• The Korean Journal of Pain
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• 제26권3호
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• pp.242-248
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• 2013

Varicella (chickenpox) is a highly contagious airborne disease caused by primary infection with the varicella zoster virus (VZV). Following the resolution of chickenpox, the virus can remain dormant in the dorsal sensory and cranial ganglion for decades. Shingles (herpes zoster [HZ]) is a neurocutaneous disease caused by reactivation of latent VZV and may progress to postherpetic neuralgia (PHN), which is characterized by dermatomal pain persisting for more than 120 days after the onset of HZ rash, or "well-established PHN", which persist for more than 180 days. Vaccination with an attenuated form of VZV activates specific T-cell production, thereby avoiding viral reactivation and development of HZ. It has been demonstrated to reduce the occurrence by approximately 50-70%, the duration of pain of HZ, and the frequency of subsequent PHN in individuals aged ${\geq}50$ years in clinical studies. However, it has not proved efficacious in preventing repeat episodes of HZ and reducing the severity of PHN, nor has its long-term efficacy been demonstrated. The most frequent adverse reactions reported for HZ vaccination were injection site pain and/or swelling and headache. In addition, it should not be administrated to children, pregnant women, and immunocompromised persons or those allergic to neomycin or any component of the vaccine.

• 대한한방내과학회지
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• 제39권2호
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• pp.159-164
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• 2018

A case of a 72-year-old Korean male with herpes zoster ophthalmicus revealed. He was treated with Korean-Western cooperative treatment. We used the Numeric Rating Scale (NRS) to evaluate forehead and eye pain. Pain was improved after the administration of Korean medical treatments and disappeared after eight days. Korean-Western cooperative treatment may be effective in treating acute herpes zoster ophthalmicus.

• 대한수의학회지
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• 제19권1호
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• pp.33-44
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• 1979

Herpes virus인 소의 전염성 비기관염 바이러스와 악성 카탈열 바이러스의 형태(形態)와 그 형성과정(形成過程)(형태발생(形態發生))을 조직배양(組織培養)에서 각기 시험(試驗)하였다. 이 두 종류(種類)의 바이러스는 herpes virus의 특징적(特徵的)인 구조(構造)를 가지나 그 형태발생(形態發生)이 상이(相異)함을 밝혔다. 1. 소의 전염성비기관염(傳染性鼻氣管炎) 바이러스 (IBRV/CT3) 배양에서 그 바이러스의 envelope는 세포질막(細胞質膜)으로부터 유래(由來)됨을 밝혔다. 2. IBRV/CT3 배양에서 envelope는 가진 바이러스는 세포핵내(細胞核內)에는 전혀 나타나지 않았다. 3. 소의 악성(惡性)카탈열(熱) 바이러스(MCFV/C500)의 배양에서 그 바이러스의 envelope는 세포핵막(細胞核膜)으로부터 유래(由來)됨을 밝혔다. 4. 소의 악성(惡性)카탈열(熱) 바이러스(MCFV/C500)에 감염(感染)된 토끼의 폐장(肺臟)에서 얻은 macrophage에 대해 바이러스의 소재(所在)를 추구(追究)한바, 이 바이러스는 macrophage의 세포질내(細胞質內)에만 존재(存在)함을 밝혔다. 그리고 이 바이러스는 탐식(貪食)된 바이러스임을 알았다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권3호
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• pp.177-183
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• 2012

Herpes zoster is a viral infection caused by the reactivation of the varicella zoster virus, an infection most commonly affecting the thoracolumbar trunk. Herpes Zoster Infection (HZI) may affect the cranial nerves, most frequently the trigeminal. HZI of the trigeminal nerve distribution network manifests as multiple, painful vesicular eruptions of the skin and mucosa which are innervated by the infected nerves. Oral vesicles usually appear after the skin manifestations. The vesicles rupture and coalesce, leaving mucosal erosions without subsequent scarring in most cases. The worst complication of HZI is post-herpetic neuralgia; other complications include facial scarring, motor nerve palsy and optic neuropathy. Osteonecrosis with spontaneous exfoliation of the teeth is an uncommon complication associated with HZI of the trigeminal nerve. We report several cases of osteomyelitis appearing on the mandible, caused by HZI, and triggering osteonecrosis or spontaneous tooth exfoliation.

• 한국한의학연구원논문집
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• 제2권1호
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• pp.417-429
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• 1996

Herpes simplex viruses(HSV) are one of the most common infectious virus of man. Though chemotherapies and antibiotics against HSV have been developed in many countries, but anti-HSV agents were not satisfactory to mankind by their toxic reaction and side effects. In order to search for anti-HSV agents from Korean traditional prescriptions, we extended the number of specimens. Both methanol extract and boilling water extract of the Korean traditional prescriptions were screened to detect anti-HSV activities by MTT assay. Korean traditional prescriptions showing anti-HSV activities as methanl extracts were Paekyopsan, Chesupwilyungtang, Yongdamsagantang, and prescription 11. Four methanol extracts showing anti-HSV activities were freationated by hexane and their efficacies were tested. Hexane freationations of Paekyopsan, Chesupwilyungtang, and prescription 11 showed in anti-HSV activities both haxane and methanol fractionation.

