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Clinical Practice Guidelines for the Medical and Surgical Management of Primary Intracerebral Hemorrhage in Korea

  • Kim, Jeong Eun;Ko, Sang-Bae;Kang, Hyun-Seung;Seo, Dae-Hee;Park, Sukh-Que;Sheen, Seung Hun;Park, Hyun Sun;Kang, Sung Don;Kim, Jae Min;Oh, Chang Wan;Hong, Keun-Sik;Yu, Kyung-Ho;Heo, Ji Hoe;Kwon, Sun-Uck;Bae, Hee-Joon;Lee, Byung-Chul;Yoon, Byung-Woo;Park, In Sung;Rha, Joung-Ho
    • Journal of Korean Neurosurgical Society
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    • v.56 no.3
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    • pp.175-187
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    • 2014
  • The purpose of this clinical practice guideline (CPG) is to provide current and comprehensive recommendations for the medical and surgical management of primary intracerebral hemorrhage (ICH). Since the release of the first Korean CPGs for stroke, evidence has been accumulated in the management of ICH, such as intracranial pressure control and minimally invasive surgery, and it needs to be reflected in the updated version. The Quality Control Committee at the Korean Society of cerebrovascular Surgeons and the Writing Group at the Clinical Research Center for Stroke (CRCS) systematically reviewed relevant literature and major published guidelines between June 2007 and June 2013. Based on the published evidence, recommendations were synthesized, and the level of evidence and the grade of the recommendation were determined using the methods adapted from CRCS. A draft guideline was scrutinized by expert peer reviewers and also discussed at an expert consensus meeting until final agreement was achieved. CPGs based on scientific evidence are presented for the medical and surgical management of patients presenting with primary ICH. This CPG describes the current pertinent recommendations and suggests Korean recommendations for the medical and surgical management of a patient with primary ICH.

A New Early-Heading and High Forage Yielding Rye Variety "Egreen" (극조숙, 다수성 조사료 및 녹비용 호밀 신품종 "이그린")

  • Heo, Hwa-Young;Park, Hyoung-Ho;Hwang, Jong-Jin;Kim, Hong-Sik;Han, Ouk-Kyu;Park, Tae-Il;Seo, Jae-Hwan;Kim, Dea-wook;Kim, Su-Yong;Kim, Si-Ju;Park, Ki-Hun
    • Korean Journal of Breeding Science
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    • v.41 no.4
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    • pp.620-624
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    • 2009
  • "Egreen" rye (Secale cereale L.) was developed by National Institute of Crop Science (NICS), RDA. It was released in 2007 because of its excellent earliness and yield potential. Crossing was made by an open pollination with 10 rye lines in 1995. Many lines from the open pollinated population were handled in a mass selection program in subsequent generations. Among them the line 'SR95POP-S1-116-1-1-2'was selected for earliness and promising agronomic appearance and placed in yield trial for two years from 2003 to 2004. In 2005, it was designated "Homil 34" and subjected to regional yield trials. Over 3 years, "Egreen" averaged 8.34 MT ha-1 of forage yield (based on dry matter) harvested at the heading date of check variety "Olhomil", which was superior to other varieties such as "Olhomil" and "Koolgrazer" with an increase of 8% and 10%, respectively. Heading date of "Egreen" was April 22, 3 days earlier than that of "Olhomil". It would be recommended as a winter crop forforage and green manure before planting either maize or rice in Korea.

Evaluation of Respiration Reproducibility of Chest General X-ray Examination using Self-made Respiratory Synchronization Device (자체 제작한 호흡 동기화 장치를 통한 흉부 일반촬영 검사의 호흡 재현성 평가)

