• The Journal of Korean Physical Therapy
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• v.22 no.6
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• pp.1-6
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• 2010

Purpose: This study investigated the effects of visual feedback during abdominal hollowing (AH) in four point kneeling position, using real-time ultrasound imaging through measurement of the changes in the thickness of transversus abdominis (TrA), internal abdominal oblique (IO), and external abdominal oblique (EO). Methods: The subjects of this study were 32 healthy males who were divided intothe experimental group of 16 subjects and the control group of 16 subjects. The real-time ultrasound feedback was applied to the experimental group while they were educated on the AH exercise in four point kneeling whereas only general education and training were given to the control group. After the training, the changes in the thickness of abdominal muscles during AH in four point kneeling were compared between the experimental group and the control group. Results: The differences of the changes in the thickness of TrA and EO between the two groups were statistically significant. Conclusion: The experimental group experienced a higher increase in the thickness of TrA than the control group while the thickness of IO and EO of the experimental.

• The Journal of the Korean Society for Microbiology
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• v.3 no.1
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• pp.25-30
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• 1968

Shigella antibodies in 50 sera from healthy persons and 110 sera from patients with diarrhea were tested using microdetermination of the indirect bacterial hemagglutination with the polyvalent antigen, and the following results were obtained. A survey of sera collected from healthy persons revealed that 4% had positive titers, 1:64 or above, to Shig. flexneri, Shig. dysenteriae, and Shig. boydii, respectively, whereas all subjects were negative for Shig. sonnei, less than 1:64. Namely, 6 cases among the 50 subjects were positive. Among the patients with diarrhea, positive antibody titers were demonstrated in 29.9% against Shig. flexneri, 11.9% against Shig. boydii, 7.2% against Shig. dysenteriae, and 6.4% aginst Shig. sonnei, respectively. Therfoe, the total positive cases were 55.4% among 110 subjects. No correlation between Shigella and Salmonella antibody titers among patients with dirrhea was found.

• Journal of Korean Physical Therapy Science
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• v.18 no.3
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• pp.63-69
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• 2011

Purpose : The purpose of study is activation of lumbar multifidus muscle by needle EMG during shoulder flexion in chronic low back pain patients. The subject were consisted of 10 women patients with chronic low back pain and healthy asymtomatic subject 10 women. Methods : 10 women patients with chronic low back pain and healthy asymptomatic subject 10 women is voluntary participated for the research. Subjects were positioned in standing. The needle EMG were measured activation of multifidus. Needle electrode was used to 28 gauge. The shoulder flexion movement used to activate the multifidus was then measured. Results : Results of the analysis showed that asymptomatic subjects had significantly larger multifidus muscle activation compared with CLBP subjects during shoulder flexion. Conclusion : This study will be used as multifidus measurement method of patient with chronic LBP. The multifidus muscle in chronic LBP patient clinical significance. Most of chronic LBP patients have multifidus contraction pattern. Therefore chronic LBP patients necessary multifidus activation measurement with needle EMG.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.421.1-421.1
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• 2002

The purposes of this study were to evaluate the population pharmacokinetics of terbinafine according to two-compartment model will, lag time and to investigate the influence of characteristics or subjects such as body weight and age on the pharmacokinetic parameters of terbinatine. Serum data from 73 healthy male Korean subjects were used for this analysis. After overnight fast. each subject received a single 125 mg oral dose of terbinafine. (omitted)

• The Journal of Korean Physical Therapy
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• v.28 no.2
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• pp.112-118
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• 2016

Purpose: This study examined thickness changes in abdominal muscles according to difficulty level of core stabilization exercise in healthy subjects. Methods: Thirty healthy subjects (age range: 21-30 years) volunteered under three conditions. In the first condition, the subjects performed an abdominal draw-in maneuver (ADIM). In the second condition, they performed the ADIM during quadruped exercise using a suspension device without extending their lower limbs. In the third condition, the subjects performed the ADIM during quadruped exercise using a suspension device while extending both lower limbs. The changes in thickness of transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) muscles were measured by ultrasonography (US) imaging during the three experimental conditions, and US was used to measure the improvement ratio of muscle thickness at rest. The interventions were conducted over three trials in each condition, and measurements were performed on each subject by one examiner. Results: Our results showed a significantly greater increase in the muscle thickness of TrA and IO muscles after performance of quadruped exercise using a suspension device without knee extension (p<0.05) compared to the other conditions. The results also showed a significantly greater increase in the thickness changes of EO muscle in those who performed the ADIM during quadruped exercise using a suspension device with knee extension (p<0.05) compared with the ADIM only. Conclusion: These findings demonstrated positive evidence that a low-level core stabilization exercise could improve thickness of abdominal muscles.

• The Journal of Korean Physical Therapy
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• v.25 no.2
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• pp.71-75
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• 2013

