• Nutrition Research and Practice
• /
• 제7권3호
• /
• pp.233-241
• /
• 2013

There are limited data on healthy dietary patterns protective against metabolic syndrome (MetSyn) development. We identified dietary patterns among middle-aged and older adults and investigated the associations with the incidence of MetSyn. A population-based prospective cohort study included 5,251 male and female Koreans aged 40-69 years. At baseline, all individuals were free of MetSyn, other major metabolic diseases, and known cardiovascular disease or cancer. Cases of MetSyn were ascertained over a 6-year of follow-up. Dietary patterns and their factor scores were generated by factor analysis using the data of a food frequency questionnaire. We performed pooled logistic regression analysis to estimate multivariable-adjusted relative risk (RR) and 95% confidence interval (CI) for associations between factor scores and MetSyn risk. Two dietary patterns were identified; (1) a healthy dietary pattern, which included a variety of foods such as fish, seafood, vegetables, seaweed, protein foods, fruits, dairy products, and grains; and (2) an unhealthy dietary pattern, which included a limited number of food items. After controlling for confounding factors, factor scores for the healthy dietary pattern were inversely associated with MetSyn risk (P-value for trend < 0.05) while those for the unhealthy dietary pattern had no association. Individuals in the top quintile of the healthy diet scores showed a multivariable-adjusted RR [95% CI] of 0.76 [0.60-0.97] for MetSyn risk compared with those in the bottom quintile. The beneficial effects were derived from inverse associations with abdominal obesity, low HDL-cholesterol levels, and high fasting glucose levels. Our findings suggest that a variety of healthy food choices is recommended to prevent MetSyn.

• 한국식생활문화학회지
• /
• 제17권5호
• /
• pp.629-637
• /
• 2002

This study sought to determine family restaurant patrons' attitudes toward nutrition and healthy menus. A written questionnaire was handed out to 300 dine-in customers at the three different sites of T brand family restaurant. A total of 265 questionnaires were usable for data analysis, resulting in 88% response rate. Two attitude statements eliciting the strongest agreement were that 'Diet and chronic diseases risk are closely connected each other(4.44)' and 'Koreans are more nutrition & health conscious than they were in the past(4.41)'. The attitude statement-that nutrition is important when I eat out- received the lowest scores(2.92), which indicated that nutrition was not yet considered the most important factor when dining out. 23% of the respondents were interested in healthful foods, while 30% said they were unconcerned. Nutrition conscious group showed significantly (p<.000) higher attitude scores for most of statements than unconcerned group. Significant differences were found in age groups(p<.05, p<.01, p<.001), income levels(p<.05), educational levels(p<.05), health status groups(p<.05), and weight control interest groups(p<.05). Older respondents, respondents with higher income and educational levels were more interested in nutrition and healthy menus. Respondents who reported good health status and showed higher interest in weight control were more interested in nutrition and healthy menus. These findings indicate that restaurant firms should respond to consumers' increased interest in nutrition and healthy menus by offering healthful menus and increasing nutrition marketing activities. This may positively result in increasing customer counts and revenue as well as customer satisfaction level and brand image of restaurant firms. Moreover, restaurant firms are strongly encouraged to play an active role in promoting public's nutritional and health status because increasing consumption of meals away from home will seriously affect good health of our consumers.

• 약학회지
• /
• 제46권1호
• /
• pp.63-68
• /
• 2002

The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors influencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, weight, sect creatinine (Scr) and dose and pharmacokinetic parameters were estimated with stepwise linear recession analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 h $r_{-1}$, CL/F was 37.71 L/hr, Vd/F was 200 L and t/ sub 1/2 / was 3.68 hrs for a male Korean with 170 m height and 1.0 mg/dL Scr.

• Journal of Nutrition and Health
• /
• 제36권1호
• /
• pp.83-92
• /
• 2003

Improving dietary patterns, na, in turn, improving nutritional status, is now viewed as a key to improve public health and to prevent chronic diseases. There has been a peat needs to assess diet quality to identify nutritional risk group, however, little research has been done on methods to assess overall diet quality. The purpose of this study was to develope a mini dietary assessment (MDA) index for evaluation of overall dietary quality. A 10-component system was devised based on dietary guidelines and food Tower for Koreans. The system contained 4 food elements of which use is encouraged, such as milk, meat, vegetables, fruits, and 3 food elements of which use is limited, such as fat, salt, or sugar. Also the included were elements on dietary regulation and variety. A subject is to check one of ‘always' 'generally'seldom', which has score of 5, 3, and 1, respectively, so the total possible index score is 50. This index is to use without dietary survey and is to use even by non-nutritionist. A sample of 432 healthy males and females in their 30's and 40's contributed diet intake data based on 24-hour recall for the validation of MDA. The mean MDA score was 31.34 of a possible 50 points. The main nutrients for each MDA component was correlated very well with the results of 24-hour recall. Also, very good correlation was found between healthy eating index (HEI) score and MDA score. However, some of MDA components were needed a modification of term or/and statement. So the Uh was revised and another effort for validation was made with new sample of 169 subjects and even better correlation was found. The revised MDA could be used with minor modification to assess diet quality and to screen nutritional status. (Korean J Nutrition 36(1): 83-92, 2003)

