• 한국환경농학회지
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• 제40권2호
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• pp.127-133
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• 2021

BACKGROUND: Dithiocarbamte fungicides have been used in crop cultivation for diseases protection and treatment. And cultivated agricultrual products were used as feedstuff, and residual pesticides are likely to be absorbed and transferred to livestock. But the maximum residue limits (MRLs) were not established for dithiocarbate fungicides in livestock products, and thus an analysis method was developed and validated for dithiocarbamate fungicides to establish MRLs. METHODS AND RESULTS: Samples were prepared using CS₂ trap method and detected with UV/VIS spectrophotometer. Calibration line (0.1 ~ 10 ㎍/mL) was linear with r² > 0.99. For validation, the recovery tests were carried out at three fortification levels (MLOQ, 10 MLOQ and 50 MLOQ) from livestock samples (egg, milk, beef, pork, and chicken). The results for mancozeb, propineb, and thiram ranged between 76.8 to 109.6%, 79.4 to 108.8%, and 80.2 to 107.8%, respectively and % RSD (relative standard deviation) values were below 9.5%. Furthermore, inter-laboratory analysis was performed to validate the method. CONCLUSION: All values were corresponded with the criteria ranges requested by both the CODEX (CAC/GL 40-1993, 2003) and MFDS guidelines (2016). This might be used as an official analytical method for determination of dithiocarbamate fungicides at established MRLs and monitoring.

• 한국정보통신학회논문지
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• 제23권6호
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• pp.666-674
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• 2019

질량 분석기의 질량 스펙트럼에서 높은 피크값을 갖는 스펙트럼에 인접한 낮은 피크값의 스펙트럼은 서로 연결되어 분리가 어렵다. 이러한 스펙트럼간 겹칩은 질량 스펙트럼의 검출 성능과 해상도를 저하시키는 원인이 된다. 본 논문에서는 잔류 가스 분석기의 질량 스펙트럼 검출 성능과 피크값의 정확도를 향상시키는 방법을 제안한다. 이온 신호블록의 특성에 따른 유형 판별과 피크위치오차에 대한 사전 보정은 인접한 스펙트럼에 연결된 낮은 피크값의 스펙트럼 분리 및 검출할 수 있다. 제안된 방법의 성능을 확인하기 위해 질량분석기에서 얻은 실제 이온 신호를 사용하여 제안한 방법과 기존 방법을 비교하였다.

• Psychiatry investigation
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• 제15권12호
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• pp.1135-1143
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• 2018

Objective The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). Methods The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. Results In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. Conclusion The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.

• 한국정보통신학회논문지
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• 제22권11호
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• pp.1435-1441
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• 2018

온라인 서명 검증은 간단하면서도 효율적인 본인 확인 방법의 하나로 생체 인식에 따른 거부감이 적은 장점으로 본인 확인 용도로 사용되고 있다. 서명 검증을 분류 문제로 접근하기 위해서는 모조서명이 필요하지만, 대부분의 실용적인 응용에서 모조서명을 확보하기는 쉽지 않으며 진서명 역시 많은 양을 확보하기는 쉽지 않다. 이 논문에서는 모조서명의 확보가 어려운 문제를 해결하기 위해 단일 클래스 SVM을 사용하고, 진서명의 양이 제한되는 문제는 다른 사람의 서명 데이터를 일반 필기 데이터로 사용하여 해결하는 방법을 제시한다. 다른 사람의 서명 데이터는 검증하고자 하는 서명과 형태적인 유사점을 찾을 수 없지만, 서명에서의 일반적인 특징을 반영하고 있으므로 적은 수의 진서명만을 확보할 수 있는 경우에 사용하면 검증률을 높일 수 있으며 이는 실험 결과를 통해서 확인할 수 있다.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.793-801
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• 2018

BACKGROUND: The aim of this study was to evaluate the combined effect of low-level laser treatment (LLLT) and recombinant human bone morphological protein-2 (rhBMP-2) applied to hypoxic-cultured MC3T3-E1 osteoblastic cells and to determine possible signaling pathways underlying differentiation and mineralization of osteoblasts under hypoxia. METHODS: MC3T3-E1 cells were cultured under 1% oxygen tension for 72 h. Cell cultures were divided into four groups: normoxia control, low-level laser (LLL) alone, rhBMP-2 combined with LLLT, and rhBMP-2 under hypoxia. Laser irradiation was applied at 0, 24, and 48 h. Cells were treated with rhBMP-2 at 50 ng/mL. Alkaline phosphatase activity was measured at 3, 7, and 14 days to evaluate osteoblastic differentiation. Cell mineralization was determined with Alizarin red S staining at 7 and 14 days. Western blot assays were performed to evaluate whether p38/protein kinase D (PKD) signaling was involved. RESULTS: The results indicate that LLLT and rhBMP-2 synergistically increased alkaline phosphatase (ALP) activity and mineralization. Western blot analyses showed that expression of type I collagen, runt-related transcription factor 2 (RUNX2), and Osterix (Osx), increased and expression of hypoxia-inducible factor 1-alpha ($HIF-1{\alpha}$), decreased more in the LLLT and rhBMP-2 combined group than in the rhBMP-2 or LLL alone groups. Moreover, LLLT and rhBMP-2 stimulated p38 phosphorylation and rhBMP-2 and LLLT increased Prkd1 phosphorylation. CONCLUSION: Combined treatment with rhBMP-2 and LLL induced differentiation and mineralization of hypoxic-cultured MC3T3-E1 osteoblasts by activating p38/PKD signaling in vitro.

