• 대한핵의학회지
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• 제25권1호
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• pp.110-116
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• 1991

To elucidate alteration of peripheral T cell subsets in thyroid tumors, the author enumerated T cell subsets in periphral blood by indirect immunofluorescent method, using monoclonal antibodies (CD3, CD4 and CD8) in 17 cases of thyroid cancer, 12 cases of thyroid adenoma, and 16 cases of adult healthy subjects as controls. Diagnoses were confirmed histopatologically in thyroid cancer and adenoma, and were established on the basis of commonly accepted clinical and biochemical criteria in Hashimoto's thyroiditis. The blood was drawn from veins of the patients and control subjects in Pusan National University Hospital during the period of January to October 1990. The results obtained were summarized as follow: 1) The percentage of CD3+ cells was significantly decreased in thyroid cancer as compared with healthy subjects. 2) The percentage of CD4+ cells was not different among thyroid cancer, thyroid adenoma, Hashimoto's thyroiditis and control subjects each other. 3) The percentage of CD8+ cells was significantly decreased in thyroid cancer as compared with adult healthy subjects, and tended to be decreased as compared with thyroid adenoma and Ha-shimoto's thyroiditis. 4) The CD/CD8 ratio was significantly increased in thyroid cancer as compared with control subjects, and tended to be increased as compared with thyroid adenoma and Hashimoto's thyroiditis. On the basis of the results, it can be suggested that the immunodysfunction may be due to decreased soppressor/cytotoxic T cells in thyroid cancer.

• 한국식품영양과학회지
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• 제30권1호
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• pp.168-174
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• 2001

This study was conducted to investigate correlation between soybean and their products consumption and risk factors for atherosclerosis in the healthyKorean adults. Health behaviors such as smoking, exercise, alcohol consumption and dietary patterns and nutrient intakes of 193 healthy adult subjects aged from 26 to 69 were assessed by using interview and semiquantitative food frequency questionnaire. The BMI, blood pressure and biochemical parameters of blood were examined as well as preferences for taste and family history of disease. Data were expressed as quartile according to soybean and their products consumption. The average daily soybean and their product consumption for 1st, 2nd, 3rd, and 4th percentile group were 36, 78, 112, and 182g, respectively. The more consumption of soybean and their products, the more intake of energy, protein, lipid, fiber, Ca, cholesterol as well as frequency of exercise, smoking and drinking. Serum TG, total cholesterol and LDL-cholesterol and AI as risk factors of atherosclerosis were positively correlated with smoking and drinking (p<0.05). Especially, serum TG was positively correlated with hypertension and BMI (p<0.01). But, no correlation between exercise, salty taste, meat preference, soybean products consumption and atherosclerosis risk factors was found, which means that life styles such as smoking and drinking rather than dietary habits might influence atherosclerosis in healthy adults. In conclusion, present soy products consumption should be increased by way of developing new generation soy products in order to exert anti-atherosclerotic effect by soybean in human.

• 가족자원경영과 정책
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• 제28권1호
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• pp.13-25
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• 2024

1인가구 증가는 전 세계적 현상으로 한국 또한 1인가구 비중의 증가가 급속히 진행 중이다. 1인가구는 그 형성 계기, 성별, 생애주기 등에 따라 매우 다양한 스펙트럼을 갖고 있으며, 각각의 특성을 반영한 지원이 가능하도록 1인가구 집단을 세분화하여 연구할 필요가 있다. 이 연구는 생애주기에 따라 청년기, 중장년기, 노년기 1인가구 등 세 개의 집단으로 분류하고, 1인가구 건강성 수준에 있어 집단 간 유의한 차이가 있는지, 나아가 건강성에 영향을 미치는 인구사회학적 특성 및 1인가구 삶의 특성에는 어떠한 것들이 있는지 살펴보았다. 분석을 위해 2022년도 김포시 거주 1인가구 237명을 대상으로 설문조사를 통해 수집된 자료를 이용하였고, 기술통계, 평균차이 검증(t-test, ANOVA), 중다회귀분석 등을 실시하였다. 1인가구의 전반적 건강성 수준을 살펴보면 생애주기별로 차이가 있었는데, 청년기 1인가구가 노년기 1인가구에 비해 건강성 수준이 유의하게 높았다. 중다회귀분석 결과, 1인가구 건강성에는 성별, 교육수준, 자발성, 차별경험 여부가 유의한 영향을 미치는 것으로 나타났으며, 건강성을 구성하는 하위영역별로 영향을 미치는 변수에는 차이가 있었다. 생애주기에 따른 1인가구의 건강성 수준에 대한 결과를 토대로 하여 1인가구 정책의 방향성을 논의하고 실천적 함의를 제공하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.305.2-306
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• 2001

