• BMB Reports
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• 제40권3호
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• pp.302-314
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• 2007

N type calcium channels (CaV2.2) play a key role in the gating of transmitter release at presynaptic nerve terminals. These channels are generally regarded as parts of a multimolecular complex that can modulate their open probability and ensure their location near the vesicle docking and fusion sites. However, the proteins that comprise this component remain poorly characterized. We have carried out the first open screen of presynaptic CaV2.2 complex members by an antibody-mediated capture of the channel from purified rat brain synaptosome lysate followed by mass spectroscopy. 589 unique peptides resulted in a high confidence match of 104 total proteins and 40 synaptosome proteome proteins. This screen identified several known CaV2.2 interacting proteins including syntaxin 1, VAMP, protein phosphatase 2A, $G_{o\alpha}$, G$\beta$ and spectrin and also a number of novel proteins, including clathrin, adaptin, dynamin, dynein, NSF and actin. The unexpected proteins were classified within a number of functional classes that include exocytosis, endocytosis, cytoplasmic matrix, modulators, chaperones, and cell-signaling molecules and this list was contrasted to previous reports that catalogue the synaptosome proteome. The failure to detect any postsynaptic density proteins suggests that the channel itself does not exhibit stable trans-synaptic attachments. Our results suggest that the channel is anchored to a cytoplasmic matrix related to the previously described particle web.

• Journal of Nutrition and Health
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• 제47권5호
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• pp.374-384
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• 2014

Purpose: Health professionals and policy makers confront the failure of provider-administered, conventional behavioral interventions in the fight against obesity epidemic. The aim of this study was to develop a tailored, cost-effective delivery system for a child obesity prevention and management program through technology convergence using Web-enabled smart cellular phones. Methods: Assessment of service needs and development of a delivery system for the program were based on a comprehensive literature review and expert reviews, and results from in-depth interviews and a need-assessment survey. Results: The user- and site-centered service delivery system using Web-enabled cellular telephones as the hardware platform for obesity prevention and management has been developed. A tailored informational service and intervention will be provided interactively between stakeholders through the platform. The potential legal issues associated with the service design have also been considered. Conclusion: The user-centered convergence design and platform based on principles of Transtheoretical Model and Stages of Change using the Health Promoting School framework could enable effective intervention and promote acceptance in the long-run.

• 동서간호학연구지
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• 제19권2호
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• pp.159-167
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• 2013

Purpose: The purpose of the study is to develop and to evaluate a internet-based social support program for the mothers of congenitally abnormal children. The theoretical basis of the study is the moderating effect model of social support theory (Cobb, 1976). Methods: In first phase, an internet support program was developed according to the practical web development stages proposed by Boling and Frick (2002). In the second phase, the internet support program was provided and evaluated to 18 mothers who reared congenitally abnormal children from March to May 2008. Results: In the first stage, demands of the program were collected from interviews of eighteen mothers of congenitally abnormal children of ages one to three. At the same time, literature review and validity of the contents were also examined. In the second stage, the correspondence of the program contents to the social support needed was also examined. In the third and fourth stages, prototype of the social program was prepared in documents and that of computer program was prepared. In the final stage, an internet-based web site was constructed. The social support provided by the web site were composed of informational support, emotional support and appraisal support including bulletin board system and chatting service. After program development, pre-tests and post-test were performed to investigate the effect of the program on maternal confidence and mood. Data were analyzed using Wilcoxon signed rank test. The analysis showed that maternal confidence of post-test was improved than that of pre-test with statistically meaningful figure (Z=-2.54, p<.05). The positive mood of post-test was also improved than that of pre-test and the result was statistically supported (Z=-2.20, p<.05). Conclusion: It is suggestive that the internet based social support programs is accessible and appropriate service to congenitally abnormal children's mother. It is necessary to develop and use the internet based social support programs in public health system.

• 환경위생공학
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• 제18권2호
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• pp.42-51
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• 2003

Public awareness of air pollution problem has increased the need for real time air pollution information system about changes in air pollution level. The purpose of this study is to construct e-AIR, a user-friendly air pollution information system for urban air quality using GIS(geographic information system) technology for windows. GIS was ideally suited featuring a geographical characteristics(e.g., road, traffics, buildings) and very effectively used in mapping and symbolization for the distribution of the spatial/periodic pollution status(e.g., pie or column chart, graduated symbols) which can be effectively applied to a information system on the web-site. And a user interface, GUI(graphic user interface) was designed very diversely and simply enabled the users connect with e-AIR and obtain a useful information of air quality. A interpretive technique, air pollution health index(e.g., PSI, AEI) was used also which transforms complex data on measured atmospheric pollutant concentrations into a single number or set of numbers in order to make the data more understandable. Eventually the final-step of this study was to construct e-AIR based on Web GIS could be assessed anywhere if internet is available and offer a very useful information services of the air pollution to the public like a weather news.

• Journal of Nutrition and Health
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• 제35권7호
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• pp.791-799
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• 2002

The performance of educational program for preventive nutrition is more beneficial for children than for the adults based on the cost reduction and the effect of this education. Also children's education helps them to grow and to live as a healthy adult. The purpose of this study is to solve the nutritional problem in children by developing nutrition education program for children and correct their nutritional problems. The characteristics of this program (www.food79.net) are the customized program for grade level based on the level of learning ability, the various education method such as game, cooking practice, and quiz, animation, and the self educated method by managing children's meal management as the result. The contents of this site are constructed not only for children but also for parents, the teachers and the school dietitians to increasing educational effect. The children room consists of food tower, nutrition kingdom, calculation of obesity index, food information, nutrient exploration, cooking world, and evaluation of dietary life. In the room for dietitian and teachers include the contents of the easy gymnastics, nutrition counseling methods, the teaching plans for nutrition education, and the information interchange corner. The third room for parents is constructed of nutrition evaluation, food 114, correction of living habits, and free discussion. Through this site, we are expecting to contribute to national health promotion by correcting the food habits of children.

