• 제목/요약/키워드: Hepatocellular

검색결과 1,079건 처리시간 0.039초

Role of Kupffer Cells in Hepatic Drug Metabolizing Dysfunction during Polymicrobial Sepsis

  • Lee, Sang-Ho;Kim, Joo-Young;Eum, Hyun-Ae;Lee, Sun-Mee
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.229-229
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    • 2002
  • Although hepatocellular dysfunction occurs during sepsis. the mechanism responsible for this remains unclear. Since Kupffer cells provide signals that regulate hepatic response in endotoxin and inflammation. the aim of this study was to investigate the role of Kupffer cells in the alterations in the hepatic microsomal drug metabolizing function during sepsis. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP)followed by fluid resuscitation. (omitted)

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Cellular Localization of The P-Glycoprotein, Alpha Fetoprotein, And Von Willerbrand Factor In Canine Hepatocellular Carcinoma And Liver Cirrhosis Tissues

  • Tashibaeva, Roksana E.;Kim, Hee-Jung;Lyoo, Young-Soo;Lee, Sang-Jin;Kim, Hwi-Yool;Sur, Jung-Hyang
    • 한국수의병리학회:학술대회논문집
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    • 한국수의병리학회 2005년도 Proceedings of The 2nd Asian Society of Veterinary Pathology Symposium(Vol.2) and 2005 Annual Meeting of The Korean Society of Veterinary Pathology(Vol.9)
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    • pp.62-62
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    • 2005
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Effect of Ascorbic Acid on the Activity and Gene Expression of Cytochrome P450 in Sepsis

  • Kim, Joo-Young;Park, Sang-Woo;Lee, Sun-Mee
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.127.2-128
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    • 2003
  • Sepsis remains common surgical problems with high morbidity and mortality despite improvement in the management for septic patient. Although hepatocellular dysfunction occurs during sepsis, the mechanism responsible for this remains unclear. In sepsis, a state of severe oxidative stress is encountered, with host endogenous antioxidant defenses overcome. Therefore, the aim of this study was to determine whether specific abnormality exists in cytochrome P450 (CYP)-mediated metabolizing function associated with polymicrobial sepsis and whether role of ascorbic acid (AA) in the alterations during sepsis. (omitted)

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