• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.37-37
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• 2001

Cyclic nucleotide-gated (CNG) channels are composed of homo or hetero tetramer of ${\alpha}$ and ${\beta}$ subunits. The a subunits of these channels have a conserved glutamate residue within the pore-forming region. This residue determines the selectivity as well as the affinity for the extracellular divalent cations. Using the high affinity mutant (E363D) of bovine retinal CNG channel in which the Glu was replaced to Asp at position 363, we constructed tandem dimers and investigated the binding symmetry of divalent cation to the site.(omitted)

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.443-450
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• 2017

Nowadays, Power Line Communication (PLC) is gaining high attention from industry and electric supply companies for the services like demand response, demand side management and Advanced Metering Infrastructure (AMI). The reliable services to consumers using PLC can be provided by utilizing an efficient PLC channel for which sophisticated channel modeling is very important. This paper presents characterization of a Low Voltage (LV) access network for Narrowband Power Line Communications (NB-PLC) using transmission line (TL) theory and a Simulink model. The TL theory analysis not only includes the constant parameters but frequency selectivity is also introduced in these parameters such as resistance, conductance and impedances. However, the proposed Simulink channel model offers an analysis and characterization of capacitive coupler, network impedance and channel transfer function for NB-PLC. Analysis of analytical and simulated results shows a close agreement of the channel transfer function. In the absence of a standardized NBPLC channel model, this research work can prove significant in improving the efficiency and accuracy of NB-PLC communication transceivers for Smart Grid communications.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.1
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• pp.61-70
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• 2009

We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on $Ba^{2+}$ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary(CHO) cells and used the whole cell patch-clamp technique to record $K^+$ currents in the absence and presence of externally applied $Ba^{2+}$. Wild type Kir2.1 was blocked by externally applied $Ba^{2+}$ in a voltage and concentration dependent manner. Mutants of Y145 in the selectivity filter showed little change in the kinetics of $Ba^{2+}$ blockage. The estimated $K_d(0)$ was 108 ${\mu}M$ for Kir2.1 wild type, 124 ${\mu}M$ for a concatameric WT-Y145V dimer, 109 ${\mu}M$ for a WT-Y145L dimer, and 267 ${\mu}M$ for Y145F. Mutant channels T141A and S165L exhibit a reduced affinity together with a large reduction in the rate of blockage. In S165L, blockage proceeds with a double exponential time course, suggestive of more than one blocking site. The double mutation T141A/S165L dramatically reduced affinity for $Ba^{2+}$, also showing two components with very different time courses. Mutants D172K and D172R(lining the central, aqueous cavity of the channel) showed both a decreased affinity to $Ba^{2+}$ and a decrease in the on transition rate constant(${\kappa}_{on}$). These results imply that residues stabilising the cytoplasmic end of the selectivity filter(T141, S165) and in the central cavity(D172) are major determinants of high affinity $Ba^{2+}$ blockage in Kir 2.1.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.1A
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• pp.1-11
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• 2009

In OFDMA or SC-FDMA systems one can generate time varying channels or frequency selective channels using multiple transmit antennas to achieve diversity without special space-time processing at the receivers. While low channel coding rate needs to be used for distributed-allocation SC-FDMA systems with a phase rolling technique to produce time fluctuation, relatively high channel coding rate can be used when cyclic delay diversity is used to increase frequency selectivity assuming quasi-static channel. On the other hand, for block-hopping SC-FDMA systems there is no significant difference between two diversity techniques in terms of optimal channel coding rates.

• Journal of Communications and Networks
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• v.9 no.1
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• pp.34-42
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• 2007

Orthogonal frequency division multiplexing (OFDM) combined with time division multiplexing (TDM), in this paper called OFDM/TDM, can overcome the high peak-to-average-power ratio (PAPR) problem of the conventional OFDM and improve the robustness against long time delays. In this paper, the bit error rate (BER) performance of OFDM/FDM in a frequency-selective Rayleigh fading. channel is evaluated by computer simulation. It is shown that the use of frequency-domain equalization based on minimum mean square error criterion (MMSE-FDE) can significantly improve the BER performance, compared to the conventional OFDM, by exploiting the channel frequency-selectivity while reducing the PAPR or improving the robustness against long time delays. It is also shown that the performance of OFDM/FDM designed to reduce the PAPR can bridge the conventional OFDM and single-carrier (SC) transmission by changing the design parameter.

