• The Korean Journal of Nuclear Medicine Technology
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• v.20 no.1
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• pp.20-23
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• 2016

Purpose Because of heart movement, PET image of heart is very blur. So, PET scan gated with ECG is necessary to improve a spatial resolution of heart PET image. In this study, we will evaluate a image quality of both gated $^{13}N-ammonia$ PET scan and non-gated one. Materials and Methods Before start a heart PET, we attached a ECG electrode on patients (n = 5, $aged=54{\pm}17$). And we started a list mode PET scan that used by a mCT40 PET/CT (siemens, germany) during 10 minute, injected $^{13}N-ammonia$ ($378{\pm}50MBq$) to a patients at same time. By using this list mode data, we reconstructed both gated PET image and non-gated PET image. Then we analysed a profiles of those images, performed a blind test, and subtracted a gated image on non-gated image. Results FWHM of a gated image is improved about 23% and there is a differency count distribution at a subtracted image from non-gated image to a gated image. But in case of blind test, everybody select the gated image as a better quality among each images. Conclusion As a result, we can find that image quality will improve by using gated PET scan. In additional, we can calculate a EF valve, apply QGS, QPS of PET. Therefore, the gated PET scan help improving an accuracy, applying a more information for a diagnosis.

• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.124-132
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• 2005

Cardiac PET emerged as a powerful tool that allowed in vivo quantification of physiologic processes including myocardial perfusion and metabolism, as well as neuronal and receptor function for more than 25 years. Wow PET imaging has been playing an important role in the clinical evaluation of patients with known or suspected ischemic heart disease. This important clinical role is expected to grow with the availability of PET/CT scanner that allow a true integration of structure and function. The objective of this review is to provide an update on the current and future role of PET in clinical cardiology with a special eye on the great opportunities now offered by PET/CT.

• Journal of Fashion Business
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• v.8 no.3
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• pp.10-19
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• 2004

The purpose of this research is to reveal the antimicrobial activity of pet-dog clothes by investigating the bacteria resistance of 4 kinds of pet-dog clothes materials. 1. Investigation Results of Pet-Dog Clothes 64.7% of 150 survey participants, revealed they had pet-dog clothes. Hand laundering was 67.0%, while the laundering of both human and animal clothes was 9.2%. The greatest washing frequency was once every 2 weeks. So, the subjects didn't seem to think high of hygienic matters. Even though no if any relations were reported by 34.7% of the subjects, there were some experiences like sneezing or coughing (41.3%), slight itching (20.7%), and acute skin allergies. There were such hugging methods as heart to heart to the center (22.7%), face to face and around the mouth (16.7%), and below the heart with the dog's face outward (15.3%). Thus, hugging the dog near the pet-lover's face seems to be the cause of respiratory diseases including sneezes and coughs. 2. Results of the Anti-Bacteria Experiment of Pet-Dog Clothes Materials According to the analysis of the germs collected and cultured in this study to reveal the properness of pet-dog clothes materials, they were bacteria or bacilli in shapes. Spore growth was active in the order of such experimental materials as artificial leather > cotton > cotton/ nylon > polyester (finest thread). In terms of germ groups, the order was polyester(finest thread) > cotton > cotton/ nylon > artificial leather.

• Journal of Yeungnam Medical Science
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• v.38 no.2
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• pp.95-106
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• 2021

Infections involving the heart are becoming increasingly common, and a timely diagnosis of utmost importance, despite its challenges. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a recently introduced diagnostic tool in cardiology. This review focuses on the current evidence for the use of FDG PET/CT in the diagnosis of infective endocarditis, cardiac implantable device infection, left ventricular assist device infection, and secondary complications. The author discusses considerations when using FDG PET/CT in routine clinical practice, patient preparation for reducing physiologic myocardial uptake, acquisition of images, and interpretation of PET/CT findings. This review also functions to highlight the need for a standardized acquisition protocol.

