• Asian-Australasian Journal of Animal Sciences
• /
• v.23 no.4
• /
• pp.501-507
• /
• 2010

Three hundred chicks were randomly assigned among four treatments to evaluate the effect of an organic selenium supplement at various levels of dietary protein. Two levels of supplemental selenium (0 and 0.3 mg/kg) from zinc-L-selenomethionine were tested at two levels of dietary protein (normal and reduced) in a completely randomized design with $2{\times}2$ factorial layout. The experiment lasted up to 49 d of age during which all birds were exposed to $31{\pm}1^{\circ}C$. The effects of selenium or its interaction with CP on growth performance and carcass characteristics were not significant. However, feeding the reduced-CP diet decreased weight gain in the starting period and increased liver and abdominal fat weights relative to body weight. Ferric reducing ability of plasma (FRAP) was not significantly affected by dietary CP and Se or their interaction though FRAP values were numerically higher in the Se-supplemented group. Dietary CP content did not affect the activity of plasma glutathione peroxidase (GSHPx), though Se significantly elevated plasma GSHPx activity. The interaction of CP and Se was not significant for FRAP and plasma GSHPx activity.

• Parasites, Hosts and Diseases
• /
• v.53 no.6
• /
• pp.665-673
• /
• 2015

After invasion of red blood cells, malaria matures within the cell by degrading hemoglobin avidly. For enormous protein breakdown in trophozoite stage, many efficient and ordered proteolysis networks have been postulated and exploited. In this study, a potential interaction of a 60-kDa Plasmodium falciparum (Pf)-heat shock protein (Hsp60) and Pf-calpain, a cysteine protease, was explored. Pf-infected RBC was isolated and the endogenous Pf-Hsp60 and Pf-calpain were determined by western blot analysis and similar antigenicity of GroEL and Pf-Hsp60 was determined with anti-Pf-Hsp60. Potential interaction of Pf-calpain and Pf-Hsp60 was determined by immunoprecipitation and immunofluorescence assay. Mizoribine, a well-known inhibitor of Hsp60, attenuated both Pf-calpain enzyme activity as well as P. falciparum growth. The presented data suggest that the Pf-Hsp60 may function on Pf-calpain in a part of networks during malaria growth.

• Proceeding of EDISON Challenge
• /
• 2016.03a
• /
• pp.90-95
• /
• 2016

Heat Shock 70kDa Protein 1-Like(HSPA1L)는 Heat-shock protein70(HSP70) family에 속하는 chaperone protein으로 polypeptide folding, assembly, protein degradation 등 다양한 biological processes에 관여하고 있다. HSPA1L은 human methyltransferase-like protein 21A(METTL21A)에 의해 lysine residue에 methylation이 일어나게 되는데, 암세포에서 일반적인 HSPA1L은 주로 세포질에서 발견되는 반면 methylated HSPA1L의 경우 주로 핵에서 발견이 됨으로써 HSPA1L methylation이 암 세포 성장에 중요할 역할을 할 것이라 추측되며 anti-cancer drug target으로 주목 받고 있다. 하지만 현재 HSPA1L의 구조가 부분적으로만 밝혀져 있어 HSPA1L와 METTL21A가 어떤 residue들이 interaction 하여 binding을 하는지에 대해서 아직 밝혀 지지 않았다. 이로 인해 anti-cancer drug target으로서의 연구에 제한이 있다. 이번 연구에서는 homology modeling(Galaxy-TBM, Galaxy-refine)을 통해 HSPA1L 전체 구조를 밝혀 낸 후, HSPA1L 와 METTL21A를 protein-protein docking을 통해 binding pose 예측을 하였다. 이러한 binding pose를 protein interaction analysis하여 HSPA1L과 METTL21A binding에 관여하는 중요 residue들을 밝혀 냈다. 이러한 structural information은 methylated HSPA1L와 암 세포 성장간의 연관성, 더 나아가 anti-cancer drug 개발로 까지도 이어 질 수 있을 것이라 생각한다.