• Annals of Clinical Neurophysiology
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• 제16권2호
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• pp.77-80
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• 2014

Herpes simplex virus type 2 (HSV2) meningitis primarily develops during or following a primary genital HSV2 infection that was acquired from sexual contact or through the birth canal during delivery from mother. We describe a 15 year old virgin without history of previous herpes simplex infection who developed 2 episodes of HSV2 meningitis. Although recurrent meningitis due to HSV is primarily seen in young or sexually active adults. HSV2 meningitis should be in the differential diagnosis of recurrent meningitis in adolescent patients.

• The Korean Journal of Pain
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• 제33권3호
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• pp.201-207
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• 2020

Postherpetic neuralgia (PHN) is a challenging condition for pain management specialists. The prevention of herpes zoster (HZ) and subsequent PHN in individuals aged 50 years and older, via the development of new vaccines, is an ongoing research project. The live zoster vaccine (LZV, Zostavax^®) was the first proof of concept that vaccination could prevent HZ, but LZV cannot be used in various immunecompromised patients. This led to the development of a new non-live recombinant zoster vaccine (RZV, Shingrix^®). This RZV has shown promising results in many clinical trials, with high reactogenicity and similar systemic adverse effects compared to those of LZV. The National Advisory Committee on Immunization has recommended LZV as a standard vaccine for HZ prevention in adults ≥ 50 years of age, but no studies directly comparing the safety and efficacy of RZV and LZV vaccines have been conducted. This article reviews the brief history, efficacy, and safety of the two vaccines and discusses the advantage of RZV over LZV based on the available literature.

• 미생물학회지
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• 제40권1호
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• pp.23-28
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• 2004

단순포진 바이러스 감염을 유발하는Herpes simplex2형 바이러스의 감염에 관여하는 항원들과 중화항체 생산을 유발하는 주요 항원들의 위치를 확인하였다. Vero cell에 감염하였을 때 48시간 동안 31, 43, 59, 69 kDa 바이러스 항원들이 지속적으로 발현되었으며, 감염된 쥐에서 생산한 항체와의 반응에서는 51 kDa 항원이 가장 강한 반응을 보였다. 면역전자현미경으로 위치를 확인한 결과 colloidal gold가 바이러스 표면에 발견되는 것으로 보아 이 항원이 바이러스 표면에 존재하고 있는 것으로 확인되었다. 형광현미경 분석은 이 항원들이 감염된 세포 내에서 전반적으로 발견되었고 특히 세포 표면에서 많이 발현되고 있었다.

• 동의생리병리학회지
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• 제25권2호
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• pp.322-325
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• 2011

Motor paralysis by herpes zoster is rare. The incidence of herpetic motor involvement was reported to be between 0.5-31%. This case was reported to evaluate the effects of oriental medicine therapy on vocal cord paralysis and upper limb motor paralysis caused by herpes zoster. The subject was a 48-year-old man who suffering from hoarseness, right upper limb paralysis, right upper limb weakness, right post ear pain, headache. After our treatment, clinical symptoms were improved and VAS score significantly decreased. This study suggests that herbal medicine and acupuncture complex therapy is probably effective in the treatment of vocal cord paralysis and upper limb motor paralysis.

• Journal of Oral Medicine and Pain
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• 제46권1호
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• pp.9-13
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• 2021

Herpes zoster is caused by reactivation and multiplication of a latent varicella-zoster virus infection. Reactivation can frequently occur in older adults and immunosuppressed individuals. It is hypothesized that this is related to an aging society and a corresponding increase in the number of people with underlying chronic diseases, such as cancer and diabetes, that lower immunity. Clinically, the patient complains of pain, and a vesicular rash presents on one side of the face up to the midline in the dermatomes associated with the affected ganglion. Herpes zoster of the oral mucosa is rare. When oral lesions do occur, they are most often concurrent with pathognomonic unilateral linear vesicular skin lesions, facilitating both clinical diagnosis and management of the condition. Cases limited to the oral mucous membrane alone are most unusual. Treatment includes antiviral agents and analgesics for pain control. Antivirals should be administered within 72 hours of onset. Early diagnosis and treatment are important to avoid complications, such as postherpetic neuralgia. The present case report describes the adequate management of a patient diagnosed with shingles which affected the right side of the face and oral cavity. In addition, a literature review is presented.