• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.99-107
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• 2004

The validation of many synthetic chemicals that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, the regulation and evaluation of the chemical hazard playa very important role to environment and human health. The clastogenicity of 11 synthetic chemicals was evaluated in Chinese hamster lung (CHL) fibroblast in vitro. Benzoyl chloride (CAS No. 98-88-4) induced chromosomal aberrations with statistical significance at the concentration of 31-123 $\mug/ml$ and 43 $\mug/ml$ in the absence and presence of S-9 metabolic activation system, respectively. 2-Propyn-l-o1 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed clastogenicity only at the highest concentration in the presence of S-9 mixture. However, 1-naphthol (CAS No. 90-15-3) which is one of the most cytotoxic chemical among 11 chemicals tested revealed no clastogenicity both in the presence and absence of S-9 metabolic activation system. From the results of chromosomal aberration assay with 11 synthetic chemicals in CHL fibroblast in vitro, Benzoyl chloride (CAS No. 98-88-4), 2-Propyn-l-01 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed positive clastogenic results in this study.

• 한국환경농학회지
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• 제41권4호
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• pp.261-275
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• 2022

BACKGROUND: Prior to implementing a positive list system (PLS), there is a need to establish acceptable daily intake (ADI) and maximum residue limit (MRL) for veterinary drugs that have been approved a few decades ago in South Korea. On top of that, chronic dietary exposure assessment of veterinary drug residues should be performed to determine whether the use of these veterinary drugs would cause health concerns or not. METHODS AND RESULTS: To establish the ADI, the relevant toxicological data were collected from evaluation reports issued by international organizations. A slightly modified global estimate of chronic dietary exposure (GECDE) model was employed in the exposure assessment owing to the limited residual data. Therefore, only the ADI of ephedrine was established due to insufficient data for the other veterinary drugs. Thus, instead of ADI, the threshold of toxicological concern (TTC) value was used for the other drugs. Lastly, the hazard index (HI) was calculated, except for etizazole hydrochloride, due to the potential of mutagenicity. CONCLUSION(S): The HI values of ephedrine, menichlopholan, and anacolin were found to be as high as 6.4%, suggesting that chronic dietary exposure to the residues from these uses was unlikely to be a public health concern. Further research for exposure assessment of veterinary drug residues should be performed using up-todate Korean national health and nutrition examination survey (KNHANES) food consumption data. In addition, all relevant available data sources should be utilized for identifying the potentials of toxicity.

• 한국산업보건학회지
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• 제26권3호
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• pp.237-252
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• 2016

Objectives: This study was conducted in order to improve the current understanding of rare earths(RE) and to provide supporting data for establishing occupational health policies by reviewing the toxicological data and issues caused by the use of RE compounds in various fields. Methods: To evaluate the potential toxicity of RE from the viewpoint of occupational health, we summarized extensive reviews of relevant articles in the toxicology(animals and cells), occupational health and safety, and epidemiologic literature. Results: Although occupational RE exposure occurs extensively from ore mining and refining to end users in various industrial applications, epidemiologic study has not been performed among workers up to now. Bioaccumulation and adverse effects of RE have also been mentioned in ore mining regions and nearby residences, but safety standards for each process are insufficient. Moreover, because new commercial recycling technology will soon be applied to various industries, regulation and policies are needed for preventing abuse of recycling. In the results of animal toxicity for a few REs(mostly cerium, lanthanum, and gadolinium), toxicities of liver, lung, blood, and the nervous system were identified due to oxidative stress, but study of long-term RE exposure is required. Understanding the dual effect for RE and discovery of biomarkers pose a scientific challenge in further mechanism studies. Conclusions: In the future, additional hazard evaluation based on animal experiments is required, alongside continuous research for developing analytical methods and discovering biomarkers. Finally, RE occupational health and safety management needs to be integrated into the sustainable use of these materials.

• 한국환경농학회지
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• 제32권4호
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• pp.245-251
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• 2013

BACKGROUND: The objectives of this study are to investigate the contamination levels of heavy metals in soil, ground water, and agricultural product near the abandoned Boeun and Sanggok mine areas in Korea and to assess the health risk for these local residents exposed to the toxic heavy metals based on analytical data. METHODS AND RESULTS: By the results of human health risk assessment for local residents around Boeun and Sanggok, human exposure to cadmium, copper, arsenic from soil and to lead, cadmium, and arsenic from rice grain were higher in Sanggok, but human exposure to zinc and arsenic from ground water was higher in Boeun. By the results of hazard index (HI) evaluation for arsenic, cadmium, copper, lead, and zinc, HI values in both areas were higher than 1.0. This result indicated that the toxicity hazard through the continuous exposure to lead, cadmium, arsenic from rice, ground water, and soil would be likely to occur to the residents in the areas. Cancer risk assessment for arsenic, risks from the rice were exposed to one to two out of 10,000 people in Boeun and one of 1,000 people in Sanggok. These results showed that the cancer risks of arsenic in both areas were 10~100 times greater than the acceptable cancer risk range of US EPA ($1{\times}10^{-6}{\sim}1{\times}10^{-5}$). CONCLUSION(S): Therefore, if these two local residents consume continuously with arsenic contaminated soil, ground water, and rice, the adverse health effects (carcinogenic potential) would be more increased.

