• Title/Summary/Keyword: High- and low-dose-rate

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Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice

  • Liu, Lin-Na;Guo, Zhi-Wei;Zhang, Yan;Qin, Hua;Han, Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1401-1405
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    • 2012
  • Aim: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice. Methods: Kunming mice were randomly divided into five groups: normal group (NC), irradiation control group (IC), RTP1 low dose (200 mg/kg), middle dose (400 mg/kg) and high dose (800 mg/kg) groups. RTP1 was adminstered by the gastric route for 14 d, mice in the NC and IC groups being given by 0.9% sodium chloride solution in the same way. The mice in all groups except NC group were irradiated with 2.0 Gy $^{60}Co{\gamma}$-ray on the fourteenth day. Immune indives of non-specific immune function, cellular immunity and humoral immunity were assessed at the 24th hour after radiation. Results: Compared with the IC group, the spleen index, thymus index, rate of carbon clearance, phagocytic function of macrophages, lymphocyte proliferation, hemolysin value of blood serum and NK activity were increased markedly (P < 0.05 or P < 0.05). Conclusion: RTP1 has an obvious protective effects on damage in ${\gamma}$-ray radiated mice.

A detector system for searching lost γ-ray source

  • Khan, Waseem;He, Chaohui;Cao, Yu;Khan, Rashid;Yang, Weitao
    • Nuclear Engineering and Technology
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    • v.52 no.7
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    • pp.1524-1531
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    • 2020
  • The aim of this work is to develop a Geiger-Muller (GM) detector system for robot to look for a radioactive source in case of a nuclear emergency or in a high radiation environment. In order to find a radiation source easily, a detector system, including 3 detectors, was designed to search γ-ray radiation sources autonomously. First, based on GEANT4 simulation, radiation dose rates in 3 Geiger-Muller (GM) counters were simulated at different source-detector distances, distances between detectors and angles. Various sensitivity analyses were performed experimentally to verify the simulated designed detector system. A mono-energetic 137Cs γ-ray source with energy 662 keV and activity of 1.11 GBq was used for the observation. The simulated results were compared with the experimental dose rate values and good agreements were obtained for various cases. Only based on the dose rates in three detectors, the radiation source with a specific source activity and angle was localized in the different location. A method was adopted with the measured dose rates and differences of distances to find the actual location of the lost γ-ray source. The corresponding angles of deviation and detection limits were calculated to determine the sensitivity and abilities of our designed detector system. The proposed system can be used to locate radiation sources in low and high radiation environments.

Pharmacological Actions of New Wonbang Woohwangchungsimwon Liquid on Cardiovascular System (신원방우황청심원액의 심혈관계에 관한 약효)

  • 조태순;이선미;김낙두;허인회;안형수;권광일;박석기;심상호;신대희
    • Biomolecules & Therapeutics
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    • v.7 no.1
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    • pp.66-78
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    • 1999
  • In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10$^{-6}$ M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD$_{90}$ and V$_{max}$ at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.s.

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Pharmacological Actions of New Woohwangchungsimwon Liquid on Cardiovascular System (신우황청심원액의 심혈관계에 관한 약효연구)

  • 조태순;이선미;김낙두;허인회;안형수;박대규
    • Biomolecules & Therapeutics
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    • v.5 no.4
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    • pp.390-401
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    • 1997
  • In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), effects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10$^{-6}$ M) without regard to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no effects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.

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Radioresistance of Acorus calamus to Gamma Ray Irradiation

  • Lee, Ja-Hyun;Kang, Si-Yong;Lee, Geung-Joo;Lee, Seong-Gene;Kim, Sun-Kook;Han, Tae-Ho
    • FLOWER RESEARCH JOURNAL
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    • v.19 no.2
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    • pp.119-125
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    • 2011
  • Acorus calamus is an indigenous hydrophyte used as phytoremediation and water purification as well as medicinal herb. Irradiation of gamma ray was performed to investigate the effect on radioresistance of A. calamus on in vitro. Various doses (20-500 Gy) of gamma rays were irradiated to in vitro plantlets. The effect of irradiation was studied on survival rate, shoot formation and growth rate. The survival and multiplication rate was remarkably decreased with the increase of radiation dose. The growth of plantlets was significantly increased in comparison to the control at low doses. The hermetic effect of radiation was appeared in A. calamus. It was significantly decreased or interrupted above 250 Gy. The mean 50% lethal dose ($LD_{50}$) was extremely high as 240 Gy. We conclude that A. calamus had remarkably high radioresistance compared with other plant species.

