• Molecules and Cells
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• v.44 no.3
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• pp.146-159
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• 2021

DNA methylation, and consequent down-regulation, of tumour suppressor genes occurs in response to epigenetic stimuli during cancer development. Similarly, human oncoviruses, including human papillomavirus (HPV), up-regulate and augment DNA methyltransferase (DNMT) and histone deacetylase (HDAC) activities, thereby decreasing tumour suppressor genes (TSGs) expression. Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1), an epigenetic regulator of DNA methylation, is overexpressed in HPV-induced cervical cancers. Here, we investigated the role of UHRF1 in cervical cancer by knocking down its expression in HeLa cells using lentiviral-encoded short hairpin (sh)RNA and performing cDNA microarrays. We detected significantly elevated expression of thioredoxin-interacting protein (TXNIP), a known TSG, in UHRF1-knockdown cells, and this gene is hypermethylated in cervical cancer tissue and cell lines, as indicated by whole-genome methylation analysis. Up-regulation of UHRF1 and decreased TXNIP were further detected in cervical cancer by western blot and immunohistochemistry and confirmed by Oncomine database analysis. Using chromatin immunoprecipitation, we identified the inverted CCAAT domain-containing UHRF1-binding site in the TXNIP promoter and demonstrated UHRF1 knockdown decreases UHRF1 promoter binding and enhances TXNIP expression through demethylation of this region. TXNIP promoter CpG methylation was further confirmed in cervical cancer tissue by pyrosequencing and methylation-specific polymerase chain reaction. Critically, down-regulation of UHRF1 by siRNA or UHRF1 antagonist (thymoquinone) induces cell cycle arrest and apoptosis, and ubiquitin-specific protease 7 (USP7), which stabilises and promotes UHRF1 function, is increased by HPV viral protein E6/E7 overexpression. These results indicate HPV might induce carcinogenesis through UHRF1-mediated TXNIP promoter methylation, thus suggesting a possible link between CpG methylation and cervical cancer.

• Journal of the Korea society of information convergence
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• v.8 no.1
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• pp.49-56
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• 2015

Health Medical Act contains the reponsibility of Nation about People's Right and Obligation and aim at promoting health and welfare of People. The old age officially means time when Health is weakened. To complete the social security it is on the one hand necessary to provide an elaborate system of coordination in the field of social security. It should be pursued on policy. Medical benefits should be comparatively analysed to have implications for the national legislation.

• Journal of Digital Convergence
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• v.13 no.8
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• pp.483-493
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• 2015

Industrialization and urbanization have caused health inequality between rural areas and cities. Health care in rural area is insufficient comparing to urban areas. This study examined the effects of social capital, Health Information, and medical communication factors on Health status in rural community using structural equation modeling. First, social capital has an effect on medical communication with physicians and medical communication impacts on health status. Second, health information orientation has an impact on health behavior and Internet health information. Lastly, health information orientation influenced by Internet health information as a mediator affects health status. As a whole, this study contributes to theoretical explanation about determinants of health status in communities by examining structural path of the effects of social factors and communication factors on health status in rural area.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.4
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• pp.333-339
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• 2014

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.01a
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• pp.45-46
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• 2021

의료영상이란 의료영상장비로부터 DICOM이라는 의료영상표준에 따라 저장되며, 의료영상관리 시스템인 PACS를 통해 관리된다. 이러한, 의료영상장비 ICT기술이 융합되어 급격하게 발전되고 있으며 다양한 의료영상장치가 개발되어지고 있다. 하지만, 기술력은 높아지고 있으나 개발된 의료영상장비로부터 촬영된 영상품질관리에 대한 문제점이 제기되고 있다. 이와 관련하여 다기관의 의료영상장비 개발과 해당 기기로부터 수집된 의료영상에 대한 품질을 관리할 필요성이 증가하고 있다. 따라서 코로나 19와 같은 상황에서 의료기기 개발 지원과 관리를 비대면 관리서비스 시스템 개발과 의료영상장치 개발 정도를 관리할 수 있을 뿐만 아니라 의료영상에 대한 품질까지 모니터링하여 및 개선 할 수 있는 시스템을 제안하고자 한다.