• Fibers and Polymers
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• v.7 no.4
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• pp.446-449
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• 2006

The purpose of this study was to evaluate the comfort of PET clothing treated by UV. The physiological responses of the human body were investigated. Mean skin temperature and physiological signals such as Electroencephalogram (EEG), and heart rate (Electrocardiogram, (ECG)) were examined for 20 minutes during stable wearing conditions. Mean skin temperature was measured every two seconds using Ramanathan's method. Physiological responses were measured using Biopac MP100 series and analyzed using the software, Acqknowledge 3.5.2. Psychological effects were analyzed every five minutes. Comfort of untreated PET clothing decreased with the passage of time. Compared with PET clothing untreated, treated for 30 minutes, and treated for 90 minutes, the analysis of EEG showed that PET clothing treated for 90 minutes was the most comfortable after 20 minutes. In addition, the interval of the heart rate shown on the ECG was the highest in PET clothing treated for 90 minutes. Skin temperature was the lowest in PET treated for 90 minutes. We thus conclude that suitable UV irradiation would improve comfort.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.2
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• pp.33-37
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• 2010

Purpose: In the early stage of using PET/CT, it was used to damper revision but recently shows that CT with MDCT is commonly used and works well for an anatomical diagnosis. This hospital makes the accuracy and convenience more higher in the diagnosis and evaluate of coronary heart disease through concurrently running myocardial perfusion SPECT examination, myocardial PET examination with FDG, and CT coronary artery CT angiography(coronary CTA) used PET/CT with 64-slice. This report shows protocol and image based on results from about 400 coronary heart disease examinations since having 64 channels PET/CT in July 2007. Materials and Methods: An Equipment for this examination is 64-slice CT and Discovery VCT (DVCT) that is consisted of PET with BGO ($Bi_4Ge_3O_{12}$) scintillation crystal by GE health care. First myocardial perfusion SPECT with pharmacologic stress test to reduce waiting time of a patient and get a quick diagnosis and evaluation, and right after it, myocardial FDG PET examination and coronary CTA run without a break. One-stop evaluation protocol of ischemic heart disease is as follows. 1)Myocardial perfusion SPECT with pharmacologic stress: A patient is injected with $^{99m}Tc$-MIBI 10 mCi and does not have any fatty food for myocardial PET examination and drink natural water with ursodeoxcholic acid 100 mg and we get SPECT image in an hour. 2)Myocardial FDG PET: To reduce blood fatty content and to increase uptake of FDG, we used creative oral glucose load using insulin and Acipimox to according to blood acid content. A patient is injected with $^{18}F$-FDG 5 mCi for reduction of his radiation exposure and we get a gated image an hour later and get delay image when we need. 3) Coronary CTA: The most important point is to control heart rate and to get cooperation of patient's breath. In order to reduce a heart rate of him or her below 65 beats, let him or her take beta blocker 50 mg ~ 200 mg after a consultation with a doctor about it and have breath-practices then have the examination. Right before the examination, we spray isosorbide dinitrate 3 to 5 times to lower tension of bessel wall and to extension a blood wall of a patient. It makes to get better the shape of an anatomy. At filming, a patient is injected CT contrast with high pressure and have enough practices before the examination in order to have no problem. For reduction of his radiation exposure, we have to do ECG-triggered X-ray tube modulation exposure. Results: We evaluate coronary artery stenosis through coronary CTA and study correlation (culprit vessel check) of a decline between stenosis and perfusion from the myocardial perfusion SPECT with pharmacologic stress, coronary CTA, and can check viability of infarction or hibernating myocardium by FDG PET. Conclusion: The examination makes us to set up a direction of remedy (drug treatment, PCI, CABG) because we can estimate of effect from remedy, lesion site and severity. In addition, we have an advantage that it takes just 3 hours and one-stop in that all of process of examinations run in succession and at the same time. Therefore it shows that the method is useful in one stop evaluation of ischemic heart disease.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.3
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• pp.203-206
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• 2009

Nuclear cardiac imaging has been widely used to assess viable myocardium in patients with ischemic heart disease, The assessment of viable myocardium is important in selecting patients who will be benefit from revascularization. Although revascularization is indicated in patients with sufficient myocardium, patients with scar tissue should be treated medically. Nuclear imaging methods including myocardial perfusion SPECT and FDG PET have been shown to be effective modalities for identifying viable myocardium.

