• Journal of Preventive Medicine and Public Health
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• 제42권6호
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• pp.371-376
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• 2009

In this article, we reviewed the literature on risk assessment (RA) models with and without molecular genomic markers and the current utility of the markers in the pharmacogenetic field. Epidemiological risk assessment is applied using statistical models and equations established from current scientific knowledge of risk and disease. Several papers have reported that traditional RA tools have significant limitations in decision-making in management strategies for individuals as predictions of diseases and disease progression are inaccurate. Recently, the model added information on the genetic susceptibility factors that are expected to be most responsible for differences in individual risk. On the continuum of health care, from diagnosis to treatment, pharmacogenetics has been developed based on the accumulated knowledge of human genomic variation involving drug distribution and metabolism and the target of action, which has the potential to facilitate personalized medicine that can avoid therapeutic failure and serious side effects. There are many challenges for the applicability of genomic information in a clinical setting. Current uses of genetic markers for managing drug therapy and issues in the development of a valid biomarker in pharmacogenetics are discussed.

• 한국안전학회지
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• 제39권2호
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• pp.9-21
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• 2024

Static-electricity-induced fires and explosions persistently occur every year, averaging approximately 80 and 20 cases annually according to fire statistics provided by the National Fire Agency and industrial accident statistics provided by the Ministry of Employment and Labor, respectively. Despite the relatively low probabilities of these accidents, their potential risks are high. Consequently, effective risk assessment methodologies and accident investigation strategies are essential for efficiently managing static-electricity hazards in fire- and explosion-prone areas. Accordingly, this study aimed to identify the causal variables essential for accident investigations, thereby facilitating risk assessments and the implementation of effective recurrence prevention measures to mitigate static-electricity hazards in fire-and explosion-prone regions. To this end, industrial accident statistics recorded over the past decade (2012 to 2021) by the Ministry of Employment and Labor were analyzed to identify major fire and explosion incidents and related industrial accidents wherein static electricity was identified as a potential ignition source. Subsequently, relevant investigation reports (63 cases) were thoroughly analyzed. Based on the results of this analysis, existing electrostatic fire and explosion risk assessment techniques were refined and augmented. Moreover, factors essential for investigating electrostatic fire and explosion disasters were delineated, and the primary causal variables necessary for effective risk assessments and scientific investigations were derived.

• 한국산업보건학회지
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• 제26권3호
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• pp.267-276
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• 2016

Objectives: This study, aims to examine the distribution characteristics of asbestos-containing building materials; risk assessment and area of distribution of asbestos-containing building materials depending on year of construction; building materials; types of building materials; and usage in public buildings in order to create fundamental data for safe management of public buildings. Methods: The asbestos investigation was conducted by an asbestos research institution from March to May 2014, targeting 41 public buildings which were subject to asbestos investigation in South Chungcheong-do Province. With respect to 381 presumed asbestos-containing materials, an investigation was conducted into whether they contained asbestos, asbestos type, content, year of construction, and use in the building were examined, and a risk assessment was performed. Results: Asbestos-containing building materials were used in 35 buildings(85.4%). Among them, 31(88.6%) were public buildings. Asbestos was detected in 73% of 381 suspected asbestos-containing materials, which were mostly ceiling materials (85.2%). The older the buildings, the more they showed a tendency to have a significantly higher risk assessment score. The ratio of average area with asbestos-containing building materials to total floor area was 57.6%, 44.1%, and 17.8% for buildings built in the 1980s, 1990s, and 2000s, respectively. This showed a tendency to be significantly higher with the age of the building. Conclusions: From the results above, it can be concluded that with the age of the buildings, the risk assessment score and the ratio of average area with asbestos-containing building materials to total floor area became significantly higher. Given the concern about the exposure to asbestos of residents and civil petitioners, safety management of older public buildings and measures for dismantling and removal of asbestos-containing building materials should therefore be urgently established.

