• Journal of Applied Biological Chemistry
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• 제58권1호
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• pp.75-79
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• 2015

Extracted mushroom water showed an ability to suppress the accumulation of body fat in female mice after feeding 5 weeks with high fat diet. Particularly, in parametrial and mesenteric adipose, it significantly reduced 44 and 47% of weight, respectively. In non-obese mice, maturated NK cell ($CD11b^{hi}CD27^{lo}$) population were increased ($70.9{\pm}3.8%$) in mushroom water fed mice compared to control ($61.4{\pm}4.3%$) and NK cell population were augmented in mushroom fed mice compared to control.

• Preventive Nutrition and Food Science
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• 제19권2호
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• pp.69-74
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• 2014

The present study investigated the anti-obesity effects of Mycoleptodonoides aitchisonii (MA) in mice fed a high-fat (HF) diet. Two groups were fed either a normal control diet or an HF (45% kcal fat) diet for 12 weeks and three groups were fed an HF diet supplemented with powdered MA (MAP, 1%, 3%, and 5%) for 12 weeks. The anti-obesity effects of MAP supplementation on body weight, fat mass development, and lipid-related markers were assessed. Consumption of an HF diet resulted in increased body weight, serum lipids, relative adipose tissues weight, and liver fat accumulation. However, administration of MAP significantly decreased body weight gain, food intake, food efficiency ratio, hepatic cholesterol level, and adipose tissue weight in a dose-dependent manner. In addition, treatment with MAP significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited an HF diet-induced increase in adipocyte size. These results suggest that dietary supplementation with MAP exerts anti-obesity effects and indicate that MAP could be used as a functional food to control obesity.

• 동아시아식생활학회지
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• 제16권3호
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• pp.251-260
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• 2006

To study the correlation between body composition values and practice of the Standard Guideline for Korean Dietary Life, a nationwide cross-sectional survey was conducted with 378 female college students living in four Korean cities in December 2005. Among the student subjects, 98 were analyzed for body fat mass, percent body fat, waist-hip ratio(WHR), body mass index(BMI) and obesity degree using Inbody 3.0(Biospace Co, Seoul, Korea). Percent body fat was at a high level of 54.1 %, WHR was at a high level of 58.2% and BMI was at a high level of 41.8%. However, both weight and body fat were below normal at 79.5% and 77.6%, respectively. Percent body fat, WHR, and BMI were slightly negatively correlated with vegetable consumption, but slightly positively correlated with beer intake. WHR > 0.8 was significantly negatively correlated with exercise. Standard Guideline for Korean Dietary Life was practiced to and above normal level by 64.6% of the female college students. However, female college students who are within the normal range of body composition value should notice that obesity will relate to abdominal or visceral fat on their body.

• Asian-Australasian Journal of Animal Sciences
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• 제1권1호
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• pp.7-12
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• 1988

Twenty cows, by order of calving, were used in a completely randomized $2{\times}2$ factorial experiment. Variables were tow protein levels (14 and 18% crude protein) and concentration of fat (2 and 6% ether extract) in diets. Fat addition, via unprocessed whole sunflower seed, insured forage utilization in diets to meet energy requirement of cows. A total of 36 wks of lactation was subdivided into three 12-wk stages of lactation. Net energy lactation was set at 1.72, 1.57 and 1.42 Mcal/kg for each stage. Higher protein diets improved the efficiency of energy (FCM/net energy intake) which was particularly noted for diets containing high fat (85.7%). However, diets with low protein-high fat resulted in the lowest efficiency (67.7%). No difference in milk yield and butterfat was due to different levels and combinations of protein and lipid in diets. High protein diets depressed blood cholesterol and glucose compared to low-protein counterparts. Relative decline in milk production was slower for lower fat diets than for higher fat groups, especially mid to later stage of lactation. Results of this experiment tend to support our thesis on the synergistic effect of dietary protein and energy (lipid) upon efficiency of lactation.

• Preventive Nutrition and Food Science
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• 제15권4호
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• pp.262-266
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• 2010

This study was performed to investigate the anti-obesity effect of Eisenia bicyclis in mice fed a high-fat diet (HFD). Male C57BL/6J mice were divided into three groups that were fed a normal diet, an HFD, or an HFD supplemented with a 5% powder of Eisenia bicyclis (PEB) for 8 weeks. The PEB group showed lower body weight gains than the HFD group. The PEB group also exhibited reduced body fat mass and adipose cell size in epididymal adipose tissue. The concentrations of serum cholesterol, leptin, and insulin in the PEB group were significantly lower than those in the HFD group. Liver triglyceride content was significantly decreased by PEB supplementation. Furthermore, hematoxylin and eosin staining revealed that PEB supplementation reduced lipid droplet formation in the liver induced by HFD. These results suggest that PEB supplementation reduces body weight gain and fat accumulation in HFD-induced obese mice.