• KSBB Journal
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• 제26권3호
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• pp.183-188
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• 2011

Adult stem cells, which have characteristic of self-renewal and multipotency, are specialized cell types, responsible for the tissue regeneration of the damaged tissue. Recent studies suggest that stem cells senescence (or stem cells' ageing) is closely associated with the variety of ageing-related phenotypes such as tissue atrophy, degenerative diseases and onset of cancers. During ageing, declining of stem cells function and subsequently occurring mal-differentiation of stem cells would be important to understand the biological process of development of ageing-related phenotypes such as tissue degenerations and cancers. This review focuses on the DNA damage stress as a cause of senescence of stem cells and their mal differentiation, which is closely link to defect of regeneration potentials and neoplastic transformation. Understanding of molecular mechanisms governingsuch events is likely to have important implications for developing novel avenues for balancing tissue homeostasis longer period of time, further leading to 'Healthy ageing'.

• 여성건강간호학회지
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• 제6권4호
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• pp.594-605
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• 2000

The purpose of this study is to collect fundamental data for adult female health improvement based on urban adult female obesity and cardiopulmonary function. Surveyed were 859 adult females who visited a health improvement center in D district in Seoul between April, 1999, and December, 1999, and the resulting data are as follows: 1. The adult female mean BMI was $23.97{\pm}3.11kgm^2$, which comes within the range of overweight. Among them, BMI of the females aged 41-60, and over 60, were significantly higher. Mean percentage of body fat was $32.07{\pm}4.63$, and it significantly increased in accordance with age, recording the highest among those aged over 60. 2. The systolic blood pressure significantly increased in accordance with age, recording highest among those aged over 60. Those aged 41-60 and over 60 showed significantly higher diastolic blood pressure than those in their 20s and 30s; however, they had a significantly lower heart rate. Vital capacity and maximum oxygen intake significantly decreased in accordance with age, and those aged over 60 were lowest. 3. As to health perception, 20.6% of the subjects perceived themselves as healthy, and those who perceived themselves as unhealthy showed significantly higher BMI than those who perceived themselves to be of moderate health. 4. There were no significant differences in blood pressure, heart rate and maximum oxygen intake in accordance with health perception, but those who perceived themselves as healthy showed significantly higher vital capacity than those who didn't. 5. As to cardiopulmonary function in accordance with obesity, the obese group showed significantly higher systolic blood pressure than those whose weight was normal to overweight. The diastolic blood pressure of the normal weight group was the lowest, while the obese group showed significantly lower vital capacity and maximum oxygen intake. These findings indicate that the womens' health promotion program must include an effective strategy for preventing obesity, and strengthening cardiopulmonary function.

• Toxicological Research
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• 제20권4호
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• pp.299-305
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• 2004

Adult periodontitis (AP) is a chronic inflammatory disease whose etiology is not well defined. Some studies suggested that the clinical characteristics of this disease may be in part explained by genetic factors, and some attempts to find genetic markers for this disease were successful. The interleukin-1 (IL-1) gene family as one of genetic factors may influence the expression of adult periodontitis. The aim of present study is to investigate the frequencies of genetic polymorphisms in the IL-1 gene family encoding three genes (IL-1A, IL-1B and IL-1RN) in Korean AP patients and periodontically healthy controls. There were no significant differences in genotype and allele frequencies of these polymorph isms between two groups, respectively. However, -511 polymorphism of IL-1 B gene was significantly associated with mean pocket depth (MPD, mm) value in AP patients (P<0.05). Therefore, our results suggest that -511 polymorphism in the IL-1B gene may be useful as a genetic marker for the severity of AP in Koreans.

