• Archives of Pharmacal Research
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• 제28권7호
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• pp.775-783
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• 2005

The ethanol extract of the peony root (Paeonia Lactiflora Pall, Paeoniaceae) as well as its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and lipid peroxidation. In addition, the protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were examined. The ethanol extracts of the peony root (PREs) and its active constituents, gallic acid and methyl gallate, exhibited a significant free radical scavenging effect against 1,1-diphenyl-2-picryl hydrazine (DPPH) radical generation and had an inhibitory effect on lipid peroxidation, as measured by the level of malondialdehyde (MDA) formation. The PREs did not have any pro-oxidant effect. They strongly inhibited the hydrogen peroxide-induced DNA damage from NIH/3T3 fibroblasts, as assessed by single cell gel electrophoresis. Furthermore, the oral administration of 50% PRE (50% ethanol extract of peony root), gallic acid and methyl gallate potently inhibited the formation of micronucleated reticulocytes (MNRET) in the mouse peripheral blood induced by a $KBrO_3$ treatment in vivo. Therefore, PREs containing gallic acid and methyl gallate may be a useful antigenotoxic antioxidant by scavenging free radicals, inhibiting lipid peroxidation and protecting against oxidative DNA damage without exhibiting any pro-oxidant effect.

• 문화기술의 융합
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• 제5권2호
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• pp.271-278
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• 2019

조선 말기 진도(珍島) 출신의 소치(小癡) 허련(許鍊)(1808~1893)은 시(詩) 서(書) 화(畵) 삼절작가(三絶作家)로서, 호남 화단의 실질적 종조(宗祖)라 불리운 대표적 화가이다. 초의선사(艸衣禪師)로부터 유(儒) 불(佛) 도(道)와 함께 회화의 기초를 배웠고, 초의(艸衣)의 소개로 추사(秋史) 김정희(金正喜)의 문하생이 되었다. 이후 추사(秋史)의 문인지향적(文人指向的) 서화정신과 화이재도적(畵以載道的) 회화심미를 정확히 이해하고 이를 계승하였다. 그의 생애와 예술활동의 특징은 70이 넘은 만년(晩年)까지 지속된 주유(周遊)와 다작(多作) 활동, 그리고 주유(周遊) 기간의 세부사항까지 서술한 "소치실록(小癡實錄)"의 기록이다. 소치(小癡)는 사의적(寫意的) 남종화(南宗畵)를 지향하여 예황풍(倪黃風)의 산수화에서 자유분방한 갈필(渴筆)과 소산간일(蕭散簡逸)한 충담미(沖澹美)를 발현하였다. 또한, '허목란(許牧丹)'이라 불리울 만큼 운필변용(運筆變容)의 생동미(生動美)를 자아내는 모란은 괴석(怪石)을 함께 그려 부귀공명(富貴功名)에 대한 욕망과 문사적(文士的) 취향을 동시에 만족시켰고, 이후 가전(家傳)되어 '운임산방(雲林山房)'의 대표적 화목(畵目)이 되었다. 그의 토착화된 화풍(畵風)과 회화(繪畵) 심미(審美)는 200여년의 5대(代) 직계(直系) 화맥(畵脈)을 형성하여 지금까지 현대 한국화단에 큰 영향을 끼치고 있다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.61-61
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• 2003

The ethanol extract of peony root (Paeonia Lactiflora Pall, Paeoniaceae) and its major active components including gallic acid and methyl gallate were evaluated for their protective effects against free radical generation and lipid peroxidation. And protective effects against hydrogen peroxide-induced oxidative DNA damage in a mammalian cell line were performed. The ethanol extract of peony root (PRE), gallic acid and methyl gallate were shown to possess the significant free radical scavenging effect against 1,1-diphenyl-2-picryl hydrazine (DPPH) radical generation and were revealed the inhibitory effect of lipid peroxidation as expressed by malondialdehyde (MDA) formation. They were also found to strongly inhibit hydrogen peroxide-induced DNA damage from NIH/3T3 fibroblasts, assessed by single cell gel electrophoresis. Furthermore, oral administration of 50% PRE (50% ethanol extract), gallic acid and methyl gallate potently inhibited micronucleated reticulocyte (MNRET) formation of mouse peripheral blood induced by KBrO3 treatment in vivo. Therefore, PRE containing gallic acid and methyl gallate may be a useful natural antioxidant by scavenging free radicals, inhibition of lipid peroxidation and protecting oxidative DNA damage.

• 한국자원식물학회지
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• 제36권5호
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• pp.446-454
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• 2023

본 연구에서는 작약(Paeonia lactiflora Pall.) 종자 오일과 유박의 생리활성의 비교를 통해 작약 종자 유박 활용에 가능성을 평가하고자 수행되었다. 작약 종자 유박 추출물의 추출 수율은 22-45%로 추출용매에 따른 차이를 보였다. 총 폴리페놀 및 플라보노이드와 radical소거능은 오일보다 유박 추출물에서 유의하게 높았다. 작약 유박 추출물의 항균활성은 양성대조군에 비해 우수하였으며, 이는 48시간까지 지속되었다. 또한 LPS로 유도된 염증 반응은 유박 추출물 처리시 현저하게 감소하여 작약 종자 유박의 항염증 활성이 입증되었다. 본 연구를 통해 작약 종자 오일 뿐만 아니라 유박 추출물의 우수한 항산화, 항균 및 항염증 활성을 나타내어 바이오헬스 소재로서 작약 종자 유박의 활용 가능성이 확인되었다.

• 한국의상디자인학회지
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• 제24권2호
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• pp.131-146
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• 2022

The purpose of this study is to implement the textile design applying the floral pattern shown in Korean traditional fabrics and the New-Hanbok Chulic Dress in 3D through a virtual fitting system. As a research method, first, we analyzed the floral pattern types of fabrics in the literature related to traditional Korean textiles. Second, we developed textile designs of traditional flower motifs using 13 extracted flower types. Third, we applied the floral textile designs to the 3D original form of new-Hanbok Dress produced based on design preference survey results. The findings derived through this study are as follows. First, among Korean traditional patterns, the type of flowers used in textiles were blossom of chrysanthemum, orchid, camellia, apricot, peony, peach, pomegranate, hydrangea, narcissus, lotus, plum, chinese rose, and rosa rugosa. Second, this study found that the value of traditional culture can be further increased by using traditional flower patterns as an infinite source of creative design. Third, it was confirmed that the new-Hanbok can be developed endlessly as a clothing design that combines various morphological modifications and patterns without departing from traditional designs. In the future, if the research on costume design using various items of traditional clothing and the development of textile designs based on traditional culture continues, the development of new clothes design that leads to the development of Korean traditional clothing culture and meets the sensibilities of modern people will be endless.