개하였는데, 국내의 경우 127예의 골육종 중 1예가 고등급 표면 골육종이었음을 기술한 논문이 있으나, 환자 및 진단과 치료에 대한 정보가 포함되어 있지 않았다. 저자들은 66세 여자 환자의 대퇴골 전자하부에서 발생한 고등급 표면 골육종 1예를 진단하고, 수술 전 항암 화학 요법, 광범위 절제술과 사지 구제술 및 수술 후 항암 화학 요법을 시행하였다. 이 종양은 위치만 골 표면에서 발생할 뿐 조직학적으로 전형적인 골수강내 골육종과 같으며, 다른 표면 골육종과는 달리 치료나 예후에 있어 전형적인 골수강 내 골육종과 같기 때문에, 진단과 치료에 있어 방골성 골육종이나 골막성 골육종 등의 표면 골육종과 구별하여야 할 것으로 생각한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5303-5307
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• 2016

Objective: Brain tumors cause great mortality and morbidity worldwide, and success rates with surgical treatment remain very low. Several recent studies have focused on introduction of novel effective medical therapeutic approaches. Genistein is a member of the isoflavonoid family which has proved to exert anticancer effects. Here we assessed the effects of genistein on the expression of MMP-2 and VEGF in low and high grade gliomas in vitro. Materials and Methods: High and low grade glioma tumor tissue samples were obtained from a total of 16 patients, washed with PBS, cut into small pieces, digested with collagenase type I and cultured in DMEM containing 10% FBS. When cells reached passage 3, they were exposed to genistein and MMP-2 and VEGF gene transcripts were determined by quantitative real time PCR (qRT-PCR). Results: Expression of MMP-2 demonstrated 580-fold reduction in expression in low grade glioma cells post treatment with genistein compared to untreated cells (P value= 0.05). In cells derived from high grade lesions, expression of MMP-2 was 2-fold lower than in controls (P value> 0.05). Genistein caused a 4.7-fold reduction in VEGF transcript in high grade glioma cells (P value> 0.05) but no effects were evident in low grade glioma cells. Conclusion. Based on the data of the present study, low grade glioma cells appear much more sensitive to genistein and this isoflavone might offer an appropriate therapeutic intervention in these patients. Further investigation of this possibility is clearly warranted.

• 한국도로학회논문집
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• 제15권4호
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• pp.177-186
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• 2013

PURPOSES: The purpose of this study theoretically reviews vertical grade deriving process in super high speed environment and compares overseas design criteria with Domestic Standardization also draws suitable vertical grade design criteria of high standard for Domestic Circumstances in Korea. METHODS : By researching domestic vehicle registration status, calculating typical vehicle, using Vissim which is traffic simulation program, Speed-distance curve of the vehicle is derived under each design speed condition. Through Speed-distance curve, estimating critical length of grade and considering critical length of grade, maximum longitudinal incline is proposed. RESULTS : The result of domestic vehicle registration status, the typical vehicle for deriving vertical grade is calculated based on gravity horsepower ratio 200 lb/hp. For calculating critical length of grade, according to change speed of uphill entry, speed-distance curve is derived by using Vissim. Critical length of grade is calculated based on design speed 20 km/h criteria which is point of retardation. Estimated critical length of grade is 808 m and based on this result, maximum longitudinal incline was confirmed in the design speed between 130km/h to 140km/h. CONCLUSIONS: The case of the typical vehicle(truck) which is gravity horsepower ratio 200 lb/hp, maximum longitudinal incline 2% is desirable at the super high speed environment in the design speed between 130km/h to 140km/h.

• Korean Journal of Radiology
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• 제1권1호
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• pp.11-18
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• 2000

Objective: To evaluate the hydrodynamic changes occurring in cerebrospinal fluid (CSF) flow in cervical spinal stenosis using the spatial modulation of magnetization (SPAMM) technique. Materials and Methods: Using the SPAMM technique, 44 patients with cervical spinal stenosis and ten healthy volunteers were investigated. The degree of cervical spinal stenosis was rated as low-, intermediate-, or high-grade. Low-grade stenosis was defined as involving no effacement of the subarachnoid space, intermediate-grade as involving effacement of this space, and high-grade as involving effacement of this space, together with compressive myelopathy. The patterns of SPAMM stripes and CSF velocity were evaluated and compared between each type of spinal stenosis and normal spine. Results: Low-grade stenosis (n = 23) revealed displacement or discontinuity of stripes, while intermediate- (n = 10) and high-grade (n = 11) showed a continuous straight band at the stenotic segment. Among low-grade cases, 12 showed wave separation during the systolic phase. Peak systolic CSF velocity at C4-5 level in these cases was lower than in volunteers (p < .05), but jet-like CSF propulsion was maintained. Among intermediate-grade cases, peak systolic velocity at C1-2 level was lower than in the volunteer group, but the difference was not significant (p > .05). In high-grade stenosis, both diastolic and systolic velocities were significantly lower (p < .05). Conclusion: Various hydrodynamic changes occurring in CSF flow in cervical spinal stenosis were demonstrated by the SPAMM technique, and this may be a useful method for evaluating CSF hydrodynamic change in cervical spinal stenosis.

