• 제목/요약/키워드: Harvard University

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Coexistence of Excessive Weight Gain and Celiac Disease in Children: An Unusual Familial Condition

  • Calcaterra, Valeria;Regalbuto, Corrado;Made, Alexandra;Magistrali, Mariasole;Leonard, Maureen M.;Cena, Hellas
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제22권4호
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    • pp.407-412
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    • 2019
  • Excessive weight gain in children diagnosed with celiac disease (CD) is becoming more common. We describe 2 siblings (9-year and 6 months-old female and 6-year and 9 months-old male) with obesity showing attenuated gastrointestinal and atypical symptoms in which CD was diagnosed in the absence of a known family history of CD. After children's diagnosis, CD in their parents was also investigated. It was detected in their father affected by overweight. The presentation of patients with CD has changed. While patients with overweight and obesity commonly have symptoms such as abdominal pain, reflux, headache, and constipation due to lifestyle factors, CD should also be considered in patients with or without a family history of CD. Careful nutritional status assessment and follow-up monitoring after the diagnosis of CD are mandatory, especially in subjects who are already overweight at the presentation of this disease.

What is the Role of Epidural Injections in the Treatment of Lumbar Discogenic Pain: A Systematic Review of Comparative Analysis with Fusion

  • Manchikanti, Laxmaiah;Staats, Peter S.;Nampiaparampil, Devi E.;Hirsch, Joshua A.
    • The Korean Journal of Pain
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    • 제28권2호
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    • pp.75-87
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    • 2015
  • Background: Lumbar discogenic pain without pain mediated by a disc herniation, facet joints, or the sacroiliac joints, is common and often results in chronic, persistent pain and disability. After conservative treatment failure, injection therapy, such as an epidural injection, is frequently the next step considered in managing discogenic pain. The objective of this systematic review is to determine the efficacy of lumbar epidural injections in managing discogenic pain without radiculopathy, and compare this approach to lumbar fusion or disc arthroplasty surgery. Methods: A systematic review of randomized trials published from 1966 through October 2014 of all types of epidural injections and lumbar fusion or disc arthroplasty in managing lumbar discogenic pain was performed with methodological quality assessment and grading of evidence. The level of evidence was based on the grading of evidence criteria which, was conducted using 5 levels of evidence ranging from levels I to V. Results: Based on a qualitative assessment of the evidence for both approaches, there is Level II evidence for epidural injections, either caudal or lumbar interlaminar. Conclusions: The available evidence suggests fluoroscopically directed epidural injections provide long-term improvement in back and lower extremity pain for patients with lumbar discogenic pain. There is also limited evidence showing the potential effectiveness of surgical interventions compared to nonsurgical treatments.

GABAergic neuronal development in the embryonic mesencephalon of mice

  • Kim, Mun-Ki;Lee, Si-Joon;Vasudevan, Anju;Won, Chung-Kil
    • 대한수의학회지
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    • 제59권4호
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    • pp.201-205
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    • 2019
  • This study presents neurogenesis and neuronal migration patterns of gamma-aminobutyric acid-ergic (GABAergic) neurons during mesencephalic development of mouse. After neurons from embryonic day (E) 10-16 were labelled by a single injection of 5-bromo-2'-deoxyuridine (BrdU), immunohistochemistry was performed. Neurogenesis were mainly generated in the mesencephalic region at E10 to E13. After E14, BrdU positive cells were observed only in the dorsal mesencephalon. GABAergic neurons were mainly originated in the ventrolateral region of the mesencephalon at the early embryonic stage, especially at E11 to E13. E10-labeled cells showed positive for GABAergic neuron in the basal plate of the mesencephalon at E13. At E15, GABAergic neurons were observed in the entire basal plate and some regions of the ventral and dorsal mesencephalon. They were present in the whole basal plate, the ventral and dorsal mesencephalon of E17, spreading more outward of the mesencephalon at P0. Our study demonstrates that major neurogenesis of GABAergic neurons occurs at E11 to E13. However, neuronal migration continues until neonatal period during mesencephalic development.

