• Earthquakes and Structures
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• 제12권3호
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• pp.285-296
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• 2017

Base isolation is a quite practical control strategy for enhancing the response of structural systems induced by strong ground motions. Due to the dynamic effects of base isolation systems, reduction in the interstory drifts of the superstructure is often achieved at the expense of high base displacement level, which may lead to instability of the structure or non-practical designs for the base isolators. To reduce the base displacement, several hybrid structural control strategies have been studied over the past decades. This study investigates a particular strategy that employs Tuned Mass Dampers (TMDs) for improving the performance of base-isolated structures and unlike previous studies, specifically focuses on the effectiveness of this hybrid control strategy in structures that are equipped with nonlinear base isolation systems. To consider the nonlinearities of base isolation systems, a Bouc-Wen model is selected and nonlinear dynamic OpenSees models are used to perform several time-history simulations in time and frequency domains. Through these numerical simulations, the effects of several parameters such as the fundamental period of the structure, dynamic properties of the TMD and isolation systems and properties of the input ground motion on the behaviour of TMD-structure-base isolation systems are examined. The results of this study provide a better insight into the performance of linear shear-story structures with nonlinear base isolators and show that there are many scenarios in which TMDs can still improve the performance of these systems.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.225-232
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• 1995

The present study was conducted to evaluate the effect of phorbol 12,13-dibutyrate (PDBu) on the contraction of rabbit jugular vein in vitro. PDBu concentrations of greater than 10 nM induced a periodic contraction which was composed of rapid contraction, plateau and slow relaxation. The frequency of periodic contraction increased as PDBu concentration increased. The PDBu-induced contraction was inhibited by staurosporine (100 nM), it was not changed by tetrodotoxin $(1\;{\mu}M).$ In $Ca^{2+}$-free medium, PDBu induced a sustaining contraction, but not periodic contraction. Addition of $Ca^{2+}$ to medium evoked periodic contraction which was inhibited by nifedipine, PDBu concentrations of greater than $0.1\;{\mu}M$ increased ^{45}Ca^{2+}$ uptake without changing $^{45}Ca^{2+}$ efflux. Charybdotoxin and apamin, $Ca^{2+}$-activated K^{+}$ channel blockers, did not affect the PDBu-induced periodic contraction, whereas tetraethylammonium (TEA) abolished the periodicity. Pinacidil $(10\;{\mu}M).$, a potassium channel activator, blocked PDBu induced periodic contraction, which was recovered by glybenclamide $(10\;{\mu}M).$. In high potassium solution, PDBu did not produce the periodic contraction. These results suggest that the PDBu-induced periodicity of contraction is modulated by voltage dependent $Ca^{2+}$ channel and ATP-sensitive $K^{+}$ channel.

• Clinical and Experimental Pediatrics
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• 제56권8호
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• pp.332-337
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• 2013

Purpose: To identify the frequency of bacterial isolates in early-onset neonatal sepsis (EONS) and their antimicrobial resistance pattern. Methods: A retrospective study of EONS was conducted at the Beni Suef University Hospital from September 2008 to September 2012. A case of EONS was defined as an infant who had clinical signs of infection or who was born to a mother with risk factors for infection, and in whom blood culture obtained within 72 hours of life grew a bacterial pathogen. Results: Of 673 neonates screened, there were 138 positive blood cultures (20.5%) (confirmed EONS). Of the recovered isolates, 86.2% were gram-negative pathogens. Klebsiella pneumoniae (42.8%), Enterobacter cloacae (22.5%), and Escherichia coli (13.8%) were the commonest isolated organisms. The most common gram-positive microorganism was Staphylococcus aureus accounting for only 12 isolates (8.7%). All Klebsiella isolates and 93% of Enterobacter isolates were resistant to ampicillin. Gram-negative pathogens had the maximum overall sensitivity to imipenem, cefepime, and ciprofloxacin; whereas, gram-positive isolates were most susceptible to vancomycin, imipenem, and piperacillin. Conclusion: K. pneumoniae was the predominant causative bacteria of EONS followed by E. cloacae and E. coli. There was a high resistance to ampicillin. Imipenem had the maximum overall activity against the causative bacteria. Continuous surveillance is needed to monitor the changing epidemiology of pathogens and antibiotic sensitivity.

• Wind and Structures
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• 제18권5호
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• pp.567-598
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• 2014

In this paper, wind induced aerodynamic loads on a standard tall building have been evaluated through large-eddy simulation (LES) technique. The flow parameters of an open terrain were recorded from the downstream of an empty boundary layer wind tunnel (BLWT) and used to prescribe the transient inlet boundary of the LES simulations. Three different numerically generated inflow boundary conditions have been investigated to assess their suitability for LES. A high frequency pressure integration (HFPI) approach has been employed to obtain the wind load. A total of 280 pressure monitoring points have been systematically distributed on the surfaces of the LES model building. Similar BLWT experiments were also done to validate the numerical results. In addition, the effects of adjacent buildings were studied. Among the three wind field generation methods (synthetic, Simirnov's, and Lund's recycling method), LES with perturbation from the synthetic random flow approach showed better agreement with the BLWT data. In general, LES predicted peak wind loads comparable with the BLWT data, with a maximum difference of 15% and an average difference of 5%, for an isolated building case and however higher estimation errors were observed for cases where adjacent buildings were placed in the vicinity of the study building.