• 한국환경농학회지
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• 제39권4호
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• pp.319-326
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• 2020

BACKGROUND: Measurement equipment was developed for inorganic nutrient concentration inside the hydroponic culture medium with several macro- and micro compositions, and applied for measuring the compositions of conventional medium. METHODS AND RESULTS: Before the equipment development, sonicator and heater were utilized to control temperature around of the module mixing with color reagents and target samples among the inorganic compositions. The measurement module and multi-sampler were also manufactured based on the COMS (Complementary Metal-Oxide Semiconductor) and installed inside the measurement equipment. Concentration of standard solution, value measured by the equipment, standard deviation or measured average value were used for estimating the accuracy and average recall of the equipment. Yamazaki solutions with EC of 0.5, 1.5, and 2.5 dS/m were offered to confirm the equipment accuracy and standard error. CONCLUSION: It was suggested that the developed equipment could be automatically applied for measurement with accuracy of over 96% and standard errors of less than 5% on 12 macro- and micro compositions such as a NO3-N, PO43- or Fe.

• 한국정보통신학회논문지
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• 제24권10호
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• pp.1369-1375
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• 2020

아두이노는 비전공자를 위한 마이크로컨트롤러 플랫폼의 하나로 학습용으로 널리 사용되고 있다. 아두이노 보드에는 여러 종류의 AVR 시리즈 마이크로컨트롤러가 사용되지만, ATmega128은 사용하지 않는다. ATmega128은 아두이노 보드에 사용되는 ATmega328이나 ATmega2560과 비교했을 때 확장성이 우수하고 가격 경쟁력이 높아 지금도 많이 사용되고 있으므로, ATmega128을 아두이노 환경에서 사용할 수 있도록 함으로써 기존 하드웨어의 활용성을 높일 수 있음은 물론 아두이노 플랫폼 역시 활용할 수 있는 장점이 있다. 이 논문에서는 ATmega128과 아두이노 플랫폼의 장점을 결합할 수 있도록 ATmega128을 기반으로 하는 아두이노 호환 보드 설계와 이를 활용하는 방법을 제시한다. 이러한 아두이노 플랫폼의 확장은 기존 하드웨어를 활용하면서 아두이노 플랫폼의 장점을 사용할 수 있어 다양한 마이크로컨트롤러 관련 교육에서 학습 효과를 높일 수 있을 것으로 기대된다.

• 한국분말재료학회지
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• 제28권2호
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• pp.127-133
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• 2021

One-dimensional (1D) piezoelectric nanostructures are attractive candidates for energy generation because of their excellent piezoelectric properties attributed to their high aspect ratios and large surface areas. Vertically grown BaTiO₃ nanotube (NT) arrays on conducting substrates are intensively studied because they can be easily synthesized with excellent uniformity and anisotropic orientation. In this study, we demonstrate the synthesis of 1D BaTiO₃ NT arrays on a conductive Ti substrate by electrochemical anodization and sequential hydrothermal reactions. Subsequently, we explore the effect of hydrothermal reaction conditions on the piezoelectric energy conversion efficiency of the BaTiO₃ NT arrays. Vertically aligned TiO₂ NT arrays, which act as the initial template, are converted into BaTiO₃ NT arrays using hydrothermal reaction with various concentrations of the Ba source and reaction times. To validate the electrical output performance of the BaTiO₃ NT arrays, we measure the electricity generated from each NT array packaged with a conductive metal foil and epoxy under mechanical pushings. The generated output voltage signals from the BaTiO₃ NT arrays increase with increasing concentration of the Ba source and reaction time. These results provide a new strategy for fabricating advanced 1D piezoelectric nanostructures by demonstrating the correlation between hydrothermal reaction conditions and piezoelectric output performance.

• 한국정보통신학회논문지
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• 제25권11호
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• pp.1545-1550
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• 2021

다위상 분해 기법 기반의 부밴드 구조에서 단순화한 부밴드 인접투사 알고리즘(Simplified SAP; SSAP)을 위한 최적 가변 스텝사이즈 조정 방법을 제안한다. 제안한 방법은 부밴드 적응필터의 계수 갱신 시점에서 평균자승편차(MSD)를 최소화하도록 유도된 최적값을 제시한다. 유색 입력 신호를 사용하는 SSAP 알고리즘에서 제안한 최적 스텝사이즈의 적용은 빠른 수렴속도와 작은 정상상태오차를 보장한다. AR(2) 신호와 실제 음성을 입력 신호로 사용하여 수행한 컴퓨터 모의실험의 결과는 제안한 최적 스텝사이즈의 유효성을 입증한다. 또한 모의실험 결과는 기존 여러 적응 알고리즘과 비교하여 제안한 알고리즘이 더 빠른 수렴속도와 양호한 정상상태오차를 가지고 있음을 보인다.

• Journal of Acupuncture Research
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• 제39권4호
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• pp.283-296
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• 2022

In this study, the evidence of thread embedding acupuncture (TEA) in treating cervical radiculopathy in randomized controlled trials was investigated. We searched 16 databases up to August 22, 2022. Of the 2,644 studies retrieved, 22 randomized controlled trials (2,483 participants) were selected. Quality assessments were performed using Cochrane's risk-of-bias tool and RevMan 5.4 software. Outcome measures in the included studies typically showed TEA had a significant therapeutic effect compared with simple acupuncture and other remedies, and TEA was better than sham TEA. Catgut and polydioxanone had no difference in effectiveness, however, catgut was considered to be less safe. TEA was shown to be more therapeutic when inserted deeper into the skin. Ultrasound guided TEA was more effective and safer than conventional TEA, and using a flat blade needle was better than conventional needles for TEA. No serious adverse events were reported from using TEA, and only a few mild side effects were observed. However, the limited number and heterogeneity of the included studies, together with the unclear methodological quality, indicate that higher-quality studies need to be conducted to determine the effectiveness and safety of TEA for cervical radiculopathy.