• Nuclear Engineering and Technology
• /
• v.17 no.1
• /
• pp.8-15
• /
• 1985

A model for thermal interactions of debris/water with gas flow from within and below debris bed was presented for severe accident analysis in LWR. The consumption of steam, production of hydrogen in the debris bed, generation of gases from below debris bed and generation of chemical heat are included in the conservation equations. The model has been incorporated in the MARCH code to estimate the gas production due to both metal/oxidation and hot debris/concrete interaction. The results indicate that the hydrogen source can potentially give a significant impact on the containment pressure transient and the conductive heat loss to concrete and the convective gas cooling in the debris bed have a small effect on the debris bed coolability. However, the reheating and melting of the debris particles could be delayed by the interaction of debris with concrete.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.32 no.5
• /
• pp.399-402
• /
• 2019

The electromagnetic properties of heavy fermion $CePd_2Si_2$ are investigated using density functional theory using the local density approximation (LDA) and LDA+U methods. The Ce f-bands are located near the Fermi energy and hybridized with the Pd-3d states. This hybridization plays an important role in generating the physical characteristics of this compound. The magnetic moment of $CePd_2Si_2$ calculated within the LDA scheme does not match with the experimental result because of the strong correlation interaction between the f orbitals. The calculation shows that the specific heat coefficient underestimates the experimental value by a factor of 5.98. This discrepancy is attributed to the formation of quasiparticles. The exchange interaction between the local f electrons and the conduction d electrons is the reason for the formation of quasiparticles. The exchange interaction is significant in $CePd_2Si_2$, which makes the quasiparticle mass increase. This enhances the specific heat coefficient.

• Atmosphere
• /
• v.25 no.3
• /
• pp.543-557
• /
• 2015

The present study examines an interaction between the eddy and mean meridional circulation (MMC) comparing the results in three reanalysis data sets including ERA-Interim, NCEP2, and JRA-55 during the boreal winter in the Northern Hemisphere. It is noteworthy that the JRA-55 tends to produce stronger MMC compared to those of others, which is mainly due to the weak eddy flux. ERA-Interim represents the ensemble averages of MMC. The MMC-eddy interaction equation was adopted to investigate the scale interaction of the eddy momentum flux (EMF), eddy heat flux (EHF), and diabatic heating (DHT) with MMC. The EMF (EHF) shows a significant correlation coefficient with streamfunction under (above) 200 hPa-level. The perturbation (time mean) part of each eddy is dominant compared to another part in the EMF (EHF). The DHT is strongly interacted with streamfunction in the region between the equator and extra-tropical latitude over whole vertical column. Thus, the dominant term in each significant region modulates interannual variability of MMC. The inverse (proportional) relationship between MMC and pressure (meridional) derivative of the momentum (heat) divergence contributions is well represented in the three reanalysis data sets. The region modulated interannual variability of MMC by both EMF and DHT (EHF) is similar in ERA-Interim and JRA-55 (ERA-Interim and NCEP2). JRA-55 shows a lack of significant region of EHF due to the high resolution, compared to other data sets.

• Proceedings of the KSME Conference
• /
• 2008.11a
• /
• pp.729-734
• /
• 2008

A thermal stratification may occur in the horizontal parts of the surge line during operating transients of the pressurizer, which produces relatively high fatigue usage factor. Heat-up transient is the most severe case among the transient conditions. In this study, to study the relationship between the magnitude of thermal stratification and the length of vertical part of the surge line, some parametric fluid-structure interaction (FSI) analyses with different length variables of the vertical part of the surge line were performed for plant heat-up transient condition by using 3-dimensional numerical analysis. The conservativeness of the traditional finite element model for thermal stratification analysis based on the conservative assumption in the surge line was also discussed by comparison of the results of 3-dimensional transient FSI analysis of this study. Stresses calculated with 3-dimensional transient model were considerably reduced comparing with the traditional analysis.