• Applied Science and Convergence Technology
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• v.24 no.5
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• pp.196-202
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• 2015

Human blood consists of 55% of plasma and 45% of blood cells such as white blood cell (WBC) and red blood cell (RBC). In plasma, there are many kinds of promising biomarkers, which can be used for the diagnosis of various diseases and biological analysis. For diagnostic tools such as a lab-on-a-chip (LOC), blood plasma separation is a fundamental step for accomplishing a high performance in the detection of a disease. Highly efficient separators can increase the sensitivity and selectivity of biosensors and reduce diagnostic time. In order to achieve a higher yield in blood plasma separation, we propose a novel fluid wing structure that is optimized by COMSOL simulations by varying the fluidic channel width and the angle of the bifurcation. The fluid wing structure is inspired by the inertial particle separator system in helicopters where sand particles are prevented from following the air flow to an engine. The structure is ameliorated in order to satisfy biological and fluidic requirements at the micro scale to achieve high plasma yield and separation efficiency. In this study, we fabricated the fluid wing structure for the efficient microfluidic blood plasma separation. The high plasma yield of 67% is achieved with a channel width of $20{\mu}m$ in the fabricated fluidic chip and the result was not affected by the angle of the bifurcation.

• Journal of Life Science
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• v.17 no.11
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• pp.1517-1522
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• 2007

Gap junction channels formed by two adjacent cells allow the passage of small molecules up to ${\sim}\;1\;kDa$ between them. Hemichannel (connexon or half of gap junction) also behaves as a membrane channel like sodium or potassium channels in a single cell membrane. Among 26 types of connexin (Cx), $Cx32^*43E1$ (a chimera in which the first extracellular loop of Cx32 has been replaced with that of Cx43), Cx38, Cx46, and Cx50 form functional hemichannels as well as gap junction channels. Although it is known that Xenopus oocytes express endogenous connexin 38 (Cx38), its biophysical characteristics at single channel level are poorly understood. In this study, we performed single channel recordings from single Xenopus oocytes to acquire the biophysical properties of Cx38 including voltage-dependent gating and permeation (conductance and selectivity). The voltage-dependent fast and slow gatings of Cx38 hemichannel are distinct. Fast gating events occur at positive potentials and their open probabilities are low. In contrast, slow gatings dominate at negative potentials with high open probabilites. Based on hi-ionic experiments, Cx38 hemichannel is anion-selective. It will be interesting to test whether charged amino acid residues in the amino terminus of Cx38 are responsible for voltage gatings and permeation.

• Journal of Electrical Engineering and Technology
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• v.8 no.5
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• pp.1152-1156
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• 2013

We propose a compact high-order(9th) UHF bandpass filter comprising the composite right-handed and left-handed(CRLH) zeroth-order resonators(ZORs) in the form of the three cascaded-triplets(CTs) newly applied to the ZOR filter which results in very steep skirt. The method is verified by circuit and EM simulations and measurement with metamaterial properties.

• KIEE International Transactions on Electrophysics and Applications
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• v.11C no.3
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• pp.63-69
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• 2001

Holographic transmission gratings were performed by an Ar-laser( ${\lambda}$=514nm) intensity, the ratio fo LC contents to the surfactant. The addition of the surfactant to the LC and pre-polymer systems causes the droplet to maintain the ideal size at the high fraction(over 40wt%) of the LC contents that induce the films to be fabricated with high diffraction efficiency than that of no surfactant series. The image of these films was examined using a charge coupled device (CCD). We also studied the angular selectivity plots which support the important role in the multiplexer channel (MUX). Eventually, we showed the reconstructive optical image recorded in this transmission mode of HPDLCs.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.1
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• pp.7-12
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• 2008

OLETF (Otsuka Long-Evans Tokushima Fatty) rats are characterized by obesity-related insulin resistance, which is a phenotype of type 2 diabetes. Sulfonylurea drugs or benzoic acid derivatives as inhibitors of the ATP-sensitive potassium $(K_{ATP})$ channel are commercially available to treat diabetes. The present study compared sulfonylurea drugs (glimepiride and gliclazide) with one of benzoic acid derivatives (repaglinide) in regard to their long-term effect on ameliorating insulin sensitivity in OLETF rats. Each drug was dissolved and fed with drinking water from 29 weeks of age. On high glucose loading at 45 weeks of age, response of blood glucose recovery was the greatest in the group treated with glimepiride. On immunohistochemistry analysis for the Kir6.2 subunit of $K_{ATP}$ channels, insulin receptor ${\beta}$-subunits, and glucose transporters (GLUT) type 2 and 4 in liver, fat and skeletal muscle tissues, the sulfonylurea drugs (glimepiride and gliclazide) were more effective than repaglinide in recovery from their decreased expressions in OLETF rats. From these results, it seems to be plausible that $K_{ATP}$-channel inhibitors containing sulfonylurea moiety may be much more effective in reducing insulin resistance than those with benzoic acid moiety. In contrast to gliclazide, non-tissue selectivity of glimepiride on $K_{ATP}$ channel inhibition may further strengthen an amelioration of insulin sensitivity unless considering other side effects.