• Journal of Microbiology and Biotechnology
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• v.28 no.10
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• pp.1635-1644
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• 2018

Asterias amurensis (starfish) is a marine organism that is harmful to the fishing industry, but is also a potential source of functional materials. The present study was conducted to analyze the profiles of fatty acids extracted from A. amurensis tissues and their anti-inflammatory effects on RAW264.7 macrophage cells. In different tissues, the component ratios of saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids differed; particularly, polyunsaturated fatty acids such as dihomo-gamma-linolenic acid (20:3n-6) and eicosapentaenoic acid (20:5n-3) were considerably different. In lipopolysaccharide-stimulated RAW264.7 cells, fatty acids from A. amurensis skin, gonads, and digestive glands exhibited anti-inflammatory activities by reducing nitric oxide production and inducing nitric oxide synthase gene expression. Asterias amurensis fatty acids effectively suppressed the expression of inflammatory cytokines such as tumor necrosis $factor-{\alpha}$, interleukin-$1{\beta}$, and interleukin-6 in lipopolysaccharide-stimulated cells. Cyclooxygenase-2 and prostaglandin $E_2$, which are critical inflammation biomarkers, were also significantly suppressed. Furthermore, A. amurensis fatty acids reduced the phosphorylation of nuclear $factor-{\kappa}B$ p-65, p38, extracellular signal-related kinase 1/2, and c-Jun N-terminal kinase, indicating that these fatty acids ameliorated inflammation through the nuclear $factor-{\kappa}B$ and mitogen-activated protein kinase pathways. These results provide insight into the anti-inflammatory mechanism of A. amurensis fatty acids on immune cells and suggest that the species is a potential source of anti-inflammatory molecules.

• Journal of Life Science
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• v.22 no.4
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• pp.565-568
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• 2012

There are various kinds of cereals used in sunsik manufacturing. Different harmful microorganisms that can contaminate these cereals have been reported. According to the different sizes of cereals used, black bean, black rice, and millet were artificially contaminated with Escherichia $Coli.$ $E.$ $coli$ contamination in cereal samples was detected after different washing steps under different conditions. The increase of washing time did not have any effect with regard to reducing $E.$ $coli$ in samples. Among several ratios between the washing solution and sample, 2:1 that have little influence to reduce $E.$ $coli$ contamination have been determined. The temperature of the washing solution is an influencing factor as well. Washing with solution at $40^{\circ}C$ could reduce 1 log of $E.$ $coli$ in samples. Among different concentrations of saline used as a washing solution, 5% could reduce 2~3 log $E.$ $coli$ in contaminated samples. However, the saline adds a salty taste to cereals when used during the washing step. To remove that, an extra washing step and large amount of washing solution are necessary in sunsik manufacturing.

• Safety and Health at Work
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• v.7 no.4
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• pp.317-321
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• 2016

Background: This study was conducted with aim of providing an overview of the current status of occupational health services and identifying the most common harmful agents at workplaces of Iranian self-employed enterprises (Nano-Scale Enterprises). Methods: A cross-sectional study was performed among a random sample including 1,758 employees engaging in self-employed enterprises with 5 and less employees. Results: Coverage of occupational health surveillance was very poor, annual health examinations were been conducted only for 64 (3.64%) of males and 31 (1.76%) of females, and occupational health trainings were not included of the services at all. Personal Protective Equipment were available in 462 (26.3%) of the enterprises. only in 0.4% of the enterprises working processes were been equipped by a local exhaust ventilation system. Difficult postures were the most common (81.5%) adverse working conditions. Conclusion: This study revealed a poor level of the implementation of occupational health services in Iranian self-employed enterprises. Based on the findings, providing basic training on the occupational health, more enforcing in conduction of health examinations and providing PPE, and taking appropriate strategies aimed at eliminating or minimizing work environment harmful agents are the major factor that should be considered to improve the level of occupational health services among the studied enterprises.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.30 no.1
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• pp.75-86
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• 2020

Objectives: In this study, we assessed respiratory hazards in the working environment as the work-relatedness of occupational diseases were examined. Methods: The subjects of the study were three Korean meat roasting restaurants, one Chinese restaurant, and two cafeterias. Measurement items were total dust, respirable dust, fine dust (PM_2.5), PAHs, TVOCs, temperature, humidity, carbon monoxide, carbon dioxide, and nitrogen dioxide. Results: The concentration of total dust and respiratory dust in the restaurant was low. Most PAHs were undetectable, but some Napthalene and Acenaphthylene was detected. Thirteen kinds of PAHs were detected in one sample of roasted meat, and Benzo(a)pyrene was 1.496 ㎍/㎥. PM_2.5, TVOCs, CO, and CO₂ were instantaneously high, but the average concentration was low. NO₂ was not detected. Conclusions: The results show that harmful substances such as PM_2.5, PAHs, CO, and TVOCs were generated in the air in the catering industry. When roasting meat, Benzo(a)pyrene, a carcinogen related to lung cancer, was generated among PAHs. Lung cancer can occur when working for a long time in such a working environment. Therefore, it is necessary to improve the working environment for the health of restaurant workers, and it is necessary to evaluate the concentration of harmful substances by cooking method through further research.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.3
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• pp.583-589
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• 2016