• 한국안광학회지
• /
• 제4권2호
• /
• pp.119-122
• /
• 1999

조사대상 61명의 primary gaze, $45^{\circ}$ right gaze 및 $45^{\circ}$ left gaze때의 안검열폭을 측정하였다. 안검열폭의 비대칭 판정기준을 1mm 이상으로 하였을 때 생리적 안검열폭 비대칭의 prevalence는 primary gaze에 서 13.1%(8/61), right gaze에서 24.6%(15/61) 그리고 left gaze에서 16.4%(10/61) 이었다. Primary gaze에서 안검열폭의 비대칭 값을 보정한 후 two-tailed trivariate analysis를 실시한 결과 horizontal gaze에서 대부분의 경우 보정된 안검열폭 비대칭 값은 1mm 이하였고 내전안의 폭이 더 넓어지는 경향을 보였다. 동시에 이러한 효과는 right gaze와 left gaze때에 동일하게 나타났고 성에 따라 유의성 있는 차이가 없었다. 내전 안에서 안검열폭의 평균 증가는 right gaze 때에 0.29mm이고 left gaze 때에 0.21mm이었다.

• Journal of Nutrition and Health
• /
• 제35권1호
• /
• pp.124-136
• /
• 2002

As the elderly population has increased in recent years in Korea chronic degenerative diseases prevalent in the aged have garnered attention in relation to food behavior. In general, dietary intakes of elderly Koreans were inadequate in quality as well as in quantity. Especially, intakes of Ca, vitamin A, and riboflavin along with total energy were insufficient. They tended to consume high carbohydrate and low fat energy rates which may be resulted from long standing vegetable-based flood patterns. Relationships between dietary intakes and indices of cardiovascular diseases revealed that blood pressures and serum lipids patterns tended to be poor in individuals having high abdominal fat accumulations which seemed to be related with dietary consumption of high carbohydrate and insufficient intake of many nutrients. These results suggested that a nutritionally balanced diet including animal sources floods is needed in order to prevent an abdominal obesity and cardiovascular diseases. The bone health status of the Korean elderly appeared poor. It was more serious in women recording a higher prevalence rate of osteopenia and osteoporosis than in men. There were strong associations between dietary factors and bone health status. Bone mineral density was found to be higher with higher intakes of protein energy rate, the total amount of feeds, and many nutrients including Ca and p, indicating that a good quality diet is essential in maintaining healthy bone status in later life. mental health condition of the elderly as measured by cognitive function and the degree of depression was also inadequate and had strong association with dietary consumption. The positive results were obtained in individuals having an adequate dict. Therefore, it could be summarized that the physical as well as mental health in elderly Koreans are highly related with their dietary patterns. Thus, the older adults need te consume nutritionally well balanced diet in sufficient amount, which contains various flood items including significant amounts of animal source floods in a daily diet in order to maintain healthy condition.

• Journal of Nutrition and Health
• /
• 제21권5호
• /
• pp.317-323
• /
• 1988

Mean daily excretion of Ca, P, and Fe were measured in 49 healthy young Koreans(23 males and 26 females) form urine and feces samples cellected for three days. Dietary intakes of the subjects during the study periods were calculated from intake records. Main results of the study are as following: 1) Mean daily urinary, fecal, and total Ca excretions were 162$\pm$20mg, 346$\pm$39mg, and 508$\pm$50mg, respectively in males and 154$\pm$16mg, 262$\pm$26mg, and 416$\pm$24mg, respectively in females. The mean values of the two groups were not significantly different. 2) Mean daily urinary, fecal, and total P excretions were 751$\pm$45mg, 384$\pm$26mg and 1135$\pm$56mg, respectively in males and 552$\pm$29mg, 335$\pm$34mg and 894$\pm$50mg, respectively in females. Urinary and total P excretion in males were significantly higher than females(p<0.01), but such differences disappeared when the excretions were calculated per kg body weight. 3) mean daily fecal Fe excretions were 12.8$\pm$0.9mg in males and 10.1$\pm$0.8mg in females. The mean value in males was significantly higher than that in females(p<0.05) but when calculated per kg body weight, both groups excreted 0.2mg/kg body weight. 4) Mean daily intake levels of the minerals estimated from three day food intake records were Ca 543mg, P 1136mg, and Fe 14.3mg in males and Ca 533mg, P 869mg, Fe 10.8mg in females. These intake levels seem to be sufficient to supply the daily losses of the study subjects except P in females. However, the problem of estimating dietary intake levels by food intake record should be recognized. Especially females in the study are in menstration age and their Fe losses in the menstration (estimated to be 0.5mg of available Fe per day) should be also supplied in the diet.