• Convergence Security Journal
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• v.22 no.3
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• pp.69-77
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• 2022

Globally, the medical field is growing very fast with technology development and convergence with ICT technology, and Precision Medicine using personal health information, genetic information, and clinical information is growing into a next-generation medical industry. Since Precision Medicine deals with individual health and life, the issues of personal information protection and health and medical information protection are emerging.Accordingly, this paper presents security improvements by domestic and foreign standards, laws, and systems in the cloud and medical field, and proposes a plan to protect healthcare and medicine information protection for safe Precision Medicine.

• Annual Conference of KIPS
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• 2020.11a
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• pp.45-46
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• 2020

최근 의료데이터의 표준화를 기반으로 다양한 임상연구가 국내외에서 활발하게 진행되고 있다. 그러나 대부분 개발기술이 임상현장에 적용되지 못하는 이유는 상이한 인프라로 인한 일관성있는 결가를 도출하지 못하는 문제점과 부족한 진단지표와 기준 그리고 충분하지 못한 기술적·임상적 검증이 문제가 되고 있다. 본 논문에서는 이러한 문제점을 해결하기위한 새로운 통합 플랫폼을 제안하고자 한다. 이를 위해서 임상데이터는 OHDSI의 OMOP-CDM으로 표준화되어야 하며, 이외에 의료영상 정보를 포함한다. 제안한 플랫폼은 표준화된 데이터를 통해 지속적인 자가 학습을 수행하며, 질환별 진단에 필요한 개발 도구와 분석 소프트웨어 도구를 통해 다양한 타겟 질환연구를 지원한다. 제안한 플랫폼은 질환에 대한 비침습적 진단을 위해 의료영상을 기반으로 데이터표준화을 기반으로하며, 이를통해 인공지능 기술을 개발하고 병원 정보시스템과 연계하여 임상현장에 실증을 통해 검증하고자 한다.

• Korean Medical Education Review
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• v.16 no.3
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• pp.141-146
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• 2014

This study focused on investigating the future medicine and health care industry paradigm shift and suggesting the right direction for the medical education system in order for students to be better prepared in the near future. Here, I will discuss four issues related to the future of medicine: Health 2.0, digital health, personalized medicine, and innovations of the public healthcare system. Every issue has lessons for medical education and teaching for students who major in health professions. However, it is obvious that the present is an important period of time as, currently, we are at an early stage in the future health care environment. Recently, there have been rapid transformations in various fields of medicine. Therefore, if we fail to lead medical education in the right direction, medical students will suffer from major problems in coping with these changes.

• Industry Promotion Research
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• v.7 no.3
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• pp.17-26
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• 2022

As the well-being mindset to keep our minds and bodies free and healthy more than anything else in the society we live in is spreading, the meaning of health care has become a key part of the 4th industrial revolution such as big data, IoT, AI, and block chain. The advancement of the advanced medical information service industry is being promoted by utilizing convergence technology. In digital healthcare, the development of intelligent information technology such as artificial intelligence, big data, and cloud is being promoted as a digital transformation of the traditional medical and healthcare industry. In addition, due to rapid development in the convergence of science and technology environment, various issues such as health, medical care, welfare, etc., have been gradually expanded due to social change. Therefore, in this study, first, the general meaning and current status of digital health care medical information is examined, and then, developmental tasks to activate digital health care medical information are analyzed and reviewed. The purpose of this article is to improve usability to fully pursue our human freedom.

• Journal of the Korea Convergence Society
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• v.8 no.1
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• pp.221-229
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• 2017

The purpose of this study is to identify the convergence factors affecting the unmet health needs of the indigent elderly. The data the study is the Korean medical panel of 2011 and the parameters belonging to each factors were selected based on the Anderson model. We analyzed the general characteristics using frequency analysis and the correlations between variables using cross analysis. Finally, logistic regression analysis was conducted to examine the factors affecting unmet health needs. The indigent elderly with no education and elementary school graduates were 1.5 times more likely to experience unmet health needs than the poverty elderly with high school graduates. The indigent elderly who does not work for income, who were employers and self-employeds were 1.5 times more likely to experience unmet health care need than unpaid family workers. The indigent elderly with disabilities in activites of daily living were 2.9 time more likely to experience unmet health care needs than the indigent elderly with no disability in activites of daily living. The results of this study confirm that the increase in the economic burden of medical care for the indigent elderly can lead to the unmet health needs.