Volatile organic compounds(VOCs) are regarded as a harmful cause substance not only causing air pollutions but also causing global warming phenomenon. For this reason, VOCs are managed politically to reduce emissions by each country. In particular, the vapor from the gas station contains VOCs which is harmful to the human body such as carcinogens benzene and pollute the atmosphere, the Ministry of Environment defined every gas station must install vapor recovery equipment to recover volatile organic compounds. Recently, there are many accidents caused by existing vapor treatment methods, the liquefaction recovery technology is getting the spotlight to cool the vapor at the field. However, because the liquefaction recovery technology have risks of fire or explosion in accordance with temperature, the real time monitoring is critical factor. In this paper, we implement an Android-based monitoring application for liquified vapor recovery device which attached sensor module for temperature and power to monitoring real time information.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10841-10846
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• 2015

Background: Smoking is a primary risk factor for cancer development. While most research has focused on smoking cigarettes, the increasing popularity of shisha or water pipe smoking has received less attention. This study measured the prevalence and risk factors for shisha and cigarette smoking and related knowledge. Materials and Methods: This cross-sectional analytical study was conducted in Shah Alam, Malaysia. Participants aged ${\geq}18years$ were selected from restaurants. Data regarding demographic variables, smoking patterns, and knowledge about shisha smoking were collected in local languages. Logistic regression was performed to assess risk factors. Results: Of 239 participants, 61.9 % were male and 99.2% revealed their smoking status. Some 57.4% were smokers: 50.7% only cigarettes, 5.9% only shisha and 42% both. Mean age of starting cigarette smoking was $17.5{\pm}2.4years$ and for shisha smoking $18.7{\pm}2.0years$. In a univariate model, male gender, age 33-52 years and monthly income > MYR 4,000 increased the risk and unemployment and being a student decreased the risk. In a multivariate model, male gender increased the risk of smoking, while being a student decreased the risk, adjusting for age and income. The perception of shisha being less harmful than cigarettes was present in 14.6% and 7.5% had the opinion that shisha is not harmful at all, while 21.7% said that it is less addictive than cigarettes, 39.7% said that shisha did not contain tar and nicotine, 34.3% said that it did not contain carbon monoxide and 24.3% thought that shisha did not cause health problems. Conclusions: Prevalence of shisha and cigarette smoking is high in the general population in Malaysia and knowledge about shisha smoking is relatively low. The findings of our study might have implications for understanding similarities and differences in incidence of shisha and cigarette smoking in other cultural/geographic regions.

• Korean Journal of Human Ecology
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• v.17 no.6
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• pp.1215-1224
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• 2008

This research has measured the indoor environment of thirty hair salons, which are located on Gunsan-Si, Jeonlabbuk-Do, from April 1st to April 30th 2005, to examine the related factors on a work environment of hairdressers and a revelation of respiratory symptom, and has polled 260 hairdressers and 350 office workers. After measuring the physical environment of hair salons, the room temperature, the relative humidity and the illumination was in an agreeable range, and 60 percent of hair salons depended on the natural ventilation through the windows. The levels of acetone, toluene and xylene, which were measured at the hair salons, were all under the safety standards (p<0.05), but these are still harmful and volatile matters, so they can be bad for your health by the contact of skin and respiration. The harmful factors that affect a revelation of respiratory symptom were the group who has many exposures of permanent wave or bleaching/dyeing and not many experiences of hairdressing work, the group who smokes every day, and the group who never exercises at all (p<0.05). This result shows that there are possibilities of health problem for hairdressers from the constant and repeating hairdressing works with the exposure of chemicals such as the permanent, bleaching and dyeing. so that hairdressers recognize that they need appropriate ventilation facilities for their agreeable indoor-environments. And also, to prevent the direct exposure of chemicals as much as they can, they need to have an active management of an individual health care by wearing gloves, mask or something like that.

