• Journal of the Korean Magnetic Resonance Society
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• v.23 no.1
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• pp.20-25
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• 2019

The transcription factor CP2c has been recently validated as an oncogenic protein that can serve as a promising target for anticancer therapy. We have recently documented that a recombinant protein corresponding to the putative DNA-binding region (residues 63-244) of CP2c adopted two different conformers, one of which is dominated by zinc binding. However, in the present study, a longer construct encompassing residues 63-302 appeared to form a single structural domain. This domain could be considered to adopt a functionally relevant fold, as the known specific binding of a dodecapeptide to this protein was evident. Hence, the residues 63-302 region rather than 63-244 can be regarded as a natively folded structural domain of CP2c. In addition, it was confirmed that zinc ions can bind to this putative DNA-binding domain of CP2c, which resulted in reduced stability of the protein. In this context, it is suggested that the mode of action of CP2c would resemble that of tumor suppressor p53.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.56-64
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• 2008

To maintain effectively the functionality of major railroad facilities such as bridges, identifying and evaluating damage in a structure and taking appropriate action via continuous structural health monitoring are very important. However, most damage identification methods for structural health monitoring developed to date utilize modal domain responses which inevitably contain errors in transforming the domain of responses. In this paper, a damage identification method using time-domain operational deflection shapes is proposed. Since the proposed method utilizes time-domain responses, the error in the process of transformation to response domain can be avoided, and the accuracy of structural health evaluation can be improved. The feasibility of the proposed method is verified via a numerical example of a simple bridge structure.

• Journal of Korean Public Health Nursing
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• v.12 no.2
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• pp.107-121
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• 1998

The purpose of this study was to test the revised Health Promotion Model of Pender and to determine the factors to promote health behavior for adolescents' smoking behavior. The subjects of the study was 783 boys of 4 high school students. among 39. schools locating in Daejeon metropolitan city. The data was collected from July 1st to 15th. 1997 by school health nurse The research tool were HPLP of Walker. Pender. General self-efficacy scale of Sherer. control scale was measured by subconcept of hardiness scale of Pollock. and perceived barrier. perceived benefit. activity-related-affect tool were made by researcher via literature review The data were analyzed by SAS program using frequency. t-test. ANOVA. Schefee test. regression. The results were as follows 1. The mean of total health promoting behavior was $2.27\pm.35$. Among sub domain of health promoting behavior, the highest score was interpersonal support$(2.72\pm.60)$. and the lowest was health responsibility $(1.58\pm.44)$. 2. There were statistically significant difference in total health promoting behavior according to religion. parenting style. school performance. girl friend. father's smoking of individual characteristics. 3. The socioeconomic status. smoking, parent pattern. family structure of individual characteristics and experience domain associated with perceived benefit. perceived barrier. activity-related affect. interpersonal influence of behavior-specific cognition and affect domain. The perceived barrier. self-efficacy. girl friend and father's smoking of interpersonal influence. and control explained $25.8\%$ of variance of health promoting behavior. From above results school health nurse has to emphasize on health responsibility for health promotion of adolescent. But they couldn't intervene for parent pattern. socioeconomic status. family structure of individual characteristics and experience domain. it could be possible for school health nurse to promote health of adolescents through improving perceived barrier. also develop program to increase self-efficacy and through parent health class for fathers. Above results point to the importance of including parents in smoking prevention effort targeting adolescents. Because increasing control also promotes health of adolescents. it should be studied further about the specific measure. To verify the variables for increasing the fitness of health promoting model. it needs further replication of the research.