• 척추신경추나의학회지
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• 제17권2호
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• pp.131-139
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• 2022

Objectives This study aimed to analyze the medical utilization of low back pain (LBP) patients after back surgery and estimate the medical costs of Korean and Western medicine collaborative treatment, odds ratio, and hazard ratio between the two groups using the 2019 Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS-2019). Methods Data management and descriptive analysis, logistic regression, and survival analysis were conducted for defining and estimating the LBP patients after back surgery in the NPS 2019 dataset. Results A total of 216,424 patients out of 991,189 were identified as having LBP. Among the patients with LBP, 1,734 were treated with surgery while 214,690 were not. Among those who had surgery, 937 were treated with conventional treatments only and 797 underwent Korean medicine treatments. The odds ratio of the logistic regression analysis was 0.7129, suggesting that Korean medical treatment experience group had a 28.7% lower risk of reoperation than the Western medical treatments only group. The hazard ratio of the survival analysis was 0.9145; thus, the risk probability of reoperation was estimated to be approximately 8.55% lower. The 50% risk of reoperation was 69 days (0.5044) for the conventional group, and 97 days (0.5008) for the Korean medical group in the survival analysis using the Kaplan-Meier graph. Conclusions These results could be utilized in future studies in conducting economic evaluation for estimating cost-effectiveness of Western medicine and Korean medicine treatment compared to Western medicine alone in LBP patients after back surgery in a South Korean perspective. mended and should be applied while taking the necessary precautions.

• 한국환경보건학회지
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• 제36권5호
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• pp.391-401
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• 2010

A reduction in risk of occupational exposure to chemical hazards within the workplace has been the focus of attention both through industry initiatives and legislation. The aims of this study were to develop an exposure matrix by industry and process, and to apply this matrix to control the risk of occupational exposure to Dichloromethane (DCM). The exposure matrix is a tool to convert information on industry and process into information on occupational risk. The exposure matrix comprised industries and processes involving DCM, based on an exposure database provided by KOSHA (the Korean Occupational Safety and Health Agency), which was gathered from a workplace hazards evaluation program in Korea. The risk assessment of the exposure matrix was performed using Hallmark risk assessment tool. The results of the risk assessment were indicated by a Danger Value (DV) calculated from the combination of hazard rating (HR), duration of use rating (DUR), and risk probability rating (RPR) of exposure to the chemical, and were divided into four control bands which were related to control measures. The applicability of the risk assessment of the exposure matrix was evaluated by a field study, and survey of the employees of the exposure matrix groups. Among 45 industries examined, this study found that greater attention should be paid to two industries: the manufacture of other optical instruments and photographic equipment, and the manufacture of printing ink, and to one process among 47 examined, the packing process in the manufacture of printing ink, because these were regarded as carrying the highest risk. This tool of a risk assessment for the exposure matrix can be applied as a general exposure information system for hazard control, risk quantification, setting the occupational exposure limit, and hazard surveillance. The exposure matrix includes workforce data, and it provides information on the numbers of exposed workers in Korea by agent, occupation, and level of exposure and risk.

• 한국환경보건학회지
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• 제37권5호
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• pp.376-386
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• 2011

Objectives: The aim of this study was to evaluate the microbial hazards posed by food utensils and fixtures in food service operations at selected middle and high schools located in Seoul, Korea. Methods: We collected 200 samples of utensils and fixtures including cups, spoons/chopsticks, food trays and tables from five different schools in Seoul. Target microorganisms of this study were divided into two groups: total bacterial count and total coliform as indicators of microbial contamination and Bacillus cereus and Staphylococcus aureus as pathogens of food poisoning. We used selective media to quantify microbial concentration and 16S rRNA PCR assay for qualitative analysis. In addition, intensive interviews with nutritionists were conducted and observations were made to identify factors that may affect microbial contamination. Logistic regression analysis was employed to examine the relationship between the microbial concentration and operation characteristics of each operation. Results: The level of microbial concentration in school B and C were significantly lower than in school A, D and E (p<0.05). Some samples from school A, D and E showed over 3.4 log CFU/100 $cm^2$ (total bacterial count) and 1.0 log CFU/100 $cm^2$ (total coliform), which requires immediate hygienic action. The number of customers per staff member, periodicity of hygiene education for staff and daily operation time of sterilizers were also found to be important factors related with the microbial contamination of food service operations. Conclusions: These results suggested that not only a HACCP (Hazard Analysis and Critical Control Point) approach, but also efforts to assess internal risk factors within operations be needed to reduce the microbial contamination of food utensils and fixtures. This study is expected to provide preliminary data for assessing microbial hazards in food service operations.

