• 제목/요약/키워드: Hematocrit value

검색결과 200건 처리시간 0.022초

Test turnaround Time for Complete Blood Cell Count using Delta and Panic Value Checks and the Q-flag Limit

  • Koo, Bon-Kyung;Ryu, Kwang-Hyun;Lim, Dae-Jin;Cho, Young-Kuk;Kim, Hee-Jin
    • 대한임상검사과학회지
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    • 제44권2호
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    • pp.66-74
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    • 2012
  • Test turnaround time (TAT) is the lead time from reception to reporting. In the complete blood cell count (CBC), 4 units of the XE-2100 (Sysmex Corp., Japan) processed around 80% of quantity, 1 unit of the LH-780 (Beckman-Coulter Incorp., USA) processed around 10% and 1 unit of ADVIA-2120 (Siemens AG, Munich, Germany) processed around 10%. We analyzed the change in the TAT for the CBC for over 7 years, from January of 2005 to December of 2011. The delta check made alterations of delta to WBC, hemoglobin, hematocrit, platelet and metamyelocyte, however, did not made them to band neutrophil, eosinophil, basophil and monocyte. The panic value check made alterations of panic value to hemoglobin, hematocrit, platelet and monocyte. In the criteria of currently slide review, LH-780 and ADVI-2120 analyzers prepared suspect flags of "Blast, Imm NE2, Immature granulocyte, Imm NE1, Left shift, Variant lymphocyte, Atypical lymphocyte, Platelet clumps and NRBC". The New slide review in the XE-2100 analyzer altered the preparations of a smear slide more than a "Platelet clumps flag(${\geq}200unit$), a single flag excluding the "Platelet clumps flag (${\geq}250unit$) and a multiple flag (${\geq}200unit$)". Also, below the 240 unit, medical technologists prepared manual slides selectively according to their evaluations. The automatic reporting rate was 33.4% without alterations, whereas it was 41.0% without alterations, and was thus improved by 7.6%. The slide review rate was 15.2% before using the Q-flag limit, whereas it was 12.1% for a reduce 3.1%. TAT was 45 minutes without the creation alterations of the delta and panic value checks, whereas it was 35 minutes after making alterations of the delta and panic value checks and thus was shortened by 10 minutes. We came to the conclusion that the establishment and operation of delta and panic value checks and slide review criteria suitable for laboratory environment can reduce unnecessary smear slides, re-checking, re-sampling, re-testing, telephone inquiries and concentrated workloads during specific times of the day.

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양식 뱀장어 (Anguilla japonica)의 아질산 독성에 미치는 aspirin의 투여 효과 (Effects of Aspirin on Nitrite Toxicity in Cultured Eel (Anguilla japonica))

  • 김동완;구재근;박성우
    • 한국어병학회지
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    • 제20권3호
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    • pp.291-297
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    • 2007
  • 양식 뱀장어(Anguilla japonica)의 사육 중 발생하는 아질산중독에 대한 aspirin(ASA)의 효과를 알아보기 위하여 인위적으로 메트헤모글로빈혈증을 유발시킨 다음 ASA, 식염, 식염과 ASA 및 1/2 환수시키고 24시간 동안 사육하였다. 각 처리군의 뱀장어에서 동맥구에서 말초혈액을 채취하여 헤마토크리트치, 혈구의 형태 변화, 혈장 중의 아질산의 농도 및 메트헤모글로빈의 농도와 아가미의 병리조직학적 변화를 조사하였다. ASA약욕군이 헤마토크리트치가 높고, 혈장중의 아질산 농도와 메트헤모글로빈의 농도가 낮을 뿐만 아니라 적혈구의 형태도 정상어와 유사하였다. 또한 아가미의 병리조직변화도 다른 처리군에서는 상피세포의 증생과 유착 및 모세혈관의 충혈 등이 확인되었지만, ASA처리군에서는 발견할 수 없었다. 이러한 결과로부터 ASA의 약욕이 뱀장어의 아질산의 독성저하에 효과적일 것으로 판단되었다.

