• 비파괴검사학회지
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• 제18권1호
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• pp.10-16
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• 1998

사용중인 터빈 로터에서 균열이 발견된다면 그 안전성을 평가하기 위해서는 제조 당시의 재료물성 데이터가 아닌 열화된 재료의 물성 및 인성을 사용해야 한다. 본 연구에서는 시험재료로 터빈 로터재로 널리 사용되고 있는 1Cr-1Mo-0.25V강을 사용하였다. 로터강의 경우 발전소에서 실제 사용된 열화재를 종류별로 입수하는 것은 매우 어렵기 때문에 실제로 열화된 재료의 미세조직과 유사한 미세조직을 갖는 시료를 얻기 위해서 실제 사용온도보다 높은 $630^{\circ}C$에서 등온 열화처리하여 열화도가 다른 7종류의 시료를 만들었다. 열화도와 재료의 인성을 비파괴적으로 평가하기 위하여 직류 전위차법을 이용하였으며, 상온에서 전기비저항을 측정하였다. 열화도의 증가에 따라 전기비저항과 재료인성은 일정시간까지는 감소하는 것으로 나타났으며, 전기비저항과 인성과의 상관관계를 만들었다. 따라서 이를 이용하여 비파괴적으로 재료인성을 평가할 수 있는 기초를 마련하였다.

• 약학회지
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• 제51권4호
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• pp.264-269
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• 2007

Alzheimer’s disease (AD) is characterized pathologically by the presence of intracellular neurofibrillary tangles and deposition of ${\beta}-amyloid $ (A ${\beta}$) peptides, which are generated by processing of amyloid precursor protein (APP). It is urgent to develop effective therapies for the treatment of AD, since our society rapidly accelerate aging. A${\beta}$ peptides have been believed to be neurotoxic and now are also considered to have effects on the mechanism of memory formation. In this study, effects of radicicol on the metabolism of APP were analyzed. Radicicol inhibited the secretion of A${\beta}$ from the Neuro2a cell line (APPswe cell) expressing APPswe. Beta-site APP cleaving enzyme (BACE) fluorescence resonance energy transfer (FRET) assay revealed that it inhibited BACE activity in a dose dependently manner. Immunoblotting study showed that it inhibited intracellular heat shock protein (HSP)90 and it increased the secretion of HSP90 from the APPswe cells. We suggest that radicicol inhibits APP metabolism and Ap generation by the means of HSP90 inhibitory mechanism and partially BACE inhibitory mechanism. This is the first report that radicicol inhibits the secretion of A${\beta}$ peptides from neuroblastoma cells.

• 대한치과보철학회지
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• 제22권1호
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• pp.95-108
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• 1984

Even though the tarnishing and corrosion problems characteristic with dental silver-palladium alloy are not yet fully solved, it is recently widely used because of its low cost. However the effects of major alloying elements on the various properties of this system are not fully understood. The object of this research is to clarify the effects of In and Zn additives on the corrosion and tarnishing resistances and precipitation hardening behavior of this sytem, using electrodynamic polarization, immersion, and Vicker's microhardness test and X-ray diffraction and electron probe micro analysis methods. The obtained results were as follows: I. As indium content is increased, both the corrosion resistance in Cl-solution and microhardness are also increased while the tarnishing resistance is decreased. 2. As Zinc content is increased, the corrosion resistance is decreased, but tarnishing resistance is increased 3. At 70Ag-25Pd-2.5Zn-2.5In composition, the precipitation harding behavior was mot significant. The optimum aging temperature was $450^{\circ}C$ and the time was 2 hrs. The resulting specimen of this work carried 180VHN. 4. Under the heat treatment, the changes in the mechanical property are due to the changes in the shape and composition of dendrite matrix, namely, it is because of the precipitation hardening behavior which has been proved by electron probe micro analysis and optical microscopic finding.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2002년도 학술.기술논문발표회
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• pp.43-48
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• 2002

Since the basement building like the communication hole and etc. is built under the ground where it is pressed by the water, the leakage happens due to the dried-shrinking crack, the sinking crack, the creation of the work-joint of the building and etc. caused by the character of the material and construction way of the reinforced concrete building. Especially, a lot of repair for the leakage cannot help but being taken in temporary way without any noticeable countermeasure. Therefore, this kind of repair is socially criticized many times that this is defective construction even if this costs a lot. The fundamental reason of the above mentioned symptoms can be found in the creation of the work-joint caused by the character of the concrete building, the limitation of the physical performance of the existing water-proof and repair material, the limitation of the construction, the limitation of the physical sustaining performance of the concrete building, the limitation(heat-injury, deterioration) of the constancy of the durability caused by aging and etc. Therefore, in this study, we would like to present the better understanding on the water-proof seal relating to the application at the spot and its test evaluation related data since the necessity of the establishment of the quality control standard and the performance testing way on the relevant water-proof seal is rising a lot to regulate the water-proof technology and the leakage repair technology in accordance with the growth of the demand on the facility.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 추계학술발표회
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• pp.31-45
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• 2011

