• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.6
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• pp.1139-1143
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• 2007

For the possible application of monitoring or diagnosing heart sounds in an ubiquitous healthcare environment. a small and light electro-stethoscope that can be attached in human body should be exploited. With this aim, this study proposes a new style of electro-stethoscope device that is composed of four hardware modules in wearable style. For this ambulatory heart sound collecting device, the several tests must be performed to check portability and material capability for collecting heart sounds. It turned out to be that the multi-channel electro-stethoscope can detect heart sound signals well even if it is not pinpointed in the accurate stethoscope point on a heart. Consequently, our ambulatory electro-stethoscope hardware system can be applied to monitor or diagnose abnormal heart sounds in the ubiquitous healthcare system.

• Journal of Korean Academy of Nursing
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• v.37 no.1
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• pp.64-71
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• 2007

Purpose: The main purpose of this study was to develop a substantive theory on the life of patients with heart transplantation in the context of Korean society and culture. The question for the study was 'What is the life of patients like with a heart transplant?'. Method: A grounded theory method guided the data collection and analysis. Participants for this study were 12 adults who regularly visited a Cardiovascular ambulatorium in a medical center. The data was collected through an in-depth interview and analyses were performed simultaneously. Result: 'Developing a new life to live on borrowed time' was the core category in this study. It revealed two types of life, one is living in peace and another is thinking positive. Conclusion: This study provides a framework for the development of individualized nursing interventions to care for patients with Heart Transplantation. The findings may provide pointers for health professionals about ways to improve support for heart transplant recipients.

• Fashion & Textile Research Journal
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• v.19 no.6
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• pp.692-700
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• 2017

The number of elderly citizens has risen in Korea and resulted in an aging society. Correspondingly, the social interest in the aging population has escalated immensely; however, research or product development on the quality of life for seniors has shortcomings. Healthcare smart clothing is required to help the elderly with changes and weaknesses that follow aging; however, there is unfortunately insufficient amounts available. This study explores the feasibilities of smart clothing for seniors based on a universal design. Based on previous research, we analyzed the universal design theory, body shape characteristics and design requirements for seniors, and heart rate measurement method. The design is different according to body shape and body shape is different between sex, age, and body race; therefore, subjects were limited to 70-74 year old Korean males in this study. This study proposes a guideline for heart rate sensing clothing that satisfies the 'universal design' aspects as well as the functionality of heart sensing, senior's physical characteristics and needs. It has broadened the range of smart clothing, which was once limited to the younger generation and provided a foundation for the development of specialized smart clothing for seniors.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.3
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• pp.136-142
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• 2014

Distinct features in heart rate signals during the driver's wake and sleep states could provide an initiative for the development of a safe driving systems such as drowsiness detecting sensor in a smart wheel. We measured ECG from health subjects ($23.5{\pm}2.5$ in age) during the wake and drowsiness states. The proposed method is able to detect R waves and R-R interval calculation in the ECG even when the signal includes in abnormal signals. Heart rate variability(HRV) was investigated for the time domain and frequency domains. The STD HR(0.029), NN50(0.044) and VLF power(0.0018) of the RR interval series of the subjects were significantly different from those of the control group (p < 0.05). In conclusion, there are changes in heart rate from wake to drowsiness that are potentially to be detected. The results in our study could be useful for the development of drowsiness detection sensors for effective real-time monitoring.

• Journal of Life Science
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• v.25 no.11
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• pp.1230-1234
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• 2015

GATA binding protein 6 (GATA6) is a transcription factor that is expressed in the early blastocyst stage and controls the expression of important genes in the differentiation and development of the heart, pancreas, and intestine. This study confirmed the role of GATA6 in cell differentiation and organ development using mouse embryonic stem cells and zebrafish, respectively. First, the mouse embryonic stem cells were differentiated into pacemaker cardiomyocytes. An RT-PCR analysis revealed that the expression of the GATA6 gene was greatly increased from day 4 of differentiation. The expression of GATA6 was upregulated prior to increased expression of NK2 homeobox 5 (Nkx2.5) and myocyte enhancer factor 2C (MEF2C), which are critical transcription factors involved in regulating heart formation. To examine the role of GATA6 in development, GATA6 morpholino was microinjected into zebrafish embryos. Knockdown of GATA6 expression significantly decreased the heart size and heart rate in the zebrafish compared to a control. In addition, the brains were degenerated in the GATA6 morpholino-injected zebrafish. Acridine orange staining showed that knockdown of GATA6 expression increased apoptotic cells in the brain. Interestingly, knockdown of GATA6 expression decreased apoptotic cells in the early bud stage. This study points to the importance of the GATA6 gene in heart and brain development.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.2
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• pp.101-107
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• 2002