MCV와 RDW를 이용한 복합유기용제 취급 근로자의 빈혈 유형에 관한 조사 (The Type of Anemia in Organic Solvent Workers by MCV and RDW)

  • 김성준;엄상화;김대환;이채언;전진호;김성천;배기택;박형종
    • Journal of Preventive Medicine and Public Health
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    • 제25권2호
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    • pp.162-171
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    • 1992
  • The hematologic effect by low-concentration and repeated exposure to mixed organic solvent remains obscure. This study was performed to evaluate the hematologic effect by mixed organic solvent exposure, especially on the type of anemia by mean corpuscular volume(MCV) and red blood cell distribution width(RDW). The subject were 64 organic solvent workers(male 4, female 60) and 78 general workers(male 18, female 60) who showed anemic tendency in worker's health examination which carried out by Pusan Paik Hospital from January to December, 1988. The author gained some hematologic findings(hemoglobin, hematocrit, RBC, WBC, MCV, MCHC, platelet count, ESR, RDW) from auto-analysis method by coulter counter S plus IV, and compared the type of anemia by MCV and RDW. In the pilot study for estimating the prevalence of anemia according to the type of b, the prevalence rate was higher in organic solvent workers than in public officials as 10.9% and 4.1% respectively. There were statistical significance in the value of hemoglobin, hematocrit, MCV, MCHC, platelet count, ESR, RDW between the two study groups with more severe anemic tendency in organic solvent workers. The type of anemia in organic solvent workers was microcytic and anisocytic with the mean value of $68.28{\pm}8.3fL$ of MCV and $19.1{\pm}4.0%$ of RDW.

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Lidocaine이 잉어(Cyprinus carpio)의 혈액성상에 미치는 영향 (Effects of lidocaine on haematology and blood chemistry in the carp(Cyprinus carpio))

  • 정준기;정순윤;이태웅;최동림
    • 한국어병학회지
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    • 제7권1호
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    • pp.53-62
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    • 1994
  • 본 실험에서는 잉어의(Cyprinus carpio)의 혈액지수 및 혈장화학성분에 대한 lidocaine의 효과를 조사하였다. Lidocaine은 저농도군(100 및 200ppm)에서는 조사된 모든 혈액지수 및 혈장화학성분에 대하여 대조군에 비해 유의성 있는 효과를 나타내지 않았으나 고농도군(300 및 400 ppm)에서는 혈색소농도(hemoglobin concentration), 총단백량(total protein value) 그리고 GOT 및 GPT의 활성에 대해서는 유의성 있는 변화를 일으키지 않았고, 적혈구수(RBC count), 헤마토크리트(hematocrit), 혈중포도당농도 및 LDH활성은 대조군에 비해 현저히 증가시켰다. 그리고 이들 값의 증가는 적어도 60분 이상 유지되었다. 이상의 결과들을 종합하여 보면 lidocaine은 일반적으로 어류에 대하여 독작용은 나타내지 않으나 고농도에서는 어류에 대하여 마취효과 뿐만 아니라 그 자체가 스트레스 인자로 작용하여 어류체내에 여러가지 생리적 변화를 일으킨다고 사료된다.

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Replication Association Study between RBC Indices and Genetic Variants in Korean Population

  • Lee, Sang In;Park, Sangjung;Jin, Hyun-Seok
    • 대한의생명과학회지
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    • 제25권2호
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    • pp.190-195
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    • 2019
  • Hemoglobin (Hb) concentrations and hematocrit (Hct) values can be changed by factors such as erythrocyte production, destruction, and bleeding. In addition, variants in the protein expression involved in the amount of red blood cells that determine Hb metabolism or Hct value can increase susceptibility to complex blood diseases. Previous studies have reported significant single nucleotide polymorphisms (SNPs) by applying a genome-wide association study (GWAS) on Hb levels and Hct values in European population. In this study, we confirmed whether the significant SNPs are replicated in Koreans. In previous studies, 26 and 18 SNPs with a significant correlation Hb and Hct were identified in Korean genotype data, and 21 and 12 SNPs were selected, respectively. The SNPs of PRKCE (rs10495928), TMPRSS6 (rs2235321, rs5756505, rs855791) were significantly associated with Hb (P<0.05). In the association analysis of Hct, the SNPs of HBS1L (rs6920211, rs9389268, rs9483788), PRKCE (rs4953318), SCGN (rs9348689) and TMPRSS6 (rs2413450) genes showed a significant correlation (P<0.05). Replicated SNPs and not replicated SNPs showed the difference of genetic distance calculated by Fst. The replicated SNPs with a significant correlation showed similar allele frequencies, whereas the not replicated SNPs showed a large difference in allele frequency. All replicated SNPs with significant correlations had Fst values less than 0.05, indicating that the genetic distance between the groups was close. On the other hand, the not replicated SNPs showed that the Fst value was 0.05 or more and the genetic distance was relatively large.