• Korean Journal of Environmental Biology
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• v.27 no.2
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• pp.140-145
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• 2009

All organisms are being exposed to harmful factors present in the environmental. The combined action of various factors is a distinguishing feature of modern life. An interaction between two chemicals is considered as synergistic when the effect produced is greater than the sum of the two single responses. The biological effects due to the combined action of ionizing radiation with the other factor are hard to estimate and predict in advance. In the current study, we investigated the synergistic effects between ionizing and $HgCl_2$ using fish hepatoma cells (PLHC-1 cells). The results showed a dramatic decrease of cell viability after simultaneous treatment of PLHC-1 cells with ionizing radiation and $HgCl_2$. Neiither of the two had any cytotoxic effect when treated alone. The cytotoxicity of ionizing radiation was enhanced in the presence of $HgCl_2$. The synergistic effects were observed after exposure of the PLHC-1 cells to ionizing radiation combined with $HgCl_2$. The synergistic interaction was due to an increase of irreversibly damaged cells after the combined exposure. Analysis of the extent of synergistic interaction enables to make quantitative estimation of irreversibly damaged cells after the combined exposure. The present study suggests that PLHC-1 cells can serve as rapid screening tools for detecting the toxicity of harmful factors.

• Korean Journal of Oriental Medicine
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• v.10 no.2
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• pp.37-49
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• 2004

In the existing Medical Literatures in Korea and China, there is neither the same book name nor same contents of the Medical Book named ${\ulcorner}$Yoryak(要略)${\lrcorner}$, but in viewing of the different name as written as ${\ulcorner}$GyoinYoryak(敎人要略)${\lrcorner}$, it is considered that written as an unpublished manuscript-book for the purpose of Medical Education in the latter period of Chosun Dynasty. While the author, Songgyesanin(松溪散人) is even anonymous as yet, it is regarded that he was much familiar with medical science as a secluded ascetic aiming for Taoism-like Life In ${\ulcorner}$Yoryak${\lrcorner}$, the contents of Taoism Literature named as ${\ulcorner}$OjangYukbudo(五臟六腑圖)${\lrcorner}$ which was regarded that had been actually initiated since ${\ulcorner}$Euibangyoochui(醫方類聚)${\lrcorner}$ is being quoted thereat, also it attempts to combine with ${\ulcorner}$DonguiBogam(東醫寶鑑)${\lrcorner}$, the typical Medical Literature of Chosun Dynasty. With reference to Cause of Disease, since Chin Moo-Taek(陳無擇) asserted 'Theory of Three-Causes(三因說)' in his Book ${\ulcorner}$Samin Keukilbyungjeung Bangron(三因極一病證方論)${\lrcorner}$, it effects many influences to the coming generation, However, on coming up to ${\ulcorner}$Yoryak${\lrcorner}$, the medical science book of Chosun Dynasty, the 'Theory of Two-Causes(二因說)' which consisted of 'Internal Causes by Seven Emotions' and 'Exterior Causes by Six Harmful Surroundings' is also being asserted. In accordance with this Theory, it refers to the 'Seven Emotions(七情)' as the fundamental factor to possibly weaken the viscera and entrails, and also regards that the Exterior Harmful Surroundings invade to body when the viscera and entrails are under weakened condition. Therefore, since Cause of Disease naming as 'Cause Theory at Neither Interior Nor Exterior' is not tolerable in such Diagnostic System, it is daringly advocating the 'Two Causes Theory', getting free from the viewpoint of 'Three Causes Theory' that Chin Moo-Taek has ever maintained.

• Safety and Health at Work
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• v.11 no.4
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• pp.543-549
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• 2020

Background: The working conditions of bus drivers are difficult; they lead to occupational diseases and require careful study, particularly in Ukraine. The objective of the article is the description of occupational health risks of passenger bus drivers that lead to deteriorating health. Methods: The risk assessment was performed using a modified Risk Score method, which allowed determining the generalized level of danger to the driver's health. The hygienic hazards level was assessed as based on Stevenson's law, which was generalized later. Results: Based on the modification of the Risk Score method, it was possible to depart from expert assessments method of the risk level and calculate the general indicator based on the degree of dependence of the impact on the human body on its intensity, proposed by V. Minko. This allows objective determining of the impact of hygiene hazards on the health of the driver and to predict the occurrence of occupational diseases associated with the cardiovascular system, musculoskeletal system, and partial or complete disability due to the accumulation of emotional fatigue. The hazard assessment was carried out for three brands of passenger buses common in Ukraine, in which the driver is exposed to the dangers of fever, vibration, noise, harmful impurities in the bus cabin, and emotional load. Conclusion: The health of drivers in the cabins of passenger buses is most affected by hygiene hazards: fever, vibration, and emotional stress. The generalized level of risk is calculated by the modified method of Risk Score is 0.83; -0.99, -0.92 respectively.