장기간의 계단운동 훈련이 심폐기능과 혈액화학상에 미치는 영향 (Effect of Long-term Step Exercise on the Cardiopulmonary Function and Blood Constituents)

  • 황상익;최명애;고창순
    • The Korean Journal of Physiology
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    • 제21권2호
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    • pp.305-311
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    • 1987
  • To evaluate training effect, the step exercise was loaded to three mem for nine weeks. Step score, cardiopulmonary functions and blood constituents were measured before, during and after the test exercise (50 cm-step exercise and treadmill running), and were compared with the pre-tranining values. The results were as follows: 1) By the training, Harvard step score increased remarkably, expecially in the early stage of training. 2) The post-training values of maximal oxygen uptake increased very significantly and it seemed to be due to increases of stroke volume and tissue oxygen extraction. 3) After the training, the degree of increase in expired volume was small during the treadmill exercise. 4) By the training, increasing rate of respiratory quotient lessened during the exercise and it was considered to be caused by the decreases of carbohydrate consumption and anaerobic metabolism. 5) The blood cholesterol concentrations were harldy changed with this degree of training. 6) The blood lactate level decreased during the recovery periods and the values of the recovery 0 and 5 minutes decreased remarkably, in comparison with the pre-trained values. The above results suggest that the 9 week-training of the step exercise brings about the enhancement of circulatory functions and tissue oxygen utilization, and changes of food-stuffs used during the exercise.

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온천천 시범구간의 자연형 복원공법의 Monitoring 조사 (Monitoring Survey of Natural Recovery Method at Oncheon Stream)

  • 서규우;송일준;김광섭
    • 한국습지학회지
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    • 제3권2호
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    • pp.133-142
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    • 2001
  • Growth of cities and an increase in population result in the development-oriented policy, urban streams to lose their natural characteristics and functions by channelization, parking lot construction, and so forth. The streams fall into urban drains, which is the current status of urban streams. Recently, the interest in the stream environment and the ecosystem has been increased, and the efforts have been made to improve the traditional maintenance program for small streams. These efforts lead to the application of the natural recovery systems. This study applied the 240-meter model reach along the Oncheon stream, which locates in Dongrae-gu, Busan city. to analyze the natural recovery system. The efficiency of each system has been analyzed and the future improvements for the systems are presented. The results show that the stream maintenance program should consider the ecological environment. thereby minimizing the environmental effects. When the changes are inevitable, the maintenance program should adopt the methods. which closely simulate the original environmental elements. or are more favorable to the ecosystem.

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일본·독일·미국의 산재보험 간병급여체계의 비고 (Comparison of the Personal Care Benefit System under Workers' Compensation in Japan, Germany, and the United States)

  • 전경자;김재영;최윤영;최은숙
    • 한국직업건강간호학회지
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    • 제16권1호
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    • pp.58-66
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    • 2007
  • Purpose: A national long-term care system for elderly and the disabled has its unique evolution in each country. Japan, Germany and the United States may be the typical examples of respective social insurance system. This paper reviews the counterpart examples of Japan, Germany and the United States and looks at their accumulated long-term care system experiences and personal care system under workers' compensation. Methods: Literature review and website searching were conducted. Key words as 'workers' compensation insurance', 'personal care benefit' and 'long term care' were used in searching the related literatures. Results: Though the personal care benefit under current Workers'Compensation in Korea is very similar to Japan's, the long-term care system of Korea is not as well established. Germany and the United States have the provision of personal care benefit for injured workers within long term care system. Conclusions: We recommend some key issues to take into account for improving personal care benefit system in workers' compensation in Korea as follows: providing a comprehensive coverage through the linkage of long term care, introducing an assessment & evaluation system for the appropriate benefits, establishing insurer's role for quality management of personal care service, and developing a policy for family caregivers.

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Orthognathic surgery and temporomandibular joint symptoms

  • Jung, Hwi-Dong;Kim, Sang Yoon;Park, Hyung-Sik;Jung, Young-Soo
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제37권
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    • pp.14.1-14.11
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    • 2015
  • The aim of this article is to review temporomandibular joint symptoms as well as the effects of orthognathic surgery(OGS) on temporomandibular joint(TMJ). The causes of temporomandibular joint disease(TMD) are multifactorial, and the symptoms of TMD manifest as a limited range of motion of mandible, pain in masticatory muscles and TMJ, Joint noise (clicking, popping, or crepitus), myofascial pain, and other functional limitations. Treatment must be started based on the proper diagnosis, and almost symptoms could be subsided by reversible options. Minimally invasive options and open arthroplasty are also available following reversible treatment when indicated. TMD manifesting in a variety of symptoms, also can apply abnormal stress to mandibular condyles and affect its growth pattern of mandible. Thus, adaptive developmental changes on mandibular condyles and post-developmental degenerative changes of mandibular condyles can create alteration on facial skeleton and occlusion. The changes of facial skeleton in DFD patients following OGS have an impact on TMJ, masticatory musculature, and surrounding soft tissues, and the changes of TMJ symptoms. Maxillofacial surgeons must remind that any surgical procedures involving mandibular osteotomy can directly affect TMJ symptoms, thus pre-existing TMJ symptoms and diagnoses should be considered prior to treatment planning and OGS.