The amyloid ${\beta}$-peptide ($A{\beta}$), which originates from the proteolytic cleavage of amyloid precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease (AD). Mounting evidence indicates that different species of $A{\beta}$, such as $A{\beta}$ oligomers and fibrils, may contribute to AD pathogenesis via distinct mechanisms at different stages of the disease. Importantly, elevation and accumulation of soluble $A{\beta}$ oligomers closely correlate with cognitive decline and/or disease progression in animal models of AD. In agreement with these studies, oligomers of $A{\beta}$ have been shown to directly affect synaptic plasticity, a neuronal process that is known to be essential for memory formation. Our previous studies showed that $A{\beta}$ induces the breakdown of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a phospholipid that regulates key aspects of neuronal function. PI(4,5)P2 breakdown was found to be a key step toward synaptic and memory dysfunction in a mouse model of AD. To this end, we seek to identify small molecules that could elevate the levels of PI(4,5)P2 and subsequently block $A{\beta}$ oligomer-induced breakdown of PI(4,5)P2 and synaptic dysfunction.. We found that (20S)Rg3, an active triterpene glycoside from heat-processed ginseng, serves as an agonist for phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), which is a lipid kinase that mediates a rate-limiting step in PI(4,5)P2 synthesis. Consequently, (20S)Rg3 stimulates PI(4,5)P2 synthesis by directly stimulating the activity of PI4KIIalpha. Interestingly, treatment of a mouse model of AD with (20S)Rg3 leads to reversal of memory deficits. Our data suggest that the PI(4,5)P2-promoting effects of (20S)Rg3 may help mitigate the cognitive symptoms associated with AD.

• 대한기계학회논문집A
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• 제38권10호
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• pp.1133-1137
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• 2014

초음파 비선형 파라미터 ${\beta}$는 재료의 미세한 변질을 평가하는데 효과적인 인자로 알려져있다. 그런데 지금까지 대부분의 연구는 접촉식 방법을 이용하여 측정하는 연구가 수행되어왔다. 그러나, 접촉식 방법은 탐촉자와 시편사이의 접촉상태가 측정결과에 큰 영향을 미치기 때문에 측정의 재현성을 보장하기 위해 탐촉자의 접촉상태를 일정하게 유지시키기 위한 부수적인 장치가 필요하다. 이러한 불편함을 해소할 목적으로 본 연구에서는 비접촉식 기법을 도입하였다. 다만 초음파의 송신은 접촉식으로 하고 수신만 비접촉식을 적용함으로써 동일한 조건에서 접촉식으로 수신한 경우와 비접촉식으로 수신한 경우를 비교하고자 하였다. 시편은 시효 처리된 알루미늄 합금을 사용하였고, 두 방식의 측정결과 비선형 파라미터 ${\beta}$의 변화는 유사하게 나타났다. 이로부터 초음파 비선형 특성의 변화를 비접촉식 수신방법으로 용이하게 평가할 수 있음을 확인하였다.

• Journal of Chest Surgery
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• 제50권3호
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• pp.153-162
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• 2017

Background: The mesenchymal-epithelial transition factor (MET) receptor can be overexpressed in solid tumors, including small cell lung cancer (SCLC). However, the molecular mechanism regulating MET stability and turnover in SCLC remains undefined. One potential mechanism of MET regulation involves the C-terminus of Hsp70-interacting protein (CHIP), which targets heat shock protein 90-interacting proteins for ubiquitination and proteasomal degradation. In the present study, we investigated the functional effects of CHIP expression on MET regulation and the control of SCLC cell apoptosis and invasion. Methods: To evaluate the expression of CHIP and c-Met, which is a protein that in humans is encoded by the MET gene (the MET proto-oncogene), we examined the expression pattern of c-Met and CHIP in SCLC cell lines by western blotting. To investigate whether CHIP overexpression reduced cell proliferation and invasive activity in SCLC cell lines, we transfected cells with CHIP and performed a cell viability assay and cellular apoptosis assays. Results: We found an inverse relationship between the expression of CHIP and MET in SCLC cell lines (n=5). CHIP destabilized the endogenous MET receptor in SCLC cell lines, indicating an essential role for CHIP in the regulation of MET degradation. In addition, CHIP inhibited MET-dependent pathways, and invasion, cell growth, and apoptosis were reduced by CHIP overexpression in SCLC cell lines. Conclusion: C HIP is capable of regulating SCLC cell apoptosis and invasion by inhibiting MET-mediated cytoskeletal and cell survival pathways in NCI-H69 cells. CHIP suppresses MET-dependent signaling, and regulates MET-mediated SCLC motility.