• Asian-Australasian Journal of Animal Sciences
• /
• v.13 no.12
• /
• pp.1750-1757
• /
• 2000

A total of 864 broiler chicks were used at Kansas State University and the University of Nebraska to determine the effects of heat treatment of two soybean genotypes on the growth performance. The soybeans were Williams 82 variety with (+K) and without (-K) gene expression for the Kunitz trypsin inhibitor. Heat treatment (autoclaving at $121^{\circ}C$ and $1.1kg/cm^2$) was applied for 0, 3, 6, 12, 18, and 24 min, resulting in a $2{\times}6$ factorial arrangement of treatments. Station and station treatment effects occurred, indicating that response in nutritional value of the soybean genotypes to heat treatment varied from year to year and location to location. However, the interactions were in magnitude of response rather than direction of response, with greater reductions in trypsin inhibitor concentrations for the soybeans heat processed at the Nebraska location. Pooled data indicated that -K supported greater (p<0.001) ADG, ADFI and gain/feed than the +K genotype. As the length of heat treatment increased, the ADG, ADFI, and the gain/feed ratio increased for chicks fed both soybean genotypes (p<0.0001). However, heating the -K soybeans resulted in a greater response in ADG, ADFI, and gain/feed than heating the +K soybeans (genotype heat treatment interaction, p<0.001). Pancreatic weights (mg pancreas/g of BW) of chicks fed -K soybeans were reduced compared to those from chicks fed +K (p<0.001). Increasing heat treatment decreased pancreas weights in chicks fed both soybean genotypes (p<0.001). Chicks fed heated soybeans in the Nebraska experiment had lower pancreatic weights than chicks fed heated soybeans in the Kansas experiment (station heat treatment interaction, p<0.0001). Chick growth performance was improved and pancreatic weights decreased by feeding raw -K soybeans versus raw +K soybeans, and by increasing heat treatment of both soybean genotypes. However, the response to heat treatment was not independent of genotype. Both +K and -K soybeans heated for 24 min supported similar ADG, ADFI, gain/feed, and pancreas weights, although chicks fed raw +K soybeans had lower growth performance than chicks fed -K soybeans. In conclusion, raw -K soybeans supported greater growth performance in broiler chicks than raw +K soybeans, although this advantage was lost when both soybean genotypes were heated for 24 min. Heat treatment of +K soybeans supported similar growth performance to heated -K soybeans, even though +K soybeans supported lower rates and efficiencies of gain than -K soybeans when fed raw.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.15 no.3
• /
• pp.10-17
• /
• 2007

Design of experiments (DOE) technique has been used to design an exhaust heat exchanger to reduce the exhaust gas temperature under high load conditions in a spark-ignition engine. The DOE evaluates the influence and the interaction of a selected eight design parameters of the heat exchanger affecting the cooling performance of the exhaust gas through a limited number of experiments. The heat exchanger was installed between the exhaust manifold and the inlet of the close-coupled catalytic converter (CCC) to reduce thermal aging. To maximize the heat transfer between exhaust gas and coolant, fins were implemented at the inner surface of the heat exchanger. The design parameters consist of the fin geometry (length, thickness, arrangement, and number of fin), coolant direction, heat exchanger wall thickness, and the length of the heat exchanger. The acceptable range of each design parameter is discussed by analyzing the DOE results.

• Journal of KSNVE
• /
• v.5 no.1
• /
• pp.95-106
• /
• 1995

Flow-induced vibration in heat exchanger (or fuel rod) in nuclar power plant can cause dynamic interactions between tubes and tube supports resulting in fretting-wear. To increase the reliability and design life of heat exchanger components, design criteria that establish acceptable limits of vibration and minimize fretting wear are necessary. The fretting-wear rate is dependent upon material combination, contact configuration, environmental conditions and tube-to tube support dynamic interaction. It is demostrated that the fretting -wear rate correlates well with tube-to-support contact force or work rate. The tube-to-support dynamic interaction, which consists of dynamic contact forces and tube motion, is used to relate single-span wear data to real heat exchanger configurations consisting of multi-span tube bundles. This paper describes the test facility to measure tube-to-support dynamic impact force and reports its dynamic characteristics through the four impact tests - a force transduces independent and external impact tests, central ring inside impact test and additional cylinder impact test. Through the tests the impact parameter change dependent upon the material difference of impacting ball is studied, and the impact parameters of Force Transducer Assembly components are measured. And also the dynamic behavior of Force Transducer Assembly is analyzed. The force measurement technique herein is shown to provide a reasonable measure of dynamic contact forces.