• Journal of Society of Preventive Korean Medicine
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• v.25 no.2
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• pp.1-11
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• 2021

Objective : The purpose of this study is to analyze Korean patients' characteristics, who were concurrently treated with both Korean herbal medicines and Western chemical medicines using nation-wide database. Method : Using the patients sample data (HIRA-NPS 2018) provided by Health Insurance Review and Assessment Service, a group of patients who co-administered Korean herbal and Western medicines was selected, and their basic characteristics, diagnosis, and prescribed chemical medicines were analyzed. Results : Out of the 1,481,921 sample population, 17,629 patients (1.2%) were selected as a concurrent medication group. Compared to the whole sample, the concurrent medication group was composed of more women (65.8% vs. 51.1%), the more elderly people (65 or older years old) (44.5% vs. 14.6%), and the higher prevalence of chronic diseases (49.1% vs. 22.2%). The most frequent diagnosis treated with Western medicines was mental and behavioral disorders, musculoskeletal and circulatory disorders. Frequently used drugs among concurrent medication group were anti-anxiety drugs, gastric ulcer treatment drugs, and senile diseases treatment drugs. Conclusion : The evidence reported in this study is expected to provide herb-drug interaction researchers with important reference to set the priorities of research topics in the future.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.103-103
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• 2022

Ganghwaljetongyeum (GHJTY) is a complex herbal decoction comprising 18 plants; it is used to treat arthritis. In order to develop a new anti-arthritic herbal medication, we selected 5 out of 18 GHJTY plants by using bioinformatics analysis. The new medication, called ChondroT, comprised water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex. This study was designed to investigate its chondroprotective and anti-inflammatory effects to develop an anti-arthritic herb medicine. ChondroT was validated using a convenient and accurate high-performance liquid chromatography. photodiode array (HPLC-PDA) detection method for simultaneous determination of its seven reference components. The concentrations of the seven marker constituents were in the range of 0.81-5.46 mg/g. The chondroprotective effects were evaluated based on SW1353 chondrocytes and matrix metalloproteinase 1 (MMP1) expression. In addition, the anti-inflammatory effects of ChondroT were studied by Western blotting of pro-inflammatory enzymes and by enzyme-linked immunosorbent assay (ELISA) of inflammatory mediators in lipopolysaccharides (LPS)-induced RAW264.7 cells. ChondroT enhanced the growth of SW1353 chondrocytes and also significantly inhibited IL-1β-induced MMP-1 expression. However, ChondroT did not show any effects on the growth of HeLa and RAW264.7 cells. The expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was induced by LPS in RAW264.7 cells, which was significantly decreased by pre-treatment with ChondroT. In addition, ChondroT reduced the activation of NF-κB and production of inflammatory mediators, such as IL-1β, IL-6, PGE2, and nitric oxide (NO) in LPS-induced RAW264.7 cells. These results show that ChondroT exerted a chondroprotective effect and demonstrated multi-target mechanisms related to inflammation and arthritis. In addition, the suppressive effect was greater than that exhibited by GHJTY, suggesting that ChondroT, a new complex herbal medication, has therapeutic potential for the treatment of arthritis.

• The Journal of Korean Medicine
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• v.30 no.1
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• pp.137-149
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• 2009

Objectives: Pregnant women could have various diseases, but the treatment of medication has the limitation that could cause fetal injury. So pregnant women have used complementary and alternative medicine in the world, but korean medicine had not been actively studied on obstetrics. This study is to investigate efficacy and safety of complementary and alternative medicine on obstetrics. Methods: We searched for papers which had pregnancy, obstetrics, complementary medicine, acupuncture and herb in the pubmed since 2000. Results: 41 papers were found. Acupuncture have the efficacy and safety on nausea, pelvic pain in pregnancy and breech presentation. Complementary alternative medicine had been studied as randomized controlled trial at various diseases in obstetric. But the method were without coordination, results were different from methods. So more clinical trials about complementary and alternative medicine would be needed. Massage and acupressure would be helpful for pregnant mood complaint. Conclusion: Complementary and alternative medicine has been proved as efficacy and safety in obstetrics, so complementary and alternative medicine would be helpful method in pregnant women. For making guidelines on complementary and alternative medicine treatment during pregnancy, more research will be needed.

• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.153-159
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• 2002

To study clinical characteristics of patients complained of the tremor, I analyzed a database of twenty four patients managed at the Sasang Constitutional Department in Wonkwang University Oriental Medical Hospiyal from June 1999 to October 2000. 54% of patients who had adequate follow-up were improved with herb medication, electric acupuncture, physical therapy, aromatherapy. 46% of them were not improved in spite of above mentioned treatment. None of patients was aggravated. 71 % of them have male sex and 42% in 7th decade. The distribution ratio was 46% Soyang Constitution, 42% Taeumin Constitution, 13% Soum Constitution. I diagnosed 75% of them as essential tremor or physiological tremor or neurosis. Most of them had the tremor in upper extremities. The period of history were various distribution. Herb medicines were used in the Sasang Constitutional Theory. The Sasang Constitutional Medicine has the significant effects of treating patients complained of the tremor..