A Study on the Evolution of 3,4-DCA and TCAB in Some Selected Soils(Part II) -Degradation of $^{14}C-3,4-DCA\;and\;^{14}C-TCAB$- (수종토양중(數種土壤中)에서 3,4-DCA 및 TCAB의 변화(變化)에 관(關)한 연구(硏究)(제2보(劑二報)) -$^{14}C-3,4-DCA$$^{14}C-TCAB$ 의 분해(分解)-)

  • Lee, Jae-Koo;Fournier, J.C.
    • Applied Biological Chemistry
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    • v.21 no.2
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    • pp.71-80
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    • 1978
  • In an attempt to elucidate the fate of 3,4-DCA and TCAB in various French soils, uniformly $^{14}C-ring-labeled$ 3,4-DCA and TCAB mere utilized and the following results obtained. 1) The rate of breakdown of $^{14}C-3,4-DCA$ into $^{14}CO_2$ was relatively higher in the early stage than that in the later stage. In 6 months of incubation in alkaline soil (pH 7.9), the rate was as high as 6.5% at dose 1 (1.5 ppm) and as low as 1.92% at dose 2(94 ppm), whereas in organic acid soil (pH 5.5) the rate was 4.91% at dose 1 and 4.24% at dose 2, respectively, without making any great difference between the two levels. 2) At dose 1, 47.70% of the initial radioactivity of $^{14}C-3,4-DCA$ was bound to soil in organic acid soil and 29.49% bound in alkaline soil, whereas at dose 2, 38.40% in organic acid soil and 20.30% in alkaline soil, respectively. 3) The amount of formation of $^{14}C-TCAB$ from $^{14}C-3,4-DCA$ seems to depend largely on the concentration of 3,4-DCA applied rather than on soil types. At dose 2, the amount was 50% of the total radioactivity extracted in organic acid soil and 30% in alkaline soil, corresponding to 1.8% and 1.4% of the initial radioactivity applied to soil, respectively. Cis-TCAB also seemed to be formed at dose 2 in both soils. Meanwhile, at dose 1, even though $^{14}C-TCAB$ was detected in trace on tlc and glc in both soils, the amount does not exceed 2 to 3% of the radioactivity extracted, corresponding to 0.05 to 0.1% of the initial radioactivity. 4) The rate of breakdown of $^{14}C-TCAB$ into $^{14}CO_2$ ranged from 0.05 to 0.20% in all the four soils. Most of the applied $^{14}C-TCAB$ remained intact after 3 months, not producing any detectable metabolites. 5) The fact that much more $^{14}C-TCAB$ was adsorbed to alkaline soil than to the other soils strongly indicates that in alkaline condition trans-isomer was converted tocisisomer which has the higher adsorption affinity than the former.

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Removal of Microcystis aeruginosa using Pine Needle Extracts (솔잎추출액을 이용한 Microcystis aeruginosa 제거 연구)

  • Choi, Hee-Jeong
    • Journal of Korean Society on Water Environment
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    • v.33 no.1
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    • pp.8-14
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    • 2017
  • Microcystis aeruginosa (M. aeruginosa) is a cyanobacterium species that can form harmful algal blooms in freshwater bodies worldwide. The use of pine needle extract (PNE) to control nuisance algae by allelopathic inhibition will be environmentally friendly and promising. PNE removed successfully upto 98% of M. aeruginosa at the following optimal conditions: pH 7, $25^{\circ}C$ of temperature, 100 rpm of mixing rate, 5 min of mixing time. These results was indicated that the amount of 1 g/L PNE was removed 1g dryweight/L of M. aeruginosa. The kinetic data showed substrate inhibition kinetics and maximum growth rate was obtained when the M. aeruginosa was grown in medium containing 0.5 g/L of initial concentration of PNE. Different substrate inhibition models were fitted to the kinetic data and found the Luong model was best. The model predicted kinetic parameters were in agreement with the experimental findings. The natural extract, PNE, can be a promising inhibition due to its high efficiency and low dose requirements.