  • Kwon, Oh-Young;Lee, Chang-Hun;Yong, Keum-Ju;Jin, Seon-Hui;Jung, Da-Bin;Heo, Yeong-Cheol
    • Journal of the Korean Society of Radiology
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    • v.15 no.7
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    • pp.1049-1056
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    • 2021
  • The purpose of this study was to develop a respiratory synchronization device for X-ray (X-RSD) to increase the reproducibility of inspiration when examining the Chest X-ray of a patient who difficulty in breathing coordination. The X-RSD was self-made using an air pressure sensor and air was injected by connecting a ventilator to the mannequin for CPR. At this time, the amount of injected air was quantified using the SkillReporting device. After placing the X-RSD on the chest of the mannequin, the amount of air was tested in 6 steps from 200 to 700 cc by 100 cc increased. For the accuracy evaluation, the sensitivity of X-RSD was measured by repeating a total of 80 measurements, and the sensitivity was 100%, and very precise results were obtained. After that, the images examined while viewing the X-RSD of the chest lateral examination and the images obtained by the blind examination were compared and evaluated. The lung volume of X-RSD was larger than that of the blind test, and the deviation was smaller. Overall, the use of X-RSD can help with chest X-ray examination of patients who have difficulty in cooperating, and it is thought that it will be possible to contribute to the reduction of exposure dose by reducing the repeat rate of general X-ray examinations.

A New Early-Heading and High-Yielding Forage Winter Oat Cultivar, "Punghan" (내한 조숙 다수 추파 조사료용 귀리 신품종 "풍한")

  • Han, Ouk-Kyu;Park, Hyong-Ho;Heo, Hwa-Young;Park, Tae-Il;Seo, Jae-Hwan;Park, Ki-Hun;Kim, Jung-Gon;Ju, Jung-Il;Hong, Yun-Gi;Jeung, Jae-Hyun;Park, Nam-Geon
    • Korean Journal of Breeding Science
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    • v.41 no.2
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    • pp.168-172
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    • 2009
  • 'Punghan' (Avena sativa L.), a winter oat for forage use, was developed by the breeding team at the Department of Rice and Winter Cereal Crop, NICS, RDA in 2008. It was derived from a cross between 'Beltsville 61-150 (IT133501)' and $F_1$ between 'Sikyonggwiri' and 'PA202-210'. A oat cultivar from USA, 'Beltsville 61-150', has a high cold tolerance, while the $F_1$ between 'Sikyonggwiri' and 'PA202-210' has early heading and high yielding with large-size grain. Subsequent enerations followed by the cross were handled in bulk and pedigree selection programs at Suwon and Yeoncheon, respectively. A line, 'SO99013-B-YB-31', was selected for earliness and good agronomic characteristics and designated as a line name of 'Gwiri 60'. The line 'Gwiri 60' was subsequently evaluated for winter hardiness, earliness, and forage yield in five locations, Yesan, Cheongwon, Iksan, Kimjae, and Jeju, from 2006 to 2008 and finally named as 'Punghan'. Over 3 years, the average forage dry matter yield of 'Punghan' harvested at milk-ripe stage was $14.5\;ton\;ha^{-1}$, compared with $13.6\;ton\;ha^{-1}$ of check cultivar 'Samhan'. 'Punghan' is about 2 days earlier in heading date than check cultivar. 'Punghan' is adapted primarily for winter planting use in the mid-southern regions of Korean peninsula.

Analysis of Physicochemical Properties and Firing Temperature for the Clay Bricks Excavated from the Maritime Province of Severia (연해주 콕샤로프카-1 평지성 출토 토벽의 물리화학적 특성 및 소성온도 분석)

  • Kim, So-jin;Heo, Jun-su;Kim, Jin-hyoung;Kim, Dong-hun;Han, Min-su
    • Korean Journal of Heritage: History & Science
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    • v.46 no.2
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    • pp.206-219
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    • 2013
  • This study aims to estimate firing temperature and physicochemical properties of the four clay bricks excavated from the Maritime Province of Siberia. Analysis result shows that the specimens are composed of clay, quartz and feldspar, and some specimens include carbonized organic materials which were probably added in order to enhance its physical strength in bricks. Major mineral components of the bricks are quartz, illite and clay minerals. The result identifying the existence of silimanite by XRD suggests that white material of the Koc 1 was painted for a certain purpose. Unlike most specimens which contained hematite, several samples contain Mullite. Such result suggests that some bricks were fired at high temperature. Furthermore, the results from TG analysis which does not display exothermic peak which appears at between $800^{\circ}C$ to $1,000^{\circ}C$ but display endothermic peak at $900^{\circ}C$ and it also confirms that they were exposed at $900^{\circ}C$ or higher.