• Journal of Chest Surgery
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• v.45 no.1
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• pp.35-39
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• 2012

Background: The aims of the study were to determine the accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting pulmonary metastasis through video-assisted thoracoscopic surgery (VATS), a technique that allows the excisional biopsy of small pulmonary nodules in patients with known malignancies. Materials and Methods: Between October 2007 and April 2010, 28 patients with known malignancies and small pulmonary nodules underwent VATS excisional biopsies. All patients were in follow-up for a previously treated malignancy. The malignancies included the following: colorectum (9), breast (6), head and neck (5), stomach (3), lymph (1), ovary (1), uterus (1), bladder (1), and liver (1). Results: There were 16 men and 12 women whose mean age was 56.7 years old (range, 38 to 77 years). The sizes of the mean nodules removed were 11.3 mm (range, 7 to 21 mm). Diagnoses included metastatic (11), bronchioloalveolar carcinoma (1), primary adenocarcinoma (1), pulmonary tuberculosis (6), fibrosis (5), organizing pneumonia (3), lymphoid hyperplasia (1). Among these lesions, 46.4% were malignant. Conclusion: True positive FDG-PET was 39.2%. FDG-PET is not a sensitive test in the evaluation of patients with a history of an extrathoracic malignancy and newly diagnosed small pulmonary nodules. VATS excision allows the early diagnosis of small pulmonary nodules, with low morbidity, in patients with known malignancies.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.193-198
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• 2004

PET/CT combines the functional information from a positron emission tomography (PET) exam with the anatomical information from a computed tomography (CT) exam into one single exam. A CT scan uses a combination of x-rays and computers to give the radiologist a non-invasive way to see inside your body. One advantage of CT is its ability to rapidly acquire two-dimensional pictures of your anatomy. Using a computer these 2-D images can be presented in 3-D for in-depth clinical evaluation. A PET scan detects changes in the cellular function - how your cells are utilizing nutrients like sugar and oxygen. Since these functional changes take place before physical changes occur, PET can provide information that enables your physician to make an early diagnosis. The PET exam pinpoints metabolic activity in cells and the CT exam provides an anatomical reference. When these two scans are fused together, your physician can view metabolic changes in the proper anatomical context of your body. PET/CT offers significant advantages including more accurate localization of functional abnormalities, and the distinction of pathological from normal physiological uptake, and improvements in monitoring treatment. A PET/CT scan allows physicians to measure the body's abnormal molecular cell activity to detect cancer (such as breast cancer, lung cancer, colorectal cancer, lymphoma, melanoma and other skin cancers), brain disorders (such as Alzheimer's disease, Parkinson's disease, and epilepsy), and heart disease (such as coronary artery disease).

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.331-337
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• 1994

In order to develop a $^{18}F$-labelled myocardial perfusion agent(flow tracer) for PET, $^{18}F$-labelled organic ammonium cations were synthesized and evaluated in relation to their biodistribution. Five quaternary organic ammonium compounds were labelled with $^{18}F$ in a side chain with moderate to good yields by direct introduction of $^{18}F$-fluoride. Radiochemical yields have been achieved in 30-40min by the precursors (tosylates) in dimethylsulfoxide 15-60% (decay corrected). The reaction was found to be autocatalyzed. A remote controlled procedure was developed in these synthesis. $^{18}F$-Labelling and HPLC-purification of com-pounds needed about 60 min(Yield; 7-20%). Up to now the two compounds N-4-[$^{18}F$]fluorobutyl-pyridinium cation(1) and N, N dibenzyl-4(2-[$^{18}F$]fluoroethyl)piperidinium cation(2) were investigated in relation to their biodistribution in mice. Compound 1 showed at 1 min post injection the high uptake of 19.22% ID/g organ in the myocardium but a following fast decline to 1.12% ID/g organ after 40min. Uptake of compound 2 was after 1min in the heart 5.90% ID/g organ but after 40min at the relative high value of 4.33% ID/g organ. Heart:blood ratio for compound(1) at 1 min was 8.3, at 40 min 2.6 for compound II 2.0(1min) and 15.0(40 min). As data of compound 2 showed greater heart uptake, slower myocardial release, and higher heart: blood ratios, compound 2 is a good candidate for further evaluation.