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.276-285
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• 2008

Purpose: This study is to report of the effect of oriental treatments to urinary infection in hyperemesis gravidarum. Methods: Hyperemesis gravidarum is a severe and intractable from of nausea and vomiting in pregnancy. And urinary infection is frequent medical cause of hospitalization, during the course of pregnancy. Hyperemesis gravidarum and urinary Infection is associated with risk to the mother and fetus. We treated a patient who had urinary infection in hyperemesis gravidarum at Se- Myung university Oriental Hospital in affiliation by herbal medication, acupuncture and moxibustion. After the treatment, we got good result. Results: After the treatment, symptoms are remarkably alleviated. Conclusion: It is effective to cure the urinary infection in hyperemesis gravidarum through the herb-medication and acupuncture treatment.

• Journal of Oriental Neuropsychiatry
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• v.18 no.3
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• pp.209-224
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• 2007

Metabolic syndrome consists of several risk factors of metabolic origin like elevated blood pressure, abdominal obesity, elevated triglyceride concentrations, decreased HDL-cholesterol concentrations, and elevated fasting glucose. It appear to directly increase the development of atherosclerotic cardiovascular diseases which leading to cardiovascular diseases in later life. This 39 years female patient was diagnosed schizophrenia at the age of 17. but she didn't take reasonable treatments. during 20 years, she stayed in home and lived unsuited life with her family. As a result she gains heavy weight and centeral obesity, diabetic mellitus and hypertention, and developed cerevral vascular accident twice. This patient was treated with herb medication, acupuncture, western medication, psychotherapy primarily in focusing of pre-illness state(未病) as well as the stagnation of phelm. During 140 days of treatment from admission, before 2nd attack tbe patient showed improvement of Lt. hemiparesis but after second attack improved a little. And symptom of schizophrenia improved considerably. Also diet habit changed.

• Herbal Formula Science
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• v.15 no.2
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• pp.21-33
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• 2007

At this moment, because there're lots of necessity to have an attention on diabetus mellitus (DM), in this article searched over all the Korean oriental medical academic journals about DM from 2003 to 2007, Method: Through data base system that Daegu Haany University affiliated information center & Korean Studies Information Center manage, selected 60 articles worthy to look up that are searched by the keyword 'DM' & '消渴'. Result and Conclusion: 5 articles of observing 'DM' & '消渴' itself academically, 29 articles of experimental study, 8 articles of clinical research study and 18 articles of case report. For experimental study, mostly it were concerning type II DM modeled rat medicated herb and its effect, so there were only a few type I experimental study. For observing articles, generally the causes, pathology, treatments, acupuncture methods and medication et al., variable studies were done. In clinical research, diverse categories were subject, which is to prove the efficacy of medication, acupuncture, physical therapy and diet supplements. And in case reports, focused not only on improvement in blood sugar level but also its complications.

• 대한상한금궤의학회지
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• v.11 no.1
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• pp.103-111
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• 2019

Objective : The purpose of this study was to report the improvement in a patient with edema treated by herb medication based on Shanghanlun provisions. Methods : According to 'A disease pattern identification diagnostic system based on Shanghanlun provisions (DPIDS)', a patient was diagnosed with Taeyang-byung, no. 46 provision and was administered with Mahwang-tang herbal medication for 30 days. The Numeric rating scale (NRS) was used to estimate the response. Results : The NRS score changed from 10 to 1 and the edema disappeared by 46th provision of Mahwang-tang selected according to Shanghanlun provisions. Conclusions : This case report suggests that the two words in the 46th provision of Shanghanlun, '陽氣重, 無汗' (Yang qi heavy, Absence of sweating) indicate a close relationship between photosensitivity and absence of sweating, thereby affecting edema in this case.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.1
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• pp.9-22
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• 2007

Objectives : This study was designed to collect the latest papers and to find more effective approach for childhood obesity. Methods : We searched 107 papers in English from Pubmed(www.ncbi.nlm.nih.gov) and selected 52 in favor of our study. In addition to that, we searched 29 papers in Chinese from www.cnki.net. Results are as follows. Results and Conclusions : There are not completely new treatments for childhood obesity. Instead of that, many studies aimed for prevention through family education, nutrition education, and exercises education. Specially, because some diseases including hypertension, diabetes and heart disease are connected with obese children, medication can be prescribed optionally. In that case, their mental health must be laid emphasis. And in China, TCM(Traditional Chinese Medicine) is very common treatment for childhood obesity. Acupuncture, herb medication and manual therapy could be used usefully. It is suggested that above latest treatments can be combined with Korean traditional treatments method in treating obese children.

• The Journal of Korean Medicine
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• v.25 no.1
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• pp.142-151
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• 2004

Objectives : To document the use and out-of-pocket expenditure of complementary and alternative medicine(CAM) in Korean adult population. Methods : Nationwide, random-sampled, and population-weighted telephone survey was conducted. The sample size of respondents was 1,000(age over 18). The respondents were asked about their use, out-of pocket expenditure of CAM in the past 12 months. SAS 8.0 statistic package was used for checking the relevance between each variables by performing $x^2-test$ and variance evaluation. Results : In 2001, 64.0% of people experienced more than one alternative therapy and the beneficiary took therapy average figure of 2.07. Alternative therapies were generally used for health promotion(73.7%) rather than curing the disease(26.3%). The most common therapies included Medication(30.2%), Physical-therapy(21.9%) health implements(20.8%), herb medication(19.2%), diet therapy(14.3%) etc. Average annual out-of-pocket expenditure was ￡<192,186. Use varied according to age, living province, income, and education, while cost expenditure did according to sex, health condition, income, education. Conclusions : The use of CAM in Korea is very large and the expenditure for them is 22.6% of national medical expenditure. It shows great need of political and academic approach.