Realization Method for Landscape Architecture Design Using Virtual Reality Technology - Focused on the Residential Garden Design - (가상현실(VR)기법을 이용한 조경설계 구현방법 - 주택정원 설계 중심으로 -)

  • Deng, Bei-Jia;Kim, Young-Hun;Cao, Lin-Sen;Heo, Sang-Hyun
    • Journal of the Korean Institute of Landscape Architecture
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    • v.47 no.3
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    • pp.71-80
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    • 2019
  • The Fourth Industrial Revolution, centered on intelligence and information, began to take hold in 2016. This study uses virtual reality technology, which is the most popular technology of the Fourth Industrial Revolution. The purpose of this study is to explore a Virtual Walk-through method, which can be easily applied to landscape architecture. At present, virtual reality technology is widely used in the fields of games, emergency training, and architectural design. However, in the field of landscape architecture, it is still in the development stage. In addition, most of the traditional ways to display virtual reality use 2D images, but such methods have some limitations. Therefore, this research addresses the three stages of "design-exhibition-experience" and puts forward a new simple method called 'Virtual Walk-through' that breaks from traditional landscape design exhibitions. The results show that compared with traditional methods, virtual reality has many advantages, such as the freedom of experience, a diversity of viewing angles, information supply, interaction, etc. It can show high quality images and effects, which are suitable for landscape design. It provides an evaluation method for garden design that can be utilized in the future. It is simple and has value as it can reflect the method and the expected effects. Virtual reality technology can bring an infinite number of prospects to the development of landscape architecture.

A Study on the Measurement of Explosion Range by CO2 Addition for the Process Safety Operation of Propylene (프로필렌의 공정안전 운전을 위한 CO2 첨가량에 따른 폭발범위 측정에 관한 연구)

  • Choi, Yu-Jung;Heo, Jong-Man;Kim, Jung-Hun;Choi, Jae-Wook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.7
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    • pp.599-606
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    • 2019
  • Most facilities that manufacture products made from the hazardous materials operate at high temperatures and pressures. Therefore, there is a risk of fire explosion. In particular, an explosion accident is a major risk factor for facilities with hazardous materials, such as oil, chemical, and gas. Propylene is often used in sites producing basic raw materials and synthetic materials by addition polymerization at petrochemical plants. To prevent an explosion in the business using propylene, the explosion range with the oxygen concentration was calculated according to the changes in temperature and pressure using an inert gas, carbon dioxide. In these measurements, the temperature was $25^{\circ}C$, $100^{\circ}C$, and $200^{\circ}C$ and the amount of carbon dioxide in the container was $1.0kgf/cm^2.G$, $1.5kgf/cm^2.G$, $2.0kgf/cm^2.G$, and $2.5kgf/cm^2.G$. The explosion limit was related to temperature, pressure, and oxygen concentration. The minimum oxygen concentration for an explosion decreased with increasing temperature and pressure. The range of explosion narrowed with decreasing oxygen concentration. In addition, no explosion occurred at concentrations below the minimum oxygen concentration, even with steam and an ignition source of propylene.

The Effect of Heat Treatment Condition on the Mechanical Properties of oxi-PAN Based Carbon Fiber (Oxi-PAN 섬유를 기반으로 제조한 탄소섬유의 탄화 조건에 따른 구조 및 물성의 변화)

  • Choi, Kyeong Hun;Heo, So Jeong;Hwang, Sang-Ha;Bae, Soo Bin;Lee, Hyung Ik;Chae, Han Gi
    • Composites Research
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    • v.31 no.6
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    • pp.385-391
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    • 2018
  • In this study, carbon fibers were fabricated via carbonization of oxidized polyacrylonitrile (oxi-PAN) under different carbonization conditions. Carbonization of oxi-PAN fiber was performed under four different temperature (1300, 1400, 1500, $1600^{\circ}C$) with four different fiber tensions (14, 25, 35, 45 MPa). Effect of carbonization process on the structural development and mechanical properties of carbon fiber were characterized by single filament fiber tensile test and Raman spectroscopy. A clear correlation exists between the Raman spectrum and the tensile modulus of carbon fiber and effect of carbonization temperature on the tensile modulus showed increased tendency only at higher fiber tension (${\geq}25MPa$) while tensile strength showed decreased or random tendency. Therefore, it may be concluded that the optimization of carbonization temperature of oxi-PAN fiber also requires optimization of fiber tension.

