• 대한관절경학회지
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• 제13권1호
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• pp.39-45
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• 2009

목적: 슬관절 치환술 후에 발생한 합병증의 치료를 위해 시행한 관절경술의 결과를 알아보고 그 효용성을 확인하고자 하였다. 대상 및 방법: 1992년 5월부터 2008년 6월까지 본원에서 슬관절 치환술을 시행받은 후 합병증으로 인하여 관절경적 치료를 받았던 25예를 연구 대상으로 하였다. 25예 중 슬관절 전치환술을 시행받았던 경우가 19예, 부분치환술을 시행받았던 예가 6예였다. 모든 환자에서 관절경을 시행하기 전에 합병증의 원인을 밝히기 위해서 이학적 검사와 방사선 검사를 시행하였으며, 감염이 의심되는 경우 관절액 천자 및 혈액학적 검사를 추가로 시행하였다. 결과: 관절경술 시행 시 진단으로는 전치환술을 시행한 예에서는 감염 11예, 관절의 유착 및 섬유화로 인한 운동 제한 6예, 연부 조직의 충돌 2예 등이 있었으며, 부분 치환술을 시행한 예에서는 반월상 연골 파열, 유동성 치환물의 아탈구, 혈관절증, 관절 내 시멘트 유리체, 연부 조직 충돌 및 슬관절 강직으로 인한 운동 제한이 각각 1예 씩 총 6예가 있었다. 감염이 있던 11예 중 9예에서 관절경술만으로 치료가 되었고, 관절 강직이 있던 7예는 평균 슬관절 운동 범위가 술 전 $65^{\circ}$에서 최종 추시 시 $105^{\circ}$로 향상 되었으며, 나머지 예에서도 관절경술로 성공적인 치료 결과를 보였다. 결론: 슬관절 치환술 후 발생한 합병증의 치료로 시행한 관절경술은 적절한 환자의 선택 시 안전하고 효과적인 방법임을 확인할 수 있었다.

• Journal of Acupuncture Research
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• 제19권2호
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• pp.189-200
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• 2002

Objective : This study is designed to find out the effects of Carthmi-Flos herbal acupuncture theraphy on knee joint with osteoarthritis. Methods : 32 cases of diagnostic patient with the osteoarthritis of knee joints by biochemical method, X-ray analysis and hematologic & serologic tests are divided Carthmi-Flos herbal acupuncture theraphy Group(HAG, 16 peples) and non-Carthmi-Flos herbal acupuncture theraphy Group(NHAG, 16 peoples) at Ik-San Oriental medical hospital in wonkwang university from 1th June 2000 to 31th January 2002. After treatment, we evaluated the effect per each group . Results : 1. In the both HAG and NHAG females were much more than males. Sixty aged patients were the most in the HAG(56.3%) and Seventy aged patients were the most in the NHAG(68.8%). 2. Over 5 years duration of disease in HAG was the most(37.5%). 6 months and over 5 years duration of disease in NHAG was the most(each 31.3%). 3. Two groups were not improved chronic stage(over 5 years). 4. The effect of treatment by condition of patients was follows: After treatment, Grade IV & III were decreased 75.0% in HAG and 56.2% in NHAG 5. In the distribution of treatment progression : 15 cases(93.7%) were recoverd in HAG but 14 cases(87.5%) in NHAG. 6. After comparing the results before and after treatment, we found 93.3% of patients showed recovery at anterior area and 88.9% showed at posterior. Conclusion : These results shows that Carthmi-Flos(CF) herbal acupuncture treatment has good effect on osteoarthritis in knee joint. Futhermore it is possible that CF acupuncture is one of the promising candidates for long-term therapy of osteoarthritis.

• Toxicological Research
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• 제33권3호
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• pp.239-253
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• 2017

Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide ($Nd_2O_3$) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized $Nd_2O_3-containing$ aerosols via a nose-only inhalation system at doses of $0mg/m^3$, $0.5mg/m^3$, $2.5mg/m^3$, and $10mg/m^3$ for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the $2.5mg/m^3$ and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the $0.5mg/m^3$ treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the $0.5mg/m^3$ group, but were exacerbated in the $10mg/m^3$ group. The lowest-observed-adverse-effect concentration of nano-sized $Nd_2O_3$ was determined to be $0.5mg/m^3$, and the target organ was determined to be the lung, under the present experimental conditions in male rats.