스트레스와 비스트레스 조건에서 Clone 은어의 혈액성상에 대한 유전율 추정 (Heritability Estimation of Haematological Traits in Clonal Lines of Ayu, Plecoglossus altivelis, under Stressed and Hon-Stressed Conditions)

  • Han, Hyon-Sob
    • 한국발생생물학회지:발생과생식
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    • 제4권2호
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    • pp.147-152
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    • 2000
  • 본 연구는 은어의 clone을 생산하여 생리적 형질에 대한 유전적 특성을 조사하고 또 clone의 유전율을 추정했다. 성숙한 완전 동형접합형 자성발생 2배체(난할형 2배체)에서 채란한 후 자성발생을 반복하여 4계통의 clone을 생산하였으며 부화 전부터 같은 수조에 혼합하여 사육하였다. 10개월간 사육한 후 사육수조의 수심을 낮추었을 때의 스트레스가 clone의 혈액성상과 유전율에 미치는 영향에 대해서 조사했다. 생산된 각 계통의 clone은 실험에 사용하기 전에 DNA fingerprint법을 이용하여 유전적 균질성을 확인한 후 스트레스어와 비스트레스어의 hematocrit 값, hemoglobin량, 적혈구수 및 평균적 혈구용적 (MCV)을 측정하였다. 비스트레스어에서 측정한 hematocrit값과 MCV에서 각 clone간에 유의차가 인정되었다. 실험어는 모두 같은 환경에서 사육하였기 때문에 이러한 유의차는 주로 각 clone의 유전적인 차이를 반영한 것으로 생각한다. 스트레스 반응률 (SRR)은 기대값보다 낮았으며 유전율 (h$^2$)은 비스트레스 group에서는 평균 0.238로 높았으나 스트레스 group에서는 매우 낮거나 거의 0에 가까웠다. 따라서 혼합 사육한 clone 계통은 생리적 형질의 유전적 특성을 조사하는데 좋은 수단이 된다. 또한 선발 육종의 선발형질로서도 유용하다.

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Polytetrafluoethylene 인조혈관을 이용한 좌쇄골하동맥-좌폐동맥단락술에 관한 연구 (A study on left subclavian artery-left pulmonary artery shunt operation using polytetrafluoroethylene [PTFE])

  • 조중구;김근호
    • Journal of Chest Surgery
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    • 제16권1호
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    • pp.91-96
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    • 1983
  • A study was carried out to observe the clinical progress and results after modified Blalock-Taussing shunts on II patients with cyanotic complex heart diseases unsuitable for corrective surgery. The operation was performed by interposing a vascular prosthesis [PTEE] between the left subclavian artery and the left pulmonary artery. Vascular prostheses larger than the diameter of left subclavian artery were selected. The results were as follows: 1. The postoperative courses in 10 patients were uneventful without any complications. One patient died of low cardiac output syndrome immediate postoperatively. 2. The average value of RBC count before operations was 751.2291.68 [xl00]/cubic mm. It was decreased to 588.11 90.45 [xl 0,000]/cubic mm. After the operation. 3. The average value of Hemoglobin before operations was 20.07 3.01 mg/dl. The value was decreased to 15.361.68mg/dl after the operation. 4. The value of Hematocrit before operations was 62.878.89%. The value was decreased to 49.6 5.84% 5. Patency after the shunt operations using PTFE was good for maximal 16 months follow-up period. 6. The physiological impairment like anoxic spells, degree of cyanosis and other clinical symptoms were markedly improved after the shunt operations. Although a longer follow-up seems to be necessary to assess the validity of these shunts, the early results were encouraging.

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한국 재래 염소의 성장에 따르는 혈액상의 변동 (Blood Picture of the Korean Native Goats from Birth to Maturity)

