• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.23-29
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• 2008

The causes of liver disease in children and abnormal liver function test are more diverse than those in adult. Therefore, the first step to evaluate the liver disease is the understanding the liver disease and interpreting the appropriate liver function test in children. The characteristics of each test and various conditions which we encounter in outpatients settings will be discussed in this article, especially focused on elevation of aminotransferase level without identifiable causes.

• 생약학회지
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• 제45권2호
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• pp.154-160
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• 2014

The aim of this study was to determine the incidence and contamination levels of aflatoxin in Medicinal Herbs for Food and Medicine at Yakyeang market in seoul. 191 Samples 11 items medicinal herbs for food and medicine were evaluated for the aflatoxin contamination. in result 41 samples 10 items (21.5%) were detected in the alfatoxin, a high incidence of aflatoxins items are cassiae semen (50.0%), testudinis plastrum (43.8%) and Batryticatus Bombyx (40.0%), Polygalae Radix (31.2%), Zizyphi Semen (23.5%), Dolichoris Semen, Myristicae Semen (20.0%), Nelumbinis Semen (15.8%), Glycyrrhizae Radix et Rhizoma (7.4%), Hoveniae Semen Cum Fructus (4.3%). AFB1 were detected 27 cases (14.1%), AFB2, AFG1 and AFG2 were detected 18cases (9.4%), 16cases (8.4%) and 5cases (2.6%). The excess cancer risk estimated using the cancer potency of aflatoxin B1 (7(mg/kg/day)-1 for HBsAg-and 230(mg/kg/day)-1 HBsAg+) was N.D ~ $3.79{\times}10^{-6}$ for hepatits B surface antigen negative (HBsAg-) and N.D ~ $9.68{\times}10^{-5}$ hepatits B surface antigen positive (HBsAg+) respectively.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.243-246
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• 2005

급성 A형 간염에서 흉막 삼출은 드물게 발생하는 합병증으로 불리한 예후인자는 아니며 대개는 양성의 경과를 취한다. 저자들은 전신쇠약과 황달로 내원한 12세 여아에게서 A형 간염에 동반된 흉막 삼출을 진단 하였고 특별한 치료 없이 안정 후에 호전된 1예를 경험하였기에 보고하는 바이다.

• 대한한의학회지
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• 제19권1호
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• pp.100-108
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• 1998

We treated 1 case of primary infertility woman. She had three clinical problems. The first was endometrosis stage II, the second was tubar obstruction and the third was chronic persistent hepatitis B. Eometrosis and tubar obstruction are similar to 'blood stagnation'. And another clinical symptoms could be considered with 'asthenia of spleen and stagnation of wetness-evil'. So our prescriptions for this case were Heylbudu.Jcgeu-Tang and Samchulgunbi-Tang. And the prescription of acupuncture therapy was consist with Sp. 6, Ren. 4, Jagung, P. 6, and St. 36. So we got a successful result from above therapies. But we have to take continued follow-up plans for endometriosis and chronic persistent hepatits B.

• Environmental Analysis Health and Toxicology
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• 제13권3_4호
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• pp.63-70
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• 1998

In order to elucidate the prevalence of anti-HEV, anti-HCV and HBsAg in ALT (Alanine Aminotransferase)-elevated patient group and healthy person control group, we examined anti-HEV, anti-HCV and HBsAg in 92 persons, respectively. The prevalence of anti-HEV in ALT-elevated patient group (4.3%) was not significantly higher than that (2.2%) of healthy person control group(P>0.05). While in healthy person control group the prevalence of anti-HEV in female (2.4%) was higher than that (2.0%) in male, and in ALT-elevated group male (4.8%) was higher than female (3.3%), there were no significances. The positive rate of anti-HEV was not significantly increased with age between healthy person control and ALT-elevated patient group. The odds ratio's of HEV, HCV and HBV with ALT-elevated patient group were 2.05 (95% CI: 0.31-16.54), 8.67 (95% CI: 1.06-188.63) and 7.23 (95% CI: 2.47-22.71), respectively, but had no significance. It was turned out that HCV and HBV were significantly correlated with ALT-elevated patient group, but HEV had no significance with it in this paper.

• 한국건강관리협회지
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• 제3권2호
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• pp.181-188
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• 2005

Background : Osteopenia has been recognized as one of potential complication of chronic liver diseases. Its correlation with hepatits B virus(HBV) carrier, however, has not been reported. Thus this study was aimed to clarify the relationship between the osteopenia and HBV carrier. Methods : Bone densities in 192 HBV carrier women and 200 healthy women were measured; the lumbar spine and three sites of the proximal femur(neck, Ward's triangle, greater trochanter) by dual-photon absorptiometry. And liver function tests(AST, ALT, Albumin, GGT, ALP) were also performed. Results : Bone densities at the four sites measured, were significantly correlated with one another(r=0.34 to 0.99, P<0.01). Compared with control group, HBV carriers had significant decreases in bone densities of femur(P<0.05), particularly marked at Ward's triangle. A negative correlations between bone densities and serum total alkaline phosphatase were also found(r=-0.44, P<0.01). Conclusions : Osteopenia was more prevalent in HBV carrier, particularly in the groups before-fifties. Serum total alkaline phosphatase was higher in those with reduced bone densities Thus measurement of bone densities seems to be necessary in female HBV carriers.