Effects of different UV-8 levels on the growth, photosynthesis and pigments in cucumber(Cucumis sativus L.) (UV-B 강도 변화가 오이(Cucumis sativus L.)의 생장, 광합성 및 색소에 미치는 영향)

  • Kim, Hak-Yoon;Lee, In-Jung;Shin, Dong-Hyun;Kim, Kil-Ung
    • Journal of Life Science
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    • v.8 no.3
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    • pp.272-278
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    • 1998
  • To investigate the effects of different UV-B levels on plant growth, cucumber plants were subjected to three levels of biologically effective ultraviolet-B(UV--$B^{BE}$ radiation [daily dose : 0.03(No UV-B), 6.40(Low UV-B) and 11.30 (High UV-B) kJ $m^{-2}$, UV--$B^{BE}$] in the growth chambers for 3 weeks during the early growth period. High and low levels of UV-B irradiation drastically decreased both dry weight and leaf area, but increased specific leaf weight of cucumber. Plants subjected to UV-B resulted in 30% and 20% reduction of photosynthesis rate by high and low UV-B, respectively. However, respiration rate was not affected by the UV-B. With increasing UV-B intensity, total chlorophyll contents were decreased linearly, while the contents of flavonoid were increased linearly. These results suggest that the present levels of UV-B may affect the growth of cucumber plant compared with a UV-B-free condition. It is likely that the growth of cucumber will be affected by enhanced UV-B due to ozone depletion in the near future.

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Germination and Seedling Growth Affected by Seed Specific Gravity

  • Yun, Myoung-Hui;Shin, Jin-Chul;Yang, Woon-Ho;Son, Ji-Young;Kim, Jun-Hwan;Park, Geun-Soo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.53 no.4
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    • pp.434-439
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    • 2008
  • The amount of salt to make seed sorting solution of the specific gravity of 1.13 was reconsidered and determined as 3.8 kg salt in 18 L water, which is lower amount than currently used. Five rice cultivars were examined. Percent germination and seedling emergence were not similar. Seedling emergence rate of Japonica varieties, Nampyungbyeo and Daerypbyeo-1 were 87% and 95% under specific gravity of 1.13, respectively. Seedling emergence rate of Tongil type variety, Dasanbyeo was as high as 67% in specific gravity of 1.06. Seedling emergence rate of waxy rice, Hwasunchalbyeo and Aranghangchalbyeo were examined. Seedling emergence rate was 94% in both cultivars in specific gravity of 1.04. Seedling emergence rate was same in specific gravity of 1.08 which is generally used for selecting seed currently. Early growth (plant height, leaf number, and dry weight) were not significantly different by specific gravity within species. In all cultivars except waxy rice, highest seedling emergence rate was observed in specific gravity of 1.13 which is currently used for selection and decreased as specific gravity is lowed. However, considering total amount of seeds in each group of specific gravity, amount of seed in lower specific gravity group is relatively small and total seedling emergence rate within variety dose not show big difference. However, if seeds with low speicific gravity are produced due to the bad grain filling condition and consequently total seed content of low specific gravity increases, results will be differnt. Reduction in total growth and yield could occur. It will be important to comply with the seed sorting criterion of 1.13 for Japonica, 1.06 for Tongil, and 1.04 for waxy rice variety to ensure the maximum rice growth and yield.

The Experiment of Grid Characteristics for High-voltage Radiography of Chest (흉부촬영시 관전압과 선질에 따른 적절한 격자의 선택을 위한 실험)

  • Kim, Jung-Min;Ahn, Bong-Seon
    • Journal of radiological science and technology
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    • v.15 no.2
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    • pp.31-36
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    • 1992
  • Grids can improve the diagnostic quality of chest radiography by trapping the greater part of scattered radiation thus providing more detailed. chest radiographic images. It is most effective mathod of reduce the scatter ratio but must increase the expour factor. The benefit of use of grid is improve the contrast and the loss is increase of patient dose. In chest radiography especially hard quality high voltage radiography it will have to be considered to select the optimum grid with view point of benefit and loss. In this experiment, author got some result of characteristics about 4 different grids with film method. 1. There was no difference the scatter ratio in case of no grid and the scatter ratio was about 60%. 2. 16 : 1 grid was excellent of scatter reduction factor in high voltage chest radiography, next was 10 : 1, CROSS, MICRO FINE grid have low scatter reduction rate compare to 16:1, 10:1 grid. 3. The bucky factor of CROSS grid in accordance of kVp was find out the highest in 4 grids, on the contraly 10 : 1 grid was profitable to the exposure does. 4. With careful consideration in the point of scatter reducion rate and bucky factor, author suggest the 10 : 1 linear grid on the use of chest radiography in $80{\sim}120\;kVp$, 16 : 1 grid in $120{\sim}140\;kVp$.

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