• 한국환경보건학회지
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• 제43권5호
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• pp.438-445
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• 2017

Objectives: The purpose of this study was to develop exposure factor data for the Korean child population, with a specific focus on behavior characteristics such as hand-to-mouth and object-to-mouth and an analysis of influential factors. Methods: We divided environments into two places, which were house/indoor and nursery. A total of 400 children (house/indoor) and a total of 162 children (nursery) were recruited from the cities of Seoul, Incheon, Daegu, and Gwangju. The children were divided into two groups. We conducted direct measurement by using one hour of videotaping alongside questionnaire surveys. This was performed to calculate behavior rates, such as how many children perform hand-to-mouth and object-to-mouth behaviors. Results: The respective average frequencies of hand-to-mouth and object-to-mouth were $0.8{\pm}2.23$ and $0.82{\pm}2.64contacts/hr$ for house/indoor. The respective average frequencies of hand-to-mouth and object-to-mouth were $2.87{\pm}4.63$ and $1.47{\pm}3.84contacts/hr$ in the nursery group. For the mouthing participants, the average frequencies of hand-to-mouth and object-to-mouth were 3.31 and 3.20 contacts/hr in house, and 4.80 and 3.26 in nursery. Compared to other countries such as the USA, the frequencies of hand-to-mouth and object-to-mouth behaviors found in this study were relatively lower. Conclusions: Children have the potential for exposure to toxic substances through non-dietary ingestion pathways by mouthing objects or their fingers. In this study, the mouthing frequency was relatively lower than that found in Western countries. This can be explained that mouthing behaviour may be affected by culture and lifestyle characteristics.

• Environmental Analysis Health and Toxicology
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• 제4권1_2호
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• pp.55-65
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• 1989

Nevertheless the serious environmental pollution in Korea has been discussed in concern with health effect, the significant effect are not determined easily. Toxicological method has been used to establish safe levels of exposure for environmental pollutants to have threshold health effect below which significant effects are unlikely to occur. However the conventional method cannot to establish safe levels of exposure for non-threshold pollutants have been used to express comprehensive pollution degree, not in detailed toxic effects. Acceptable exposure or risk levels are decides by policymakers who consider descriptions and estimates of risks together with social and economic benefits. This paper focuses on the concept development of risk assessment and describes some risks of environmental pollution based on the surveyed date in Korea. The current concepts of risk assessment in policy descisions can be explored and areas for possible improvement, given current scientific knowledge are identified. The experience of foreign countries can provide a realistic basis for evaluating the existing data of environmental pollutants. To improve the environmental quality, risk regulation should be managed as soon as possible in Korea.

• 한국대기환경학회지
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• 제12권5호
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• pp.567-576
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• 1996

Air pollution has been recognized for many years as a factor which heightens the risk of cancer. Extractable polycyclic organic matters in air particulates have been recognized as to have carcinogenic effects. This study examined the health risks posed by organic substances of air particulates in Seoul based on methodelogies that have been developed for conducting risk posed by organic substances of sir particulates in Seoul based on methodologies that have been developed for conducting risk assessment of complex -chemical-mixture. The data used in this study was obtained from air samples collected in a heavy traffic area of Seoul (Shinchon) from 1986 to 1994. The mean concentration of total supended pariculates was 158.0.mu.g/m/msup 3/, 5% of which is consisted of organic matter. The excess cancer risk from benzo(a)pyrene (BaP) was estimated to be 3.48.times.10$^{-6}$ by applying BaP unit risk estimates to the mean concentration. 8.74ng/m BaP equivalents of potency method was 1.0.times.10$^{-3}$ . The calculated risk from EOM were comparably higher than that from benzo(a)pyrene and exceeded the acceptable risk level.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.11.1-11.6
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• 2016