• Journal of Hospice and Palliative Care
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• 제21권3호
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• pp.75-83
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• 2018

목적: 호스피스 완화의료에서 환자의 기대 여명 예측뿐 아니라 퇴원형태를 예측하여 적절한 치료를 제공할 필요가 있다. 이번 연구에서는 입원 초기 환자의 퇴원 형태 예측에 유의한 요소들을 알아보고 효율적인 완화의료의 방향에 대해 제시하고자 한다. 방법: 2016년 4월 1일부터 2017년 12월 31일까지 P병원 호스피스 병동에 입원한 말기암환자 568명 중 377명을 대상으로 하였으며 입원 시 사정한 환자의 수행 지수, 증상 및 징후, 사회 경제적 상태와 혈액검사 자료를 바탕으로 연구를 진행하였다. 결과: 입원 당시 높은 수행지수, 양호한 증상 및 징후, 정상에 가까운 혈액검사 수치를 보일 때 생존 퇴원할 가능성이 높았다. 결론: 환자의 퇴원형태 예측에 ECOG, KPS, Global health, Mental status와 같은 수행지수, dyspnea, anorexia, dysphagia, fatigue와 같은 증상 및 징후, CBC, LFT, BUN, CRP 혈액검사 수치가 유의한 지표임을 확인하였다.

• 한국어병학회지
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• 제30권1호
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• pp.41-49
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• 2017

생균제는 성장촉진, 면역증진 및 질병예방에서 넙치 Paralichthys olivaceus 치어의 양식에서 우수한 생산효과로 적용될 수 있다. 성장률, 선천성면역 및 항병력을 증강시킬 수 있는 생균제의 효과를 조사하기위해 Bacillus subtilis, Bacillus licheniformis 및 Lactobacillus plantarum (BSL-LAB)이 혼합되어있는 생균제와 NBS (nitrifying bacteria con- sortium) 분말을 사료에 첨가 또는 수조에 투입하여 시험을 수행하였다. 생균제 첨가사료는 7주간 투여하였고 3가지의 생균제 조합 시험군 모두에서 넙치의 성장과 항병력에서 대조군에 비해 높은 유효성을 발휘 하였다. 어병세균에 대한 항병력의 긍정적인 결과는 생균제에 대한 면역기능의 향상으로 나타난 효과이며 상기 시험결과로 볼 때, 넙치치어 양식에서 생균제의 혼합첨가는 성장 및 선천성면역 뿐만 아니라 질병저항성에 좋은 효과를 나타낼 수 있을 것으로 사료된다.

• 대한수의학회지
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• 제20권2호
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• pp.175-178
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• 1980

Normal values of serum electrolytes were determined for adult 36 females and 18 males, 1 to 6 years old, of Jindo dogs. The mean values, standard deviation and rangEs of sodium, potassium, chloride, calcium and inorganic phosphorus were studied and data analyzed to determine whether differences existed between the values of female and those of male dogs. The results obtained in this study were as follows: 1. The mean value of serum sodium was $143{\pm}1.5mEq/liter$, ranged from 138mEq/liter to 152 mEq/liter. The mean values for the females and males were $144{\pm}2.0mEq/liter$ and $142{\pm}1.7mEq/liter$, respectively. They showed that the female dogs had a tendency toward higher values than the male dogs, but no significant sex-related differences were observed. 2. The mean value of serum potassium was $4.6{\pm}0.2mEq/liter$, ranged frem 3.5mEq/liter to 6.0mEq/liter. The mean values for the females and males were $4.7{\pm}0.4mEq/liter$ and $4.5{\pm}0.3mEq/liter$. They showed that the female dogs had a tendency toward higher values than the male dogs, but sex differences were not found to be significant. 3. The mean value of serum chloride was $103{\pm}3.0mEq/liter$ ranged from 95mEq/liter to 117mEq/liter. The mean values for the females and males were $103{\pm}3.2mEq/liter$ and $103{\pm}3.3mEq/liter$, no sex differences showed. 4. The mean value of serum calcium was $5.2{\pm}0.1mEq/liter$ ranged from 4.7mEq/liter to 5.8mEq/liter. The mean values for the females and males were $5.4{\pm}0.1mEq/liter$ and $5.2{\pm}0.09mEq/liter$ respectively, no significant sexd iffere-nces were observed. 5. The mean value of serum inorganic phosphorus was $4.3{\pm}0.7mg/100ml$, ranged from 2.5mg/100ml to 5.8mg/100ml. The mean values for the females and males were $4.3{\pm}0.9mg/100ml$ and $4.1{\pm}0.8mg/100ml$, respectively, no sex differences showed.