• Archives of Pharmacal Research
• /
• 제28권6호
• /
• pp.660-666
• /
• 2005

The intestinal microbiota are important to the host with regard to resistance they impart against bacterial infections and their involvement in mediating metabolic functions. Lactic acid producing bacteria such as Lactobacillus play an important physiological role in these matters. The aim of the present study was to isolate Lactobacillus sp. that inhibits enteric pathogens. Initially, 17 isolates from healthy Koreans were collected on Lactobacillus selective medium. Resistance of the isolates to antibiotics including rifampicin, streptomycin, clindamycin and vancomycin was measured. One of the isolate was identified as Lactobacillus ruminus on the basis of bacterial cell morphology, cultural characteristic and biochemical characteristics, 16S rRNA sequence analysis and PCR-RAPD. Antimicrobial activity of the bacterium against Vancomycin Intermediate Resistant Staphylococcus aureus (VISA) and Vancomycin-Resistant Enterococci (VRE) was measured. About $10^4$ cells of VISA or VRE were mixed with 1, 5, and 9 mL of L. ruminus SPM 0211 and the final volume was adjusted to 10 mL with brain heart infusion (BHI) broth. The cell suspension was incubated for 3, 6, 9, and 24 h, serially diluted and then plated on BHI agar plates. As numbers of L. ruminus SPM 0211 were increased, viable cell count of VISA and VRE decreased. The strongest antimicrobial activity of SPM 0211 was observed after 9 h incubation in any mixture, almost completely inhibiting the growth of these two bacteria. The results suggest that the freshly isolated L. ruminus SPM 0211 may be used as a pro-biotic microbe that prevents the colonization of enteric pathogens and can thereby promote good gastrointestinal health.

• 대한지역사회영양학회지
• /
• 제16권3호
• /
• pp.353-363
• /
• 2011

The objective of the current study was to examine associations of whole grain consumption with socio-demographic (i.e.: sex, age, household income, education, marriage status) and certain eating behavior factors (i.e.: dish source, eating place, meal type) among a generally healthy Korean population. Using twenty-four hour recall data from the 2007-2008 National Health and Nutrition Examination Surveys, whole grain intake (g/day) was calculated for a total of 8,836 generally healthy Koreans aged 6 years and higher. The study subjects had very low whole grain intake. Specifically approximately 60% of the subjects reported no whole grain consumption on the survey day, and mean daily intake ranged from 8.0 g to 15.1 g in different gender and age groups. Living with a spouse was found to be a positive environment factor for whole grain consumption, especially among men. As household income levels increased, whole grain consumption status also improved. The proportion of non-consumer was lowest in a 6-19 year group, and mean intake amount was highest in middle-aged adults. Major dish sources for whole grain consumption included boiled rice with mixed grains, corn, boiled rice with brown rice, cereal products, and other types of boiled rice. It was found that whole grain consumption was highly affected by eating places rather than meal types. The best contributing eating place was home in each age and gender group. The study findings may be useful in planning nutrition education strategy and formulating dietary behavior guidelines for whole grain consumption improvement.

• 보건행정학회지
• /
• 제21권4호
• /
• pp.511-526
• /
• 2011

This study aims at surveying how Koreans look upon and prepare for the age of longevity("age of 100 years") drawing near at hand, analyzing factors affecting such a perception and behavior. To this end, a telephone survey was launched for 1200 persons sampled to evenly comprise the young, middle-aged, and elderly groups. Our findings indicate that more Koreans looked upon the upcoming "age of 100 years" as a 'disaster' rather than a 'blessing.' The sense of combined uneasiness over the aged life being further elongated while they are unprepared for it, anxiety over maintaining health and so forth came into play. However, the better a person is prepared by way of health management, savings for retirement, preparation for leisure activities and employment for the later life, the more positively he or she looked upon the "age of 100 years". An analysis by group indicates that women rather than men, the elderly rather than the young, the less educated rather than the highly educated, the low-income bracket rather than the high-income bracket looked upon the "age of 100 years" more negatively. Under such circumstances, it is suggested that the nation's social system tailored to a life expectancy of 80 years should be readjusted, tailored to a 'longevity paradigm' and that to this end social systems should be reoriented toward the direction where 'healthy aging' and 'active aging' are fully supported.