• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.1023-1026
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• 2013

The electronic equipment which was exposed to high level pulsed radiation is damaged as Upset, Latchup, and Burnout. Those damages has come from the instantaneous photocurrent from electron-hole pairs generated in itself. Such damages appeared as losses of power in military weapon system or of blackout in aerospace equipment and eventually caused in gross loss of national. In this paper, we have implemented a RDC(Radiation detection and control module) as part of the radiation protection technology of the electronic equipment or devices from the pulsed gamma radiation. The RDC which is composed of pulsed gamma-ray detection sensor, signal processors, and pulse generator is designed to protect the important electronic circuits from the pulse radiation. To verify the functionality of the RDC, LM118s which had damaged by the pulse radiation were tested. The test results showed that the test sample applied with a RDC was worked well in spite of the irradiation of the same pulse radiation. Through the experiments we could confirm that the radiation protection technology implemented with RDC had the functionality of radiation protection to the electronic devices.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.3
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• pp.274-280
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• 2016

Hinge driving type holding and release mechanism based on the burn wire release for application of cubesat is main payload of STEP Cube Lab. (Cube Laboratory for Space Technology Experimental Project) to be launched at 2015. It has high constraint force, low shock level as well as surmounting drawbacks of conventional nichrome burn wire release method that has relatively low constraint force and system complexity for application of multi-deployable systems. In this paper, we have proposed a flight model of holding and release mechanism for the verification of the constraint force and deployment status signal acquisition. To validate the effectiveness of the flight model, launch and on-orbit environment verification test have been performed.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.6
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• pp.507-513
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• 2000

ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular effectors of the ErbB2/ErbB3 are mitogen-activated protein kinase (MAPK) and phosphoinositide (PI) 3-kinase. In the present study, we studied relative contributions of above two distinct signaling pathways to the heregulin-induced mitogenic response via activated ErbB3. For this, clonal NIH-3T3 cell lines expressing wild-type ErbB3 and ErbB3 mutants were stimulated with $heregulin{\beta}_1$. While cyclin D1 level was markedly high and further increased by treatment of heregulin in cells expressing wild-type ErbB3, the elimination of either Shc binding or PI 3-kinase binding lowered both levels. This result was supported by the reduction of cyclin $D_1$ expression by preteatment with MAPK kinase inhibitor or PI 3-kinase inhibitor before stimulation with heregulin. In accordance with the cyclin $D_1$ expression, elimination of either Shc binding or PI 3-kinase binding reduced the heregulin-induced DNA synthesis and cell growth rate. Our results obtained by the comparison of wild-type and ErbB3 mutants indicate that the full induction of the cell cycle progression through $G_1/S$ phase by ErbB3 activation is dependent on both Shc/MAPK and PI 3-kinase signal transduction pathways.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.75-84
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• 1996

Platelets from a patient with a mild inherited bleeding disorder and abnormal platelet aggregation and secretion show reduced generation of inositol 1,4,5-trisphosphate (IP$_3$), mobilization of intracellular Ca$\^$2+/, and phosphorylation of pleckstrin in response to several G protein mediated agonists, suggesting a possible defect at the level of phospholipase C (PLC) activation. A procedure was developed that allows quantitation of platelet PLC isozymes. After fractionation of platelet extracts by high-performance liquid chromatography, seven, out often known PLC isoforms were detected by immunoblot analysis. The amount of these isoforms in normal platelets decreased in the order PLC-${\gamma}$2 > PLC-${\beta}$2 > PLC-${\beta}$3 > PLC-${\beta}$l > PLC-${\gamma}$ > PLC-$\delta$1 > PLC-${\beta}$4. Compared with normal platelets, platelets from the patient contained approximately one-third the amount of PLC-${\beta}$2, whereas PLC-${\beta}$4 was increased threefold. These results suggest that the impaired platelet function in the patient in response to multiple G protein mediated agonists is attributable to a deficiency of PLC-${\beta}$2. They document for the first time a specific PLC isozyme deficiency in human platelets and provide an unique opportunity to understand the role of different PLC isozymes in normal platelet function.

• Journal of Microbiology
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• v.44 no.4
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• pp.369-374
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• 2006

To investigate the mechanism of salt tolerance of gram-positive moderately halophilic bacteria, two-dimensional gel electrophoresis (2-D PAGE) was employed to achieve high resolution maps of proteins of Halobacillus dabanensis $D-8^T$. Approximately 700 spots of proteins were identified from these 2-D PAGE maps. The majority of these proteins had molecular weights between 17.5 and 66 kDa, and most of them were distributed between the isoelectric points (pI) 4.0 and 5.9. Some protein spots were distributed in the more acidic region of the 2-D gel (pI <4.0). This pattern indicated that a number of proteins in the strain $D-8^T$ are acidic. To understand the adaptation mechanisms of moderately halophilic bacteria in response to sudden environmental changes, differential protein profiles of this strain were investigated by 2-D PAGE and $Imagemaster^{TM}$ 2D Platinum software after the cells were subjected to salt shock of 1 to 25% salinity for 5 and 50 min. Analysis showed 59 proteins with an altered level of expression as the result of the exposure to salt shock. Eighteen proteins had increased expression, S proteins were induced, and the expression of 33 proteins was down-regulated. Eight of the up-regulated proteins were identified using MALDI-TOF/MS and MASCOT, and were similar to proteins involved in signal transduction, proteins participating in energy metabolism pathways and proteins involved in stress.

• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.159-165
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• 2003

We developed a 37-channel magnetoencephalogram (MEG) measurement system based on low-noise superconducting quantum interference device (SQUID) magnetometets, and operated the system to measure MEG signals. By using double relaxation oscillation SQUIDs with high flux-4o-voltage transfers, the SQUID outputs could be measured directly by room temperature preamplifiers and compact readout circuits were used for SQUID operation. The average field noise level of the magnetometers is about 3 fT/√Hz in the white region, low enough for MEG measurements when operated inside a magnetically shielded room. The 37 magnetometers were distributed on a hemispherical surface haying a radius of 125 mm. In addition to the 37 sensing channels. 11 reference channels were installed to pickup external noise and to form software gradiometers. A low-noise liquid helium dewar was fabricated with a liquid capacity of 30 L and boil-off rate of 4 L/d. The signal processing software consists of digital filtering, software gradiometer, isofield mapping and source localization. By using the developed system, we measured auditory-evoked fields and localized the current dipoles, demonstrating the effectiveness of the system.

• Aerospace Engineering and Technology
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• v.3 no.1
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• pp.242-250
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• 2004

This paper describes the detection method of wire-like obstacles using millimeter-wave radar system. Passive sensor like CCD camera can be used for the detection of high power electric cables on the hills or mountains and it can give very good quality of obstacle target information. But this system is very limited to use by bad weather condition. The detection capability for different diameters of wire targets using millimeter radar system have been accomplished. To simulate the target on the moving helicopter, rotating targets are used with fixed radar system. In the experiment 11mm, 16mm and 22mm diameter of wires have been detected in single, two and three wires in one position. The detected signal from single wire was very clear on gray level image. Three wires placed very closely together could be recognized in range, cross range image plane. For two and three wires, blur effect due to mutual scattering effect is observed.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.396-405
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• 2009

An interlocking equipment of railway signalling systems should have very high functional safety and reliability properties because of its vital railway protection functionality. In order to achieve the required safety and reliability level, an engineer, in general, designs and implements the interlocking equipment to operate under RTOS(Realtime Operating System) environment, and the control hardware architecture redundant to cope with the random failures of system or subsystem. In such an architecture, it's very difficult to implement the interlocking equipment to communicate with various interface systems including the signal operator's terminal. In this paper, we propose a dual ethernet network topology and dual packet seamless transfer protocol algorithm for railway signaling system such as the interlocking equipment. We verify in this paper that the proposed DPST protocol algorithm has the evidence of its robust properties against the random hardware faults and communication errors. The proposed communication structure and algorithm is implemented in the electronic interlocking equipment for the private railway system of Hyundai Steel Company and its performance and properties are validated on the guideline of European Railway Standard EN50159.

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.41-45
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• 2013

Following are brief statements about the delayed encephalopathy of a patient who recovered without disturbance of consciousness after acute carbon monoxide poisoning. A 72-year-old male was found without consciousness at home and then visited the ER center. Later we learned that the patient was using briquettes as a household heating source. Blood carbon monoxide hemoglobin level was 17.5%. As carbon monoxide poisoning was uncertain after the first interview with the patient, hyperbaric oxygen therapy was not administered at the early stage. After supplying 100% oxygen, the patient recovered consciousness, however, the strength of the lower limb muscle had decreased to class II. The patient showed continued weakening of the lower limb muscle and an increase of CPK; therefore, he was diagnosed as carbon monoxide intoxication and rhabdomyolysis and then admitted to the intensive care unit (ICU) for conservative treatment. During the hospitalization period, continued weakening of the lower limb muscle was observed and he was diagnosed as myopathy after EMG/MCV. However, he suddenly showed altered mentality on the 20th day of hospitalization, and underwent brain MRI. T2 weighted MRI showed typically high signal intensity of both globus pallidus and periventricular white matter; therefore, he was diagnosed as delayed carbon monoxide encephalopathy. This case showed delayed encephalopathy accompanied by rhabdomyolysis and myopathy of a patient who recovered without disturbance of consciousness.

• Journal of Biomedical Engineering Research
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• v.35 no.4
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• pp.87-94
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• 2014

Recent technological advances have increased interest in personal health monitoring. Electrocardiogram(ECG) monitoring is a basic healthcare activity and can provide decisive information regarding cardiovascular system status. In this study, we developed a capacitive ECG measurement system that can be included within a cloth mattress pad. The device permits ECG data to be obtained during sleep by using capacitive electrodes. However, it is difficult to detect R-wave peaks automatically because signals obtained from the system can include a high level of noise from various sources. Because R-peak detection is important in ECG applications, we developed an algorithm that can reduce noise and improve detection accuracy under noisy conditions. Algorithm reliability was evaluated by determining its sensitivity(Se), positive predictivity(+P), and error rate(Er) by using data from the MIT-BIH Polysomnographic Database and from our capacitive ECG system. The results showed that Se = 99.75%, +P = 99.77%, and Er = 0.47% for MIT-BIH Polysomnographic Database while Se = 96.47%, +P = 99.32%, and Er = 4.34% for our capacitive ECG system. Based on those results, we conclude that our R-peak detection method is capable of providing useful ECG information, even under noisy signal conditions.