Comparison of Overall Immunity Levels among Workers at Grape Orchard, Rose Greenhouse, and Open-Field Onion Farm

  • Maharjan, Anju;Gautam, Ravi;Jo, JiHun;Acharya, Manju;Lee, DaEun;Pramod, Bahadur KC;Gim, Jin;Sin, Sojung;Kim, Hyocher;Kim, ChangYul;Lee, SooYeon;Lee, SooJin;Heo, Yong;Kim, HyoungAh
    • Safety and Health at Work
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    • v.13 no.2
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    • pp.248-254
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    • 2022
  • Background: Occupational hazards in crop farms vary diversely based on different field operations as soil management, harvesting processes, pesticide, or fertilizer application. We aimed at evaluating the immunological status of crop farmers, as limited systematic investigations on immune alteration involved with crop farming have been reported yet. Methods: Immunological parameters including plasma immunoglobulin level, major peripheral immune cells distribution, and level of cytokine production from activated T cell were conducted. Nineteen grape orchard, 48 onion open-field, and 21 rose greenhouse farmers were participated. Results: Significantly low proportion of natural killer (NK) cell, a core cell for innate immunity, was revealed in the grape farmers (19.8±3.3%) in comparison to the onion farmers (26.4±3.1%) and the rose farmers (26.9±2.5%), whereas cytotoxic T lymphocyte proportion was lower in the grape and the onion farmers than the rose farmers. The proportion of NKT cell, an immune cell implicated with allergic response, was significantly higher in the grape (2.3±0.3%) and the onion (1.6±0.8%) farmers compared with the rose farmers (1.0±0.4%). A significantly decreased interferon-gamma:interleukin-13 ratio was observed from ex vivo stimulated peripheral blood mononuclear cells of grape farmers compared with the other two groups. The grape farmers revealed the lowest levels of plasma IgG1 and IgG4, and their plasma IgE level was not significantly different from that of the onion or the rose farmers. Conclusion: Our finding suggests the high vulnerability of workplace-mediated allergic immunity in grape orchard farmers followed by open-field onion farmers and then the rose greenhouse farmers.

A Study on Melanin Reduction through Autophagy by 2'-Fucosyllactose (2'-푸코실락토오스의 자가포식을 통한 멜라닌 감소 연구)

  • Jung, So Young;Yoo, Han Jun;Heo, Hyojin;Lee, So Min;Brito, Sofia;Cha, Byungsun;Lei, Lei;Lee, Sang Hun;Bin, Bum-Ho;Lee, Mi-Gi;Kwak, Byeong-Mun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.2
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    • pp.105-112
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    • 2022
  • 2'-fucosyllactose (2'-FL) is the most abundant human milk oligosaccharide (HMO) present in breast milk, promoting the growth of beneficial microorganisms in the gut and aiding in the relief of allergic and inflammatory reactions. In this study, the anti-melanogenic effects of 2'-FL, and its potential for application in whitening cosmetics, were evaluated. MTT assay was performed on MNT-1 cells, human-derived melanocytes. 2'-FL was treated and replaced at 48 h intervals for 7 days, and it was confirmed that there was no cytotoxicity at 20 g/L or less, while a 40% reduction in melanin production was also observed. Western blot analysis of TYR and TYRP1, factors involved in melanogenesis, revealed that 2'-FL treatment reduced their expression levels. In addition, 2'-FL application and observation of the autophagy marker microtubule-associated protein 1 light chain 3 (LC3) revealed it was converted from LC3-I to LC3-𝚷, indicating increased autophagy. Likewise, confocal microscopy revealed an increase in LC3 puncta after 2'-FL treatment. Therefore, it is suggested that 2'-FL-mediated activation of autophagy reduces melanogenesis by inhibiting the expression levels of TYR and TYRP1 proteins. In conclusion, it has been confirmed that 2'-FL induces autophagy and suppresses melanin production, so its potential as a whitening cosmetic material is expected.