• 농업과학연구
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• 제47권3호
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• pp.437-443
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• 2020

The aim of this study was to evaluate the effect of Lactobacillus acidophilus probiotic (LAP) product supplementation on the blood profile, fecal noxious gas emission, and fecal shedding of lactic acid bacteria and coliform bacteria in healthy adult Beagle dogs. In total, 14 Beagle dogs with an average initial body weight of 10.19 ± 0.61 kg were randomly assigned into two dietary treatments,with and without LAP supplementation, for a 28-day feeding trial. At the end of the experiment, there was no significant (p > 0.05) difference in the concentration of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell (WBC), red blood cell (RBC), blood lymphocyte percentage, fecal hydrogen sulfide (H₂S) and total mercaptans (R.SH) emission, and fecal coliforms counts. However, the serum concentrations of the triglyceride and fecal ammonia (NH₃) emission of the LAP treatment were significantly (p < 0.05) decreased in the group compared with the CON dogs. Fecal total lactic acid bacteria counts were significantly (p < 0.05) increased in the LAP treatment. In conclusion, the supplementation of LAP in Beagle dog diets could decrease the blood triglyceride level and enhance the gut Lactobacillus count which may have positive effects on dogs.

• 식품보건융합연구
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• 제6권3호
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• pp.1-4
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• 2020

This study analyzed in nutrient contents changes of adult's favorite foods between March 2019 and July 2020 after policy implementation nutrient-poor foods based on special act on safety control of adult's dietary life in Korea. Among adult's favorite foods manufactured or sold in 2020 as well as 2019, calories and key nutrients in breads, ice creams and pizzas were improved in comparison to those in the other food groups. However, most of the changes in calories or key nutrient contents exist. The newly introduced candies, breads showed slightly greater improvements in calories and key nutrient contents than in 2019. On the other hand, some negative changes were found in newly introduced chocolates in comparison to previous ones. Overall, policy implementation on foods seemed to induce changes in nutrient contents of adult's favorite foods. In particular, nutrition education is reported to have a positive impact on adult's frequency and preference for processed foods, and more systematic and continuous nutrition education measures should be devised to help adult as consumers selectively purchase healthy foods. This research is meaningful in that it is the first study to analyze the quality changes of adult's favorite foods since the high-calorie and low-nutrient food management policy.

• 대한임상검사과학회지
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• 제49권4호
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• pp.337-344
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• 2017

To date, no clear threshold that has been established for defining an adequate store of vitamin D for bone health. Therefore, this study aims to determine the required level of vitamin D to maintain a healthy skeleton based on bone remodelling process among healthy adult population. This was a cross sectional study, involving a healthy adult population in Kota Bharu, Malaysia, aged 18~50 years. We measured serum 25(OH)D (vitamin D), serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen (CTX), and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adults selected via multi stage sampling (64 males, 56 females) from 6 subdistricts in Kota Bharu. The mean level of 25(OH)D was 23.50 (${\pm}8.74$) nmol/L. There was a significant difference of the vitamin D level between genders ($26.81{\pm}8.3nmol/L$ vs $19.72{\pm}7.68nmol/L$ in males and females respectively) (p value<0.001). More than 50% of female subjects had 25(OH)D less than 20 nmol/L, while only 20.3% of male subjects had 25(OH)D below 20 nmol/L. Based on the LOESS plot, the bone turnover markers showed a plateauing result, at the 25(OH)D level of 35 nmol/L for CTX and 20 nmol/L for P1NP. Contrastingly, PTH showed a step rise in the 25(OH)D level of 20 nmol/L. Based on the LOESS plot for CTX, P1NP and PTH versus 25(OH)D, level of vitamin D between 20 to 35 nmol/L is recommended to maintain healthy skeleton.