• Journal of the Korean Magnetic Resonance Society
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• v.22 no.3
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• pp.64-70
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• 2018

Human Tid1, belonging to the family of the Hsp40/DnaJ, functions as a co-chaperone of cytosolic and mitochondrial Hsp70 proteins. In addition, the conserved J-domain and G/F-rich region of Tid1 has been suggested to interact with the p53 tumor suppressor protein, to translocate it to the mitochondria. Here, backbone NMR assignments were achieved for the putative p53-binding domain of Tid1. The obtained chemical shift information identified five ${\alpha}$-helices including four helices characteristic of J-domain, which are connected to a short ${\alpha}$-helix in the G/F-rich region via a flexible loop region. We expect that this structural information would contribute to our progressing studies to elucidate atomic structure and molecular interaction of the domain with p53.

• Child Health Nursing Research
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• v.8 no.4
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• pp.449-457
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• 2002

The main purpose of this study is to examine the concepts appeared on researches and provide the future research directions in field of child health nursing. A descriptive study was conducted. 205 studies were included in an analysis the concepts in terms of the domain of client for a total 321 researches. All were originally published between 1990 and 2000 in Korea. An analysis of concepts for this study was used the metaparadigm framework for nursing proposed by H.S. Kim(2000). The concepts for this study were categorized by essentialistic concepts, problematic concepts, health-care experiential concepts with the following results. 1. Based on the four domains suggested Kim (2000), 205 studies(63.9％) belong to the domain of client ; 109 studies(34％) belong to the practice domain of nursing; 3 studies(0.9％) belong to the client-nurse domain; and 4 studies belong to the domain of environment, respectively. 2. In the domain of client, 117(57.1％) studies used concept of parent. Among them, mother was the prevailing research population(103 studies). 64 studies(31.2％) used child population and the developmental stage of children varied from preterm to puberty but school aged children was the most target population(28 studies). Family as a concept of client was used in 20 studies(9.8％) but most primary care provider was the mother. 3. In terms of research design, non-experimental design(83.5％) is the most and among them survey was 159 studies(77.6％). Qualitative research(23 studies) and experimental research(10 studies) methods were used relatively few. 4. In terms of the categories of concepts, 196 (61.4％) studies included the essentialistic concepts like stress and coping(20.4％), mothering role and child care(7.8％), health (5.6％), breast feeding(4.7％). 31 studies included problematic concepts like power-lessness, safety, obesity, pain, anxiety. And 65 studies included health-care experiential concepts like compliance, growth, hope, environment but relatively few. The findings of this study provide the evidence that research related problematic concept and health-care experiential concept should be conducted actively to improve the practice of child health nursing. Also to deeply understand the phenomena of client in field of child health nursing, interpretive research methods should be conducted actively, too.

• Safety and Health at Work
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• v.12 no.2
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• pp.272-276
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• 2021

This brief report aims to establish the keyword content of studies on occupational health and safety-the key framework of the world of work in the trade and health domain. Data were collected from the SCOPUS database, focusing on articles on occupational health and safety and related keywords, with an emphasis on abstracts and titles. Data were analyzed and summarized based on keywords included from the MeSH database. There were 24,499 manuscripts in the domain and 1,346 (5.40%) occupational health-related keywords, including those that overlapped. The most frequently referenced occupational health-related keyword was "occupational health" (452 articles), followed by "occupational safety" (141 articles). There were fewer keywords on occupational health in the trade and health literature. As the world of work has been prioritized because of the recent new normal of work life since the COVID-19 pandemic, examining the focus of occupational health priorities within the global perspective is crucial.

• Journal of the Korean Data and Information Science Society
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• v.18 no.4
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• pp.1179-1189
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• 2007

In this paper, we estimate the proportion of individuals having health insurance in a given year for several small domains cross-classified by age, sex and other demographic characteristics using the data provided by the National Center for Health Statistics(NCHS). We employ Bayesian as well as frequentist methodology to obtain small domain estimates and the associated measures of precision. One of the new features of our study is that we utilize the survey weights along with the model to derive the small domain estimates.

