• Title/Summary/Keyword: Harvard University

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NIR Fluorescence Imaging Systems with Optical Packaging Technology

  • Yang, Andrew Wootae;Cho, Sang Uk;Jeong, Myung Yung;Choi, Hak Soo
    • Journal of the Microelectronics and Packaging Society
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    • v.21 no.4
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    • pp.25-31
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    • 2014
  • Bioimaging has advanced the field of nanomedicine, drug delivery, and tissue engineering by directly visualizing the dynamic mechanism of diagnostic agents or therapeutic drugs in the body. In particular, wide-field, planar, near-infrared (NIR) fluorescence imaging has the potential to revolutionize human surgery by providing real-time image guidance to surgeons for target tissues to be resected and vital tissues to be preserved. In this review, we introduce the principles of NIR fluorescence imaging and analyze currently available NIR fluorescence imaging systems with special focus on optical source and packaging. We also introduce the evolution of the FLARE intraoperative imaging technology as an example for image-guided surgery.

Two Dimensional Electronic Spectroscopy

  • Fleming, Graham R.;Yang, Min-O;Agarwal, Ritesh;Prall, Bradley S.;Kaufman, Laura J.;Neuwahl, Fred
    • Bulletin of the Korean Chemical Society
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    • v.24 no.8
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    • pp.1081-1090
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    • 2003
  • Two different electronically resonant two-dimensional spectroscopies are described. The first, two-color photon echo peak shift spectroscopy, is sensitive to correlations in transition frequency between the initial and probed (final) states. It provides new insight into the mechanism of ultrafast solvation and should prove useful for characterizing dynamics in inhomogeneous systems in general. The second technique, fifth order threepulse scattering, contains two coherence periods whose durations are controlled. The entire two-dimensional surface was recorded for a dye molecule in dilute solution and a photosynthetic light-harvesting complex. The data provide insight into the short-time dynamics of solvation and exciton relaxation, respectively.

STRUCTURAL ANALYSIS OF RAPAMYCIN'S ROLE IN BINDING FKBP12 AND FRAP

  • Park, Jungwon;Jie Chen;Stuart Schreiber;Jon Clardy
    • Proceedings of the Korean Biophysical Society Conference
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    • 1996.07a
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    • pp.9-9
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    • 1996
  • The immunosuppressive and cell cycle arrest agent rapamycin works by binding together two proteins: the FK506 binding protein (FKBP12) and the FKBP-rapamycin associated protein (FRAP). A 2.7 $\AA$ resolution crystal structure of the triple complex of human FK506 binding protein (FKBP12), rapamycin, and FKBP12-rapamycin binding domain (FRB) of FRAP, reveals two proteins bound together through rapamycin' s ability to simultaneously occupy two different hydrophobic binding pockets. (omitted)

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An Analysis Of Entrepreneurship Programs at U.S. College and Universities: Focusing on Implications for Entrepreneurship Ecosystem of Korean Universities (미국 주요대학들의 창업 프로그램 분석: 한국 대학의 창업생태계 구축의 시사점 연구)

  • Lee, Tae Hyun;Kim, Hui Taek;Kim, Yoon Kyoung
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.10 no.1
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    • pp.175-185
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    • 2015
  • This article focuses on an analysis of entrepreneurship education programs at U.S. college and universities in order to determine distinctive features of those programs. To this end, we delved into the entrepreneurship programs including Martin Trust Center for MIT, Harvard University VIP program, Polsky Center of Chicago University and Stanford University program. By analyzing major roles, curriculums, and characteristics of the programs, three types of distinctive features emerged. The first feature is dynamic education-focused programs, which provide students with opportunities for applying what they have learned through startup competitions. The second is local-based programs, which take the lead in local startups by focusing on the local industry. The third is the programs with support and encouragement for startups. Based on the three types of features, we suggested critical factors for successful entrepreneurship education.

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