In the present study, the postnatal developmental changes in the expressional levels of cardiac sarcoplasmic reticulum (SR) $Ca^{2+}$ regulatory proteins, i.e. $Ca^{2+}-ATPase,$ phospholamban, and $Ca^{2+}$ release channel, were investigated. Both SR $Ca^{2+}-ATPase$ and phospholamban mRNA levels were about 35% of adult levels at birth and gradually increased to adult levels. Protein levels of both SR $Ca^{2+}-ATPase$ and phospholamban, which were measured by quantitative immunoblotting, were closely correlated with the mRNA levels. The initial rates of $Ca^{2+}$ uptake at birth were about 40% of adult rates and also increased gradually during the myocardial development. Consequently, the relative phospholamban/$Ca^{2+}-ATPase$ ratio was 1 in developmental hearts. $Ca^{2+}$ release channel (ryanodine receptor) mRNA was about $50{\sim}60%$ at birth and increased gradually to adult level throughout the postnatal rat heart development. $^3[H]ryanodine$ binding increased gradually during postnatal myocardial development, which was closely correlated with ryanodine mRNA expression levels during the development except the ryanodine mRNA level at birth. These findings indicate that cardiac SR $Ca^{2+}-ATPase,$ phospholamban, and $Ca^{2+}$ release channel are expressed coordinately, which may be necessary for intracellular $Ca^{2+}$ regulation during the rat heart development.

• Journal of Korean Academy of Nursing
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• v.29 no.6
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• pp.1445-1454
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• 1999

This study was designed to investigate the effects of a sensory stimulation program on the growth (weight, height, head circumference, and chest circumference), behavioral development, behavioral states, and the heart rate of the infants. A total of 23 infants of 2 weeks old were divided into sensory stimualtion group (11 infants) and control group (12 infants). The infants of sensory stimulation group had received sensory stimulation for 6 weeks. Sensory stimulation program was composed of tactile and kinesthetic stimulation. We assessed growth, behavioral state and heart rate every week and behavioral development every 2 weeks. The results were as follows: 1. Body weight in sensory stimulation group, from two weeks after the sensory stimulation program, was significantly increased more than control group, but there was no significant difference in height, head circumference, and chest circumference between the two groups. 2. Behavioral developmental score of sensory stimulation group was significantly higher than that of control group from two weeks after the sensory stimulation program. Developmental states of sensory stimulation group showed more 'high average developmental state' than the control group from 4 weeks after sensory stimulation program. 3. Behavioral states of sensory stimulation group after the sensory stimulation program, the 'sleeping state' was significantly increased more than control group. The 'awakening state' and the state of fuss or crying were significantly less than those of the control group. 4. The heart rate of the sensory stimulation group after the sensory stimulation was significantly lower than the control group. These results indicate that the sensory stimulation program decreases heart rate and improves the sleeping state to be effective on promoting the growth and development of the infants. In view of these experiments, we suggest sensory stimulation program might be considered as a nursing intervention for growth and development of the infants not only in clinical settings but also at homes and in the communities.

• Journal of Korean Medical classics
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• v.32 no.2
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• pp.147-163
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• 2019

Objectives : Morning Sickness, or Nausea and Vomiting of Pregnancy(NVP) is a frequently experienced phenomenon among pregnant women whose cause is still unknown. While the key trait of this symptom is its temporality, it is hardly considered in existing studies on the cause of NVP based on Korean Medical(KM) literature. We hope to remedy this. Methods : We looked for contents on fetal development in Korean Medical literature from the Siku Quanshu as well as other key literature of KM and examined the results together with contents on NVP to find any correlation. Results : We found that the beginning stages, namely the third month marked a significant change in the course of fetal development where the fetus's own Shen(神) is first developed by work of the mother's Heart(心). In other words, the third month is when the mother's and child's Shen first encounter. Conclusions : We hypothesized that NVP whose symptoms are closely linked to the functions of the Heart, is likely to be related to this event, which was supported by the common involvement of the Heart which was involved in both fetal development and NVP during the third month of pregnancy.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.51 no.4
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• pp.167-174
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• 2002

This study describes a fetal heart rate(FHR) estimation algorithm using phonogram. Using a phonogram amplifier, various fetal heart sounds are collected in a university hospital. The FHR estimation algorithms consists of a lowpass filter, decimation, envelop detection, pitch detection, and post-processing. The post-processing is the FHR decision procedure using all informations of fetal heart rates. Using the algorithm and other parameters of fetal heart sound, a fetal monitoring software was developed. This can display the original signals, the FFT spectra, FHR and its trajectory. Even though the fetal phonogram amplifier detects the fetal heart sounds well, the sound quality is not so good as the ultrasonography. In case of very week fetal heart sound, autocorrelation of it showed clear periodicity. But two main peaks in one period is an obstacle in pitch detection and peaks are not so vivid. The proposed FHR estimation algorithm showed very accurate and stable results. Since the developed software displays multiple parameters in real time and has convenient functions, it will be useful for the phonogram-style fetal monitoring device.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.58.1-58.1
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• 2005