• The Journal of Pediatrics of Korean Medicine
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• v.32 no.3
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• pp.44-54
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• 2018

Objectives The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in rhinosinusitis. Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on rhinosinusitis from the Pubmed in recent 10 years (from 2008 to 2018). Results 11 RCTs were reviewed. In 10 out of 11 studies showed that the herbal medicine may be effective in the treatment of chronic rhinosinusitis without nasal polyp and uncomplicated acute rhinosinusitis. However, inclusion and exclusion criteria, and outcome measures were varied among different studies. No serious adverse reactions were reported from the herbal medicine treatment. Conclusions The results of these trials showed that herbal medicine may be effective in the treatment of rhinosinusitis. Well-designed RCTs for domestic herbal medicine treatment on rhinosinusitis are needed to prove its efficacy clearly.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.1
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• pp.104-121
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• 2021

Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of functional abdominal pain in children by analyzing randomized controlled trials conducted in China. Methods Literatures from China National Knowledge Infrastructure published up to 23 November, 2020 were searched. Then they were collected and analyzed by their publication year, demographic information, treatment methods used, duration of illnesses, duration of treatments, follow-up periods, outcome measurement and adverse events. Results A total of 27 studies were selected for the analysis. In all studies, the total efficacy of the herbal medicine treatment group was reported to be higher than that of the control group. The most frequently used medical herb was Root of Glycyrrhiza uralensis Fischer (甘草). The most frequently used classes of herbal medications are Qi regulating medicine (理氣藥), Qi tonics (補氣藥), Aromatic wet medicine (芳香化濕藥), and Digestant (消食藥). The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that herbal medicine treatment can be effective and safe option for treating pediatric functional abdominal pain. However, additional well-designed clinical studies are needed to solidify the findings.

• The Journal of Korean Medicine
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• v.39 no.4
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• pp.16-29
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• 2018

Introduction: We aimed to investigate the predictive factors and optimal age for response to herbal medicine treatment for height gain in children. Methods: This retrospective chart review included 61 children (age range, 5-16 years) treated for height gain between 2011 and 2015. A predictive model was established by multiple linear regression analysis. Dependent variables were defined by the differences in percentile before and after herbal medicine treatment. The optimal cutoff value of patient age was determined by receiver operating curve analysis. Results : The age of initiation of herbal medicine therapy (p = 0.012) and administration of Forsythiae fructus (p = 0.002) were significant variables for treatment response. The adjusted R2 value was 0.231. The mean ages of the responder and non-responder groups were significantly different (p = 0.023). The optimal cutoff value of age for predicting treatment response was 9.75 years. Treatment response was better among children below 9.75 years of age. Conclusions: Patient age and administration of Forsythiae fructus were identified as determinants of response to herbal medicine treatment. Treatment of rhinitis and initiation of height gain treatment at an early age are critical for better response. These findings will provide fundamental data for further research.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.3
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• pp.119-135
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• 2020

Objectives: The purpose of this study is to confirm the effectiveness and safety of herbal medicine treatment for treating pregnancy-induced hypertension. Methods: We searched for randomized controlled trials of pregnancy-induced hypertension treated with herbal medicine, through nine databases. Interventions and results of the selected clinical studies were analyzed. Results: Eleven randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in two studies, and with herbal medicine and western medicine in nine studies. Control group was treated with western medicine. Taxilli Ramulus (桑寄生) (54.5%) was the most frequently used herb in herbal medicine treatment. In all of eleven studies, treatment group was more effective for pregnancy-induced hypertension than the control group. Conclusions: This study suggested that herbal medicine treatment alone or combined with western medicine treatment could be helpful in improving the therapeutic effect on pregnancy-induced hypertension and reducing side effects as well. However, in order to obtain stronger evidence of herbal medicine treatment for pregnancy-induced hypertension, more high-quality and well-designed randomized controlled trials should be conducted.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.3
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• pp.87-98
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• 2014