Objectives A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both domestic and international references, examined the chemical management system, working environment, level of exposure, and possible associated risks. This information may be utilized in the future to determine appropriate exposure levels in working environments. Methods Hazard assessment was performed using chemical hazard information obtained from international agencies, such as Organization for Economic Cooperation and Development-generated Screening Information Data Set and International Program on Chemical Safety. Information was obtained from surveys conducted by the Minister of Employment and Labor ("Survey on the work environment") and by the Ministry of Environment ("Survey on the circulation amount of chemicals"). Risk was determined according to exposure in workplaces and chemical hazard. Results In 229 workplaces over the country, 831 tons of DEHP have been used as plasticizers, insecticides, and ink solvent. Calculated 50% lethal dose values ranged from 14.2 to 50 g/kg, as determined via acute toxicity testing in rodents. Chronic carcinogenicity tests revealed cases of lung and liver degeneration, shrinkage of the testes, and liver cancer. The no-observed-adverse-effect level and the lowest-observed-adverse-effect level were determined to be 28.9 g/kg and 146.6 g/kg, respectively. The working environment assessment revealed the maximum exposure level to be $0.990mg/m^3$, as compared to the threshold exposure level of $5mg/m^3$. The relative risk of chronic toxicity and reproductive toxicity were 0.264 and 0.330, respectively, while the risk of carcinogenicity was 1.3, which is higher than the accepted safety value of one. Conclusions DEHP was identified as a carcinogen, and may be dangerous even at concentrations lower than the occupational exposure limit. Therefore, we suggest management of working environments, with exposure levels below $5mg/m^3$ and all workers utilizing local exhaust ventilation and respiratory protection when handling DEHP.

• 한국환경보건학회지
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• 제44권3호
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• pp.217-226
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• 2018

Objectives: Despite the positive effects of Off-site risk assessment (ORA) system such as prevention of chemical accidents, some problems have been constantly raised. The purpose of this study is to analyze the problems that have occurred through the implementation of the ORA system for the past three years and to suggest reasonable directions for improvement in the future. Methods: In order to identify the problems with the methodology and procedure of ORA system, we analyzed statutes, administrative rules and documents related to the ORA system. A survey of ORA reviewers in National Institute of Chemical Safety was conducted to investigate the weight of determinants considered when judging the level of total risk in ORA. Results: In this study, we found out the uncertainty of the estimation of the number of people in the impact range in the procedure of the risk assessment of individual handling facilities, the lack of quantitative risk analysis methods for environmental receptors, and the ambiguity of the criteria for the total risk. In addition to suggesting solutions to the problems mentioned above, we also, suggested a decision tree for total risk in ORA. Conclusion: We anticipate that the solutions including the systematic decision tree for total risk suggested will contribute to the smooth operation of the ORA system.

• 한국안전학회지
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• 제26권1호
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• pp.49-57
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• 2011

A questionnaire study was carried out to understand the status of performing the risk assessment of work-related musculoskeletal disorders(WMDSs), which is the employers' legal responsibility when the employees are involved in doing tasks with risk factors. Employers or managers from 340 companies and the representative employees from 250 companies participated in the survey. According to the participated employers and employees, 35.0~46.2% of companies had performed the first risk assessment before the end of 2005. However, it is presumed that the real condition might not be as much as the result, because most companies were very reluctant to took part in the survey. It was found that the type of business and size of the company are the main factors affecting the performance of the risk assessment in terms of the performing ratio, method, and so on. The participants were positive in the thought that the assessment would be helpful in preventing msuculoskeletal disorders, while there was a little difference between the employers and employees in the thought that the assessment would be helpful in finding the injuries in the early stage. It was found that it is necessary to modify and improve the definition and criteria of the tasks to be examined in the assessment.

• Journal of Preventive Medicine and Public Health
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• 제47권1호
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• pp.7-17
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• 2014

Risk assessment considers the situations and characteristics of the exposure environment and host. Various physiological variables of the human body reflects the characteristics of the population that can directly influence risk exposure. Therefore, identification of exposure factors based on the Korean population is required for appropriate risk assessment. It is expected that a handbook about general exposure factors will be used by professionals in many fields as well as the risk assessors of the health department. The process of developing the exposure factors handbook for the Korean population will be introduced in this article, with a specific focus on the general exposure factors including life expectancy, body weight, surface area, inhalation rates, amount of water intake, and soil ingestion targeting the Korean population. The researchers used national databases including the Life Table and the 2005 Time Use Survey from the National Statistical Office. The anthropometric study of size in Korea used the resources provided by the Korean Agency for Technology and Standards. In addition, direct measurement and questionnaire surveys of representative samples were performed to calculate the inhalation rate, drinking water intake, and soil ingestion.