• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2031-2037
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• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• Journal of Preventive Medicine and Public Health
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• 제54권1호
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• pp.55-62
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• 2021

Objectives: After heart disease, brain stroke (BS) is the second most common cause of death worldwide, underscoring the importance of understanding preventable and treatable risk factors for the outcomes of BS. This study aimed to model the survival of patients with BS in the presence of competing risks. Methods: This longitudinal study was conducted on 332 patients with a definitive diagnosis of BS. Demographic characteristics and risk factors were collected by a validated checklist. Patients' mortality status was investigated by telephone follow-up to identify deaths that may be have been caused by stroke or other factors (heart disease, diabetes, high cholesterol, etc.). Data were analyzed by the Lunn-McNeil approach at alpha=0.1. Results: Older age at diagnosis (59-68 years: adjusted hazard ratio [aHR], 2.19; 90% confidence interval [CI], 1.38 to 3.48; 69-75 years: aHR, 5.04; 90% CI, 3.25 to 7.80; ≥76 years: aHR, 5.30; 90% CI, 3.40 to 8.44), having heart disease (aHR, 1.65; 90% CI, 1.23 to 2.23), oral contraceptive pill use (women only) (aHR, 0.44; 90% CI, 0.24 to 0.78) and ischemic stroke (aHR, 0.52; 90% CI, 0.36 to 0.74) were directly related to death from BS. Older age at diagnosis (59-68 years: aHR, 21.42; 90% CI, 3.52 to 130.39; 75-69 years: aHR, 16.48; 90% CI, 2.75 to 98.69; ≥76 years: aHR, 26.03; 90% CI, 4.06 to 166.93) and rural residence (aHR, 2.30; 90% CI, 1.15 to 4.60) were directly related to death from other causes. Significant risk factors were found for both causes of death. Conclusions: BS-specific and non-BS-specific mortality had different risk factors. These findings could be utilized to prescribe optimal and specific treatment.

• 치위생과학회지
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• 제15권5호
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• pp.636-641
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• 2015

본 연구의 목적은 승무원의 구강건강과 심미적 관심도에 관한 연구로 A항공사에서 근무하는 승무원 314명을 대상으로 2014년 6~7월 동안 자기기입식 설문으로 조사되었다. 사용한 도구는 건강과 구강건강 인식, 구강건강관리, 외적이미지, 외적이미지가 직장생활에 미치는 영향이다. 수집된 자료는 PASW Statistics 18.0을 이용 하여 분석하였다. 연구결과 연령별, 경력별 구강건강 인식에 유의한 차이가 있었고, 교육수준별 삶의 질 인식에 유의한 차이가 있었다. 외적이미지가 직장생활에 미치는 영향은 연령별 유의한 차이가 있었으며, 외모관리 연간 지출비는 성별, 경력별, 소득 집단에서 유의한 차이가 있었다. 승무원은 구강건강이 전신건강보다 건강하지 않다고 인식하고 있어, 외적이미지에 구강건강이 주요한 영향요인이며, 심미증진을 위한 주기적 예방처치 및 심미처치를 시행하고 있었다. 그러나 직무 특성상 구강관리 자가평가가 낮게 조사되어 구강관리 행위 실천을 위한 방안모색이 요구된다. 또한 구강관리가 전신건강을 유지하는데 필수적인 만큼 이에 대한 관심 증대가 요구된다.

• Clinical and Experimental Pediatrics
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• 제61권5호
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• pp.135-149
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• 2018

Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index (BMI) values in boys, and smaller 3rd percentile values in height-for-age charts. Thus, new growth charts have been developed to improve the previous version. The 2006 World Health Organization Child Growth Standards, regarded as the standard for breastfed infants and children, were introduced for children aged 0-35 months. For children and adolescents aged 3-18 years, these new growth charts include height-for-age, weight-for-age, BMI-for-age, weight-for-height, and head circumference-for-age charts, and were developed using data obtained in 1997 and 2005. Data sets and exclusion criteria were applied differently for the development of the different growth charts. BMI-for-age charts were adjusted to decrease the 95th percentile values of BMI. Criteria for obesity were simplified and defined as a BMI of ${\geq}95th$ percentile for age and sex. The 3rd percentile values for height-for-age charts were also increased. Additional percentile lines (1st and 99th) and growth charts with standard deviation lines were introduced. 2017 Korean National Growth Charts are recommended for the evaluation of body size and growth of Korean children and adolescents for use in clinics and the public health sector in Korea.

• 한국보건간호학회지
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• 제27권1호
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• pp.190-202
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• 2013

Purpose: To survey relationships between health literacy, disease-related knowledge and compliance to medical recommendations in patients with hypertension. Methods: The subjects were 315 patients conveniently selected from public health centers in Gangwon province. Data were collected through a questionnaire (from January 10, 2013 to February 10, 2013) and analyzed by descriptive statistics, t-test, ANOVA, Duncan test and Pearson's correlation coefficient using the PASW statistics 18.0 program. Results: There were significant differences in health literacy according to age, marital status, monthly family income and education. In regard to disease-related knowledge, there were significant differences according to gender, marital status and monthly family income. There were positive correlations between health literacy and disease-related knowledge (r = .39, p = <.001), disease-related knowledge and compliance to medical recommendations (r = .28, p = <.001). However, there was no correlation between health literacy and compliance to medical recommendations. Conclusion: Health literacy and disease-related knowledge have a significantly positive correlation. Further studies are needed to confirm the effects of health literacy on chronic diseases.