Objectives The present study aimed to investigate the effects of acupuncture and herbal external preparation on wound healing procedure in a deep partial thickness burn model in rats. Methods A total of 40 male Sprague-Dawley rats were allocated into four groups with an equal number in each group: acupuncture treatment group, herbal external perparation group, Silver sulfadiazine dressing group and control group. We describe the effect of acupuncture and herbal external preparation on morphologic and histologic changes, epithelial growth factor (EGF), hematological value of the deep partial thickness burn wound in rats. Results At 21th day after wounding the wound size in acupuncture treat group and herbal external preparation group were decreased more significantly compared to control group. In addition, epidermal regeneration on acupuncture treatment was than other treatment and control group in histological finding. Hematological findings revealed that acupuncture treatment group and herbal external prepartion group was more effective than control group in reducing inflammation response induced by burn. In acupuncture treated group, neutrophil and leukocyte level were significantly decreased compared to other treatment group. Also, this study showed that EGF was obviously expressed in nascent tissue when wounds were treated with the acupuncture and herbal external preparation after injury. In particular, acupuncture treatment group had a significant increase of EGF expression in burn wound healing area when compared with the other treatment groups. Conclusions These findings suggest that acupuncture and herbal external prepration may improve burn wound healing through decreasing inflammatory reaction, increasing tissue regeneration and expression of EGF. Moreover, acupuncture treatment could be more effective in comparison with Silver sulfadiazine dressing.

• The Journal of Internal Korean Medicine
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• v.33 no.1
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• pp.39-53
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• 2012

Objectives : Many studies have shown that helicobacter pylori (H. pylori) infection is associated with gastroduodenal diseases. The purpose of this report was to evaluate recently published research on the influence of oriental herbal medicine on H. pylori infections. Methods : Recently published literature were systematically compared with their findings of how oriental herbal medical treatment affects H. pylori-associated disease. Results : The eradication rate of H. pylori in oriental herbal medicine groups was 66.93% while it was 66.02% in western medicine groups. In oriental herbal plus western medicine groups, interestingly, the rate increased to 84.78%. On the other hand, the total treatment efficacy rate of H. pylori in oriental herbal medicine groups was 91.27%. The treatment efficacy rate in oriental herbal plus western medicine groups rose to a record 93.22%, which was 15.34% higher than the rate in western medicine groups. In addition, the rate of adverse effects was 2.71%, 4.85%, 15.80% in oriental herbal medicine, western medicine, and oriental herbal plus western medicine groups, respectively. Diarrhea was most frequently observed in oriental herbal medicine groups, while nausea was most frequently observed in the other groups. Conclusions : The results of this study showed that herbal medicinal treatment can increase the rate of H. pylori eradication and improve H. pylori-related gastrointestinal symptoms. These findings suggest that herbal medicine can solve the problems including side effects due to antibiotic resistance of standard triple therapy.

• Journal of Acupuncture Research
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• v.26 no.1
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• pp.23-28
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• 2009

Objectives & Methods : The main point of this literatual study was to develop an external treatment on sprain using adhesive herbal pack. Results & Conclusions : The herbs which was used in adhesive treatment matched the same function with oral herb medicine such as, promoting blood flow to remove blood stasis, relieving rheumatic conditions, and removing obstruction in meridians and collaterals. Based on these function it was reviewed that adhesive herbal pack directly effected the sprain region from herbs by using alcohol, water to produce the pack. But even though it is known that the method of adhesive herbal treatment changes, most treatment still uses the traditional method. So researching on adhesive herbal treatment is required in the future.