• Women's Health Nursing
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• v.14 no.2
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• pp.83-92
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• 2008

Purpose: This study aimed to analyze the trends in nursing research on sexuality in Korea and to provide guidance to the future research in sexual health. Method: Total 163 published articles in Korea from 2000 to 2007 year were reviewed using a structured analysis form which consists of the domains of nursing journal, research designs, research purpose, research subjects, and the key words. Result: Of those articles, 25.8% was published in J. of Korean Academy of Women Health Nursing and 13.5% in J. of Korean Academy of Community Health Nursing. In terms of the research design, quantitative research methods were commonly used in 88.4% of them which only 6.1% used qualitative methods. The nursing process on purpose were classified assessment(86.3%), nursing intervention(11.3%), and nursing evaluation(2.5%); Most of subjects were early adults(35.3%), adolescents(27.9%), and adults(25.6%); The most frequently reported key words were classified into socio-psychological domain(33.5%), cognitive domain(25.6%), clinical domain(12.6%). Conclusion: Research on sexuality in nursing have been continued. The major key words were founded in socio-psychological and cognitive domains. It is recommended that more various subjects, research methodology, and various key words be investigated.

• Biomedical Science Letters
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• v.24 no.4
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• pp.430-434
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• 2018

Candida glabrata is the second most prevalent causative agent for candidiasis following C. albicans. The opportunistic yeast, C. glabrata, is able to cause the critical bloodstream infections in hospitalized patients. Conventional identification methods for yeasts are often time consuming and labor intensive. Therefore, recent studies on sequence-based identification have been conducted. Recently, sequencing the D1/D2 domain of the large subunit ribosomal RNA gene and the internal transcribed spacers (ITS) 1 and ITS2 regions of the ribosomal DNA has proven useful for DNA-based identification of most species of fungi. In the present study, therefore, fungal ITS and D1/D2 domain regions were targeted and analyzed by DNA sequencing for the accurate identification of C. glabrata clinical isolates. A total of 102 C. glabrata clinical isolates from various clinical samples including bloodstream, catheterized urine, bile and other body fluids were used in the study. The results of the DNA sequence analysis showed that the mean standard deviation of species identity percent score between ITS and D1/D2 domain regions was $97.8%{\pm}2.9$ and $99.7%{\pm}0.46$, respectively. These results revealed that the D1/D2 domain region might be a better target for identifying C. glabrata clinical isolates based on DNA sequences than the ITS1 and ITS2 regions. However, in order to evaluate the usefulness of D1/D2 domain region for species identification of all Candida species, other Candida species such as C. albicans, C. tropicalis, C. dubliniensis, and C. krusei should be verified in further studies additionally.

• Journal of Korean Academy of Nursing Administration
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• v.3 no.1
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• pp.107-118
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• 1997

This study was designed to obtain basic data for development of evaluation tool which would be needed to measure the outcome of general quality nursing care of individual patient. The purpose of this study was to analyze and classify the outcome indicators of quality nursing care. The 29 articles of quality nursing care and outcome measures were selected coveniently, and analyzed to classify the outcome indicators of quality nursing care using open coding method. The results of this study were as follows: 1. Quality nursing care was defined as level of excellence of nursing care to achieve good patient outcome. 2. The 6 domains of which were health status, satisfaction, self care, patient progress and prognosis, and compliance were identified in outcome indicators of quality nursing care 3. Seven indicators of health status domain which were perceived health status, quality of life, well-being, daily activities, physical-physiological status, psychoemotional status, and social role functioning were identified. 4. Two indicators of satifaction domain which were patient satisfaction and family satisfaction were identified. 5. Three indicators of self care domain which were skill, knowledge, and home management were identified. 6. Seven indicators of patient progress and prognosis domain which were change of clinical status, resolution of nursing diagnosis and problem, days of stay, dicahrge state, recovery state, survival were identified. 7. compliance with therapeutic direction compliance was identified as an indicator of compliance domain. 8. It was sugested that studies for development of evaluation tools for outcomes of quality nursing the results of this study could be executed