• 동아시아식생활학회지
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• 제16권5호
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• pp.542-549
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• 2006

The purpose of this study was to develop a web site providing sound and specific diet and nutritional information for internet users in different age groups to protect themselves from junk nutritional information. Among 660 internal users (436 in their 20s, 154 in their 30s, and 63 in their 40s), 66.4% had access to a computer to get nutritional information. Almost 38% of those in their 20s searched in the internet using the term 'diet', whereas 25.9% of those in their 30s and 27.1% of those in their 40s searched using 'cooking and recipe'(p<0.001). The main purpose of using nutritional information on the internet of the subjects was 'to take care of health'(p<0.001). Seventy percent of subjects answered 'so-so' for the satisfaction about the content of nutritional information that was self-explored. Contents related to nutritional information which needed to be improved was 'sound information' for 47.2% of those in their 30s, 'convenience for the application to daily life' for 51.1% of those in their 20s, and 39.6% of those in their 40s. A specialized nutritional information site must to be developed for users to gain access to reliable and valuable information without difficulty, as the variety of the interested area and application area for each user.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.324-331
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• 2022

Prior abdominal liposuction can be viewed as a relative or absolute contraindication to abdominally based autologous breast reconstruction given concerns for damaged perforators and scarring complicating intraoperative dissection. This systematic review aims to explore the outcomes of abdominally based breast reconstruction in patients with a history of abdominal liposuction. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-guided literature search was conducted using PubMed, Scopus, and Web of Science from the earliest available date through June 2020. Deep inferior epigastric perforator, muscle-sparing transverse rectus abdominis musculocutaneous (TRAM), superficial inferior epigastric artery, and pedicled TRAM flaps were included for evaluation. Complications included total or partial flap loss, fat necrosis, seroma, delayed wound healing, and donor site complications. After inclusion criteria were applied, 336 non-duplicate articles were screened, yielding 11 for final review, representing 55 flaps in 43 patients. There was no instance of total flap loss, eight (14.5%) flaps developed partial loss or fat necrosis, three (5.4%) flaps had delayed wound healing, and two (4.6%) patients had donor site complications. Most authors (8/11) utilized some type of preoperative imaging. Doppler ultrasonography was the most used modality, and these patients had the lowest rate of partial flap loss or flap fat necrosis (8%), followed by those without any preoperative imaging (10%). In conclusion, this review supports that patients undergoing abdominally based autologous breast reconstruction with a history of abdominal liposuction are not at an increased risk of flap or donor site complications. Although preoperative imaging was common, it did not reliably decrease complications. Further prospective studies are needed to address the role of imaging in improving outcomes.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.496-507
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• 2001

An expert system for the diagnosis and indication of hypertension is implemented through HTML-based backward inference. HTML-based backward inference is performed using the hypertext function of HTML, and many HTML files, which are hyperlinked to each other based on the backward rules, should be prepared beforehand. The development and maintenance of the HTML files are conducted automatically using the decision graph. Still, the drawing and input of the decision graph is a time consuming and tedious job if it is done manually. So, automatic generator of the decision graph for the diagnosis and indication of hypertension was implemented. The HTML-based backward inference ensures accessibility, multimedia facilities, fast response, stability, easiness, and platform independency of the expert system. So, this research reveals that HTML-based inference approach can be used for many Web-based intelligent site with fast and stable performance.

• 대한한의학회지
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• 제31권2호
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• pp.64-70
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• 2010

Objective: This study aimed to construct an overview of health-related quality of life (HRQOL) scales for application in studies of traditional Korean medicine (TKM). Methods: We analyzed all HRQOL scales from the PROQOLID web site (www.proqolid.org) regarding to classification, application purposes, and translation to Korean version. We also searched clinical studies focused on "Quality of Life" using TKM. Results: A total of 660 HRQOL instruments were analyzed; 99 were for general condition while 559 were disease-specific. Twenty clinical studies for TKM were conduced using HRQOL scales. Conclusion: The adaptation of the international HRQOL instrument is strongly recommended in TKM-associated clinical study, and development of a TKM-specific HRQOL scale is needed for globalization of TKM.

• 여성건강간호학회지
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• 제8권2호
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• pp.222-231
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• 2002

This study was done to develop a digital textbook for students to use over the internet for maternity nursing practice. The textbook is not only for student nurses, but also for nurse midwives and nurses working in the maternity. The process used was as follows; 1. Existing educational media on maternity nursing were reviewed and examined. 2. Workshops and meetings were held to decide the most appropriate type of presentation. 3. The digital content including text, pictures, audios, and videos were developed using Macromedia Dreamweaver, Adobe Photoshop and Adobe Premier. 4.Revisions were made recursively as the content was previewed and implemented over the internet by professionals and the end-users. 5. A database of members and a web survey module were developed and posted. The clinical implication of a digital textbook over the internet is the possibility of using it to educate many student nurses throughout the country and to disseminate the content for whoever needs it in practice settings and facilities. Another implication is that this site stressed interactivity by developing member database and web survey. In conclusion, the study found this first trial of digital textbook to be a unique educational media for nursing skills practice. Further refinement of this media is strongly recommended.