Purpose: Although use of a tilt table is recommended in clinical practice, there are no published guidelines regarding pressure and inclination for tilt table use. The aim of the current study was to assess the changes of pressure on sacrum and buttock according to different inclination of the tilt table in healthy subjects. Methods: Thirty two healthy subjects participated in this study. Subjects were positioned supine on the tilt table and safety straps were secured across the chest, pelvic, and knee with sufficient tension to prevent the subjects from falling. Pressure and peak pressure of sacrum and buttock were measured using pressure mapping system with the tilt table standing at $0^{\circ}$, $15^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, $75^{\circ}$, and $85^{\circ}$ inclination. Results: A significant decrease in the pressure of sacrum and buttock was achieved by increasing tilt table inclination (p<0.05): $0^{\circ}{\sim}15^{\circ}$ (8.16%), $15^{\circ}{\sim}30^{\circ}$ (8.02%), $30^{\circ}{\sim}45^{\circ}$ (11.61%), $45^{\circ}{\sim}60^{\circ}$ (16.18%), $60^{\circ}{\sim}75^{\circ}$ (16%), and $75^{\circ}{\sim}85^{\circ}$ (11.48%). A significant decrease in the peak pressure was achieved by increasing tilt table inclination (p<0.05): $30^{\circ}{\sim}45^{\circ}$ (9.91%), $45^{\circ}{\sim}60^{\circ}$ (19.24%), $60^{\circ}{\sim}75^{\circ}$ (19.93%), and $75^{\circ}{\sim}85^{\circ}$ (11.48%). No significant peak pressure change was observed in $0^{\circ}{\sim}15^{\circ}$, $15^{\circ}{\sim}30^{\circ}$ tilt table inclination (p>0.05). Conclusion: The results of this study showed that the pressure of sacrum and buttock were decreased according to increasing tilt table inclination in healthy subjects. Guidelines are needed in order to optimize patient safety and overall outcome for tilt table standing.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1327-1330
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• 2015

Background: Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Results: Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674, p=0.001) and also between MMP-9 and lymph node involvement (r=0.474, p=0.03). Conclusions: Both markers are significantly increased in oral SCC compared to healthy subjects. However, MMP-2 was better for evaluating lymph node involvement and tumor grade.

• Journal of Korean Physical Therapy Science
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• v.24 no.1
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• pp.29-37
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• 2017

Purpose : The purpose of this study was to examine the effect of rope-skipping exercise on body composition and basic physical fitness in healthy subjects: a randomized control trial. Method : Twenty two subjects were randomly allocated to two groups: rope-skipping group (n=11) and control group (n=11). The rope-skipping group participated in rope-skipping exercise for 30 minutes a day, three days a week for four weeks. Body composition was measured using the subjects' weight, body mass index (BMI), and waistline. Basic Physical fitness was measured flexibility and agility. Result : The rope-skipping showed significant differences in waistline and agility. The control group showed no significant differences. There were significant difference in agility between the rope-skipping and the control group. Conclusion : The rope-skipping exercise increased waistline and agility in healthy subjects. Additional research on rope-skipping exercise for improving body composition and basic physical fitness is need.

• Korean Journal of Community Nutrition
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• v.9 no.6
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• pp.695-705
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• 2004

The risks of the metabolic syndrome (MS) is known to be related to the dietary behavior. The objective of this study is to evaluate the association between the relative risks of MS and the dietary habit and to provide the ideal dietary habits for prevention of chronic disease of the middle-aged. Healthy subjects aged 40-64 years (male n=122, female n=173) were recruited throughout Seoul area. MS was defined according to NCEP-ATP III criteria except central obesity, and Asia-Pacific Area criteria for central obesity (2000) was adapted. Subjects were stratified into 3 groups according to the number of total risk factors:'MS group' was defined as the subjects who have three or more risk factors, 'Risk group' was defined as ones to have one or two risk factors, and 'Healthy group' defined as ones with no risk factor. In this study, 'Health group' comprised of $40.7\%$, the percentage of 'Risk group' was $49.0\%$, and the 'MS group' was $9.5\%$ of the total subjects. The MS incidence was associated with low education (p<0.001), low economic status (p<0.05), and low self-assessed health recognition (p<0.05). The risk of MS increased with adverse life styles such as cigarette smoking (p<0.05), irregular meal time (p<0.05), skipping lunch (p<0.05), low interests in balanced diet (p<0.05), and higher salt intake (p<0.01). Healthy group self-evaluated nutritional knowledge more highly (p<0.05) and scored higher nutritional knowledge (p<0.001). However, there was no difference in overall nutritional behavior among the three groups, which implies that nutritional education method should be developed for the subjects to practice their teaming efficiently.

• Archives of Pharmacal Research
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• v.29 no.6
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• pp.525-533
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• 2006

The aim of this study was to evaluate the bioequivalence of risperidone in healthy male subjects representing different CYP2D6 genotypes with respect to risperidone, 9-hydroxyrisperidone (9-OH-risperidone), and active moiety. A total of 506 Korean subjects were genotyped for $CYP2D6^*10$ by means of allele-specific polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Based on the genotype analysis, 24 subjects, 7 homozygous for $CYP2D6^*1$ for $^*10$, and 7 heterozygous for $^*10$, were recruited and received a single oral dose of 2 mg risperidone tablet in this study. Serum concentrations of risperidone and 9-OH-risperidone up to 48 h were simultaneously determined. There were no significant differences of the active moiety, risperidone, and 9-OH-risperidone between the two preparations in AUC_{0-{\propto}}$ and $C_{max}$. The 90% confidence intervals (Cls) for the ratio of means of the log-trans-formed AUC_{0-{\propto}}$ and $C_{max}$ for the active moiety, risperidone, and 9-OH-risperidone were all within the bioequivalence acceptance criteria of 0.80-1.25. The $CYP2D6^*10$ allele particularly was associated with higher serum concentrations of risperidone and the risperidone/9-OH-risperidone ratio compared with the $CYP2D6^*1$ allele. The results demonstrate that the two preparations of risperidone are bioequivalent and it can be assumed that they are therapeutically equivalent and exchangeable in clinical practice. Furthermore, the pharmacokinetic parameters of risperidone and the risperidone/9-OH-risperidone ratio are highly dependent on the CYP2D6 genotypes.