• 한국식품영양과학회지
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• 제42권10호
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• pp.1701-1706
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• 2013

식품은 인간의 건강과 생존 유지를 위해 매우 중요한 역할을 하고 있으며, 건전하고 안전한 식품을 섭취하는 것은 인간의 삶에 무엇보다도 중요하다. 최근에는 기후변화 등 식품 안전과 관련한 주위 환경이 더욱 열악해지고 있는 실정이다. 정부차원에서도 다양한 방법으로 식품안전에 관한 소비자 교육 홍보 방법을 개발하고, 홈페이지, 리플렛 등 교육 자료를 통해 유해물질에 대한 정보를 제공하고 있다. 본 연구에서는 국내외 관련 정보 분석을 통해 상대적으로 인지도가 낮은 제조가공 과정 중 생성물질과 환경유래오염물질을 대상물질로 선정하였고, 이에 대한 교육 콘텐츠를 개발하였다. 이에 대해 서울시에 거주하는 여대생 120명을 대상으로 인식의 변화, 태도의 변화, 행동의 변화 등 교육효과를 확인하였다. 조사결과, 식품 중 유해물질에 대한 인식도는 교육 전에 비해 교육 후 98.8% 이상으로 증가함을 확인하였다. 건강을 해칠 수 있다는 불안감에 대해서는 교육 전 77.8%에서 교육후에는 막연한 불안감이 52.8%로 약 25.0% 포인트 감소하였다. 정부에서 식품 중 유해물질에 대한 저감화 방안을 홍보할 때 어떤 행동을 취할 것인 지를 질문했을 때 교육 전에 는 적극적으로 실천할 것이라고 응답한 경우가 12.3%, 노력한다는 응답자가 73.5%이었으나, 교육 후에는 56.1%가 적극적으로 실천할 것이라고 응답함에 따라, 좀 더 적극적으로 참여하겠다는 태도의 변화를 이끌어 냈다. 식품 중 유해물질 정보를 알았을 때의 소비 행동 조사결과, 관련 정보에 대해 자세히 알아보고 결정한다는 응답자가 교육 전 49.6%에서 교육 후에는 77.4%로 27.8% 포인트 증가하였고, 관련 식품은 무조건 구매하지 않겠다고 응답한 경우는 교육 전 45.4%에서 교육 후 20.9%로 24.5% 포인트 감소하였다. 이와 같이 유해물질에 대한 설득력 있는 정보제공을 통해 막연한 불안감을 해소할 수 있을 것이며, 앞으로 소비자와의 식품안전 소통채널 확대를 위해서는 지속적으로 소비자 대상 안전정보 제공을 위한 콘텐츠 개발 및 교육 홍보를 강화해 나가야 할 것이다.

• Environmental Analysis Health and Toxicology
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• 제18권2호
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• pp.137-143
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• 2003

합성화학물질들이 환경중에 유입되어 인체에는 물론 환경생태계에 많은 영향을 미치고 있어 이들의 유해성 검증은 매우 중요한 일이라 할 수 있다. 실제 산업체에서 사용되는 수많은 화학물질들의 유전적 손상 유발유무는 더욱이 중요한 일이라 할 수 있다. 이에 산업체 공정과정에서 널리 사용되는 것으로 알려진 8종의 합성화학물질에 대해 마우스의 골수세포를 이용한 in vivo 소핵시험을 수행하여, 소핵형성 유발유무를 관찰하였다. 양성대조군으로 사용된 mitomycin는 음성대조군과 비교시 유의하게 소핵을 유발하는 반면, 비교적 마우스에서 높은 50% 치사량을 보이는 phenylisocyanate, m-aminochlorobenzene 및 2-chloro-4-nitroaniline 등의 합성물질들을 비롯한 나머지 5종의 물질들은 본 실험결과 통계적으로 유의하게 소핵을 유발하지 않는 것을 관찰 할 수 있었다.

• 한국방재학회 논문집
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• 제6권3호
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• pp.9-16
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• 2006

기존 대부분의 구조물 건전도 모니터링 시스템에서는 제한적인 위치와 범위에서의 변형률 계측이 가능한 국부 변형률 센서를 이용하여 구조물 또는 구조 부재의 부재력을 계측하고 이에 기반하여 구조 안전성을 평가하고 있다. 그러나 실 구조물의 부재력 계측을 통한 안전성 평가는 하중의 크기 및 분포에 대한 불확실성 등의 다양한 이유로 부재 내 최대응력 작용점을 정확하게 파악하기 어렵다. 이러한 경우 구조물의 사이즈에 비하여 센서의 길이가 미소한 국부 변형률 센서를 이용한 안전성 평가의 적절성은 센서의 위치 및 개수에 좌우되는 한계를 가지게 된다. 이러한 한계를 극복하기 위하여 센서의 수를 증가시키면 처리해야하는 데이터의 양과 비용이 증가하게 되므로 현실적인 적용성에 문제점을 가지게 된다. 그러므로 본 연구에서는 이러한 한계와 문제점을 극복할 수 있는 대안으로 장대광변형센서에 의한 평균변형률을 이용한 보-기둥의 부재력 계측 기법을 제시하였다.