• 대한수의학회지
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• 제40권1호
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• pp.173-186
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• 2000

This experiment was carried out to investigate the tendency of incident diseases in pre- and post- weaning piglets which ages were 1 to 7 weeks old by laboratory diagnosis and in order to minimize death in preweaning piglets and of stunted growth in postweaning piglets. The result of this experiment used as the basic data for the preventive programs in pre- and post- weaning piglets and were as follows: 23 different diseases diagnosed in 331 cases were studied in relation to age, season, and etiology. The most prevelent diseases of pre- and post- weaning piglet were Colibacillosis(79 case, 23.9%) and the major diseases were Salmonellosis(44 cases, 13.3%), Anemia(37 cases, 11.2%). Unknown viral disease(20 case, 6.1%), Rota viral infection(19 case, 5.8%), Porcine reproductive & respiratory syndrome(PRRS; 15 case 4.5%), Transmissible gastroenteritis(TGE; 12 case, 3.6%). The gastrointestinal disease, such as Colibacillosis, Salmonellosis, Swine dysentery, Clostridial infection, Rotaviral infection, TGE, Porcine epidemic diarrhea(PED) and Ballantidiosis occured pro- dominently in the period of pre- and post- weaning, which were 178 cases(53.8%) and not related to occurrence according to age and season. The respiratory diseases were Atrophic rhinitis(AR), Swine enzootic pneumonia, Pneumonic pasteurellosis, Pleuropneumonia, Branchopneumonia, PRRS and which were 48 cases(14.5%) and higher prevalent in spring and summer. The viral diseases was 73 cases(22.1%) that occurred in the period of 5 weeks piglet and prevalent mainly in spring. The bacterial diseases were 188 cases(56.8%) that were not related to occurrence according to age and season. Salmonellosis was prevalent in 3 to 5 weeks piglet and mainly occurred in summer. Viral septicemia and rotaviral infection occurred after 5 weeks piglets intensively and 3 to 5 weeks, respectively. And the both occurred without relation with season. PRRS occurred after 4 weeks piglet and prevalent in summer. TGE occurred 1 to 7 days old piglets and prevalent in spring and winter. Hematologic values of anemia was decrease in number of Red Blood Cell, concentration of Hemoglobin and Hematocrit. Amikacin, cephalothin, colistin, norfloxacin were effective to E coli, and amikacin, cephalothin, nortloxacin, neomycin were effective to Salmonellra spp. but clindamycin, erythromycin, penicillin, sulfonamides were resistant to E coli and Salmonella spp.

• 대한핵의학회지
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• 제13권1_2호
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• pp.15-21
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• 1979

1975년(年) 1월(月)부터 1978년(年) 3월(月)까지 경북의대부속병원(慶北醫大附屬病院)에서 진단(診斷)된 만성골수성백혈병(漫性骨髓性白血病) 가운데 18례(例)에서 $^{198}Au$교질(膠質)을 사용(使用)하여 간비주사(肝脾走査)를 시행(施行)하여 다음과 같은 소견(所見)을 얻었다. 1) 만성골수성백혈병(漫性骨髓性白血病)의 남녀비(男女比)는 2:1이였고 연령적(年齡的)으로 30대(代)와 40대(代)가 많았다. 2) 간비주사(肝脾走査)에서 간(肝)의 공간점유병변(空間占有病變)을 의심(疑心)할 만한 소견(所見)은 없었다. 3) 비섭취(脾攝取)는 well visualization 군(群) 4례(例) poor visualization 군(群) 7례(例), nonvibualization 군(群) 7례(例)였고, visualization 군(群)에서 비내공간점유병변(脾內室間占有病變)을 의심(疑心)할 소견(所見)은 없었다. 4) 비(脾) well visualization 군(群)과 poor visualization군간(群間)에는 임상(臨床所見) 간기능검사소견(肝機能檢査所見) 및 혈액학적소견(血液學的所見)에서 큰 차이(差異)가 없었다. 5) 비(脾) nonvibualization 군(群)에서는 visualigation 군(群)에 비(比)해서 증상기간(症狀期間)이 비교적(比較的) 길었던 례(例)가 많았고, 혈소판감소증(血小板減少症) 및 골수(骨髓)의 거핵구감소증(巨核球減少症)의 례(例)가 많았으나 간기능검사소견(肝機能檢査所見)에서는 별차이(別差異)가 없었다. (본(本) 논문교열(論文校閱)의 노고(勞苦)를 아끼지 않으신 황기석학장(黃基錫學長)님께 충심(衷心)으로 감사(感謝)드립니다.)