• 음성과학
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• 제6권
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• pp.219-233
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• 1999

This paper presents a real-time implementation of a speaker independent speech recognition system based on a discrete hidden markov model(DHMM). This system is developed for a car navigation system to design on-chip VLSI system of speech recognition which is used by fixed point Oak DSP core of DSP GROUP LTD. We analyze recognition procedure with C language to implement fixed point real-time algorithms. Based on the analyses, we improve the algorithms which are possible to operate in real-time, and can verify the recognition result at the same time as speech ends, by processing all recognition routines within a frame. A car noise is the colored noise concentrated heavily on the low frequency segment under 400 Hz. For the noise robust processing, the high pass filtering and the liftering on the distance measure of feature vectors are applied to the recognition system. Recognition experiments on the twelve isolated command words were performed. The recognition rates of the baseline recognizer were 98.68% in a stopping situation and 80.7% in a running situation. Using the noise processing methods, the recognition rates were enhanced to 89.04% in a running situation.

• 한국수산과학회지
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• 제45권6호
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• pp.654-658
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• 2012

Vibrio alginolyticus, a marine fish and shellfish pathogen, has been found at a high frequency around the coastal areas of Korea. Vibrio alginolyticus was purified from various diseased fish, and a V. alginolyticus-specific bacteriophage was isolated from seawater obtained from fish farms located on the west coast of Korea. In a bacterial lysis experiment using the phage and antibiotics, tetracycline, $10^3$ cfu/ml of V. alginolyticus were completely lysed by both the phage and the antibiotic, suggesting that the purified phage in the study could be utilized as an alternative to antibiotics in the control of fish and shellfish diseases caused by V. alginolyticus.

• Archives of Plastic Surgery
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• 제34권3호
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• pp.406-408
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• 2007

Purpose: Despite a high frequency of acquired nail disease, congenital absence of the nail, also called as anonychia, is a rare anomaly. It may be seen as an isolated of phalangeal bone(ectrodactyly), nail-patella syndrome, birth trauma, impaired peripheral circulation, alopecia areata, and pemphigus, idiopathic atrophy of the nail, bullous drug eruptions, periodic shedding, lichen planus, Stenvens-Johnson syndrome and so forth. Methods: We have experienced a rare case of 40-day-old neonate, suffering from intrauterine growth retardation, but without familial history, chromosomal anomalies or any other diseases. Results: There was no nail on left 5th finger and distal phalangeal bone of same finger. So, We diagnosed as Congenital Anonychia with ectrodactyly of 5th Finger. Conclusion: We report this case as congenital anonychia of 5th finger which have developed from underlying distal phalangeal ectrodactyly. We also review other reported cased in the literatures.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 춘계학술대회논문집
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• pp.1128-1133
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• 2003

A gas driven heat pump (GHP) core design comprises internal combustion engine, compressors incorporated to a cooling/heating system, rubber mountings and belt transmissions. Main excitation farces are generated by an engine, compressors themselves and belt fluctuation. It leads to high vibration level of the mount that can cause damage of GHP elements. Therefore an appropriate design of the mounting system is crucial in terms of reliability and vibration reduction. In this paper oscillation of the engine mount is explored both experimentally and analytically. Experimental analysis of natural frequencies and operational frequency response of the GHP engine mounting system enables to create simplified model for numerical and analytical investigations. It is worked out criteria f3r vibration abatement of the isolated structure. Influence of bracket stiffness between engine and compressors, suspension locations and damper performance is investigated. Ways to reduce excitation forces and improve dynamic performance of the engine-compressor mounting system are considered from these analyses. Implementation of the proposed approach permits to choose appropriate rubber mountings and their location as well as joining elements design A phase matching technique can be employed to control forces from main exciters. It enables to changing vibration response of the structure by control of natural modes contribution. Proposed changes lead to significant vibration reduction and can be easily utilized in engineering practice.

• 전기학회논문지
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• 제65권5호
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• pp.785-793
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• 2016

This paper analyzes an LCL-type isolated dc-dc converter operating for constant output voltage in the continuous conduction mode(CCM) with resistances of parasitic losses-static drain-source on resistance of power switch, ESR of resonant network(L-C-L)-using a high loaded quality factor Q assumptions and fourier series techniques. Simple analytical expressions for performance characteristics are derived under steady-state conditions for designing and understanding the behavior of the proposed converter. The voltage-driven rectifier is analyzed, taking into account the diode threshold voltage and the diode forward resistance. Experimental results measured for a proposed converter at low input voltage and various load resistances show agreement to the theoretical performance predicted by the analysis within maximum 4% error. Especially in the case of low output voltages and large loads, It is been observed that introduction of both rectifier and the parasitic components of converter had considerable effect on the performance.

• Molecules and Cells
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• 제37권5호
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• pp.383-388
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• 2014

Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could upregulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.