• 보건의료산업학회지
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• 제10권4호
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• pp.97-107
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• 2016

Objectives : This study aims to : (i) characterize and differentiate between two different periods of baby boomers, (ii) study the utilization of their health care services, and (iii) establish effective ways of providing better health service utilization and preventive policy strategies for upcoming and older generations. Methods : A multiple regression analysis using descriptive statistics, frequency analysis, and dummy variables was utilized to access the presence of correlations between socio-demographic factors and health care service utilization. Results : Medical insurance type, marital status, and chronic disease were factors that influenced health care service utilization. Furthermore, the factors that influenced individual medical expenses were cohabitation, inpatient days, and chronic disease. Conclusions : Primary findings and exploratory statistics revealed that there were strong correlations and interaction among some of the predictor variables. Because of the chronologically limited nature of the sample data set gathered in 2012, it would be helpful to continue to develop or research related constructs that may capture relationships more effectively among extended populations.

• 가정간호학회지
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• 제27권2호
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• pp.210-218
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• 2020

Purpose: The purpose of this study was to analyze research trends, using the keyword home health care, in articles published in the Journal of Korean Academic Society of Home Health Care Nursing over the past 10 years. Methods: An analysis was conducted of 50 home health care-based studies chosen from among the 206 studies published in the Journal of Korean Academic Society of Home Health Care Nursing from 2010 to 2019. The analysis focused on research methodology and keyword. Descriptive statistics were used to examine the frequency distribution of research methods and keywords. Results: Study participation was mainly focused on nurses (52.0%). Most of the studies used quantitative methods (96.0%), and 43 studies (86.0%) used self-report structured questionnaires. The most commonly used data analyses methods were descriptive statistics, t-test, analysis of variance, correlation, and regression. Major keywords were home health nursing, elderly care facility, visiting nurse, home care service, home healthcare nurse, home care agencies, long-term care, and home care. Conclusion: The results of this study identified current trends and interests in the Journal of Korean Academic Society of Home Health Care Nursing. This study suggests that future studies include a variety of research methods and maintain appropriate standards of research ethics.

• 보건행정학회지
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• 제31권2호
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• pp.188-196
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• 2021

Background: This study purposed to analyze the relationship between extinction risk regions and amenable mortality. Methods: This was a cross-sectional study based on the statistics of 2018 which was extracted from the 228 administrative districts in Korea. Cause of death statistics on each region in 2018 was used to produce the age-adjusted amenable mortality. Regional characteristics were measured by demographic factors, health behavior factors, socioeconomic factors, and medical resources factors. Multiple linear regression model was applied to test their relationship. Results: Results showed that extinction risk regions, crude divorce rates, national cancer screening rates, and independent rate of finance were significantly related to the amenable mortality. Conclusion: The study demonstrated differences in health status by the extinction risks of regions. This study suggests that the use of customized community care program can provide integrated services such as housing, health care or the use of information and communications technology which can make early diagnosis.

• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.555-563
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• 2011

Osteoarthritis (OA) and rheumatoid arthritis (RA) are most popular types of arthritis in Korea. This study compared health-related quality of life (HRQoL) of homedwelling people with OA and RA in Korea. Data were drawn from the Korean nationwide representative survey. Subjects were 3,352 people with arthritis over 19 years of age (2,953 OA respondents and 399 RA respondents). Good HRQoL in OA respondents was dierentiated with limitation of mobility, perceived health status, age, economic status, presence of arthralgia, gender, medical coverage, and educational level. Good HRQoL in RA respondents was dierentiated with limitation of mobility, perceived health status, economic status, educational status, and presence of arthralgia. In conclusion, HRQoL and predictors of good HRQoL among people with arthritis diers for OA or RA. These results can be of use in development of health programs and clinical interventions for community-dwelling people with arthritis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.793-796
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• 2014

Background: This study aimed to examine possible effects of implementing a national query program on site-specific cancer mortality rates. Materials and Methods: A total of 2,874 query letters were sent out by the Department of Statistics, Ministry of Health and Welfare of Taiwan between January 2009 and December 2011 to medical certifiers who reported "neoplasm with uncertain nature" on the death certificate asking for more detailed information for coding. Results: Of the 2,571 responses, in 1,398 cases (54%) medical certifiers were still unable to determine the nature of the neoplasm. There were four neoplasm sites for which more than 50% of the responses changed the category to malignant, the gastrointestinal system (73%), urinary system (60%), stomach (55%) and rectum (53%). The liver was the cancer site that showed the largest absolute increase in the number of deaths after the query; however, the brain showed the largest relative increase, at 12%. Conclusions: Different neoplasm sites showed different magnitudes of change in nature after the query. Brain cancer mortality rates exhibited the largest increase.