Application of Representative $PM_{2.5}$ Source Profiles for the Chemical Mass Balance Study in Seoul

  • Kang, Choong-Min;Kang, Byung-Wook;SunWoo, Young;Lee, Hak-Sung
    • Journal of Korean Society for Atmospheric Environment
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    • 제24권E1호
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    • pp.32-43
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    • 2008
  • Source samples were collected to construct source profiles for 9 different source types, including soil, road dust, gasoline/diesel-powered vehicles, a municipal incinerator, industrial sources, agricultural/biomass burning, marine aerosol, and a coal-fired power plant. Seasonal profiles for 'Chinese aerosol', aerosols derived from the urban area of China, were reconstructed from seasonal $PM_{2.5}$ compositions reported in Beijing, China. Ambient $PM_{2.5}$ at a receptor site was also measured during each of the four seasons, from April 2001 to February 2002, in Seoul. The Chemical Mass Balance receptor model was applied to quantify source contributions during the study period using the estimated source profiles. Consequently, motor vehicle exhaust (33.0%), in particular 23.9% for diesel-powered vehicles, was the largest contributor affecting the $PM_{2.5}$ levels in Seoul, followed by agricultural/biomass burning (21.5%) and 'Chinese aerosol' (13.1%), indicating contributions from long-range transport. The largest contributors by season were: for spring, 'Chinese aerosol' (31.7%); for summer, motor vehicle exhaust (66.9%); and for fall and winter, agricultural/biomass burning (31.1% and 40.1%, respectively). These results show different seasonal patterns and sources affecting the $PM_{2.5}$ level in Seoul, than those previously reported for other cities in the world.

HCN(1-0) OBSERVATIONS OF STARLESS CORES

  • SOHN J,;LEE C, W,;LEE H, M.;PARK Y.-S.;MYERS P. C.;LEE Y.;TAFALLA M.
    • 천문학회지
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    • 제37권4호
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    • pp.261-263
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    • 2004
  • We present a progress report on HCN(1-0) line observations toward starless cores to probe inward motions. We have made a single pointing survey toward the central regions of 85 starless cores and performed mapping observations of 6 infall candidate starless cores. The distributions of the velocity difference between HCN(1-0) hyperfine lines and the optically thin tracer $N_2H^+$(1-0) are significantly skewed to the blue, meaning that HCN(1-0) frequently detects inward motions. Their skewness to the blue is even greater than that of CS(2-1) Lee et al., possibly implying more infall occurrence than CS(1-0). We identify 19 infall candidates by using several characteristics illustrating spectral infall asymmetry seen in HCN(1-0) hyperfine lines, CS(3-2), CS(2-1), $DCO^+(2-1)$ and $N_2H^+$ observations. The HCN(1-0) F(O-l) with the least optical depth usually shows a similar intensity distribution to that of $N_2H^+$ which closely traces the density distribution of the cores, indicating that HCN(1-0) is less chemically affected and so believed to reflect kinematics occurring in rather inner regions of the cores. Detailed radiative transfer model fits of the spectra are underway to analyze central infall kinematics in starless cores.

Adaptive Mode Switching in Correlated Multiple Antenna Cellular Networks

  • Lee, Chul-Han;Chae, Chan-Byoung;Vishwanath, Sriram;Heath, Jr., Robert W.
    • Journal of Communications and Networks
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    • 제11권3호
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    • pp.279-286
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    • 2009
  • This paper proposes an adaptive mode switching algorithm between two strategies in multiple antenna cellular networks:A single-user mode and a multi-user mode for the broadcast channel. If full channel state information is available at the base station, it is known that a multi user transmission strategy would outperform all single-user transmission strategies. In the absence of full side information, it is unclear what the capacity achieving method is, and thus there are few criteria to decide which of the myriad possible methods performs best given a system configuration. We compare a single user transmission and a multi user transmission with linear receivers in this paper where the transmitter and the receivers have multiple antennas, and find that neither strategy dom inates the other. There is instead a transition point between the two strategies. Then, the mode switching point is determined both ana lytically and numerically for a multiple antenna cellular downlink with correlation between transmit antennas.