  • 최희인
    • 대한수의학회지
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    • 제14권1호
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    • pp.115-133
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    • 1974
  • Although considerable research has been done on the changes associated with age in the blood picture of domestic and laboratory animals, little work has been made of the changes occurring at different age in the blood picture of goats. And a comprehensive survey of the bood picture of Korean native goats has not been made. The object of the present investigation was to suggest standards for the blood picture of Korean native goats at frequent intervals from birth to maturity. The goats were kept under average farming conditions in this country. Observations were made at the following ages: at birth; 2,4 and 7 days; 2, 3, 4, 5, 6, 7, 8 and 9 weeks; 2.5, 3,6 and 12 months. Blood samples were drawn from the jugular vein. It was taken between 8 and 9 a.m. except those for the at-birth period. Erythrocyte and leukocyte enumerations and, determinations of hemoglobin in blood and hematocrit value were made in the usual manner. Reticulocytes were enumerated per 1,000 erythrocytes in blood smears stained with briIliant cresyl blue and counterstained with Wright's stain. Erythrocytes counts declined from $8.7{\times}10^8/mm^3$ at birth to a low of 7.0 at 4 days of age. These values increased to 11.5 at 5 weeks and reached a maximum of 14.0 at 3 months of age; it then fell to 11.5 at 12 months of age. Concentrations of hemoglobin in blood and hematocrit values were not related to the changes of erythrocyte counts. The values at birth were higher than at any other period during the first year of life. These fell from highs of 12.3 g/100 ml and 38.0 ml/100 ml to lows of 9.2 and 29 at 4 weeks for concentration of hemoglobin in blood and hematocrit value, respectively. There was a common pattern for the hematocrit value and hemoglobin in blood which showed three phases-a fall during the first month, a rise to the third month, and a fall to the mature level at 12 months of age. Mean corpuscular volume and mean corpuscular hemoglobin showed a common pattern. The values were $44.2{\mu}m^3$ and 14.2 pg at birth and fell, at first slowly and then rapidly, to reach adult levels of 24.1 and 7.9 at 6 weeks of age for mean corpuscular volume and mean corpuscular hemoglobin, respectively. Mean corpuscular hemoglobin concentration was little affected by age. Reticulocyte was observed from birth to 4 weeks of age. Percentage of reticulocyte decreased from 0.85% at birth to 0.06% at 4 weeks of age. Total leucocyte counts increased from $5.64{\times}10^3/mm^3$ at birth to a maximum of 13.4 at 3 months; it then fell to 11.5 at 12 months of age. In differential counts myelocyte, juvenile and band form decreased with advancing age. No myelocyte and juvenile were seen after the age of 7 and 9 weeks, respectively, and band forms were rare after the age of 3 months. Percentage of mature neutrophil showed a quick decline from 52.5% at birth to reach a minimum level (34.5%) at 3 months of age; it then rose to 38% at 12 months of age. Percentage of lymphocyte increased from 39.2% at birth to maximum of 59% at 3 month of age; it then fell to 54.9% at 12 months of age. Percentage of monocyte was not affected with advance of age. Percentage of eosinophil and basophil were increased with advance of age to reach a maximum at 2 to 3 month of age. It then fell to adult level at 12 month of age.

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팔진탕이 비소 중독된 흰쥐의 혈액에 미치는 영향 (Effects of Paljin-Tang on the Blood of Arsenic-poisoned Rats)

  • 서은실;김훈;임종필
    • 생약학회지
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    • 제29권4호
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    • pp.379-383
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    • 1998
  • Sodium arsenate and Paljin-Tang extract (PJT), a herbal restorative were treated p.o. 20 mg/kg and 500 mg/kg, respectively, and concurrently to rats, and examined the biochemical parameters in blood. The values of white blood cell (WBC), red blood cell (RBC), hemoglobin (Hgb) and hematocrit (Hct) in each group did not show significant variance. The value of aspartate aminotrasferase(AST) of arsenic-treated group was increased for 2 weeks significantly while that of the group of concurrent administration with PJT became low significantly compared with arsenic-treated group and the value of alkaline phosphatase (ALP) of arsenic-treated group was decreased while that of the group of concurrent administration with PJT was increased significantly compared with arsenic-treated group. The value of glucose (Glu) was increased and those of lactic dehydrogenase (LDH), blood urea nitrogen (BUN) and triglyceride (TG) were decreased at first but increased later while the group of concurrent administration with PJT showed significant recovery from the toxicity of arsenic.

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강원도 홍천군 농촌유아원 어린이의 영양실태조사 (Nutrition Survey of Young Children of Day Care Centers in the Rural Area of Hongcheon-gun, Kangwon Province)

  • 윤혜영
    • 대한가정학회지
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    • 제27권2호
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    • pp.53-63
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    • 1989
  • A untrition survey of early childhood was undertaken among 102 rural young children, aged 3 to 6, attending three day care centers of Hongcheon-gun, Kangwon province, in July of 1987, to investigate dietary and nutritional status. The results were obtained as follows: Mean values of height and arm circumference ranged from 96 to 97% of the KSRI's standards. However, mean value of weight met 91% of that standard. Mean value of hematocrit was 37.3±3.5%. According to the criterion established by the WHO, 3% of the subjects were proven to be anemic. Mean value of urinary urea nitrogen/creatinine ratio was 13.8±7.6; the higher the age lower the ratio was shown. Intake of energy and nutrients ranged from 63 to 88% of the RDAs. Carbohydrate provided 68% of total energy intake; protein accounted for 14%; fat provided 18%. Energy intake was divided among breakfast, lunch supper and snacks in a percentage ratio of 21:35:26:18. The survey clarified that the day care feeding largely supplemented the inadequate dietary intakes of these young children at home. Family factors, anthropometric measurements, biochemical results were positively correlated with nutrient intakes. Authors with this study can be contributed, as a reference, to develop the community nutrition programs as well as improving the quality of day care feeding.

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