• Journal of Oriental Neuropsychiatry
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• v.19 no.2
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• pp.141-149
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• 2008

Objective : This study was designed to analyze the herbal medicine case-control studies of tic disorder in traditional chinese medicine. Method : For this study, we searched the studies on tic disorder, which had been published 2007, through web-site CNKI(中國知識基魔設施工程) http://www.cnki.net). There were 15 herbal medicine case-control studies and we focused on those studies. Results: 1. DSM-IV(7 studies), CCMD(5 studies) and ICD-10(3 studies) were frequently used in the diagnosis of tic disorder. 2. Paeonia radix alba, Uncariae ramulus et uncus and Glycyrrhizae radix were frequently used in treatment. Moreover Scorpio, Gastrodiae rhizoma, Pinelliae rhizoma and so on were used. 3. Treatment results were assessed by improvement of symptom, YGTSS and so on. 4. Herbal medicine treatment was more effective than western medicine treatment in most studies, and side effects of herbal medicine were far less than those of western medicine. Conclusion : There have been reported many herbal medicine treatment studies of tic disorder in traditional chinese medicine. We believe that these studies can be applied to the clinical practices in Korean medicine.

• Journal of Oriental Neuropsychiatry
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• v.28 no.4
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• pp.419-429
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• 2017

Objectives: We conducted a public health promotion program in Korean medicine for participants suffering from chronic insomnia in 2016~2017. A significant improvement effect was obtained through the 8-week herbal medicine treatment program. The object of this study is to report the results of this public health promotion program. Methods: Seventy patients diagnosed with chronic insomnia participated in the program, 49 of whom completed the program. Participants were treated with the herbal medicine for insomnia treatment for 8 weeks. A sleep diary was used to assess the total sleep time, sleep latency, and number of times the participants woke. The treatment satisfaction was then evaluated. Results: Through the 8-week herbal medicine treatment program, the total sleep time was significantly increased by $109.59{\pm}70.77$ minutes, the sleep latency was significantly decreased by $63.53{\pm}47.79$ minutes, and the number of times the participants woke was significantly decreased by $1.54{\pm}1.19$ times compared to the baseline (all, p=0.000). Among the 24 patients who were examined for the treatment satisfaction, the average score was 4.33 points of a total of 5 points. Six patients had adverse events. Except for one patient, the symptoms of other patients were mitigated by changing or discontinuing the herbal medicine. Conclusions: For patients with chronic insomnia, the 8-week herbal medicine treatment program was effective, with few side effects and high treatment satisfaction. This study has significance as this is the first report in Korea on the effect of a herbal medicine treatment program for chronic insomnia through Korean medicine public health promotion.

• Herbal Formula Science
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• v.25 no.3
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• pp.391-412
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• 2017

Objective : In this study, we searched the experimental research about combined treatment of anticancer drug and herbal medicine for killing or inhibiting proliferation of Cancer cells searched in OASIS and KISS. This study aimed to analyze the experimental research paper about anticancer drug combined treatment with herbal medicine. Methods : We collected the research paper including killing or inhibiting proliferation of Cancer cells in OASIS and KISS using keyword anticancer drug with herbal medicine, tumor suppressor with herbal medicine, inhibition of Cancer with herbal medicine and combined treatment with herbal medicine. Assorting by cancer cells, we analyzed experimental results cancer cell viability, anticancer drug dosage, tumor weight and survival rate. Also, we checked the effects of herbal medicine on cancer and additive effect reducing side effect of anticancer drug. Results : Total 45 studies were selected. 38 studies reported combined treatment of anticancer drug and herbal medicine was more effective than only anticancer drug. The death of cancer cells was synergistically induced by the cotreatment of anticancer drug and herb extracts. The studies suggest that the cotreatment of anticancer drug and herb extracts could reduce side effect of anticancer drug. In addition, some studies reported cotreatment mechanism like apoptotic death signal processes. In combined treatment of anticancer drug and herb extracts, The expression of Fas/Fas L, Bax, Bcl2, Caspase-3 etc.. was markedly increased in cancer cells. Conclusions : Our results suggest that anticancer drug combined treatment with herbal medicine could be efficient for killing or inhibiting proliferation of cancer cells. However, this paper had some limitation as follows: First, collected studies have been published only for korean journal. Second, results of research and effects of combined treatment are not collected objectively. To solve these problems, more objective and balanced studies should be performed.