• 한국압력기기공학회 논문집
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• 제9권1호
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• pp.15-19
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• 2013

The auxiliary feedwater is an important to remove the heat from the reactor core when the main feedwater system is unavailable. In most initiating events in Probabilistic Safety Assessment(PSA), the operaton of this system is required to mitigate the accidents. For one of domestic nuclear power plants, a design change of a turbine-driven auxiliary feedwater pump(TD-AFWP), pipe, and valves in the auxiliary system is implemented due to the aging related deterioration by long time operation. This change includes the replacement of the TD-AFWP, the relocation of some valves for improving the system availability, a new cross-tie line, and the installation of manual valves for maintenance. The design modification affects the PSA because the system is critical to mitigate the accidents. In this paper, the safety effect of the change of the auxiliary feedwater system is assessed with regard to the PSA view point. The results demonstrate that this change can supply the auxiliary feedwater from the TD-AFWP in the accident with the motor-driven auxiliary feedwater pump(MD-AFWP) unavailable due to test or maintenance. In addition, the change of MOV's normal position from "close" to "open" can deliver the water to steam generator in the loss of offsite power(LOOP) event. Therefore, it is confirmed that the design change of the auxiliary feedwater system reduces the total core damage frequency(CDF).

• Applied Biological Chemistry
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• 제25권4호
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• pp.218-223
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• 1982

밤(품종, 은기) 전부의 성상, 이화학적 특성 및 전분 겔의 노화속도를 조사하였다. 전분의 입자는 장축 및 단축의 비가 1.4 : 1인 불규칙한 타원형으로서 크기는 $2.9{\sim}21.4{\mu}$(평균 $10\;{\mu}$)이었다. X-ray 회절도는 $2{\theta}$가 $5.6^{\circ},\;15.3^{\circ},\;17.2^{\circ},\;22.0^{\circ},\;23.8^{\circ}$에서 peak를 보였으며, B형에 속하였다. 전분의 아밀로스 함량은 22.7%, 물 결합 능력은 81.5%, 호화온도는 $55^{\circ}C$이었다. 전분의 swelling은 $55^{\circ}C$까지는 큰 변화가 없었고, 이후 급격히 증가하였으나 $65^{\circ}C$ 이후에는 그 변화가 완만하였다. 아밀로그라프에 의한 전분의 호화는 농도(5 및 6%)에 관계없이 비슷한 양상을 보였으며, 최고 점도는 나타나지 않았다. 밤 전분은 입자간의 결합강도가 강하며, 열 및 shear force에 의한 swollen granule의 저항성이 큰 특징을 보였다. 전분 겔(건물중으로 45%)의 노화 시간상수(속도 상수의 역수)는 $21^{\circ}C$에서 1.68일이었다.

• Journal of Pharmaceutical Investigation
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• 제37권4호
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• pp.243-247
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• 2007

Retinoids have many important and diverse functions and particularly, have been widely used as anti-aging agent and for the treatment of acne and psoriasis in cosmetics. However, retinoids have low stability against the air, light, water, oxygen and heat, thus, to stabilize the retinoids in formulations is very critical procedure. In this study, cubic liquid crystalline phase of monoolein was applied to stabilize the retinylpalmitate (RP) and to enhance the transdermal permeation. Cubic liquid crystalline phase significantly enhanced the stability of RP. After 15 days, the content of RP in the cubic formulation was 94.7% while the content of RP in ethanol solution was below 0.5% at room temperature. Although BHT containing crystalline phase showed the slightly increased stability of RP, there were no significant differences in RP stability between with or without antioxidants (ascorbic acid, ${\alpha}$-tocopherol, BHT, BHA) at $40^{\circ}C$. The skin retention of RP in crystalline formulations was approximately $5.3{\sim}6.4$ times greater than that of o/w cream formulation. Incorporation of RP into cubic liquid crystalline phase of monoolein effectively stabilized the RP and worked as excellent topical vehicle for RP. Liquid crystalline phase is considered to be suitable formulation for RP for topical delivery system as a stabilizer and permeation enhancing agent.