• 한국임상수의학회지
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• 제38권4호
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• pp.179-183
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• 2021

A 12-year-old male American Cocker Spaniel was diagnosed with a type of chronic hepatits (CH) called cholangioheaptits. Routine supportive medication was administered to the patient, and ex vivo boosted immune cell (EBI-C) therapy was used for the treatment. A histopathologic examination of the liver 19 months later revealed that the cholangiohepatitis had progressed to cholangiocarcinoma. The medication and immune cell therapy was maintained. Two months after the new diagnosis, the patient's state worsened, and the dog died 635 days after the first visit. EBI-C therapy is a type of immunotherapy, where immune cells are isolated from the patient's peripheral blood mononuclear cells, expanded ex vivo, and then infused into the patient intravenously every two weeks. EBI-Cs (mean: 2.78 × 10⁸ cells) were obtained 38 times and infused every two weeks. Most EBI-C were T-lymphocytes (99.24% of total EBI cells). T-lymphocytes produce large interferon (IFN)-γ, and IFN-γ inhibits liver fibrosis in dogs with CH. Moreover, in bile duct cancer, an increase in T-lymphocytes correlates with decreasing tumor invasion and metastasis. Thus, we propose that EBI-C therapy is applicable as a new supportive therapy for canine liver disease if other treatments like drug medication, surgery, or radiation are unavailable.

• KSBB Journal
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• 제15권3호
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• pp.243-246
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• 2000

B형간염 바이러스 연구에 관한 최근의 주제는 혈중 B형간염 표면항원농도(HBsAg)를 예후 판정의 지표로 활용하는 것이다, 본 연구에서는 B형간염에 대한 자가진단을 목적으로 하여 컴퓨 터 상 분석 기법을 사용하는 HBsAg에 대한 정량적 면역크로마 토그래피 측정법을 개발하였다. 본 방법을 사용하였을 때 측정 된 integrated optical density(IOD)은 2~200 ng/mL의 범위 내에 서 표준 HBsAg 농도의 log값에 비례하여 증가하였데, ELISA 측정법은 0.1~100 ng/mL의 범위 내에서 표준 HBsAg 농도의 log값에 비례하여 증가하였다. 3개의 혈청 겸제를 가지고 두 가 지의 측정법으로 각각 시험하여 표준곡선에 대입하였을 때 동일 한 농도를 나타내 었는데 그 값이 각각 9,000, 7,000, 4,000 ng/mL 이었다. 또한 컴퓨터 상 분석 기법을 사용하는 HBsAg에 대한 정량적 면역크로마토그래피 측정법으로 동일 겸체를 5회 반복 시험하였을 때 측정된 IOD값이 재현성이 있었으며, 변이계수가 1.38 ~ 6.30% 이내였다.

• Toxicological Research
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• 제14권3호
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• pp.307-313
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• 1998

Dimethyl dimethoxy biphenylate (DDB) is an agent used to treat hepatits. DDB-S (DDB-soluble), a new DDB derivative, was synthsized to increase water solubility of the original DDB. In the present study, the antigenic potential of DDB-S was examined by active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA) and passive hemagglutination (PHA) tests. The experimental groups consist of a low dosage group, a high dosage group, he group emulsified with Freund's complete adjuvant (FCA, ASA test) or an alum (PCA and PHA tests) and the macromolecule conjugate group emulsified with FCA or an alum. In the ASA test, all experimental groups showed negative responses whereas the positive control group given ovalbumin plus FCA showed severe anaphylactic responses. In the heterologous PCA test using mice and rats, positive responses were not detected in any of the experimental groups. In the PHA test, all experimental groups showed negative responses whereas the positive control group given ovalbumin plus an alum showed 512~2048 PHA titers. These results demonstrated that DDB-S does not have any antigenic potential. These can be utilized as a part of preclinical data for the development of DDB-S as an intravenous injection.

• Journal of Gastric Cancer
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• 제11권1호
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• pp.23-30
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• 2011

Purpose: ${\alpha}$-fetoprotein (AFP)-producing gastric cancer is a rare tumor with high rates of liver metastasis and a poor prognosis. Many studies have been performed but there have been no comprehensive investigations of the clinicopathological and prognosis. Materials and Methods: Six hundred ninety four patients with gastric cancer who underwent a curative gastric resection in Hanyang University Hospital from February 2001 to December 2008 were evaluated retrospectively after excluding active or chronic hepatits, liver cirrhosis and preoperative distant metastasis. Among them, thirty five patients had an elevated serum level of AFP (>7 ng/ml) preoperatively. The clinicopathological features of AFP-producing gastric cancer were analyzed. Results: There was poorer differentiation, a higher incidence of lymph node metastasis, more marked lymphatic and vascular invasion in the AFP-positive group than in the AFP-negative group. The 5-year survival rate of the AFP-positive group was significantly poorer than that in the AFP-negative group (66% vs. 80%, P=0.002). A significantly higher incidence of liver metastasis was observed in the AFP-positive group than in the AFP-negative group (14.3% vs. 3.6%, P=0.002) with a shorter median time period from the operation to the metachronous liver metastasis (3.7 months vs. 14.1 months, P=0.043). Multivariate survival analysis revealed the depth of invasion, degree of lymph node metastasis and AFP-positivity to be the independent prognostic factors. Conclusions: AFP-producing gastric cancers have an aggressive behavior with a high metastatic potential to the liver. In addition, their clinicopathological features are quite different from the more common AFP-negative gastric cancer.