• 대한두경부종양학회지
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• 제17권1호
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• pp.32-37
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• 2001

Objectives: We performed this study to compare the short term results of induction chemotherapy and radiotherapy versus concurrent chemoradiotherapy in patients with locally advanced head and neck cancer. Materials and Methods: From Oct. 1985 to May 1998, 121 patients with locally advanced head and neck cancer were treated with induction chemotherapy and radiotherapy (induction group) or concurrent chemoradiotherapy (concurrent group), and a retrospective analysis was done. Induction chemotherapy was done for 97 patients, and concurrent chemotherapy for 24 patients. Age, sex, performance status, and pathologic types were evenly distributed between two groups. Primary site showed nasopharynx(72.2%), oropharynx(27.8%) in induction group, and nasopharynx(50%), oropharynx(50%) in concurrent group. Chemotherapy regimen was CF(cisplatin and 5-fluorouracil) for 67 patients and CVB (cisplatin, vincristine, bleomycin) for 30 patients in induction group, and CF for all of 24 patients in concurrent group. Proportion of patients treated with more than 2 cycles of planned chemotherapy was 94.8% in induction group and 87.5% in concurrent group. Conventionally fractionated radiotherapy with daily fraction size of 1.8-2.0Gy and 5 fractions/week was done. Total dose was 61-95Gy (median 73.4Gy) for induction group, and 69.4-75.4Gy (median 69.4Gy) for concurrent group. Follow-up time was 4-161 months (median 38 months) for induction group, 7-35 months (median 21.5 months) for concurrent group, respectively. Results: According to treatment modality, overall 2-year survival rates were 68.0% for induction group, 74.3% for concurrent group (p>0.05). two-year disease-free survival rates were 51 % and 74% (p=0.05). Complete response rates were 67.4% for induction group and 83.3% for concurrent group (p=0.09). The incidence of grade 3-4 hematologic toxicity (2.1% vs. 25%, p=0.001) and grade 3-4 mucositis (9.3% vs. 37.5%, p=0.002) during radiotherapy was higher in concurrent group. Conclusion: Concurrent chemoradiotherapy showed a trend of improvement in short-term survival and treatment response when compared with induction chemotherapy and radiotherapy in locally advanced head and neck cancer. A more controlled randomized trial is needed.

• 대한임상검사과학회지
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• 제36권1호
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• pp.27-32
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• 2004

Bone marrow transplantation(BMT) is widely used as curative means of various malignant and nonmalignant hematologic disorders, and early and accurate determination of engraftment is very important for critical management decisions. Reticulocyte counts performed by automated flow cytometric methods is a good indicator of erythropoietic activity and its evaluation has been proposed as an early predictor of bone marrow regeneration. Some reports highlighted the usefulness of the percentage of highly fluorescent reticulocytes and the sum of highly and medium fluorescent reticulocytes(immature reticulocyte fraction, IRF). In Asan Medical Center, the criteria for engraftment following BMT or PBSCT was defined as the first day of a 3-day trend of absolute neutrophil count(ANC)${\geq}500/uL$ and platelet count${\geq}30{\times}10^3/uL$. In 1999, Grotto et al proposed an indidator of bone marrow recovery as the first day on which the IRF was twice the minimum value after bone marrow transplantation. To compare the both criterias, we got consecutive datas of immature reticulocyte fraction, absolute neutrophil count(ANC), WBC count, platelet count and reticulocyte count by XE-2100 automated hematology analyzer(Sysmex Co. Japan) from 33 patients daily after BMT. When compared to standard neutrophil engraftment(10-30 days, $16.2{\pm}4.6days$), IRF engraftment (5-21 days, $11.0{\pm}3.9days$) occured significantly earlier in 87.9% of patients(P<0.05). The mean engraftment day for WBC count(11-29 days, $16.4{\pm}4.3days$) was similar to ANC, but platelet count and reticulocyte count revealed more delayed data (10-49 days, $19.1{\pm}7.4days$ vs 17-64 days, $31.4{\pm}14.1days$). In conclusion, our results confirm that an increase in the immature reticulocyte population is the earliest sign of the hematopoietic recovery after BMT and that automated reticulocyte quantification including immature fraction may be integrated into clinical protocols to evaluate bone marrow reconstitution.