• 핵의학기술
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• 제27권1호
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• pp.62-65
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• 2023

Purpose The purpose of this study is to determine whether the glucose loading method (GLM) is useful in the differentiation of cerebral gliomas by comparing it with fasting images. Materials and Methods The patients were 70 people diagnosed with cerebral gliomas, and the equipment was Discovery 710 (GE Healthcare, MI, USA). All patients fasted for more than 6 hours, and fasting images and GLM were performed under the same imaging conditions, and the examination interval was 1 to 14 days. GLM administered 250 ㎖ of 10% glucose solution prior to radiopharmaceutical injection. SUVmax of cerebral glioma and SUVmean of cerebral cortex were measured and then compared and analyzed by tumor-to-normal brain cortex ratio (TNR). Statistical analysis confirmed the difference between the two images with an independent-sample t-test. Results The averages of GLM and fasting TNR were 1.26 and 1.09, respectively, which were 15.6% higher in GLM. In low-grade, the difference in TNR was insignificant at 4%, but in high-grade, 23%, GLM was high. There was a statistically significant difference between the two images (P=0.008), but there was no statistically significant difference in TNR in the low grade (P=0.473), and there was a very significant difference in the high grade (P=0.005). Conclusion GLM increased TNR for cerebral gliomas. In particular, it was found that the TNR increased more in the high grade. Therefore, GLM is considered to be useful for the differentiation of high-grade gliomas.

• 대한방사선기술학회지:방사선기술과학
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• 제31권4호
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• pp.355-365
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• 2008

대뇌 종양의 질환에서 Tumor의 정도를 M.R.S(MR Spectroscopy)를 이용하여 질환의 등급별 비교 분석과 특성을 연구하고자 하였다. M.R.S의 STEAM과 PRESS의 Protocol를 이용하여 High grade Tumor와 Low grade Tumor의 성분을 절편화 하고 질환별 Voxel의 Spectrum의 신호를 얻어서 질환의 생화학적 정보를 정량 분석하고, 각각 실험 결과에 대하여 비교 분석하여 질환의 성분 분석과 질환의 유형을 이해하고자 하였다. High grade Tumor에서는 NAA/Cr이 29.4%와 53.9%의 신호 감소를 보였고, Cho/Cr은 570%와 711%의 급격한 신호 증가를 보임을 알 수 있었고, Low grade Tumor에서는 NAA/Cr이 42.6%와 58.1%의 신호 감소를 보였고, Cho/Cr은 188%와 195%의 신호 증가를 보임을 알 수 있었다. 그리하여, 각 신호의 비교분석을 통한 종양의 정도와 특성을 이해할 수 있었고, 여러 인체장기에 폭 넓은 연구와 자료 확립을 하여야 할 것이다.

• 대한세포병리학회지
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• 제6권1호
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• pp.18-26
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• 1995

In order to compare cytologic findings ol breast carcinoma in fine needle aspiration cytology (FANC) with histologic findings and prognostic factors including histologic grading, lymph node metastasis and stage, 79 cases of infiltrating ductal carcinoma diagnosed by FANC and confirmed by histology were analysed. We especially attempted to col relate nuclear grade, cellularity and smear pattern with histologic grade, type, status of lymph node metastasis and stage. The results are as fellows. 1. High nuclear grade was correlated with high histologic grade, lymph node metastasis and advanced stage. 2. Individual cell pattern was more frequently identified in high histologic grade and scirrhous or solid-tubular type than in low histolgic grade and papillotubular type. 3. Cellularity increased with higher histologic grade and lymph node metastsis. However cellularity was low in scirrhous type. 4. There is no relationship between nuclear grade and histologic type, between smear pattern and lymph node metastasis or stage, and between cellularity and stage. These results suggest that cytologic findings of breast carcinoma such as nuclear grade, cellularity and smear pattern are indicative of histologic findings in relation to histolgic grade and type. Especially, nuclear grade of FANC may yield valuable prognostic information.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.505-513
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• 2021

Objective : The adaptive immune response following subarachnoid hemorrhage (SAH) is not well understood. We evaluated and compared the T cell receptor (TCR) immune repertoire of good-grade and poor-grade SAH patients to elucidate the T cell immunology after ictus. Methods : Peripheral blood from six SAH patients was collected at two different times, admission and at the 7-day follow-up. Composition and variation of the TCR β-chain (TCRB) complimentary determining regions (CDR) 3 repertoire was examined using high-throughput sequencing; the analysis was based on sampling time and disease severity (good vs. poor-grade SAH). Results : Clonality at admission and follow-up were 0.059 (0.037-0.038) and 0.027 (0.014-0.082) (median, 25th-75th percentile). Poor-grade SAH (0.025 [0.011-0.038]) was associated with significantly lower clonality than good-grade SAH (0.095 [0.079-0.101]). Poor-grade SAH patients had higher diversity scores than good-grade SAH patients. CDR length was shorter in good-grade SAH vs. poor-grade SAH. Differences in clonotype distribution were more prominent in TCRBV gene segments than TCRBJ segments. TCRBV19-01/TCRBJ02-04 and TCRBV28-01/TCRBJ02-04 were the most increased and the most decreased V-J pairs in the 7-day follow-up compared to admission in good-grade SAH. The most increased and decreased V-J pairs in poor-grade SAH patients were TCRBV28-01/TCRBJ02-06 and TCRBV30-01/TCRBJ02-04, respectively. Conclusion : The TCRB repertoire is dynamic in nature following SAH. TCRB repertoire may facilitate our understanding of adaptive immune response according to SAH severity.