• 대한방사선기술학회지:방사선기술과학
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• 제44권4호
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• pp.315-325
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• 2021

The purpose of this study is to investigate the changes in lipid proton (LP) composition according to the induced obese fatty liver and to use it as basic data for treatment and diagnosis of fatty liver in the future. The phantom study was conducted to identify differences between STEAM and PRESS Pulse sequences in LP concentration. A high-fat diet (60%) was administered to eight Sprague-Dawley rats to induce obesity and fatty liver disease. Baseline magnetic resonance imaging /spectroscopy data were obtained prior to the introduction of high-fat diet, and data acquisition experiments were performed after eight weeks using procedures identical to those used for baseline studies. The six lipid proton metabolites were calculated using LCModel software. The correlation between the fat percentage and each LP, revealed that the methylene protons at 1.3 ppm showed the highest positive correlation. The α-methylene protons to carboxyl and diallylic protons showed negative correlation with fat percentage. The methylene proton showed the highest increase in the LP; however, it constituted only 71.86% of the total LP concentration. The methylene proton plays a leading role in fat accumulation in liver parenchyma.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2495-2502
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• 2013

Background: Dietary fat has been inconsistently associated with the risk of breast cancer. The purpose of this study was to examine the relationship between meat and animal and plant fat intake and breast cancer risk in subgroups by total lifetime physical activity, using data from a case-control study conducted in the Region of Western Pomerania, Poland. Materials and Methods: The study included 858 women with histological confirmed breast cancer and 1,085 controls, free of any cancer diagnosis. The study was based on a self-administered questionnaire including questions about socio-demographic characteristics, current weight and height, reproductive factors, family history of breast cancer and lifestyle habits. Unconditional logistic regression was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: High animal fat intake significantly increased OR from 1.7 times (OR=1.66, 95%CI=1.07-3.59) to 2.9 times (OR=2.9, 95%CI=1.37-6.14) independent of physical activity level, comparing the third versus the lowest quartile. Women with a high intake of red meat or processed meat and low physical activity showed increased risk of breast cancer: OR=2.70, 95%CI=1.21-6.03 and 1.78, 95%CI=1.04-3.59, respectively. The plant fat dietary pattern was negatively associated with breast cancer in sedentary women (OR=0.57, 95%CI=0.32-0.99). Conclusions: These results indicated that a diet characterized by a high consumption of animal fat is associated with a higher breast cancer risk in sedentary women, while consumption of plant fat products may reduce risk in the same group.

• Journal of Nutrition and Health
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• 제44권4호
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• pp.284-291
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• 2011

The purpose of the present study was to examine the effects of water extracts from red pepper seeds powder on antioxidative enzyme activities and oxidative damage in groups of rrats fed high-fat and high-cholesterol diets group (HFC). The Rrats were divided into the following five experimental groups which are : composed of a normal diet group, a high fat high cholesterol diet group, and a high fat high cholesterol diet group supplemented with different amounts contents (1%, 2% and 4%) of red pepper seeds powder water extracts supplemented groups (HFCW1, HFCW2 and HFCW4, respectively). Body weight gains and food intake were lower ofin the red pepper seed water extracts groups were lower than those inof the HFC group. Hepartic xanthine oxidase (XOD) activity was decreased in the HFCW2 and HFCW4 groups compared to the HFC group. Hepartic glutathione peroxidase (GSH-px) activitiyactivity was increased in the HFCW4 group compared to the HFC group. Hepatic superoxide radicals within the mitochondria and microsomes of cells were significantly reduced in the HFCW2 and HFCW4 groups compared to the HFC group. Hepartic hydrogen peroxide in the cytosol was significantly reduced in the HFCW3 and HFCW4 groups compared to the HFC group. Hepatic carbonyl values in the microsomes and mitochondria were significantly reduced in the HFCW4 group compared to the HFC group. Hepartic thiobarbituric acid reaction substance (TBARS) activity was decreased in the HFCW2 group compared to the HFC group. These results suggest that water extracts of red pepper seeds powder may reduce oxidative damage by activation of antioxidative defense systems in rats fed high fat-high cholesterol diets.

• 동의생리병리학회지
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• 제23권3호
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• pp.562-566
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• 2009

The aim of this study was to investigate the effects of herbal remedy using onion (HRO-1) supplementation on body weight change and cholesterol, triglyceride. free fatty acid, total lipid, phospholipid serum level in obesity mice. This study classified 32 of 4 weeks-old male C57BL/6 mice which have obesity caused by high fat fed into four groups of 8 mice and made the subjects medicated them HRO-1 for 6 weeks. Male C57BL/6 mice were divided into four groups; a normal group, a high-fat group, a high-fat group supplemented with HRO-1 (500 mg/kg), a high-fat group supplemented with HRO-1 (1000 mg/kg). In respect to the body weight change, there was statistically significant difference between the HRO-1 (1000 mg/kg) group compared to high-fat group (p<0.05). In the total cholesterol and LDL cholesterol level, there was statistically significant difference between the HRO-1 (1000 mg/kg) group compared to high-tat group (p<0.05). In the triglyceride and free fatty acid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). In the total lipid and phospholipid level, there was statistically significant difference between the normal group compared to high-fat group (p<0.05). Also in the total lipid level, there was statistically significant difference between the HRO-1 group compared to high-fat group (p<0.05). The above results suggests that HRO-1 medicated is effective to prevention and treatment of obesity.

• 한방비만학회지
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• 제20권2호
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• pp.88-96
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• 2020

Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice. Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured. Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly. Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.